Kevin J Verstrepen
Affiliation: Harvard University
- Flocculation, adhesion and biofilm formation in yeastsKevin J Verstrepen
Harvard University Bauer Center for Genomics Research, 7 Divinity Avenue, Room 104, Cambridge, MA 02138, USA
Mol Microbiol 60:5-15. 2006..These aspects of fungal adhesion exemplify the impressive phenotypic plasticity of yeasts, allowing them to adapt quickly to stressful environments and exploit new opportunities...
- Unstable tandem repeats in promoters confer transcriptional evolvabilityMarcelo D Vinces
FAS Center for Systems Biology, Harvard University, 52 Oxford Street, Cambridge, MA 02138, USA
Science 324:1213-6. 2009..Tandem repeats are variable elements in promoters that may facilitate evolutionary tuning of gene expression by affecting local chromatin structure...
- FLO1 is a variable green beard gene that drives biofilm-like cooperation in budding yeastScott Smukalla
FAS Center for Systems Biology, Harvard University, Northwest Labs, Cambridge, MA 02138, USA
Cell 135:726-37. 2008..Moreover, FLO1 is highly variable among strains both in expression and in sequence, suggesting that flocculation in S. cerevisiae is a dynamic, rapidly evolving social trait...
- Genes with internal repeats require the THO complex for transcriptionVladimir Voynov
Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA
Proc Natl Acad Sci U S A 103:14423-8. 2006..The Tho- defect in transcription is suppressed by overexpression of topoisomerase I, suggesting that the THO complex functions to rectify aberrant structures that arise during transcription...
- Glucose and sucrose: hazardous fast-food for industrial yeast?Kevin J Verstrepen
MIT Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA
Trends Biotechnol 22:531-7. 2004..Alternatively, avoiding unnecessary exposure to glucose and sucrose could also improve the performance of industrial yeasts...
- Intragenic tandem repeats generate functional variabilityKevin J Verstrepen
Whitehead Institute for Biomedical Research Massachusetts Institute of Technology, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA
Nat Genet 37:986-90. 2005..We propose that variation in intragenic repeat number provides the functional diversity of cell surface antigens that, in fungi and other pathogens, allows rapid adaptation to the environment and elusion of the host immune system...
- Rapid expansion and functional divergence of subtelomeric gene families in yeastsChris A Brown
Faculty of Arts and Sciences Center for Systems Biology, Harvard University, 52 Oxford Street, Cambridge, MA 02138, USA
Curr Biol 20:895-903. 2010..However, most genome sequences do not contain assembled subtelomeric sequences, and, as a result, subtelomeres are often overlooked in comparative genomics...
- Origins of variation in the fungal cell surfaceKevin J Verstrepen
Whitehead Institute for Biomedical Research MIT, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
Nat Rev Microbiol 2:533-40. 2004
- Sequence-based estimation of minisatellite and microsatellite repeat variabilityMatthieu Legendre
FAS Center for Systems Biology, Harvard University, Cambridge, Massachusetts 02138, USA
Genome Res 17:1787-96. 2007..Our analysis indicates that tandem repeats used for genotyping should have a VARscore between 1 and 3. SERV is publicly available from http://hulsweb1.cgr.harvard.edu/SERV/...
- Using the SERV Applet to Detect Tandem Repeats in DNA Sequences and to Predict Their VariabilityMatthieu Legendre
FAS Center for Systems Biology, Harvard University, Cambridge, MA 02138, USA
CSH Protoc 2008:pdb.ip50. 2008..Hence, it can be used to select repeats that are suitable markers for genotyping or interesting candidates for functional studies...
- Flavour formation in fungi: characterisation of KlAtf, the Kluyveromyces lactis orthologue of the Saccharomyces cerevisiae alcohol acetyltransferases Atf1 and Atf2Stijn D M Van Laere
Centre for Malting and Brewing Science, Centre for Food and Microbial Technology, Department of Microbial and Molecular Systems, Katholieke Universiteit Leuven, Kasteelpark Arenberg 22, 3001 Leuven Heverlee, Belgium
Appl Microbiol Biotechnol 78:783-92. 2008..cerevisiae ATF2 and K. lactis ATF overexpression only caused a moderate increase in acetate esters. This study is the first report of the presence of an ester synthesis gene in K. lactis...
- Isolation and characterization of brewer's yeast variants with improved fermentation performance under high-gravity conditionsLies Blieck
Laboratory of Molecular Cell Biology, Institute of Botany and Microbiology, Katholieke Universiteit Leuven, Belgium
Appl Environ Microbiol 73:815-24. 2007..The results are of interest to the beer and bioethanol industries, where the use of more-concentrated medium is economically advantageous...
- Controlled expression of homologous genes by genomic promoter replacement in the yeast Saccharomyces cerevisiaeKevin J Verstrepen
Leiden Amsterdam Center for Drug Research, Leiden University, The Netherlands
Methods Mol Biol 267:259-66. 2004....
- The Saccharomyces cerevisiae alcohol acetyl transferase gene ATF1 is a target of the cAMP/PKA and FGM nutrient-signalling pathwaysKevin J Verstrepen
Centre for Malting and Brewing Science, Department of Food and Microbial Technology, K U Leuven, Kasteelpark Arenberg 22, 3001 Heverlee, Leuven, Belgium
FEMS Yeast Res 4:285-96. 2003..In addition, the complex regulation provides new insights into the physiological role of Atf1p in yeast...