Eric J Vallender

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Multiple independent origins of sex chromosomes in amniotes
    Eric J Vallender
    New England Primate Research Center, Division of Neurochemistry, Harvard Medical School, Southborough, MA 01772 9102, USA
    Proc Natl Acad Sci U S A 103:18031-2. 2006
  2. doi request reprint Human expression variation in the mu-opioid receptor is paralleled in rhesus macaque
    Eric J Vallender
    Division of Neurochemistry, New England Primate Research Center, Harvard Medical School, Southborough, MA 01772, USA
    Behav Genet 38:390-5. 2008
  3. ncbi request reprint Ongoing adaptive evolution of ASPM, a brain size determinant in Homo sapiens
    Nitzan Mekel-Bobrov
    Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA
    Science 309:1720-2. 2005
  4. ncbi request reprint A highly unexpected strong correlation between fixation probability of nonsynonymous mutations and mutation rate
    Gerald J Wyckoff
    Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA
    Trends Genet 21:381-5. 2005
  5. ncbi request reprint Evolutionary and biomedical insights from the rhesus macaque genome
    Richard A Gibbs
    Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA
    Science 316:222-34. 2007
  6. pmc Uncovering the mutation-fixation correlation in short lineages
    Eric J Vallender
    Howard Hughes Medical Institute, Department of Human Genetics, and Committee on Genetics, University of Chicago, USA
    BMC Evol Biol 7:168. 2007
  7. ncbi request reprint Effects of chromosomal rearrangements on human-chimpanzee molecular evolution
    Eric J Vallender
    Department of Human Genetics, Howard Hughes Medical Institute, University of Chicago, Chicago, Illinois 60637, USA
    Genomics 84:757-61. 2004
  8. pmc Functional characterization of the human TPH2 5' regulatory region: untranslated region and polymorphisms modulate gene expression in vitro
    Guo Lin Chen
    New England Primate Research Center, Division of Neurochemistry, Harvard Medical School, One Pine Hill Drive, Southborough, MA, 01772 9102, USA
    Hum Genet 122:645-57. 2008
  9. ncbi request reprint Extensive contribution of embryonic stem cells to the development of an evolutionarily divergent host
    Andy Peng Xiang
    Center for Stem Cell Biology and Tissue Engineering, Sun Yat Sen University, Guangzhou 510080, China
    Hum Mol Genet 17:27-37. 2008
  10. ncbi request reprint Rhesus monkey trace amine-associated receptor 1 signaling: enhancement by monoamine transporters and attenuation by the D2 autoreceptor in vitro
    Zhihua Xie
    Division of Neurochemistry, New England Primate Research Center, Harvard Medical School, One Pine Hill Dr, Southborough, MA 01772, USA
    J Pharmacol Exp Ther 321:116-27. 2007

Collaborators

Detail Information

Publications24

  1. pmc Multiple independent origins of sex chromosomes in amniotes
    Eric J Vallender
    New England Primate Research Center, Division of Neurochemistry, Harvard Medical School, Southborough, MA 01772 9102, USA
    Proc Natl Acad Sci U S A 103:18031-2. 2006
  2. doi request reprint Human expression variation in the mu-opioid receptor is paralleled in rhesus macaque
    Eric J Vallender
    Division of Neurochemistry, New England Primate Research Center, Harvard Medical School, Southborough, MA 01772, USA
    Behav Genet 38:390-5. 2008
    ..Together, the functional variations reported here have implications for future studies seeking to model the opioid system and its associated phenotypes in rhesus macaques...
  3. ncbi request reprint Ongoing adaptive evolution of ASPM, a brain size determinant in Homo sapiens
    Nitzan Mekel-Bobrov
    Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA
    Science 309:1720-2. 2005
    ..These findings, especially the remarkably young age of the positively selected variant, suggest that the human brain is still undergoing rapid adaptive evolution...
  4. ncbi request reprint A highly unexpected strong correlation between fixation probability of nonsynonymous mutations and mutation rate
    Gerald J Wyckoff
    Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA
    Trends Genet 21:381-5. 2005
    ..This finding cannot be reconciled with current theories. It suggests that we should re-evaluate the current paradigms of coding-sequence evolution, and that the wide use of K(a)/K(s) as a measure of selective strength needs reassessment...
  5. ncbi request reprint Evolutionary and biomedical insights from the rhesus macaque genome
    Richard A Gibbs
    Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA
    Science 316:222-34. 2007
    ..The complete description of the macaque genome blueprint enhances the utility of this animal model for biomedical research and improves our understanding of the basic biology of the species...
  6. pmc Uncovering the mutation-fixation correlation in short lineages
    Eric J Vallender
    Howard Hughes Medical Institute, Department of Human Genetics, and Committee on Genetics, University of Chicago, USA
    BMC Evol Biol 7:168. 2007
    ..Alternatively, it may reflect a biologically meaningful difference between various lineages. Finally, the lack of positive correlation in short lineages may be the result of methodological artifacts...
  7. ncbi request reprint Effects of chromosomal rearrangements on human-chimpanzee molecular evolution
    Eric J Vallender
    Department of Human Genetics, Howard Hughes Medical Institute, University of Chicago, Chicago, Illinois 60637, USA
    Genomics 84:757-61. 2004
    ..Our results offer a general cautionary note on the importance of controlling for hidden factors in studies involving bioinformatic surveys...
  8. pmc Functional characterization of the human TPH2 5' regulatory region: untranslated region and polymorphisms modulate gene expression in vitro
    Guo Lin Chen
    New England Primate Research Center, Division of Neurochemistry, Harvard Medical School, One Pine Hill Drive, Southborough, MA, 01772 9102, USA
    Hum Genet 122:645-57. 2008
    ..In conclusion, our present study demonstrates that both the 5'-UTR and common polymorphisms (especially the 90A/G) in the 5' regulatory region of human TPH2 have a significant impact on gene expression...
  9. ncbi request reprint Extensive contribution of embryonic stem cells to the development of an evolutionarily divergent host
    Andy Peng Xiang
    Center for Stem Cell Biology and Tissue Engineering, Sun Yat Sen University, Guangzhou 510080, China
    Hum Mol Genet 17:27-37. 2008
    ..Furthermore, our study demonstrates that mammalian evolution can proceed at two starkly contrasting levels: significant divergence in genome and proteome sequence, yet striking conservation in developmental programs...
  10. ncbi request reprint Rhesus monkey trace amine-associated receptor 1 signaling: enhancement by monoamine transporters and attenuation by the D2 autoreceptor in vitro
    Zhihua Xie
    Division of Neurochemistry, New England Primate Research Center, Harvard Medical School, One Pine Hill Dr, Southborough, MA 01772, USA
    J Pharmacol Exp Ther 321:116-27. 2007
    ....
  11. doi request reprint Analysis of copy number variation in the rhesus macaque genome identifies candidate loci for evolutionary and human disease studies
    Arthur S Lee
    Department of Pathology, Brigham and Women s Hospital, 221 Longwood Ave, Boston, MA 02115, USA
    Hum Mol Genet 17:1127-36. 2008
    ..Therefore, the rhesus macaque offers an intriguing, non-human primate outbred model organism with which hypotheses concerning the specific functions of phenotypically relevant human CNVs can be tested...
  12. pmc Evidence that the adaptive allele of the brain size gene microcephalin introgressed into Homo sapiens from an archaic Homo lineage
    Patrick D Evans
    Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 103:18178-83. 2006
    ..The interhaplogroup divergence test developed here may be broadly applicable to the detection of introgression at other loci in the human genome or in genomes of other species...
  13. ncbi request reprint A primate-specific acceleration in the evolution of the caspase-dependent apoptosis pathway
    Eric J Vallender
    Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, Chicago, IL, USA
    Hum Mol Genet 15:3034-40. 2006
    ..Our results also lend further support to the hypothesis that genes regulating brain size during development might have played a particularly important role in transforming brain size during evolution...
  14. ncbi request reprint SPEED: a molecular-evolution-based database of mammalian orthologous groups
    Eric J Vallender
    Department of Human Genetics and Committee on Genetics, Howard Hughes Medical Institute, University of Chicago 920 East 58th Street, Chicago, IL 60637, USA
    Bioinformatics 22:2835-7. 2006
    ..Here, we present one of the first toolkits to aid multidisciplinary high-throughput analysis...
  15. ncbi request reprint Systematically assessing the influence of 3-dimensional structural context on the molecular evolution of mammalian proteomes
    Sun Shim Choi
    Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, USA
    Mol Biol Evol 23:2131-3. 2006
    ..Through this analysis, we offer quantitative information on how 3D structural contexts affect the level of selective constraint...
  16. ncbi request reprint How mammalian sex chromosomes acquired their peculiar gene content
    Eric J Vallender
    Howard Hughes Medical Institute and Department of Human Genetics, University of Chicago, IL 60637, USA
    Bioessays 26:159-69. 2004
    ..Our discussion will focus on the mammalian sex chromosomes, but will cross reference other species where appropriate...
  17. ncbi request reprint Reconstructing the evolutionary history of microcephalin, a gene controlling human brain size
    Patrick D Evans
    Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA
    Hum Mol Genet 13:1139-45. 2004
    ..We therefore propose that genes regulating brain size during development may have the general propensity to contribute to brain evolution in primates and particularly humans...
  18. ncbi request reprint Diverse fates of paralogs following segmental duplication of telomeric genes
    Andrew Wong
    Department of Human Genetics, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322, USA
    Genomics 84:239-47. 2004
    ..This study shows the importance of paralogous regions in the generation of transcriptional diversity and highlights the significance that large-scale telomeric duplication may play in this process...
  19. ncbi request reprint Accelerated evolution of nervous system genes in the origin of Homo sapiens
    Steve Dorus
    Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA
    Cell 119:1027-40. 2004
    ....
  20. ncbi request reprint The X chromosome: not just her brother's keeper
    Eric J Vallender
    Nat Genet 37:343-5. 2005
  21. ncbi request reprint Microcephalin, a gene regulating brain size, continues to evolve adaptively in humans
    Patrick D Evans
    Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA
    Science 309:1717-20. 2005
    ..It also makes Microcephalin an attractive candidate locus for studying the genetics of human variation in brain-related phenotypes...
  22. ncbi request reprint Molecular evolution of the brain size regulator genes CDK5RAP2 and CENPJ
    Patrick D Evans
    Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA
    Gene 375:75-9. 2006
    ....
  23. ncbi request reprint Sonic Hedgehog, a key development gene, experienced intensified molecular evolution in primates
    Steve Dorus
    Department of Human Genetics, Howard Hughes Medical Institute, USA
    Hum Mol Genet 15:2031-7. 2006
    ....
  24. ncbi request reprint Adaptive evolution of ASPM, a major determinant of cerebral cortical size in humans
    Patrick D Evans
    Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA
    Hum Mol Genet 13:489-94. 2004
    ..We therefore conclude that ASPM underwent strong adaptive evolution in the descent of Homo sapiens, which is consistent with its putative role in the evolutionary enlargement of the human brain...