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Genomes and Genes | Sara O VargasSummaryAffiliation: Harvard University Country: USA Publications
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Publications
Immunosuppression-related fibroproliferative polyps of the tongueSara O Vargas
Department of Pathology, Children s Hospital and Harvard Medical School, Boston, MA, USA
Pediatr Dev Pathol 10:256-65. 2007..Our findings indicate that these polyps are driven by both immunosuppression and chromosomal rearrangement...- Pathology of human metapneumovirus infection: insights into the pathogenesis of a newly identified respiratory virusSara O Vargas
Department of Pathology, Children s Hospital and Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
Pediatr Dev Pathol 7:478-86; discussion 421. 2004..Further, they contribute toward understanding the pathogenesis of hMPV infection... - Cytogenetic and p53 profiles in congenital cystic adenomatoid malformation: insights into its relationship with pleuropulmonary blastomaSara O Vargas
Department of Pathology, Children s Hospital Boston, and Department of Pathology, Harvard Medical School, MA, USA
Pediatr Dev Pathol 9:190-5. 2006..Overall, these findings provide evidence that CCAM is nonneoplastic. Although some may view CCAM as a PPB precursor, it remains biologically distinct in terms of karyotype and p53 status... - Childhood asymmetric labium majus enlargement: mimicking a neoplasmSara O Vargas
Department of Pathology, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
Am J Surg Pathol 29:1007-16. 2005.... - Myogenic markers in the evaluation of embryonal botryoid rhabdomyosarcoma of the female genital tractWolfram F J Riedlinger
Department of Pathology, Children's Hospital Boston, MA 02115, USA
Pediatr Dev Pathol 8:427-34. 2005..Our findings indicate that, in this anatomic site, the diagnosis of rhabdomyosarcoma and in particular determination of tumor margins remain very reliant on histomorphology... - Mucoepidermoid carcinoma of the parotid gland in children: A 10-year experienceReza Rahbar
Department of Otolaryngology, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
Arch Otolaryngol Head Neck Surg 132:375-80. 2006..To determine the presentation, pathologic features, treatment outcome, and prognosis of mucoepidermoid carcinoma of the parotid gland in children... - Role of vascular endothelial growth factor A in children with acquired airway stenosisReza Rahbar
Department of Otolaryngology and Communication Disorders, Children s Hospital Boston, 300 Longwood Ave, Boston, MA 02115, USA
Ann Otol Rhinol Laryngol 116:430-5. 2007..Vascular endothelial growth factor A (VEGF-A) is important in the angiogenic response for wound healing. This study investigated whether VEGF-A may play a role in the pathogenesis of acquired airway stenosis... - Renal carcinomas with the t(6;11)(p21;q12): clinicopathologic features and demonstration of the specific alpha-TFEB gene fusion by immunohistochemistry, RT-PCR, and DNA PCRPedram Argani
Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
Am J Surg Pathol 29:230-40. 2005..Finally, the special molecular features of the Alpha-TFEB gene fusion allow its molecular detection by DNA PCR as a robust alternative to RT-PCR in clinical tumor samples... 
PAX2-null secretory cell outgrowths in the oviduct and their relationship to pelvic serous cancerCharles M Quick
Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Boston, MA, USA
Mod Pathol 25:449-55. 2012..We propose a unique co-variable in benign oviductal epithelium-the PAX2-null SCOUT-that reflects underlying dysregulation in genes linked to serous neoplasia...- Midline carcinoma of children and young adults with NUT rearrangementChristopher A French
Department of Pathology, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
J Clin Oncol 22:4135-9. 2004..We sought to amass a more definitive series of tumors with NUT and/or BRD4 gene rearrangements and to determine distinct clinicopathologic features... - Human metapneumovirusChristina R Hermos
Department of Medicine, Children s Hospital Boston, MA 02115, USA
Clin Lab Med 30:131-48. 2010..This article describes the microbiology, epidemiology, clinical presentation, pathogenesis, diagnosis, treatment, prognosis, long-term outcome, immunity and reinfection of hMPV... - Effects of neoadjuvant chemotherapy on hepatoblastoma: a morphologic and immunohistochemical studyLarry L Wang
Department of Pathology, Children s Hospital Boston, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA, USA
Am J Surg Pathol 34:287-99. 2010..Multifocality, greater posttreatment necrosis and hepatocellular carcinoma-like morphology were more often associated with metastatic disease, but did not reach statistical significance... 
Pulmonary pathology in thyroid transcription factor-1 deficiency syndromeCsaba Galambos
Department of Pathology, Children s Hospital Boston, Massachusetts 02115, USA
Am J Respir Crit Care Med 182:549-54. 2010..These findings are consistent with experimental evidence documenting the important role of TTF-1 in pulmonary morphogenesis and surfactant metabolism...- BRD4-NUT carcinoma of the mediastinum in a pediatric patient: multidetector computed tomography imaging findingsBenjamin A Nelson
Department of Pediatrics, Pulmonary Division, Massachusetts General Hospital, Boston, MA, USA
J Thorac Imaging 25:W93-6. 2010.... - Lingual thyroid in children: a rare clinical entityReza Rahbar
Department of Otolaryngology and Communication Enhancement, Children s Hospital Boston, Boston, Massachusetts 02115, USA
Laryngoscope 118:1174-9. 2008..To study the presentation, management, and long-term outcome of children presenting with lingual thyroid... - Role of vascular endothelial growth factor-A in recurrent respiratory papillomatosisReza Rahbar
Dept of Otolaryngology and Communication Disorders, Children's Hospital, 300 Longwood Ave, Boston, MA 02115, USA
Ann Otol Rhinol Laryngol 114:289-95. 2005..Also, VEGFR-1 and VEGFR-2 mRNAs are strongly expressed by underlying vascular endothelial cells, suggesting an important role in the pathogenesis of RRP... - Bronchial atresia is common to extralobar sequestration, intralobar sequestration, congenital cystic adenomatoid malformation, and lobar emphysemaWolfram F J Riedlinger
Department of Pathology, Children's Hospital Boston and Harvard Medical School, MA, USA
Pediatr Dev Pathol 9:361-73. 2006..Bronchial atresia and CCAM nearly always coexist. It may be that both have the same etiopathogenesis with anatomic differences accounted for by aberrant genetic programs or other insults, perhaps modified by time of onset or duration... - Lipoblastoma: appreciation of an expanded spectrum of disease through cytogenetic analysisLauren Ende
Department of Pathology, Children s Hospital, Boston, MA 02115, USA
Arch Pathol Lab Med 132:1442-4. 2008..2, confirming the diagnosis of lipoblastoma and thus helping to expand the clinicopathologic spectrum of tumors in this diagnostic category... - Cytogenetic aberrations in perineurioma: variation with subtypeJane E Brock
Department of Pathology, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
Am J Surg Pathol 29:1164-9. 2005..The findings also expand previous assertions that chromosome 22 abnormalities are pathogenetic in perineurioma and suggest that diverse genetic tumorigenic mechanisms may exist, possibly depending on the subtype... - The biology and management of laryngeal neurofibromaReza Rahbar
Department of Otolaryngology and Communication Disorders, Children s Hospital, Harvard Medical School, Boston, Mass, USA
Arch Otolaryngol Head Neck Surg 130:1400-6. 2004..To review the presentation of laryngeal neurofibroma, including its association with neurofibromatosis types 1 and 2, and present guidelines for its management... - Congenital pulmonary malformations in pediatric patients: review and update on etiology, classification, and imaging findingsEdward Y Lee
Division of Thoracic Imaging, Departments of Radiology and Medicine, Pulmonary Division, Children s Hospital Boston and Harvard Medical School, 330 Longwood Avenue, Boston, MA 02115, USA
Radiol Clin North Am 49:921-48. 2011.... - Cloning of an Alpha-TFEB fusion in renal tumors harboring the t(6;11)(p21;q13) chromosome translocationIan J Davis
Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 100:6051-6. 2003..Alpha-TFEB is thus identified as a fusion gene in a subset of pediatric renal neoplasms... - An unusual case of congenital primitive neuroectodermal tumor with ocular metastasisCristian Salgado
Pontificia Universidad Catolica, Ophtalmology, Santiago, Chile
J Pediatr Hematol Oncol 34:e69-71. 2012..Eventually the patient developed cerebral metastasis, and second line therapy with topotecan/cyclophosphamide was initiated. The tumor progressed and the patient died after acute herniation... - Congenital dermal sinus tract in the lateral buttock: unusual presentation of a typically midline lesionIfeoma Ikwueke
Department of Surgery, Children s Hospital, Boston, MA 02115, USA
J Pediatr Surg 43:1200-2. 2008..Furthermore, this case provides insight into the pathogenesis of a disease that is often explained as a "defect of midline closure" and also illustrates an unusual setting for so-called "pilonidal disease.".. - Differentiation of NUT midline carcinoma by epigenomic reprogrammingBrian E Schwartz
Department of Pathology, Division of Women s and Perinatal Pathology, Brigham and Women s Hospital, Boston, Massachusetts, USA
Cancer Res 71:2686-96. 2011..An objective response was obtained after five weeks of therapy, as determined by positron emission tomography. These findings provide preclinical support for trials of HDACi in patients with NMC... - Trisomy 18 is a consistent cytogenetic feature in pilomatricomaAgoston T Agoston
Department of Pathology, Children s Hospital, Boston, MA 02115, USA
Mod Pathol 23:1147-50. 2010.... - Infantile myofibroma or lymphatic malformation: differential diagnosis of neonatal cystic cervicofacial lesionsStephen C Merrell
Department of Plastic Surgery, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
J Craniofac Surg 21:422-6. 2010..This report expands the clinical spectrum of infantile myofibromatosis and suggests its consideration in the differential diagnosis of neonatal cystic cervicofacial lesions... - Immunosuppression-related fibroproliferative polyps: a substantial subset of acquired pediatric mucocutaneous polypsBriana C Gleason
Department of Pathology, Children s Hospital and Harvard Medical School, Boston, MA, USA
Pediatr Dev Pathol 11:30-4. 2008..We suggest that there may be a relationship between these polyps and the previously described tongue lesions and that immunosuppression may be an important factor in their pathogenesis... - The role of chromosomal translocation (15;19) in the carcinoma of the upper aerodigestive tract in childrenReza Rahbar
Department of Otolaryngology, Children s Hospital, Boston, MA 02115, USA
Otolaryngol Head Neck Surg 129:698-704. 2003..To further evaluate the role of chromosomal translocation (15;19) in the presentation of the carcinoma (CA) of the upper aerodigestive tract... - Mucoepidermoid carcinoma of bronchus in a pediatric patient: (18)F-FDG PET findingsEdward Y Lee
Department of Radiology and Medicine, Pulmonary Division, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
Pediatr Radiol 37:1278-82. 2007..We report a mucoepidermoid carcinoma arising from the right upper lobe bronchus in a 15-year-old girl with an emphasis on the (18)F-FDG PET findings... - Primary synovial sarcoma of the chest: radiographic and clinicopathologic correlationAlejandra Duran-Mendicuti
Department of Radiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
J Thorac Imaging 18:87-93. 2003..The authors conclude that primary synovial sarcoma of the chest occurs in young adults, most commonly presenting with chest pain. It is characterized radiologically by a heterogeneously enhancing well-defined mass without calcifications... - Anaplastic large cell lymphoma of the esophagus in a pediatric patientAnastasia L Hryhorczuk
Department of Radiology, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
Pediatr Radiol 42:627-31. 2012..Esophageal involvement in children with non-Hodgkin lymphoma (NHL) has not, to our knowledge, been reported in the literature. This case illustrates an unusual presentation of pediatric NHL... - Myogenic markers in the evaluation of embryonal botryoid rhabdomyosarcoma of the female genital tractWolfram F J Riedlinger
Department of Pathology, Children's Hospital Boston, Boston, MA 02115, USA
Pediatr Dev Pathol 8:355-61. 2005..Our findings indicate that, in this anatomic site, the diagnosis of rhabdomyosarcoma and in particular determination of tumor margins remain very reliant on histomorphology... - Embryonic stem cell transcription factors and D2-40 (podoplanin) as diagnostic immunohistochemical markers in ovarian germ cell tumorsMartin C Chang
Department of Pathology, Division of Women s and Perinatal Pathology, Brigham and Women s Hospital, Children s Hospital Boston, Massachusetts 02115, USA
Int J Gynecol Pathol 28:347-55. 2009..The inclusion of these markers should therefore be considered in cases of pure or mixed ovarian germ cell tumors that are difficult to classify, and to exclude nongerm cell tumor mimics... - An X chromosome gene, WTX, is commonly inactivated in Wilms tumorMiguel N Rivera
Massachusetts General Hospital Cancer Center, Harvard Medical Center, Boston, MA 02114, USA
Science 315:642-5. 2007.... - Fallopian tube correlates of ovarian serous borderline tumorsAnna R Laury
Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
Am J Surg Pathol 35:1759-65. 2011..Further study is warranted to clarify the relationship of the oviduct to serous neoplasia... - Primary pleuropulmonary synovial sarcoma: reappraisal of a recently described anatomic subsetLydia R Essary
Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Cancer 94:459-69. 2002..Its clinical behavior appears more aggressive, perhaps because of relatively later presentation combined with the difficulty in obtaining a wide surgical margin... - Bilateral lung transplant for hereditary hemorrhagic telangiectasia in a pediatric patientMeghna V Misra
Department of Surgery, Division of Pediatric Surgery, Oregon Health and Science University, Portland, OR, USA
Pediatr Transplant 16:E364-7. 2012..Here we report the first successful case of a bilateral lung transplant for a four-yr-old girl with HHT... - Churg-Strauss syndrome in children: a clinical and pathologic reviewDebra Boyer
Department of Medicine, Division of Respiratory Diseases, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02155, USA
Pediatrics 118:e914-20. 2006..The relevant literature on Churg-Strauss syndrome, with specific reference to childhood cases, is reviewed... - Does the fimbria have an embryologic origin distinct from that of the rest of the fallopian tube?Leslie A Garrett
Department of Surgery, Division of Gynecology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
Fertil Steril 90:2008.e5-8. 2008..To propose a new theory describing the development of the fallopian tube fimbria... - Synovial sarcoma of the pleura: a clinical and pathologic study of three casesAmy S Colwell
Department of Surgery, Brigham and Women's Hospital, Boston, MA, USA
J Thorac Cardiovasc Surg 124:828-32. 2002..2;q11.2). This delineation of the clinical and pathologic aspects of this rare, newly recognized tumor should increase awareness among the surgical community... - Postmortem cardiac troponin-I levels predict intramyocardial damage at autopsySara O Vargas
Department of Pathology, Children s Hospital, Harvard Medical School, Boston, MA, USA
J Thromb Thrombolysis 26:132-7. 2008..Use of cardiac troponin in the postmortem diagnosis of cardiac disease may be warranted... - Congenital intra-abdominal bilateral juvenile granulosa cell tumors of the testis associated with constitutional loss of material from chromosome 4David C Yu
Department of Pediatric Surgery, Harvard Medical School, Boston, MA 02115, USA
Pediatr Dev Pathol 14:224-7. 2011..Additionally, it is the 1st report of JGCT associated with a chromosome 4 abnormality, highlighting a genetic region that may be important in JGCT development... - The role of muscle flaps in pulmonary aspergillosisAmy S Colwell
Department of Surgery, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA
Plast Reconstr Surg 111:1147-50. 2003..Despite aggressive medical and surgical therapy, pulmonary aspergillosis has a poor prognosis... - Fibroepithelial polyps causing ureteropelvic junction obstruction in childrenGregory S Adey
Department of Urology, Children's Hospital Boston and Harvard Medical School, Boston, MA, USA
J Urol 169:1834-6. 2003..Filling defects were diagnosed preoperatively in 22% of the patients in this series. Excision and dismembered pyeloplasty were curative, and recurrences were not observed. The etiology of this disease remains obscure... - Open-lung protective ventilation with pressure control ventilation, high-frequency oscillation, and intratracheal pulmonary ventilation results in similar gas exchange, hemodynamics, and lung mechanicsKhaled A Sedeek
Department of Anesthesia/Respiratory Care, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
Anesthesiology 99:1102-11. 2003.... - Psammomatous calcification in association with a benign thyroglossal duct cystCarlos Ayala
Department of Otology and Laryngology, Harvard Medical School, Boston, MA, USA
Arch Otolaryngol Head Neck Surg 129:241-3. 2003..These findings, not previously reported (to our knowledge), expand the radiologic differential diagnosis of calcified neck masses and broaden the spectrum of pathologic findings seen in association with benign thyroglossal duct cysts... - Churg-Strauss syndrome in a 7-year-old receiving montelukast and inhaled corticosteroidsStuart E Turvey
Ann Allergy Asthma Immunol 90:274. 2003