Kevin J Verstrepen

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Flocculation, adhesion and biofilm formation in yeasts
    Kevin J Verstrepen
    Harvard University Bauer Center for Genomics Research, 7 Divinity Avenue, Room 104, Cambridge, MA 02138, USA
    Mol Microbiol 60:5-15. 2006
  2. pmc Unstable tandem repeats in promoters confer transcriptional evolvability
    Marcelo D Vinces
    FAS Center for Systems Biology, Harvard University, 52 Oxford Street, Cambridge, MA 02138, USA
    Science 324:1213-6. 2009
  3. pmc FLO1 is a variable green beard gene that drives biofilm-like cooperation in budding yeast
    Scott Smukalla
    FAS Center for Systems Biology, Harvard University, Northwest Labs, Cambridge, MA 02138, USA
    Cell 135:726-37. 2008
  4. pmc Genes with internal repeats require the THO complex for transcription
    Vladimir Voynov
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 103:14423-8. 2006
  5. ncbi request reprint Glucose and sucrose: hazardous fast-food for industrial yeast?
    Kevin J Verstrepen
    MIT Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA
    Trends Biotechnol 22:531-7. 2004
  6. pmc Intragenic tandem repeats generate functional variability
    Kevin J Verstrepen
    Whitehead Institute for Biomedical Research Massachusetts Institute of Technology, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nat Genet 37:986-90. 2005
  7. pmc Rapid expansion and functional divergence of subtelomeric gene families in yeasts
    Chris A Brown
    Faculty of Arts and Sciences Center for Systems Biology, Harvard University, 52 Oxford Street, Cambridge, MA 02138, USA
    Curr Biol 20:895-903. 2010
  8. ncbi request reprint Origins of variation in the fungal cell surface
    Kevin J Verstrepen
    Whitehead Institute for Biomedical Research MIT, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nat Rev Microbiol 2:533-40. 2004
  9. pmc Sequence-based estimation of minisatellite and microsatellite repeat variability
    Matthieu Legendre
    FAS Center for Systems Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Genome Res 17:1787-96. 2007
  10. doi request reprint Using the SERV Applet to Detect Tandem Repeats in DNA Sequences and to Predict Their Variability
    Matthieu Legendre
    FAS Center for Systems Biology, Harvard University, Cambridge, MA 02138, USA
    CSH Protoc 2008:pdb.ip50. 2008

Collaborators

Detail Information

Publications14

  1. ncbi request reprint Flocculation, adhesion and biofilm formation in yeasts
    Kevin J Verstrepen
    Harvard University Bauer Center for Genomics Research, 7 Divinity Avenue, Room 104, Cambridge, MA 02138, USA
    Mol Microbiol 60:5-15. 2006
    ..These aspects of fungal adhesion exemplify the impressive phenotypic plasticity of yeasts, allowing them to adapt quickly to stressful environments and exploit new opportunities...
  2. pmc Unstable tandem repeats in promoters confer transcriptional evolvability
    Marcelo D Vinces
    FAS Center for Systems Biology, Harvard University, 52 Oxford Street, Cambridge, MA 02138, USA
    Science 324:1213-6. 2009
    ..Tandem repeats are variable elements in promoters that may facilitate evolutionary tuning of gene expression by affecting local chromatin structure...
  3. pmc FLO1 is a variable green beard gene that drives biofilm-like cooperation in budding yeast
    Scott Smukalla
    FAS Center for Systems Biology, Harvard University, Northwest Labs, Cambridge, MA 02138, USA
    Cell 135:726-37. 2008
    ..Moreover, FLO1 is highly variable among strains both in expression and in sequence, suggesting that flocculation in S. cerevisiae is a dynamic, rapidly evolving social trait...
  4. pmc Genes with internal repeats require the THO complex for transcription
    Vladimir Voynov
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 103:14423-8. 2006
    ..The Tho- defect in transcription is suppressed by overexpression of topoisomerase I, suggesting that the THO complex functions to rectify aberrant structures that arise during transcription...
  5. ncbi request reprint Glucose and sucrose: hazardous fast-food for industrial yeast?
    Kevin J Verstrepen
    MIT Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA
    Trends Biotechnol 22:531-7. 2004
    ..Alternatively, avoiding unnecessary exposure to glucose and sucrose could also improve the performance of industrial yeasts...
  6. pmc Intragenic tandem repeats generate functional variability
    Kevin J Verstrepen
    Whitehead Institute for Biomedical Research Massachusetts Institute of Technology, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nat Genet 37:986-90. 2005
    ..We propose that variation in intragenic repeat number provides the functional diversity of cell surface antigens that, in fungi and other pathogens, allows rapid adaptation to the environment and elusion of the host immune system...
  7. pmc Rapid expansion and functional divergence of subtelomeric gene families in yeasts
    Chris A Brown
    Faculty of Arts and Sciences Center for Systems Biology, Harvard University, 52 Oxford Street, Cambridge, MA 02138, USA
    Curr Biol 20:895-903. 2010
    ..However, most genome sequences do not contain assembled subtelomeric sequences, and, as a result, subtelomeres are often overlooked in comparative genomics...
  8. ncbi request reprint Origins of variation in the fungal cell surface
    Kevin J Verstrepen
    Whitehead Institute for Biomedical Research MIT, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nat Rev Microbiol 2:533-40. 2004
  9. pmc Sequence-based estimation of minisatellite and microsatellite repeat variability
    Matthieu Legendre
    FAS Center for Systems Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Genome Res 17:1787-96. 2007
    ..Our analysis indicates that tandem repeats used for genotyping should have a VARscore between 1 and 3. SERV is publicly available from http://hulsweb1.cgr.harvard.edu/SERV/...
  10. doi request reprint Using the SERV Applet to Detect Tandem Repeats in DNA Sequences and to Predict Their Variability
    Matthieu Legendre
    FAS Center for Systems Biology, Harvard University, Cambridge, MA 02138, USA
    CSH Protoc 2008:pdb.ip50. 2008
    ..Hence, it can be used to select repeats that are suitable markers for genotyping or interesting candidates for functional studies...
  11. doi request reprint Flavour formation in fungi: characterisation of KlAtf, the Kluyveromyces lactis orthologue of the Saccharomyces cerevisiae alcohol acetyltransferases Atf1 and Atf2
    Stijn D M Van Laere
    Centre for Malting and Brewing Science, Centre for Food and Microbial Technology, Department of Microbial and Molecular Systems, Katholieke Universiteit Leuven, Kasteelpark Arenberg 22, 3001 Leuven Heverlee, Belgium
    Appl Microbiol Biotechnol 78:783-92. 2008
    ..cerevisiae ATF2 and K. lactis ATF overexpression only caused a moderate increase in acetate esters. This study is the first report of the presence of an ester synthesis gene in K. lactis...
  12. pmc Isolation and characterization of brewer's yeast variants with improved fermentation performance under high-gravity conditions
    Lies Blieck
    Laboratory of Molecular Cell Biology, Institute of Botany and Microbiology, Katholieke Universiteit Leuven, Belgium
    Appl Environ Microbiol 73:815-24. 2007
    ..The results are of interest to the beer and bioethanol industries, where the use of more-concentrated medium is economically advantageous...
  13. ncbi request reprint Controlled expression of homologous genes by genomic promoter replacement in the yeast Saccharomyces cerevisiae
    Kevin J Verstrepen
    Leiden Amsterdam Center for Drug Research, Leiden University, The Netherlands
    Methods Mol Biol 267:259-66. 2004
    ....
  14. ncbi request reprint The Saccharomyces cerevisiae alcohol acetyl transferase gene ATF1 is a target of the cAMP/PKA and FGM nutrient-signalling pathways
    Kevin J Verstrepen
    Centre for Malting and Brewing Science, Department of Food and Microbial Technology, K U Leuven, Kasteelpark Arenberg 22, 3001 Heverlee, Leuven, Belgium
    FEMS Yeast Res 4:285-96. 2003
    ..In addition, the complex regulation provides new insights into the physiological role of Atf1p in yeast...