Patrick Vavken

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. doi request reprint [Outcomes after minimally invasive total knee replacement--a meta-analysis]
    P Vavken
    Department of Orthopedic Surgery, Children s Hospital Boston, Harvard Medical School, Massachusetts, USA
    Z Orthop Unfall 146:768-72. 2008
  2. pmc A systematic review of conflicting meta-analyses in orthopaedic surgery
    Patrick Vavken
    Department of Orthopedic Surgery, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Clin Orthop Relat Res 467:2723-35. 2009
  3. pmc Prophylaxis of heterotopic ossification of the hip: systematic review and meta-analysis
    Patrick Vavken
    Department of Orthopedic Surgery, Children s Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Enders 1016, Boston, MA 02115, USA
    Clin Orthop Relat Res 467:3283-9. 2009
  4. pmc Fibrin concentration affects ACL fibroblast proliferation and collagen synthesis
    Patrick Vavken
    Department of Orthopedic Surgery, Children s Hospital Boston, Harvard Medical School, Boston, MA, USA
    Knee 18:42-6. 2011
  5. pmc Substitutes of structural and non-structural autologous bone grafts in hindfoot arthrodeses and osteotomies: a systematic review
    Marc Andreas Müller
    Orthopedic Department University Hospital Basel, Spitalstrasse 21, Basel, 4031, Switzerland
    BMC Musculoskelet Disord 14:59. 2013
  6. doi request reprint Treating patella instability in skeletally immature patients
    Patrick Vavken
    Department of Orthopaedic Surgery, University Hospital Basel, Basel, Switzerland Department of Orthopaedic Surgery, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, U S A Harvard Center for Population and Development Studies, Harvard School of Public Health, Boston, Massachusetts, U S A Electronic address
    Arthroscopy 29:1410-22. 2013
  7. doi request reprint Rates of radiolucency and loosening after total shoulder arthroplasty with pegged or keeled glenoid components
    Patrick Vavken
    Department of Orthopedic Surgery, Children s Hospital Boston, 300 Longwood Avenue, Enders 260, Boston, MA 02115 E mail address
    J Bone Joint Surg Am 95:215-21. 2013
  8. pmc Effects of suture choice on biomechanics and physeal status after bioenhanced anterior cruciate ligament repair in skeletally immature patients: a large-animal study
    Patrick Vavken
    Sports Medicine Research Laboratory, Department of Orthopedic Surgery, Children s Hospital Boston, Harvard Medical School, Massachusetts, USA
    Arthroscopy 29:122-32. 2013
  9. doi request reprint Modeling the "minimally invasive surgery effect" in total joint replacement
    Patrick Vavken
    Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Surg Innov 18:268-78. 2011
  10. pmc Infraglenoidal scapular notching in reverse total shoulder replacement: a prospective series of 60 cases and systematic review of the literature
    Patrick Sadoghi
    Department of Orthopaedic Surgery, Ludwig Maximilians University Munich, Campus Grosshadern, Marchioninistrasse 15, 81377 Munich, Germany
    BMC Musculoskelet Disord 12:101. 2011

Collaborators

Detail Information

Publications39

  1. doi request reprint [Outcomes after minimally invasive total knee replacement--a meta-analysis]
    P Vavken
    Department of Orthopedic Surgery, Children s Hospital Boston, Harvard Medical School, Massachusetts, USA
    Z Orthop Unfall 146:768-72. 2008
    ..A systematic review of randomised controlled trials reporting on the comparison of minimally invasive total knee replacement and standard incision technique was carried out...
  2. pmc A systematic review of conflicting meta-analyses in orthopaedic surgery
    Patrick Vavken
    Department of Orthopedic Surgery, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Clin Orthop Relat Res 467:2723-35. 2009
    ..Thus conclusions and interpretations from meta-analyses should be scrutinized as critically as those from any other type of study and subjected to reassessment if deemed necessary...
  3. pmc Prophylaxis of heterotopic ossification of the hip: systematic review and meta-analysis
    Patrick Vavken
    Department of Orthopedic Surgery, Children s Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Enders 1016, Boston, MA 02115, USA
    Clin Orthop Relat Res 467:3283-9. 2009
    ..79 (95% confidence interval, 0.45-1.41), and, again, was independent of the aforementioned factors. We found no evidence for a statistically significant or clinically important difference between NSAIDs or radiation in preventing HO...
  4. pmc Fibrin concentration affects ACL fibroblast proliferation and collagen synthesis
    Patrick Vavken
    Department of Orthopedic Surgery, Children s Hospital Boston, Harvard Medical School, Boston, MA, USA
    Knee 18:42-6. 2011
    ..To enhance cell behavior and thus clinical results fibrin applications should build on physiologic or sub-physiologic concentrations, and those with higher concentrations, such as currently available sealants, should be used cautiously...
  5. pmc Substitutes of structural and non-structural autologous bone grafts in hindfoot arthrodeses and osteotomies: a systematic review
    Marc Andreas Müller
    Orthopedic Department University Hospital Basel, Spitalstrasse 21, Basel, 4031, Switzerland
    BMC Musculoskelet Disord 14:59. 2013
    ..However, their efficacy is unclear.The primary goal of this systematic review was to compare autologous bone grafts with structural and non-structural substitutes regarding the odds of union in hindfoot arthrodeses and osteotomies...
  6. doi request reprint Treating patella instability in skeletally immature patients
    Patrick Vavken
    Department of Orthopaedic Surgery, University Hospital Basel, Basel, Switzerland Department of Orthopaedic Surgery, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, U S A Harvard Center for Population and Development Studies, Harvard School of Public Health, Boston, Massachusetts, U S A Electronic address
    Arthroscopy 29:1410-22. 2013
    ..The purpose of this study was to comprehensively and systematically review the current evidence for orthopaedic treatment of immature and adolescent patients with acute and chronic patellar instability...
  7. doi request reprint Rates of radiolucency and loosening after total shoulder arthroplasty with pegged or keeled glenoid components
    Patrick Vavken
    Department of Orthopedic Surgery, Children s Hospital Boston, 300 Longwood Avenue, Enders 260, Boston, MA 02115 E mail address
    J Bone Joint Surg Am 95:215-21. 2013
    ..The objective of this study was to conduct a meta-analysis and cost-effectiveness analysis of the effect of glenoid design on radiolucency, loosening, and revision after total shoulder arthroplasty...
  8. pmc Effects of suture choice on biomechanics and physeal status after bioenhanced anterior cruciate ligament repair in skeletally immature patients: a large-animal study
    Patrick Vavken
    Sports Medicine Research Laboratory, Department of Orthopedic Surgery, Children s Hospital Boston, Harvard Medical School, Massachusetts, USA
    Arthroscopy 29:122-32. 2013
    ....
  9. doi request reprint Modeling the "minimally invasive surgery effect" in total joint replacement
    Patrick Vavken
    Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Surg Innov 18:268-78. 2011
    ..This study aimed at assessing what the common effects of MIS are in all clinical trials/studies...
  10. pmc Infraglenoidal scapular notching in reverse total shoulder replacement: a prospective series of 60 cases and systematic review of the literature
    Patrick Sadoghi
    Department of Orthopaedic Surgery, Ludwig Maximilians University Munich, Campus Grosshadern, Marchioninistrasse 15, 81377 Munich, Germany
    BMC Musculoskelet Disord 12:101. 2011
    ..We hypothesized that subjective instability and clinical outcome after implantation of RTSA correlates with objective scapular notching...
  11. pmc VEGF receptor mRNA expression by ACL fibroblasts is associated with functional healing of the ACL
    Patrick Vavken
    Department of Orthopedic Surgery, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Knee Surg Sports Traumatol Arthrosc 19:1675-82. 2011
    ..The purpose of this study was to test (1) whether the strength of a tissue-engineered ACL repair is associated with VEGF receptors' mRNA expression of ACL cells and (2) whether age influences this association...
  12. doi request reprint Economic evaluation of NSAID and radiation to prevent heterotopic ossification after hip surgery
    Patrick Vavken
    Department of Orthopedic Surgery, Children s Hospital Boston, Harvard Medical School, MA 02115, USA
    Arch Orthop Trauma Surg 131:1309-15. 2011
    ..While the literature focuses almost exclusively on (as it turns out the lacking) difference in effectiveness, one important difference that has been widely unacknowledged thus far is cost-effectiveness...
  13. doi request reprint Burden of musculoskeletal disease and its determination by urbanicity, socioeconomic status, age, and sex: Results from 14,507 subjects
    Patrick Vavken
    Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    Arthritis Care Res (Hoboken) 63:1558-64. 2011
    ..The availability of reliable estimates of the burden of musculoskeletal disease is of considerable importance for policymakers...
  14. pmc Rationale for and methods of superiority, noninferiority, or equivalence designs in orthopaedic, controlled trials
    Patrick Vavken
    Department of Orthopedic Surgery, Children s Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Enders 1016, Boston, MA 02115, USA
    Clin Orthop Relat Res 469:2645-53. 2011
    ..It is important to equip the reader of the orthopaedic literature with the knowledge to understand and critically evaluate the methods and findings of trials attempting to establish superiority, noninferiority, and equivalence...
  15. doi request reprint The prevalence and effect of publication bias in orthopaedic meta-analyses
    Patrick Vavken
    Department of Orthopedic Surgery, Children s Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Enders 1016, Boston, MA 02115, USA
    J Orthop Sci 16:238-44. 2011
    ....
  16. pmc The effect of platelet concentrates on graft maturation and graft-bone interface healing in anterior cruciate ligament reconstruction in human patients: a systematic review of controlled trials
    Patrick Vavken
    Sports Medicine Research Laboratory, Department of Orthopedic Surgery, Children s Hospital Boston, Harvard Medical School, Cambridge, Massachusetts 02115, USA
    Arthroscopy 27:1573-83. 2011
    ....
  17. doi request reprint An in vitro model of biomaterial-augmented microfracture including chondrocyte-progenitor cell interaction
    Patrick Vavken
    Sports Medicine Research Laboratory, Department of Orthopedic Surgery, Children s Hospital Boston, Harvard Medical School, 300 Longwood Avenue Enders 1016, Boston, MA 02115, USA
    Arch Orthop Trauma Surg 130:711-6. 2010
    ....
  18. pmc Age dependence of expression of growth factor receptors in porcine ACL fibroblasts
    Patrick Vavken
    Sports Medicine Research Laboratory, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Orthop Res 28:1107-12. 2010
    ..These findings suggest that the decrease in growth factor receptor expression as a likely reason for reduced PRP action with increasing age...
  19. pmc The use of confidence intervals in reporting orthopaedic research findings
    Patrick Vavken
    Department of Orthopedic Surgery, Children s Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Enders 1016, Boston, MA 02115, USA
    Clin Orthop Relat Res 467:3334-9. 2009
    ..Confidence intervals could help avoid such erroneous interpretation by showing the effect size explicitly...
  20. doi request reprint Effectiveness of pulsed electromagnetic field therapy in the management of osteoarthritis of the knee: a meta-analysis of randomized controlled trials
    Patrick Vavken
    Department of Orthopedic Surgery, Children s Hospital Boston, 300 Longwood Avenue, Enders 1016, Boston, MA 02115, USA
    J Rehabil Med 41:406-11. 2009
    ..To assess the effectiveness of pulsed electromagnetic fields compared with placebo in the management of osteoarthritis of the knee...
  21. pmc TRITON-X is most effective among three decellularization agents for ACL tissue engineering
    Patrick Vavken
    Sports Medicine Research Laboratory, Department of Orthopedic Surgery, Children s Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Enders 1016, Boston, Massachusetts 02115, USA
    J Orthop Res 27:1612-8. 2009
    ..Porcine ACL tissue after decellularization with TRITON-X could be successfully reseeded with human ACL fibroblasts as demonstrated by steady DNA content and increasing pro-collagen expression...
  22. doi request reprint [Introduction to methods of economic modelling: a primer for orthopaedic surgeons and traumatologists]
    P Vavken
    Department of Orthopedic Surgery, Children s Hospital Boston, Harvard Medical School, 300 Longwood Ave, Boston, MA 02115, USA
    Z Orthop Unfall 147:419-23. 2009
    ..This report presents the basics of economic evaluation to orthopaedic surgeons to facilitate informed discussion...
  23. pmc Treating anterior cruciate ligament tears in skeletally immature patients
    Patrick Vavken
    Sports Medicine Research Laboratory, Department of Orthopedic Surgery, Children s Hospital Boston, Harvard Medical School, 300 Longwood Ave, Boston, MA 02115, USA
    Arthroscopy 27:704-16. 2011
    ..To systematically review the current evidence for conservative and surgical treatment of anterior cruciate ligament (ACL) tears in skeletally immature patients...
  24. pmc Reduced platelet concentration does not harm PRP effectiveness for ACL repair in a porcine in vivo model
    Ashley N Mastrangelo
    Department of Orthopaedic Surgery, Children s Hospital of Boston, Harvard Medical School, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    J Orthop Res 29:1002-7. 2011
    ..3×: 8.6 mm vs. 7.3 mm (p = 0.012)]. The decrease in platelet concentration from 5× to 3× to enhance suture repair of the ACL did not significantly harm the mechanical outcomes in this animal model...
  25. pmc Biomechanical outcomes after bioenhanced anterior cruciate ligament repair and anterior cruciate ligament reconstruction are equal in a porcine model
    Patrick Vavken
    Sports Medicine Research Laboratory, Department of Orthopedic Surgery, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA
    Arthroscopy 28:672-80. 2012
    ..The objective of this study was to compare the biomechanical outcomes of a new method of anterior cruciate ligament (ACL) treatment, bioenhanced ACL repair, with ACL reconstruction in a large animal model...
  26. pmc Immature animals have higher cellular density in the healing anterior cruciate ligament than adolescent or adult animals
    Ashley N Mastrangelo
    Department of Orthopaedic Surgery, Children s Hospital of Boston, Harvard Medical School, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    J Orthop Res 28:1100-6. 2010
    ..Animal age had a significant effect on the density of cells populating the ACL wound site. Whether this observed cellular difference has an effect on the later biomechanical function of the repaired ACL requires further study...
  27. pmc The potential for primary repair of the ACL
    Patrick Vavken
    Department of Orthopedic Surgery, Children s Hospital Boston, Harvard Medical School, Boston, MA, USA
    Sports Med Arthrosc 19:44-9. 2011
    ..This biomaterial has shown promising functional outcomes in several large animal models of primary repair of partial and complete ACL transection over 4 to 14 weeks, suggesting potential for a successful, future clinical application...
  28. pmc Erythrocytes inhibit ligament fibroblast proliferation in a collagen scaffold
    Sophia L Harrison
    Department of Orthopaedic Surgery, Children s Hospital of Boston, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    J Orthop Res 29:1361-6. 2011
    ..009) and limited scaffold contraction (p < 0.031). Further work examining the role of the erythrocyte in the early provisional scaffold is warranted...
  29. pmc Decellularization of bovine anterior cruciate ligament tissues minimizes immunogenic reactions to alpha-gal epitopes by human peripheral blood mononuclear cells
    Ryu Yoshida
    Department of Orthopaedic Surgery, Children s Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Enders 270 4, Boston, MA 02115, USA
    Knee 19:672-5. 2012
    ..Therefore, decellularized bovine ACL tissue may be a safe, effective biomaterial for ACL injury treatments...
  30. pmc Human anterior cruciate ligament fibroblasts from immature patients have a stronger in vitro response to platelet concentrates than those from mature individuals
    Elise M Magarian
    Department of Orthopaedic Surgery, Children s Hospital of Boston, Harvard Medical School, Boston, MA 02115, United States
    Knee 18:247-51. 2011
    ..The former findings suggest that immature patients respond more favorably to treatment with PRP, which consequently might translate into better results in ACL tissue engineering...
  31. pmc The effect of skeletal maturity on the regenerative function of intrinsic ACL cells
    Ashley N Mastrangelo
    Department of Orthopaedic Surgery, Enders 1020, 300 Longwood Avenue, Children s Hospital, Boston, Boston, Machusetts 02115, USA
    J Orthop Res 28:644-51. 2010
    ..These experiments suggest that skeletal maturity may influence the biologic repair capacity of intrinsic ACL cells...
  32. pmc Initial Achilles tendon repair strength--synthesized biomechanical data from 196 cadaver repairs
    Patrick Sadoghi
    Sports Medicine Research Laboratory, Department of Orthopedic Surgery, Children s Hospital Boston, Harvard Medical School, Boston, MA, USA
    Int Orthop 36:1947-51. 2012
    ..The study aim was to describe what kind of operative technique performs best with respect to initial strength after the surgical repair of acute Achilles tendon ruptures...
  33. doi request reprint Translational studies in anterior cruciate ligament repair
    Patrick Vavken
    Sports Medicine Research Laboratory, Department of Orthopedic Surgery, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    Tissue Eng Part B Rev 16:5-11. 2010
    ....
  34. doi request reprint Effectiveness of bracing in the treatment of nonosseous restriction of elbow mobility: a systematic review and meta-analysis of 13 studies
    Andreas M Müller
    Orthopaedic Department, University Hospital of Basel, University of Basel, Basel, Switzerland
    J Shoulder Elbow Surg 22:1146-52. 2013
    ..For the purpose of this study, effectiveness was measured as the increase in total range of motion, as well as extension and flexion...
  35. pmc Safety of intra-articular use of atelocollagen for enhanced tissue repair
    Elise M Magarian
    Department of Orthopaedic Surgery, Children s Hospital Boston, 300 Longwood Ave, Boston, MA 02115, USA
    Open Orthop J 6:231-8. 2012
    ..In conclusion, the presence of collagen, with or without added platelets, did not increase the local or systemic inflammatory reactions following surgery, suggesting that Type I collagen is safe to use in the knee joint...
  36. doi request reprint Surgical management of osteoarthritis
    Benedikt Proffen
    Department of Orthopaedic Surgery, Childrens Hospital Boston, 300 Longwood Avenue, Enders 1016, Boston, MA 02115, USA
    Wien Med Wochenschr 163:243-50. 2013
    ..Careful preoperative planning, informing the patient accurately about the chances of success, and discussing the patient's expectations are essential aspects of the treatment...
  37. pmc Platelet activation by collagen provides sustained release of anabolic cytokines
    Sophia Harrison
    Department of Orthopaedic Surgery, Children s Hospital of Boston, Massachusetts 02115, USA
    Am J Sports Med 39:729-34. 2011
    ..However, little is known about the effect of platelet activator choice on growth factor release kinetics...
  38. doi request reprint A prospective cohort study on the effectiveness of 3500 IU versus 5000 IU bemiparin in the prophylaxis of postoperative thrombotic events in obese patients undergoing orthopedic surgery
    Patrick Vavken
    Department of Orthopedic Surgery, Children s Hospital Boston, Harvard Medical School, Boston, MA, USA
    Wien Klin Wochenschr 121:454-8. 2009
    ..This study asks whether present-day obese patients would benefit from higher than usual dosages of bemiparin in the prophylaxis of postoperative thrombosis...
  39. pmc Focused extracorporeal shock wave therapy in calcifying tendinitis of the shoulder: a meta-analysis
    Patrick Vavken
    Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts
    Sports Health 1:137-44. 2009
    ..Furthermore, a dose-response relationship was sought as a secondary confirmation of effectiveness...