Research Topics
| Patrick VavkenSummaryAffiliation: Harvard University Country: USA Publications
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Publications
[Outcomes after minimally invasive total knee replacement--a meta-analysis]P Vavken
Department of Orthopedic Surgery, Children s Hospital Boston, Harvard Medical School, Massachusetts, USA
Z Orthop Unfall 146:768-72. 2008..A systematic review of randomised controlled trials reporting on the comparison of minimally invasive total knee replacement and standard incision technique was carried out...
A systematic review of conflicting meta-analyses in orthopaedic surgeryPatrick Vavken
Department of Orthopedic Surgery, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
Clin Orthop Relat Res 467:2723-35. 2009..Thus conclusions and interpretations from meta-analyses should be scrutinized as critically as those from any other type of study and subjected to reassessment if deemed necessary...- Prophylaxis of heterotopic ossification of the hip: systematic review and meta-analysisPatrick Vavken
Department of Orthopedic Surgery, Children s Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Enders 1016, Boston, MA 02115, USA
Clin Orthop Relat Res 467:3283-9. 2009..79 (95% confidence interval, 0.45-1.41), and, again, was independent of the aforementioned factors. We found no evidence for a statistically significant or clinically important difference between NSAIDs or radiation in preventing HO... - Fibrin concentration affects ACL fibroblast proliferation and collagen synthesisPatrick Vavken
Department of Orthopedic Surgery, Children s Hospital Boston, Harvard Medical School, Boston, MA, USA
Knee 18:42-6. 2011..To enhance cell behavior and thus clinical results fibrin applications should build on physiologic or sub-physiologic concentrations, and those with higher concentrations, such as currently available sealants, should be used cautiously... - Rates of radiolucency and loosening after total shoulder arthroplasty with pegged or keeled glenoid componentsPatrick Vavken
Department of Orthopedic Surgery, Children s Hospital Boston, 300 Longwood Avenue, Enders 260, Boston, MA 02115, USA
J Bone Joint Surg Am 95:215-21. 2013..The objective of this study was to conduct a meta-analysis and cost-effectiveness analysis of the effect of glenoid design on radiolucency, loosening, and revision after total shoulder arthroplasty... - Effects of suture choice on biomechanics and physeal status after bioenhanced anterior cruciate ligament repair in skeletally immature patients: a large-animal studyPatrick Vavken
Sports Medicine Research Laboratory, Department of Orthopedic Surgery, Children s Hospital Boston, Harvard Medical School, Massachusetts, USA
Arthroscopy 29:122-32. 2013.... - Modeling the "minimally invasive surgery effect" in total joint replacementPatrick Vavken
Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
Surg Innov 18:268-78. 2011..This study aimed at assessing what the common effects of MIS are in all clinical trials/studies... - Infraglenoidal scapular notching in reverse total shoulder replacement: a prospective series of 60 cases and systematic review of the literaturePatrick Sadoghi
Department of Orthopaedic Surgery, Ludwig Maximilians University Munich, Campus Grosshadern, Marchioninistrasse 15, 81377 Munich, Germany
BMC Musculoskelet Disord 12:101. 2011..We hypothesized that subjective instability and clinical outcome after implantation of RTSA correlates with objective scapular notching... - Rationale for and methods of superiority, noninferiority, or equivalence designs in orthopaedic, controlled trialsPatrick Vavken
Department of Orthopedic Surgery, Children s Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Enders 1016, Boston, MA 02115, USA
Clin Orthop Relat Res 469:2645-53. 2011..It is important to equip the reader of the orthopaedic literature with the knowledge to understand and critically evaluate the methods and findings of trials attempting to establish superiority, noninferiority, and equivalence... - Economic evaluation of NSAID and radiation to prevent heterotopic ossification after hip surgeryPatrick Vavken
Department of Orthopedic Surgery, Children s Hospital Boston, Harvard Medical School, MA 02115, USA
Arch Orthop Trauma Surg 131:1309-15. 2011..While the literature focuses almost exclusively on (as it turns out the lacking) difference in effectiveness, one important difference that has been widely unacknowledged thus far is cost-effectiveness... - VEGF receptor mRNA expression by ACL fibroblasts is associated with functional healing of the ACLPatrick Vavken
Department of Orthopedic Surgery, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
Knee Surg Sports Traumatol Arthrosc 19:1675-82. 2011..The purpose of this study was to test (1) whether the strength of a tissue-engineered ACL repair is associated with VEGF receptors' mRNA expression of ACL cells and (2) whether age influences this association... - The prevalence and effect of publication bias in orthopaedic meta-analysesPatrick Vavken
Department of Orthopedic Surgery, Children s Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Enders 1016, Boston, MA 02115, USA
J Orthop Sci 16:238-44. 2011.... - Treating anterior cruciate ligament tears in skeletally immature patientsPatrick Vavken
Sports Medicine Research Laboratory, Department of Orthopedic Surgery, Children s Hospital Boston, Harvard Medical School, 300 Longwood Ave, Boston, MA 02115, USA
Arthroscopy 27:704-16. 2011..To systematically review the current evidence for conservative and surgical treatment of anterior cruciate ligament (ACL) tears in skeletally immature patients... - Burden of musculoskeletal disease and its determination by urbanicity, socioeconomic status, age, and sex: Results from 14,507 subjectsPatrick Vavken
Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
Arthritis Care Res (Hoboken) 63:1558-64. 2011..The availability of reliable estimates of the burden of musculoskeletal disease is of considerable importance for policymakers... - The effect of platelet concentrates on graft maturation and graft-bone interface healing in anterior cruciate ligament reconstruction in human patients: a systematic review of controlled trialsPatrick Vavken
Sports Medicine Research Laboratory, Department of Orthopedic Surgery, Children s Hospital Boston, Harvard Medical School, Cambridge, Massachusetts 02115, USA
Arthroscopy 27:1573-83. 2011.... - An in vitro model of biomaterial-augmented microfracture including chondrocyte-progenitor cell interactionPatrick Vavken
Sports Medicine Research Laboratory, Department of Orthopedic Surgery, Children s Hospital Boston, Harvard Medical School, 300 Longwood Avenue Enders 1016, Boston, MA 02115, USA
Arch Orthop Trauma Surg 130:711-6. 2010.... - Age dependence of expression of growth factor receptors in porcine ACL fibroblastsPatrick Vavken
Sports Medicine Research Laboratory, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
J Orthop Res 28:1107-12. 2010..These findings suggest that the decrease in growth factor receptor expression as a likely reason for reduced PRP action with increasing age... - The use of confidence intervals in reporting orthopaedic research findingsPatrick Vavken
Department of Orthopedic Surgery, Children s Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Enders 1016, Boston, MA 02115, USA
Clin Orthop Relat Res 467:3334-9. 2009..Confidence intervals could help avoid such erroneous interpretation by showing the effect size explicitly... - Effectiveness of pulsed electromagnetic field therapy in the management of osteoarthritis of the knee: a meta-analysis of randomized controlled trialsPatrick Vavken
Department of Orthopedic Surgery, Children s Hospital Boston, 300 Longwood Avenue, Enders 1016, Boston, MA 02115, USA
J Rehabil Med 41:406-11. 2009..To assess the effectiveness of pulsed electromagnetic fields compared with placebo in the management of osteoarthritis of the knee... - TRITON-X is most effective among three decellularization agents for ACL tissue engineeringPatrick Vavken
Sports Medicine Research Laboratory, Department of Orthopedic Surgery, Children s Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Enders 1016, Boston, Massachusetts 02115, USA
J Orthop Res 27:1612-8. 2009..Porcine ACL tissue after decellularization with TRITON-X could be successfully reseeded with human ACL fibroblasts as demonstrated by steady DNA content and increasing pro-collagen expression... - [Introduction to methods of economic modelling: a primer for orthopaedic surgeons and traumatologists]P Vavken
Department of Orthopedic Surgery, Children s Hospital Boston, Harvard Medical School, 300 Longwood Ave, Boston, MA 02115, USA
Z Orthop Unfall 147:419-23. 2009..This report presents the basics of economic evaluation to orthopaedic surgeons to facilitate informed discussion... - Reduced platelet concentration does not harm PRP effectiveness for ACL repair in a porcine in vivo modelAshley N Mastrangelo
Department of Orthopaedic Surgery, Children s Hospital of Boston, Harvard Medical School, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
J Orthop Res 29:1002-7. 2011..3×: 8.6 mm vs. 7.3 mm (p = 0.012)]. The decrease in platelet concentration from 5× to 3× to enhance suture repair of the ACL did not significantly harm the mechanical outcomes in this animal model... - Immature animals have higher cellular density in the healing anterior cruciate ligament than adolescent or adult animalsAshley N Mastrangelo
Department of Orthopaedic Surgery, Children s Hospital of Boston, Harvard Medical School, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
J Orthop Res 28:1100-6. 2010..Animal age had a significant effect on the density of cells populating the ACL wound site. Whether this observed cellular difference has an effect on the later biomechanical function of the repaired ACL requires further study... - The potential for primary repair of the ACLPatrick Vavken
Department of Orthopedic Surgery, Children s Hospital Boston, Harvard Medical School, Boston, MA, USA
Sports Med Arthrosc 19:44-9. 2011..This biomaterial has shown promising functional outcomes in several large animal models of primary repair of partial and complete ACL transection over 4 to 14 weeks, suggesting potential for a successful, future clinical application... - Erythrocytes inhibit ligament fibroblast proliferation in a collagen scaffoldSophia L Harrison
Department of Orthopaedic Surgery, Children s Hospital of Boston, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
J Orthop Res 29:1361-6. 2011..009) and limited scaffold contraction (p < 0.031). Further work examining the role of the erythrocyte in the early provisional scaffold is warranted... - Biomechanical outcomes after bioenhanced anterior cruciate ligament repair and anterior cruciate ligament reconstruction are equal in a porcine modelPatrick Vavken
Sports Medicine Research Laboratory, Department of Orthopedic Surgery, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA
Arthroscopy 28:672-80. 2012..The objective of this study was to compare the biomechanical outcomes of a new method of anterior cruciate ligament (ACL) treatment, bioenhanced ACL repair, with ACL reconstruction in a large animal model... - Decellularization of bovine anterior cruciate ligament tissues minimizes immunogenic reactions to alpha-gal epitopes by human peripheral blood mononuclear cellsRyu Yoshida
Department of Orthopaedic Surgery, Children s Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Enders 270 4, Boston, MA 02115, USA
Knee 19:672-5. 2012..Therefore, decellularized bovine ACL tissue may be a safe, effective biomaterial for ACL injury treatments... - Human anterior cruciate ligament fibroblasts from immature patients have a stronger in vitro response to platelet concentrates than those from mature individualsElise M Magarian
Department of Orthopaedic Surgery, Children s Hospital of Boston, Harvard Medical School, Boston, MA 02115, United States
Knee 18:247-51. 2011..The former findings suggest that immature patients respond more favorably to treatment with PRP, which consequently might translate into better results in ACL tissue engineering... - The effect of skeletal maturity on the regenerative function of intrinsic ACL cellsAshley N Mastrangelo
Department of Orthopaedic Surgery, Enders 1020, 300 Longwood Avenue, Children s Hospital, Boston, Boston, Machusetts 02115, USA
J Orthop Res 28:644-51. 2010..These experiments suggest that skeletal maturity may influence the biologic repair capacity of intrinsic ACL cells... - Translational studies in anterior cruciate ligament repairPatrick Vavken
Sports Medicine Research Laboratory, Department of Orthopedic Surgery, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
Tissue Eng Part B Rev 16:5-11. 2010.... - Initial Achilles tendon repair strength--synthesized biomechanical data from 196 cadaver repairsPatrick Sadoghi
Sports Medicine Research Laboratory, Department of Orthopedic Surgery, Children s Hospital Boston, Harvard Medical School, Boston, MA, USA
Int Orthop 36:1947-51. 2012..The study aim was to describe what kind of operative technique performs best with respect to initial strength after the surgical repair of acute Achilles tendon ruptures... - Safety of intra-articular use of atelocollagen for enhanced tissue repairElise M Magarian
Department of Orthopaedic Surgery, Children s Hospital Boston, 300 Longwood Ave, Boston, MA 02115, USA
Open Orthop J 6:231-8. 2012..In conclusion, the presence of collagen, with or without added platelets, did not increase the local or systemic inflammatory reactions following surgery, suggesting that Type I collagen is safe to use in the knee joint... - Platelet activation by collagen provides sustained release of anabolic cytokinesSophia Harrison
Department of Orthopaedic Surgery, Children s Hospital of Boston, Massachusetts 02115, USA
Am J Sports Med 39:729-34. 2011..However, little is known about the effect of platelet activator choice on growth factor release kinetics... - A prospective cohort study on the effectiveness of 3500 IU versus 5000 IU bemiparin in the prophylaxis of postoperative thrombotic events in obese patients undergoing orthopedic surgeryPatrick Vavken
Department of Orthopedic Surgery, Children s Hospital Boston, Harvard Medical School, Boston, MA, USA
Wien Klin Wochenschr 121:454-8. 2009..This study asks whether present-day obese patients would benefit from higher than usual dosages of bemiparin in the prophylaxis of postoperative thrombosis... - Focused extracorporeal shock wave therapy in calcifying tendinitis of the shoulder: a meta-analysisPatrick Vavken
Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts
Sports Health 1:137-44. 2009..Furthermore, a dose-response relationship was sought as a secondary confirmation of effectiveness...