A Veves

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint A randomized, controlled trial of Promogran (a collagen/oxidized regenerated cellulose dressing) vs standard treatment in the management of diabetic foot ulcers
    Aristidis Veves
    Joslin Beth Israel Deaconess Foot Center, One Deaconess Rd, Boston, MA 02215, USA
    Arch Surg 137:822-7. 2002
  2. ncbi request reprint Graftskin, a human skin equivalent, is effective in the management of noninfected neuropathic diabetic foot ulcers: a prospective randomized multicenter clinical trial
    A Veves
    Joslin Beth Israel Deaconess Foot Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Diabetes Care 24:290-5. 2001
  3. ncbi request reprint Topical methyl nicotinate-induced skin vasodilation in diabetic neuropathy
    Antonella Caselli
    Joslin Beth Israel Deaconess Foot Center, Department of Surgery, Microcirculation Laboratory, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Diabetes Complications 17:205-10. 2003
  4. ncbi request reprint Endothelial dysfunction and the expression of endothelial nitric oxide synthetase in diabetic neuropathy, vascular disease, and foot ulceration
    A Veves
    Department of Medicine, Microcirculation Lab, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Diabetes 47:457-63. 1998
  5. ncbi request reprint Contribution of nerve-axon reflex-related vasodilation to the total skin vasodilation in diabetic patients with and without neuropathy
    O Hamdy
    Clinical Research Center, Department of Surgery, Harvard Medical School, Boston, Massachusetts 02215, USA
    Diabetes Care 24:344-9. 2001
  6. ncbi request reprint Aerobic exercise capacity remains normal despite impaired endothelial function in the micro- and macrocirculation of physically active IDDM patients
    A Veves
    Department of Medicine, Deaconess Joslin Foot Center, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Diabetes 46:1846-52. 1997
  7. ncbi request reprint Role of C-nociceptive fibers in the nerve axon reflex-related vasodilation in diabetes
    A Caselli
    Joslin Beth Israel Deaconess Foot Center, Department of Surgery, Microcirculation Laboratory, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Neurology 60:297-300. 2003
  8. ncbi request reprint Microcirculation of the diabetic foot
    T Dinh
    Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Curr Pharm Des 11:2301-9. 2005
  9. ncbi request reprint Role of neuropathy and high foot pressures in diabetic foot ulceration
    R G Frykberg
    Deaconess Joslin Foot Center, Beth Israel Deaconess Medical Center, Division of Podiatry, Harvard Medical School, Boston, Massachusetts 02215, USA
    Diabetes Care 21:1714-9. 1998
  10. pmc Pilot study of the effects of bariatric surgery and continuous positive airway pressure treatment on vascular function in obese subjects with obstructive sleep apnoea
    J P Bakker
    Division of Sleep Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Intern Med J 43:993-8. 2013

Collaborators

Detail Information

Publications44

  1. ncbi request reprint A randomized, controlled trial of Promogran (a collagen/oxidized regenerated cellulose dressing) vs standard treatment in the management of diabetic foot ulcers
    Aristidis Veves
    Joslin Beth Israel Deaconess Foot Center, One Deaconess Rd, Boston, MA 02215, USA
    Arch Surg 137:822-7. 2002
    ..Promogran, a wound dressing consisting of collagen and oxidized regenerated cellulose, is more effective that standard care in treating chronic diabetic plantar ulcers...
  2. ncbi request reprint Graftskin, a human skin equivalent, is effective in the management of noninfected neuropathic diabetic foot ulcers: a prospective randomized multicenter clinical trial
    A Veves
    Joslin Beth Israel Deaconess Foot Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Diabetes Care 24:290-5. 2001
    ..We assessed in a randomized prospective trial the effectiveness of Graftskin, a living skin equivalent, in treating noninfected nonischemic chronic plantar diabetic foot ulcers...
  3. ncbi request reprint Topical methyl nicotinate-induced skin vasodilation in diabetic neuropathy
    Antonella Caselli
    Joslin Beth Israel Deaconess Foot Center, Department of Surgery, Microcirculation Laboratory, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Diabetes Complications 17:205-10. 2003
    ....
  4. ncbi request reprint Endothelial dysfunction and the expression of endothelial nitric oxide synthetase in diabetic neuropathy, vascular disease, and foot ulceration
    A Veves
    Department of Medicine, Microcirculation Lab, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Diabetes 47:457-63. 1998
    ..Reduced expression of ecNOS may be a major contributing factor for endothelial dysfunction. These data provide support for a close association of neuropathy and microcirculation in the pathogenesis of foot ulceration...
  5. ncbi request reprint Contribution of nerve-axon reflex-related vasodilation to the total skin vasodilation in diabetic patients with and without neuropathy
    O Hamdy
    Clinical Research Center, Department of Surgery, Harvard Medical School, Boston, Massachusetts 02215, USA
    Diabetes Care 24:344-9. 2001
    ..Acetylcholine and sodium nitroprusside cause vasodilation in the skin microcirculation through different pathways...
  6. ncbi request reprint Aerobic exercise capacity remains normal despite impaired endothelial function in the micro- and macrocirculation of physically active IDDM patients
    A Veves
    Department of Medicine, Deaconess Joslin Foot Center, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Diabetes 46:1846-52. 1997
    ..In addition, regular exercise training involving the lower extremities does not improve the endothelial function in the micro- and macrocirculation of the nonexercised upper extremity in type 1 diabetic patients...
  7. ncbi request reprint Role of C-nociceptive fibers in the nerve axon reflex-related vasodilation in diabetes
    A Caselli
    Joslin Beth Israel Deaconess Foot Center, Department of Surgery, Microcirculation Laboratory, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Neurology 60:297-300. 2003
    ..To evaluate the role of the C-nociceptive nerve fibers in nerve axon reflex-related vasodilation...
  8. ncbi request reprint Microcirculation of the diabetic foot
    T Dinh
    Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Curr Pharm Des 11:2301-9. 2005
    ..Furthermore, these changes appear to be directly related to the presence of diabetic neuropathy. These alterations in the diabetic microcirculation may explain the poor wound healing commonly observed in diabetes...
  9. ncbi request reprint Role of neuropathy and high foot pressures in diabetic foot ulceration
    R G Frykberg
    Deaconess Joslin Foot Center, Beth Israel Deaconess Medical Center, Division of Podiatry, Harvard Medical School, Boston, Massachusetts 02215, USA
    Diabetes Care 21:1714-9. 1998
    ..The objective of this study was therefore to ascertain the risk of ulceration associated with high foot pressures and peripheral neuropathy in a large and diverse diabetic population...
  10. pmc Pilot study of the effects of bariatric surgery and continuous positive airway pressure treatment on vascular function in obese subjects with obstructive sleep apnoea
    J P Bakker
    Division of Sleep Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Intern Med J 43:993-8. 2013
    ..The mechanisms by which obesity and obstructive sleep apnoea (OSA) may contribute to endothelial dysfunction are unclear...
  11. ncbi request reprint Diabetes enhances vulnerability to particulate air pollution-associated impairment in vascular reactivity and endothelial function
    Marie S O'Neill
    Department of Environmental Health, Harvard School of Public Health, Boston, Mass, USA
    Circulation 111:2913-20. 2005
    ..We examined whether endothelium-dependent and -independent vascular reactivity was associated with particle exposure in individuals with and without diabetes...
  12. ncbi request reprint Troglitazone-induced changes in adiponectin do not affect endothelial function in diabetes
    Jon Buras
    Microcirculation Laboratory, Palmer 317, West Campus, Beth Israel Deaconess Medical Center, One Deaconess Road, Boston, MA 02215, USA
    Obes Res 13:1167-74. 2005
    ..We have examined the relationship between the increase in adiponectin levels that is associated with troglitazone treatment and endothelium-dependent vasodilation in type 2 diabetic patients...
  13. ncbi request reprint Circulating adiponectin and resistin levels in relation to metabolic factors, inflammatory markers, and vascular reactivity in diabetic patients and subjects at risk for diabetes
    Greeshma K Shetty
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Diabetes Care 27:2450-7. 2004
    ....
  14. pmc Foot small muscle atrophy is present before the detection of clinical neuropathy
    Robert L Greenman
    Department of Radiology, Beth Israel Deaconess Medical Center, 330 Brookline Rd, Boston, MA 02115, USA
    Diabetes Care 28:1425-30. 2005
    ....
  15. ncbi request reprint Valsartan improves resting skin blood flow in type 2 diabetic patients and reduces poly(adenosine diphosphate-ribose) polymerase activation
    Gautam Shrikhande
    Immunobiology Research Center and Division of Vascular Surgery, Harvard Medical School, Boston, Massachusetts
    J Vasc Surg 43:760-70; discussion 770-1. 2006
    ..To examine the effect of a 12-week daily treatment with 160 mg of valsartan, an angiotensin II receptor blocker, on the microcirculation and macrocirculation of type 2 diabetic patients (T2DM) and healthy subjects...
  16. ncbi request reprint The efficacy of Apligraf in the treatment of diabetic foot ulcers
    Thanh L Dinh
    Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Mass, USA
    Plast Reconstr Surg 117:152S-157S; discussion 158S-159S. 2006
    ..Studies have demonstrated that Apligraf works through the delivery of growth factors and cytokines to the chronic wound environment...
  17. ncbi request reprint Microvascular changes in the diabetic foot
    Jordan C Schramm
    Microcirculation, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Int J Low Extrem Wounds 5:149-59. 2006
    ..Further studies are necessary to clarify the precise etiology of endothelial and smooth muscle dysfunction in diabetic patients so that potential therapeutic interventions may be identified...
  18. ncbi request reprint Talactoferrin alfa, a recombinant human lactoferrin promotes healing of diabetic neuropathic ulcers: a phase 1/2 clinical study
    Thomas E Lyons
    Beth Israel Deaconess Medical Center and Harvard Medical School, Palmer 321 A, West Campus, Boston, MA 02215, USA
    Am J Surg 193:49-54. 2007
    ..Talactoferrin alfa, a recombinant form of human lactoferrin, is a novel immunomodulatory protein with demonstrated ulcer healing properties in animal models...
  19. ncbi request reprint Treatment of diabetic ulcers
    Thanh L Dinh
    Division of Podiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Dermatol Ther 19:348-55. 2006
    ..Judicious use of advanced wound care products may provide the best means of treating these challenging wounds in an efficient and cost-effective way...
  20. ncbi request reprint Guidelines for the treatment of diabetic ulcers
    David L Steed
    University of Pittsburgh UPMC, Pittsburgh, PA, USA
    Wound Repair Regen 14:680-92. 2006
  21. ncbi request reprint The use of medical hyperspectral technology to evaluate microcirculatory changes in diabetic foot ulcers and to predict clinical outcomes
    Lalita Khaodhiar
    Joslin Beth Israel Deaconess Foot Center and Microcirculation Laboratory, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Diabetes Care 30:903-10. 2007
    ..We tested the ability of medical hyperspectral technology (HT), a novel diagnostic scanning technique that can quantify tissue oxy- and deoxyhemoglobin to predict diabetic foot ulcer healing...
  22. ncbi request reprint Early changes in the skin microcirculation and muscle metabolism of the diabetic foot
    Robert L Greenman
    Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Lancet 366:1711-7. 2005
    ..We investigated whether oxygen delivery and muscle metabolism of the lower extremity were factors in diabetic foot disease...
  23. ncbi request reprint Kidney oxygenation during water diuresis and endothelial function in patients with type 2 diabetes and subjects at risk to develop diabetes
    Panayiotis A Economides
    Joslin Diabetes Center, Boston, MA, USA
    Metabolism 53:222-7. 2004
    ..Water diuresis failed to produce an improvement in renal medullary oxygenation in both patients with diabetes and subjects at risk for diabetes...
  24. ncbi request reprint The effects of atorvastatin on endothelial function in diabetic patients and subjects at risk for type 2 diabetes
    Panayiotis A Economides
    Joslin Diabetes Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston Massachusetts 02215, USA
    J Clin Endocrinol Metab 89:740-7. 2004
    ..27 ng/ml (7-41 ng/ml) at baseline; P < 0.05] were observed. We conclude that atorvastatin improves endothelial function and decreases levels of markers of endothelial activation and inflammation...
  25. ncbi request reprint Cutaneous microcirculation in the neuropathic diabetic foot improves significantly but not completely after successful lower extremity revascularization
    Subodh Arora
    George Washington University Medical Center and Veterans Affairs Medical Center, Washington, DC, USA
    J Vasc Surg 35:501-5. 2002
    ..The purpose of this study was the examination of the effect of successful large vessel revascularization on the microcirculation of the neuroischemic diabetic foot...
  26. ncbi request reprint A prospective, randomized, controlled double-blind study of a moisturizer for xerosis of the feet in patients with diabetes
    Hau Trung Pham
    Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Mass, USA
    Ostomy Wound Manage 48:30-6. 2002
    ..The cream containing 10% urea and 4% lactic acid provided faster and better improvement with significantly less xerosis regression...
  27. ncbi request reprint The effect of aspirin and various iontophoresis solution vehicles on skin microvascular reactivity
    Karim Abou-Elenin
    Clinical Research Center, Joslin Diabetes Center, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    Microvasc Res 63:91-5. 2002
    ..In addition, a NaCl solution would be preferable to deionized water as the iontophoresis solution vehicle...
  28. ncbi request reprint Poly(ADP-Ribose) polymerase is activated in subjects at risk of developing type 2 diabetes and is associated with impaired vascular reactivity
    Csaba Szabo
    Institute of Human Physiology and Clinical Experimental Research, Semmelweis University, Budapest, Hungary
    Circulation 106:2680-6. 2002
    ....
  29. ncbi request reprint Effect of diabetes on renal medullary oxygenation during water diuresis
    Franklin H Epstein
    Department of Medicine, Beth Israel Deaconess Medical Center, Joslin Diabetes Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Diabetes Care 25:575-8. 2002
    ..To study the effect of water diuresis on renal medullary and cortical oxygenation in patients with diabetes using blood oxygenation level--dependent magnetic resonance imaging (BOLD MRI)...
  30. ncbi request reprint Lifestyle modification improves endothelial function in obese subjects with the insulin resistance syndrome
    Osama Hamdy
    Clinical Research Center, Joslin Diabetes Center, The Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    Diabetes Care 26:2119-25. 2003
    ..We also measured plasma levels of soluble intercellular adhesion molecule (sICAM), vascular adhesion molecule, von Willebrand factor, plasminogen activator inhibitor-1 (PAI-1) antigen, and tissue plasminogen activator antigen...
  31. ncbi request reprint Local anesthesia reduces the maximal skin vasodilation during iontophoresis of sodium nitroprusside and heating
    Antonella Caselli
    Joslin Beth Israel Deaconess Foot Center, Department of Surgery, Microcirculation Laboratory, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Microvasc Res 66:134-9. 2003
    ..To evaluate the effect of local anesthesia on the skin vasodilation induced by the iontophoresis of sodium nitroprusside and heating...
  32. ncbi request reprint Diabetic neuropathy and microcirculation
    Chantel Hile
    Microcirculation Laboratory, Palmer 317, Beth Israel Deaconess Medical Center, One Deaconess Road, Boston, MA 02215, USA
    Curr Diab Rep 3:446-51. 2003
    ..This renders the diabetic foot unable to mount a vasodilatory response under conditions of stress, such as injury, and makes it functionally ischemic even in the presence of satisfactory blood flow under normal conditions...
  33. ncbi request reprint Percent change in wound area of diabetic foot ulcers over a 4-week period is a robust predictor of complete healing in a 12-week prospective trial
    Peter Sheehan
    Diabetes Foot and Ankle Center, Hospital for Joint Diseases Orthopaedic Institute, New York University School of Medicine, New York, New York, USA
    Diabetes Care 26:1879-82. 2003
    ..To assess the ability of the 4-week healing rate to predict complete healing over a 12-week period in a large prospective multicenter trial of diabetic patients with foot ulceration...
  34. doi request reprint Guidelines for the prevention of diabetic ulcers
    David L Steed
    University of Pittsburgh UPMC, Pittsburgh, Pennsylvania, USA
    Wound Repair Regen 16:169-74. 2008
  35. ncbi request reprint Research profile. Foot ulcer risk. The role of circulation.
    Terri Kordella
    Diabetes Forecast 57:79-80, 82. 2004
  36. ncbi request reprint Antioxidants and CVD in diabetes: where do we stand now
    Susie Yim
    Microcirculation Laboratory, Palmer 321A, Beth Israel Deaconess Medical Center, West Campus, One Deaconess Road, Boston, MA, 02215, USA
    Curr Diab Rep 7:8-13. 2007
    ..Therefore, treatment with antioxidants cannot be currently recommended as a therapeutic option...
  37. ncbi request reprint The forefoot-to-rearfoot plantar pressure ratio is increased in severe diabetic neuropathy and can predict foot ulceration
    Antonella Caselli
    Joslin Beth Israel Deaconess Foot Center, Harvard Medical School, Department of Surgery, Boston, Massachusetts 02215, USA
    Diabetes Care 25:1066-71. 2002
    ..The aim of the present study was to evaluate both the relationship between forefoot and rearfoot plantar pressure in diabetic patients with different degrees of peripheral neuropathy and their role in ulcer development...
  38. ncbi request reprint Enhancing sensation in diabetic neuropathic foot with mechanical noise
    Lalita Khaodhiar
    Department of Medicine, Joslin Beth Israel Deaconess Foot Center and Microcirculation Laboratory, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Diabetes Care 26:3280-3. 2003
    ..This phenomenon is termed stochastic resonance (SR). In this study, we examined the effect of SR on vibratory and tactile sensation in patients with moderate to severe diabetic peripheral neuropathy...
  39. ncbi request reprint The effect of vitamin E on endothelial function of micro- and macrocirculation and left ventricular function in type 1 and type 2 diabetic patients
    Panayiotis A Economides
    Microcirculation Laboratory, Palmer 317, BIDMC West, 1 Deaconess Rd, Boston, MA 02215, USA
    Diabetes 54:204-11. 2005
    ..Because vitamin E-treated patients had a worsening in some vascular reactivity measurements when compared with control subjects, the use of high dosages of vitamin E cannot be recommended...
  40. ncbi request reprint The effects of troglitazone, an insulin-sensitizing agent, on the endothelial function in early and late type 2 diabetes: a placebo-controlled randomized clinical trial
    A Enrique Caballero
    Joslin Diabetes Center, Microcirculation Laboratory, Division of Vascular Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Metabolism 52:173-80. 2003
    ..This improvement was strongly associated with the improvement of fasting plasma insulin concentrations...
  41. ncbi request reprint Acute and prolonged effects of sildenafil on brachial artery flow-mediated dilatation in type 2 diabetes
    Lalita Khaodhiar
    Diabetes Care 26:962-3; author reply 963. 2003
  42. ncbi request reprint Noise-enhanced balance control in patients with diabetes and patients with stroke
    Attila A Priplata
    Center for BioDynamics and Department of Biomedical Engineering, Boston University, 44 Cummington Street, Boston, MA 02215, USA
    Ann Neurol 59:4-12. 2006
    ..Sway data of 12 healthy elderly subjects from a previous study on vibrating insoles were added for comparison...
  43. ncbi request reprint A review of the mechanisms implicated in the pathogenesis of the diabetic foot
    Thanh L Dinh
    Division of Podiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Int J Low Extrem Wounds 4:154-9. 2005
    ..It is essential to understand the pathogenesis of foot ulcers so that appropriate treatments may be developed...
  44. ncbi request reprint Elevated plasma levels of the atherogenic mediator soluble CD40 ligand in diabetic patients: a novel target of thiazolidinediones
    Nerea Varo
    Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Ave, Boston, Mass 02115, USA
    Circulation 107:2664-9. 2003
    ..This study therefore evaluated the hypothesis that diabetic patients have elevated plasma levels of soluble CD40L (sCD40L) and that treatment with the insulin-sensitizing thiazolidinediones lowers this index of inflammation...