Research Topics
Species | Eric J VallenderSummaryAffiliation: Harvard University Country: USA Publications
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Publications
Multiple independent origins of sex chromosomes in amniotesEric J Vallender
New England Primate Research Center, Division of Neurochemistry, Harvard Medical School, Southborough, MA 01772-9102, USA
Proc Natl Acad Sci U S A 103:18031-2. 2006
Human expression variation in the mu-opioid receptor is paralleled in rhesus macaqueEric J Vallender
Division of Neurochemistry, New England Primate Research Center, Harvard Medical School, Southborough, MA 01772, USA
Behav Genet 38:390-5. 2008..Together, the functional variations reported here have implications for future studies seeking to model the opioid system and its associated phenotypes in rhesus macaques...
Ongoing adaptive evolution of ASPM, a brain size determinant in Homo sapiensNitzan Mekel-Bobrov
Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA
Science 309:1720-2. 2005..These findings, especially the remarkably young age of the positively selected variant, suggest that the human brain is still undergoing rapid adaptive evolution...- A highly unexpected strong correlation between fixation probability of nonsynonymous mutations and mutation rateGerald J Wyckoff
Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA
Trends Genet 21:381-5. 2005..This finding cannot be reconciled with current theories. It suggests that we should re-evaluate the current paradigms of coding-sequence evolution, and that the wide use of K(a)/K(s) as a measure of selective strength needs reassessment... - Evolutionary and biomedical insights from the rhesus macaque genomeRichard A Gibbs
Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA
Science 316:222-34. 2007..The complete description of the macaque genome blueprint enhances the utility of this animal model for biomedical research and improves our understanding of the basic biology of the species... - Uncovering the mutation-fixation correlation in short lineagesEric J Vallender
Howard Hughes Medical Institute, Department of Human Genetics, and Committee on Genetics, University of Chicago, USA
BMC Evol Biol 7:168. 2007..Alternatively, it may reflect a biologically meaningful difference between various lineages. Finally, the lack of positive correlation in short lineages may be the result of methodological artifacts... - Effects of chromosomal rearrangements on human-chimpanzee molecular evolutionEric J Vallender
Department of Human Genetics, Howard Hughes Medical Institute, University of Chicago, Chicago, Illinois 60637, USA
Genomics 84:757-61. 2004..Our results offer a general cautionary note on the importance of controlling for hidden factors in studies involving bioinformatic surveys... - Functional characterization of the human TPH2 5' regulatory region: untranslated region and polymorphisms modulate gene expression in vitroGuo Lin Chen
New England Primate Research Center, Division of Neurochemistry, Harvard Medical School, One Pine Hill Drive, Southborough, MA, 01772 9102, USA
Hum Genet 122:645-57. 2008..In conclusion, our present study demonstrates that both the 5'-UTR and common polymorphisms (especially the 90A/G) in the 5' regulatory region of human TPH2 have a significant impact on gene expression... - Extensive contribution of embryonic stem cells to the development of an evolutionarily divergent hostAndy Peng Xiang
Center for Stem Cell Biology and Tissue Engineering, Sun Yat Sen University, Guangzhou 510080, China
Hum Mol Genet 17:27-37. 2008..Furthermore, our study demonstrates that mammalian evolution can proceed at two starkly contrasting levels: significant divergence in genome and proteome sequence, yet striking conservation in developmental programs... - Rhesus monkey trace amine-associated receptor 1 signaling: enhancement by monoamine transporters and attenuation by the D2 autoreceptor in vitroZhihua Xie
Division of Neurochemistry, New England Primate Research Center, Harvard Medical School, One Pine Hill Dr, Southborough, MA 01772, USA
J Pharmacol Exp Ther 321:116-27. 2007.... - Analysis of copy number variation in the rhesus macaque genome identifies candidate loci for evolutionary and human disease studiesArthur S Lee
Department of Pathology, Brigham and Women s Hospital, 221 Longwood Ave, Boston, MA 02115, USA
Hum Mol Genet 17:1127-36. 2008..Therefore, the rhesus macaque offers an intriguing, non-human primate outbred model organism with which hypotheses concerning the specific functions of phenotypically relevant human CNVs can be tested... - Evidence that the adaptive allele of the brain size gene microcephalin introgressed into Homo sapiens from an archaic Homo lineagePatrick D Evans
Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA
Proc Natl Acad Sci U S A 103:18178-83. 2006..The interhaplogroup divergence test developed here may be broadly applicable to the detection of introgression at other loci in the human genome or in genomes of other species... - A primate-specific acceleration in the evolution of the caspase-dependent apoptosis pathwayEric J Vallender
Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, Chicago, IL, USA
Hum Mol Genet 15:3034-40. 2006..Our results also lend further support to the hypothesis that genes regulating brain size during development might have played a particularly important role in transforming brain size during evolution... - SPEED: a molecular-evolution-based database of mammalian orthologous groupsEric J Vallender
Department of Human Genetics and Committee on Genetics, Howard Hughes Medical Institute, University of Chicago 920 East 58th Street, Chicago, IL 60637, USA
Bioinformatics 22:2835-7. 2006..AVAILABILITY: See http://bioinfobase.umkc.edu/speed/ for access... - Systematically assessing the influence of 3-dimensional structural context on the molecular evolution of mammalian proteomesSun Shim Choi
Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, USA
Mol Biol Evol 23:2131-3. 2006..Through this analysis, we offer quantitative information on how 3D structural contexts affect the level of selective constraint... - How mammalian sex chromosomes acquired their peculiar gene contentEric J Vallender
Howard Hughes Medical Institute and Department of Human Genetics, University of Chicago, IL 60637, USA
Bioessays 26:159-69. 2004..Our discussion will focus on the mammalian sex chromosomes, but will cross reference other species where appropriate... - Reconstructing the evolutionary history of microcephalin, a gene controlling human brain sizePatrick D Evans
Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA
Hum Mol Genet 13:1139-45. 2004..We therefore propose that genes regulating brain size during development may have the general propensity to contribute to brain evolution in primates and particularly humans... - Diverse fates of paralogs following segmental duplication of telomeric genesAndrew Wong
Department of Human Genetics, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322, USA
Genomics 84:239-47. 2004..This study shows the importance of paralogous regions in the generation of transcriptional diversity and highlights the significance that large-scale telomeric duplication may play in this process... - Accelerated evolution of nervous system genes in the origin of Homo sapiensSteve Dorus
Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA
Cell 119:1027-40. 2004.... - The X chromosome: not just her brother's keeperEric J Vallender
Nat Genet 37:343-5. 2005 - Microcephalin, a gene regulating brain size, continues to evolve adaptively in humansPatrick D Evans
Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA
Science 309:1717-20. 2005..It also makes Microcephalin an attractive candidate locus for studying the genetics of human variation in brain-related phenotypes... - Molecular evolution of the brain size regulator genes CDK5RAP2 and CENPJPatrick D Evans
Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA
Gene 375:75-9. 2006.... - Sonic Hedgehog, a key development gene, experienced intensified molecular evolution in primatesSteve Dorus
Department of Human Genetics, Howard Hughes Medical Institute, USA
Hum Mol Genet 15:2031-7. 2006.... - Adaptive evolution of ASPM, a major determinant of cerebral cortical size in humansPatrick D Evans
Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA
Hum Mol Genet 13:489-94. 2004..We therefore conclude that ASPM underwent strong adaptive evolution in the descent of Homo sapiens, which is consistent with its putative role in the evolutionary enlargement of the human brain...