Scott Valastyan

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. doi request reprint Roles of microRNAs and other non-coding RNAs in breast cancer metastasis
    Scott Valastyan
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    J Mammary Gland Biol Neoplasia 17:23-32. 2012
  2. ncbi request reprint Endogenous anticancer mechanisms: metastasis
    Scott Valastyan
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Front Biosci (Elite Ed) 4:1888-97. 2012
  3. pmc Tumor metastasis: molecular insights and evolving paradigms
    Scott Valastyan
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Cell 147:275-92. 2011
  4. pmc Concurrent suppression of integrin alpha5, radixin, and RhoA phenocopies the effects of miR-31 on metastasis
    Scott Valastyan
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    Cancer Res 70:5147-54. 2010
  5. pmc Activation of miR-31 function in already-established metastases elicits metastatic regression
    Scott Valastyan
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    Genes Dev 25:646-59. 2011
  6. pmc miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis
    Li Ma
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Nat Cell Biol 12:247-56. 2010
  7. pmc Concomitant suppression of three target genes can explain the impact of a microRNA on metastasis
    Scott Valastyan
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    Genes Dev 23:2592-7. 2009
  8. pmc Metastasis suppression: a role of the Dice(r)
    Scott Valastyan
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Genome Biol 11:141. 2010
  9. ncbi request reprint miR-31: a crucial overseer of tumor metastasis and other emerging roles
    Scott Valastyan
    Whitehead Institute for Biomedical Research, Cambridge, MA, USA
    Cell Cycle 9:2124-9. 2010
  10. pmc Roles for microRNAs in the regulation of cell adhesion molecules
    Scott Valastyan
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    J Cell Sci 124:999-1006. 2011

Detail Information

Publications13

  1. doi request reprint Roles of microRNAs and other non-coding RNAs in breast cancer metastasis
    Scott Valastyan
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    J Mammary Gland Biol Neoplasia 17:23-32. 2012
    ....
  2. ncbi request reprint Endogenous anticancer mechanisms: metastasis
    Scott Valastyan
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Front Biosci (Elite Ed) 4:1888-97. 2012
    ..Therefore, knowledge regarding endogenous anti-metastasis mechanisms may both further our comprehension of the basic etiology of metastasis and also guide the treatment of human tumors...
  3. pmc Tumor metastasis: molecular insights and evolving paradigms
    Scott Valastyan
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Cell 147:275-92. 2011
    ..Recent advances provide provocative insights into these cell-biological and molecular changes, which have implications regarding the steps of the invasion-metastasis cascade that appear amenable to therapeutic targeting...
  4. pmc Concurrent suppression of integrin alpha5, radixin, and RhoA phenocopies the effects of miR-31 on metastasis
    Scott Valastyan
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    Cancer Res 70:5147-54. 2010
    ..These findings provide mechanistic insights into the metastatic process and have implications about the importance of pleiotropy for the biological actions of miRNAs...
  5. pmc Activation of miR-31 function in already-established metastases elicits metastatic regression
    Scott Valastyan
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    Genes Dev 25:646-59. 2011
    ..Collectively, these findings raise the possibility that intervention strategies centered on restoring miR-31 function may prove clinically useful for combating metastatic disease...
  6. pmc miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis
    Li Ma
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Nat Cell Biol 12:247-56. 2010
    ..These findings uncover a regulatory and signalling pathway involving a metastasis-promoting miRNA that is predicted to directly target expression of the key metastasis-suppressing protein E-cadherin...
  7. pmc Concomitant suppression of three target genes can explain the impact of a microRNA on metastasis
    Scott Valastyan
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    Genes Dev 23:2592-7. 2009
    ..These effectors influence distinct steps of the metastatic process. Our findings have implications concerning the importance of pleiotropy for the biological actions of miRNAs and provide mechanistic insights into metastasis...
  8. pmc Metastasis suppression: a role of the Dice(r)
    Scott Valastyan
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Genome Biol 11:141. 2010
    ..Recent studies have implicated the microRNA biogenesis enzyme Dicer as a suppressor of breast carcinoma metastasis and elucidated upstream signaling pathways that control Dicer levels...
  9. ncbi request reprint miR-31: a crucial overseer of tumor metastasis and other emerging roles
    Scott Valastyan
    Whitehead Institute for Biomedical Research, Cambridge, MA, USA
    Cell Cycle 9:2124-9. 2010
    ..For these reasons, further elucidation of the biological actions of miR-31 may prove significant for the prognosis and remediation of various pathological states...
  10. pmc Roles for microRNAs in the regulation of cell adhesion molecules
    Scott Valastyan
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    J Cell Sci 124:999-1006. 2011
    ..This, in turn, holds important implications for our understanding of both the basic biology of cell adhesion and the etiology of multiple pathological conditions...
  11. pmc A pleiotropically acting microRNA, miR-31, inhibits breast cancer metastasis
    Scott Valastyan
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Cell 137:1032-46. 2009
    ..Indeed, RhoA re-expression partially reverses miR-31-imposed metastasis suppression. These findings indicate that miR-31 uses multiple mechanisms to oppose metastasis...
  12. ncbi request reprint Assaying microRNA loss-of-function phenotypes in mammalian cells: emerging tools and their potential therapeutic utility
    Scott Valastyan
    Whitehead Institute for Biomedical Research, Cambridge, MA, USA
    RNA Biol 6:541-5. 2009
    ..As such, some of these advances hold great promise in terms of their eventual utility as therapeutic agents...
  13. ncbi request reprint MicroRNAs: Crucial multi-tasking components in the complex circuitry of tumor metastasis
    Scott Valastyan
    Whitehead Institute for Biomedical Research, Cambridge, MA, USA
    Cell Cycle 8:3506-12. 2009
    ..This has important implications for our understanding of the pathogenesis of high-grade malignancies...