DALE UMETSU

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Ozone exposure in a mouse model induces airway hyperreactivity that requires the presence of natural killer T cells and IL-17
    Muriel Pichavant
    Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 205:385-93. 2008
  2. pmc Oral immunotherapy for food allergy: towards a new horizon
    Evelyne Khoriaty
    Division of Immunology and Allergy, Boston Children s Hospital, Harvard Medical School, Boston, MA, USA
    Allergy Asthma Immunol Res 5:3-15. 2013
  3. pmc Changes in antigen-specific T-cell number and function during oral desensitization in cow's milk allergy enabled with omalizumab
    D Bedoret
    Division of Immunology, Children s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Mucosal Immunol 5:267-76. 2012
  4. doi request reprint The role of type 2 innate lymphoid cells in asthma
    Ya Jen Chang
    1 Harvard Medical School, Karp Labs, Room 10127, One Blackfan Circle, Boston, MA 02115, USA Ya Jen Chang, Academia Sinica, 128, Sec 2, Academia Road, Nankang, Taipei 115, Taiwan E mail
    J Leukoc Biol 94:933-40. 2013
  5. pmc Early exposure to germs and the Hygiene Hypothesis
    Dale T Umetsu
    Division of Immunology, Karp Laboratories, Rm 10127, Children s Hospital Boston, Harvard Medical School, One Blackfan Circle, Boston, MA 02115, USA
    Cell Res 22:1210-1. 2012
  6. ncbi request reprint TIM gene family and their role in atopic diseases
    D T Umetsu
    Harvard Medical School, Division of Immunology and Allergy, Children s Hospital, Boston, MA 02115, USA
    Curr Top Microbiol Immunol 321:201-15. 2008
  7. doi request reprint The regulatory role of natural killer T cells in the airways
    Dale T Umetsu
    Division of Immunology, Children s Hospital Boston, Harvard Medical School, Boston, MA 02459, United States
    Int J Biochem Cell Biol 42:529-34. 2010
  8. pmc Natural killer T cells are important in the pathogenesis of asthma: the many pathways to asthma
    Dale T Umetsu
    Division of Immunology and Allergy, Children s Hospital Boston, Harvard Medical School, Boston, MA, USA
    J Allergy Clin Immunol 125:975-9. 2010
  9. ncbi request reprint The regulation of allergy and asthma
    Dale T Umetsu
    Division of Immunology, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Immunol Rev 212:238-55. 2006
  10. pmc 99th Dahlem conference on infection, inflammation and chronic inflammatory disorders: microbes, apoptosis and TIM-1 in the development of asthma
    D T Umetsu
    Harvard Medical School, Children s Hospital Boston, One Blackfan Circle, Boston, MA 02115, USA
    Clin Exp Immunol 160:125-9. 2010

Research Grants

Detail Information

Publications71

  1. pmc Ozone exposure in a mouse model induces airway hyperreactivity that requires the presence of natural killer T cells and IL-17
    Muriel Pichavant
    Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 205:385-93. 2008
    ....
  2. pmc Oral immunotherapy for food allergy: towards a new horizon
    Evelyne Khoriaty
    Division of Immunology and Allergy, Boston Children s Hospital, Harvard Medical School, Boston, MA, USA
    Allergy Asthma Immunol Res 5:3-15. 2013
    ..This combination may enhance both the safety and efficacy of oral immunotherapy, and could lead to a widely available and safe therapy for food allergy...
  3. pmc Changes in antigen-specific T-cell number and function during oral desensitization in cow's milk allergy enabled with omalizumab
    D Bedoret
    Division of Immunology, Children s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Mucosal Immunol 5:267-76. 2012
    ..These studies suggest that high-dose oral allergen desensitization may be associated with deletion of allergen-specific T cells, without the apparent development of allergen-specific Foxp3(+) regulatory T cells...
  4. doi request reprint The role of type 2 innate lymphoid cells in asthma
    Ya Jen Chang
    1 Harvard Medical School, Karp Labs, Room 10127, One Blackfan Circle, Boston, MA 02115, USA Ya Jen Chang, Academia Sinica, 128, Sec 2, Academia Road, Nankang, Taipei 115, Taiwan E mail
    J Leukoc Biol 94:933-40. 2013
    ..We review the recent data regarding ILCs and their role in asthma. ..
  5. pmc Early exposure to germs and the Hygiene Hypothesis
    Dale T Umetsu
    Division of Immunology, Karp Laboratories, Rm 10127, Children s Hospital Boston, Harvard Medical School, One Blackfan Circle, Boston, MA 02115, USA
    Cell Res 22:1210-1. 2012
    ..Such a scenario could explain the Hygiene Hypothesis, which has been a puzzle for decades...
  6. ncbi request reprint TIM gene family and their role in atopic diseases
    D T Umetsu
    Harvard Medical School, Division of Immunology and Allergy, Children s Hospital, Boston, MA 02115, USA
    Curr Top Microbiol Immunol 321:201-15. 2008
    ..These studies together suggest that the TIM gene family evolved to regulate immune responses by managing survival and cell death of hematopoetic cells...
  7. doi request reprint The regulatory role of natural killer T cells in the airways
    Dale T Umetsu
    Division of Immunology, Children s Hospital Boston, Harvard Medical School, Boston, MA 02459, United States
    Int J Biochem Cell Biol 42:529-34. 2010
    ..In this review, we discuss the data that support the notion that NKT cells critically regulate the development of asthma...
  8. pmc Natural killer T cells are important in the pathogenesis of asthma: the many pathways to asthma
    Dale T Umetsu
    Division of Immunology and Allergy, Children s Hospital Boston, Harvard Medical School, Boston, MA, USA
    J Allergy Clin Immunol 125:975-9. 2010
    ..These studies of NKT cells greatly expand our understanding of possible mechanisms that drive the development of asthma, particularly in the case of asthma associated with neutrophils, viral infection, and air pollution...
  9. ncbi request reprint The regulation of allergy and asthma
    Dale T Umetsu
    Division of Immunology, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Immunol Rev 212:238-55. 2006
    ..Impaired expansion of natural and/or adaptive Tregs is hypothesized to lead to the development of allergy and asthma, and treatment to induce allergen-specific Tregs could provide curative therapies for these problems...
  10. pmc 99th Dahlem conference on infection, inflammation and chronic inflammatory disorders: microbes, apoptosis and TIM-1 in the development of asthma
    D T Umetsu
    Harvard Medical School, Children s Hospital Boston, One Blackfan Circle, Boston, MA 02115, USA
    Clin Exp Immunol 160:125-9. 2010
    ....
  11. ncbi request reprint A role for natural killer T cells in asthma
    Dale T Umetsu
    Division of Immunology, Children s Hospital Boston, Department of Pediatrics, Harvard Medical School, 1 Blackfan Circle, Boston, Massachusetts 02115, USA
    Nat Rev Immunol 6:953-8. 2006
    ....
  12. ncbi request reprint Immune dysregulation in asthma
    Dale T Umetsu
    Division of Immunology, Children s Hospital Boston, Harvard Medical School, Karp Laboratories, Rm 10127, One Blackfan Circle, Boston, MA 02115, USA
    Curr Opin Immunol 18:727-32. 2006
    ..Impaired expansion of regulatory T cells is hypothesized to lead to the development of allergy and asthma, and treatment to induce allergen-specific regulatory T cells could provide curative therapies for these problems...
  13. ncbi request reprint Antigen-specific regulatory T cells develop via the ICOS-ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity
    Omid Akbari
    Division of Immunology and Allergy, Department of Pediatrics, School of Medicine, Stanford University, Stanford, California, USA
    Nat Med 8:1024-32. 2002
    ..These studies demonstrate that T(R) cells and the ICOS-ICOS-ligand signaling pathway are critically involved in respiratory tolerance and in downregulating pulmonary inflammation in asthma...
  14. ncbi request reprint Regulation of tolerance in the respiratory tract: TIM-1, hygiene, and the environment
    Dale T Umetsu
    Department of Pediatrics, Rm G309, Stanford University, Stanford, CA 94305 5208, USA
    Ann N Y Acad Sci 1029:88-93. 2004
    ..Finally, we will discuss the association in humans of TIM-1 and atopy, and the relationship between TIM1, hygiene, and the environment...
  15. pmc Glycolipid activation of invariant T cell receptor+ NK T cells is sufficient to induce airway hyperreactivity independent of conventional CD4+ T cells
    Everett H Meyer
    Division of Immunology, Children s Hospital, Harvard Medical School, One Blackfan Circle, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 103:2782-7. 2006
    ....
  16. ncbi request reprint Regulatory T cells control the development of allergic disease and asthma
    Dale T Umetsu
    Division of Immunology and Allergy, Department of Pediatrics, Room G309, Stanford University, Stanford, CA 94305 5208, USA
    J Allergy Clin Immunol 112:480-7; quiz 488. 2003
    ..A spectrum of CD4+ T cells, including T(H)1 cells, T(H)3 cells, regulatory T cells, CD25+ T cells, and natural killer T cells might play a critical role in regulating these diseases and are discussed in this review...
  17. ncbi request reprint Role of regulatory dendritic cells in allergy and asthma
    Omid Akbari
    Department of Pediatrics, Stanford University, Rm G309, 300 Pasteur Drive, Stanford, CA 94305 5208, USA
    Curr Allergy Asthma Rep 5:56-61. 2005
    ..Subsets of DCs regulate the induction of a variety of T-cell subtypes, which suppress the development of allergy and asthma, thus providing anti-inflammatory responses and protective immunity...
  18. pmc TIM-1 and TIM-4 glycoproteins bind phosphatidylserine and mediate uptake of apoptotic cells
    Norimoto Kobayashi
    Department of Medical Oncology, Dana Farber Cancer Institute, 44 Binney Street, Harvard Medical School, Boston, MA 02115, USA
    Immunity 27:927-40. 2007
    ..These results show that TIM-4 and TIM-1 are immunologically restricted members of the group of receptors whose recognition of PS is critical for the efficient clearance of apoptotic cells and prevention of autoimmunity...
  19. pmc Differential engagement of Tim-1 during activation can positively or negatively costimulate T cell expansion and effector function
    Sheng Xiao
    Center for Neurologic Diseases, Brigham and Women s Hospital and Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 204:1691-702. 2007
    ..These data indicate that Tim-1 regulates T cell responses and that Tim-1 engagement can alter T cell function depending on the affinity/avidity with which it is engaged...
  20. ncbi request reprint TNF receptor-associated factor 1 expressed in resident lung cells is required for the development of allergic lung inflammation
    Michiko K Oyoshi
    CBR Institute for Biomedical Research, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 180:1878-85. 2008
    ..Finally, we demonstrate that T cell-transfused TRAF1(-/-) recipient mice demonstrated impaired up-regulation of ICAM-1 expression on lung cells in response to OVA exposure...
  21. ncbi request reprint CD4 T-helper cells engineered to produce IL-10 prevent allergen-induced airway hyperreactivity and inflammation
    Jae Won Oh
    Division of Immunology and Allergy, Department of Pediatrics, Stanford University, CA 94305, USA
    J Allergy Clin Immunol 110:460-8. 2002
    ..T(H)2 cells play a critical role in the pathogenesis of asthma, but the precise immunologic mechanisms that inhibit T(H)2 cell function in vivo are not well understood...
  22. ncbi request reprint Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity
    Omid Akbari
    Division of Immunology and Allergy, Department of Pediatrics, Stanford University, Stanford, California, USA
    Nat Med 9:582-8. 2003
    ..Therapies that target V(alpha)14i NKT cells may be clinically effective in limiting the development of AHR and asthma...
  23. ncbi request reprint Mucosal tolerance and immunity: regulating the development of allergic disease and asthma
    Omid Akbari
    Division of Immunology and Allergy, Department of Pediatrics, Stanford University, Stanford, CA 94305 5208, USA
    Int Arch Allergy Immunol 130:108-18. 2003
    ....
  24. pmc Apoptotic cells activate NKT cells through T cell Ig-like mucin-like-1 resulting in airway hyperreactivity
    Hyun Hee Lee
    Division of Immunology and Allergy, Department of Pediatrics, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 185:5225-35. 2010
    ..Furthermore, these results provide evidence for a novel innate pathway that results in airway hyperreactivity and may help to explain how TIM-1 and NKT cells regulate asthma...
  25. ncbi request reprint Respiratory tolerance is inhibited by the administration of corticosteroids
    Philippe Stock
    Division of Immunology, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 175:7380-7. 2005
    ....
  26. ncbi request reprint CD1d restricted natural killer T cells are not required for allergic skin inflammation
    Abdallah Elkhal
    Division of Immunology, Children s Hospital, Boston MA 02115, USA
    J Allergy Clin Immunol 118:1363-8. 2006
    ..Invariant T-cell receptor-positive natural killer (iNKT) cells have been shown to be essential for the development of allergen-induced airway hyperreactivity (AHR)...
  27. ncbi request reprint Natural killer T cells regulate the development of asthma
    Dale T Umetsu
    Division of Immunology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    Int Rev Immunol 26:121-40. 2007
  28. pmc TIM genes: a family of cell surface phosphatidylserine receptors that regulate innate and adaptive immunity
    Gordon J Freeman
    Department of Medical Oncology, Dana Farber Cancer Institute, and Department of Medicine, Harvard Medical School, Boston, MA, USA
    Immunol Rev 235:172-89. 2010
    ....
  29. ncbi request reprint Natural killer T cells regulate the development of asthma
    Muriel Pichavant
    Division of Immunology and Allergy, Harvard Medical School, Children s Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA
    Expert Rev Clin Immunol 5:251-60. 2009
    ..Together, these studies suggest that iNK T cells, which can interact with many other cell types including Th2 cells, eosinophils and neutrophils, provide a unifying pathogenic mechanism for many distinct forms of asthma...
  30. pmc Exaggerated IL-17 response to epicutaneous sensitization mediates airway inflammation in the absence of IL-4 and IL-13
    Rui He
    Division of Immunology, Children s Hospital, and the Department of Pediatrics, Harvard Medical School, Boston, Mass, USA
    J Allergy Clin Immunol 124:761-70.e1. 2009
    ..Atopic dermatitis (AD) is characterized by local and systemic T(H)2 responses to cutaneously introduced allergens and is a risk factor for asthma. Blockade of T(H)2 cytokines has been suggested as therapy for AD...
  31. pmc ICOS/ICOSL interaction is required for CD4+ invariant NKT cell function and homeostatic survival
    Omid Akbari
    Division of Immunology, Children s Hospital, Harvard Medical School, Boston, MA, 02115, USA
    J Immunol 180:5448-56. 2008
    ..These results indicate that ICOS costimulation plays a major role in induction of AHR by iNKT cells and is required for CD4(+) iNKT cell function, homeostasis, and survival in the periphery...
  32. ncbi request reprint Allergen-specific MHC class II tetramer+ cells are detectable in allergic, but not in nonallergic, individuals
    Claudia Macaubas
    Department of Pediatrics, Stanford University, CA 94305, USA
    J Immunol 176:5069-77. 2006
    ..Thus, analysis using DRB1*0401 tetramers loaded with a major epitope of Lol p 1 indicates that allergen-specific CD4+ T cells in nonallergic individuals are distinct from those in allergic subjects...
  33. ncbi request reprint CD4+ invariant T-cell-receptor+ natural killer T cells in bronchial asthma
    Omid Akbari
    Division of Immunology, Children s Hospital Boston, Boston, MA 02115, USA
    N Engl J Med 354:1117-29. 2006
    ..Because mouse models of allergic asthma indicate that natural killer T cells are required for the development of allergen-induced airway hyperreactivity, we hypothesized that natural killer T cells play an important role in human asthma...
  34. ncbi request reprint The TIM gene family: emerging roles in immunity and disease
    Vijay K Kuchroo
    Center for Neurologic Diseases, Brigham and Women s Hospital, Dana Farber Cancer Institute, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nat Rev Immunol 3:454-62. 2003
    ..Here, we describe the various TIM-family members in mice and humans, and discuss the genetic and functional evidence for their role in regulating autoimmune and allergic diseases...
  35. ncbi request reprint Immunology: hepatitis A virus link to atopic disease
    Jennifer J McIntire
    Division of Immunology and Allergy, Department of Pediatrics, Stanford University, Stanford, California 94305 5208, USA
    Nature 425:576. 2003
  36. ncbi request reprint Role of regulatory dendritic cells in allergy and asthma
    Omid Akbari
    Division of Immunology and Allergy, Department of Pediatrics, Stanford University, Stanford, California 94305 5208, USA
    Curr Opin Allergy Clin Immunol 4:533-8. 2004
    ..In particular we summarize recent data regarding the relationship between dendritic cell subsets and Th1, Th2 and regulatory T (TReg) cells...
  37. pmc The costimulatory role of TIM molecules
    ROSELYNN RODRIGUEZ-MANZANET
    Department of Neurology, Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Immunol Rev 229:259-70. 2009
    ..The TIM molecules thus have surprisingly broad activities affecting multiple aspects of immunology...
  38. ncbi request reprint Role of regulatory T cells in allergy and asthma
    Omid Akbari
    Division of Immunology and Allergy, Department of Pediatrics, Stanford University, Stanford, CA 94305 5208, USA
    Curr Opin Immunol 15:627-33. 2003
    ..A better understanding of the role of regulatory cells in allergic diseases may lead to the identification of novel therapeutic targets...
  39. ncbi request reprint TIM-1, a novel allergy and asthma susceptibility gene
    Jennifer J McIntire
    Division of Allergy and Immunology, Department of Pediatrics, Stanford University, CA 94305 5208, USA
    Springer Semin Immunopathol 25:335-48. 2004
    ....
  40. ncbi request reprint CD8(+) T cells regulate immune responses in a murine model of allergen-induced sensitization and airway inflammation
    Philippe Stock
    Department of Pediatrics, Stanford University, Stanford, CA 94305 5208, USA
    Eur J Immunol 34:1817-27. 2004
    ..These data demonstrate protective effects of CD8(+)T cells against the induction of immune responses and show a functional diversity of CD8(+) T cells in different compartments of sensitized mice...
  41. ncbi request reprint TIM-1 induces T cell activation and inhibits the development of peripheral tolerance
    Sarah E Umetsu
    Department of Pediatrics, Stanford University, Stanford, California 94305, USA
    Nat Immunol 6:447-54. 2005
    ..Our studies suggest that immunotherapies that regulate TIM-1 function may downmodulate allergic inflammatory diseases...
  42. pmc The many paths to asthma: phenotype shaped by innate and adaptive immunity
    Hye Young Kim
    Division of Immunology and Allergy, Children s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Nat Immunol 11:577-84. 2010
    ..Further study of these many pathways to asthma will greatly increase understanding of the distinct asthma phenotypes, and such studies may lead to new therapies for this important public health problem...
  43. ncbi request reprint Asthma: an epidemic of dysregulated immunity
    Dale T Umetsu
    Division of Immunology and Allergy, Department of Pediatrics, Stanford University, Stanford, CA 94305 5208, USA
    Nat Immunol 3:715-20. 2002
    ..In the absence of such infections, T(H)2 cells--which are developmentally related to T(R) cells--develop instead and coordinate the development of asthmatic inflammation...
  44. ncbi request reprint Critical role of B cells in the development of T cell tolerance to aeroallergens
    Daphne C Tsitoura
    Division of Immunology and Allergy, Department of Pediatrics, Stanford University, Stanford, CA 94305 5208, USA
    Int Immunol 14:659-67. 2002
    ..Our data indicate that B cells critically influence the immune response to inhaled allergens and are required for the development of allergen-specific T cell unresponsiveness induced by respiratory allergen...
  45. pmc T cell/transmembrane, Ig, and mucin-3 allelic variants differentially recognize phosphatidylserine and mediate phagocytosis of apoptotic cells
    Rosemarie H DeKruyff
    Division of Immunology, Children s Hospital Boston, E, Boston, MA, USA
    J Immunol 184:1918-30. 2010
    ..These findings establish a new paradigm for TIM proteins as PtdSer receptors and unify the function of the TIM gene family, which has been associated with asthma and autoimmunity and shown to modulate peripheral tolerance...
  46. ncbi request reprint The development of airway hyperreactivity in T-bet-deficient mice requires CD1d-restricted NKT cells
    Hye Young Kim
    Division of Immunology and Allergy, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 182:3252-61. 2009
    ..We conclude therefore that the AHR that develops in T-bet(-/-) mice is dependent on the presence of iNKT cells, and that whereas T-bet(-/-) have reduced numbers of iNKT cells, these are sufficient for the development of AHR...
  47. ncbi request reprint Animal models of airway sensitization
    Muriel Pichavant
    Children s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Curr Protoc Immunol . 2007
    ..In this unit we discuss the induction and measurement of AHR and the two most common methodologies: noninvasive measurement using a whole-body plethysmograph (WBP) and invasive measurement of lung resistance and dynamic compliance...
  48. ncbi request reprint Respiratory tolerance in the protection against asthma
    Claudia Macaubas
    Division of Immunology and Allergy, Department of Pediatrics, Stanford University, Stanford, CA 94305 5208, USA
    Curr Drug Targets Inflamm Allergy 2:175-86. 2003
    ..Strategies to further improve mucosal immunotherapy include the use of modified allergen derived peptides, and adjuvants like CpG motifs...
  49. pmc Tim-1 signaling substitutes for conventional signal 1 and requires costimulation to induce T cell proliferation
    Christophe Mariat
    Division of Transplant Immunology and Transplant Research Center, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    J Immunol 182:1379-85. 2009
    ....
  50. pmc iNKT cells require CCR4 to localize to the airways and to induce airway hyperreactivity
    Everett H Meyer
    Division of Immunology, Karp Laboratories, Children s Hospital, Boston, MA 02115, USA
    J Immunol 179:4661-71. 2007
    ..These results establish for the first time that the pulmonary localization of iNKT cells critical for the induction of AHR requires CCR4 expression by iNKT cells...
  51. ncbi request reprint Induction of T helper type 1-like regulatory cells that express Foxp3 and protect against airway hyper-reactivity
    Philippe Stock
    Division of Immunology and Allergy, Department of Pediatrics, Stanford University, Stanford, California 94305 5208, USA
    Nat Immunol 5:1149-56. 2004
    ..Thus, adaptive T(R) cells are heterogeneous and comprise T(H)1-like T(R) cells as well as previously described T(H)2-like T(R) cells, which express Foxp3 and are induced during the development of respiratory tolerance by CD8alpha(-) DCs...
  52. ncbi request reprint TIM-4 is the ligand for TIM-1, and the TIM-1-TIM-4 interaction regulates T cell proliferation
    Jennifer Hartt Meyers
    Department of Neurology, Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Immunol 6:455-64. 2005
    ..These data suggest that the TIM-1-TIM-4 interaction is involved in regulating T cell proliferation...
  53. pmc Immunostimulatory Tim-1-specific antibody deprograms Tregs and prevents transplant tolerance in mice
    Nicolas Degauque
    Division of Transplant Immunology and Transplant Research Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 118:735-41. 2008
    ..The reciprocal effects of agonist Tim-1-specific mAbs upon effector T cells and Tregs serve to prevent allogeneic transplant tolerance...
  54. pmc In vivo regulation of the allergic response by the IL-4 receptor alpha chain immunoreceptor tyrosine-based inhibitory motif
    Raffi Tachdjian
    Division of Immunology, Allergy and Rheumatology, The Department of Pediatrics, The David Geffen School of Medicine at the University of California at Los Angeles, CA 90095 1752, USA
    J Allergy Clin Immunol 125:1128-1136.e8. 2010
    ..The function of the ITIM in the in vivo regulation of IL-4 receptor signaling remains unknown...
  55. ncbi request reprint Activation of nonclassical CD1d-restricted NK T cells induces airway hyperreactivity in beta 2-microglobulin-deficient mice
    Youngil I Koh
    Division of Immunology and Allergy, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 181:4560-9. 2008
    ....
  56. ncbi request reprint Revising the immunological theories of asthma and allergy
    Dale T Umetsu
    Department of Pediatrics, Stanford University, CA 94305, USA
    Lancet 365:98-100. 2005
  57. ncbi request reprint TIM family of genes in immunity and tolerance
    Vijay K Kuchroo
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Adv Immunol 91:227-49. 2006
    ....
  58. pmc Lack of iNKT cells in patients with combined immune deficiency due to hypomorphic RAG mutations
    Ponpan Matangkasombut
    Division of Immunology, Children s Hospital Boston, Harvard Medical School, Boston, MA, USA
    Blood 111:271-4. 2008
    ..These findings suggest that lack of this important immunoregulatory cell population may contribute to the pathophysiology of Omenn syndrome...
  59. ncbi request reprint Clinical efficacy of microencapsulated timothy grass pollen extract in grass-allergic individuals
    Elizabeth C TePas
    Division of Immunology and Allergy, Department of Pediatrics, Stanford University, Stanford, California, USA
    Ann Allergy Asthma Immunol 92:25-31. 2004
    ..It differs from other pharmacotherapies in that it can induce long-term clinical remission of these diseases. However, it requires years of treatment and is associated with serious allergic reactions...
  60. ncbi request reprint Effectiveness of a multicomponent self-management program in at-risk, school-aged children with asthma
    Richard S Shames
    Department of Pediatrics, Stanford University School of Medicine, Stanford, California 94305, USA
    Ann Allergy Asthma Immunol 92:611-8. 2004
    ..We developed a novel multiple-component intervention that included the use of an asthma education video game intended to promote adoption of asthma self-management behaviors and appropriate asthma care...
  61. pmc Direct activation of natural killer T cells induces airway hyperreactivity in nonhuman primates
    Ponpan Matangkasombut
    J Allergy Clin Immunol 121:1287-9. 2008
  62. ncbi request reprint Inhibition of the allergic response by regulatory T cells
    Philippe Stock
    Department of Pediatric Pneumology and Immunology, University Hospital Charite, Berlin, Germany
    Curr Opin Allergy Clin Immunol 6:12-6. 2006
    ..A number of recent studies indicate that regulatory T cells play an important role in controlling such T-helper type 2 biased responses not only in animal models, but in humans as well, and these will be reviewed in this article...
  63. ncbi request reprint TIM-1, hepatitis A virus and the hygiene theory of atopy: association of TIM-1 with atopy
    Dale T Umetsu
    Stanford University, Stanford, California, USA
    J Pediatr Gastroenterol Nutr 40:S43. 2005
  64. ncbi request reprint Critical role of CD81 in cognate T-B cell interactions leading to Th2 responses
    Jun Deng
    Division of Oncology, Department of Medicine, Stanford University Medical Center, CA 94305, USA
    Int Immunol 14:513-23. 2002
    ..Taken together, these results indicate that CD81 expression by T cells greatly enhances cognate T-B cell interactions and greatly augments intracellular activation pathways leading to Th2 polarization...
  65. pmc Immunoglobulin A (IgA) is a natural ligand of hepatitis A virus cellular receptor 1 (HAVCR1), and the association of IgA with HAVCR1 enhances virus-receptor interactions
    Cecilia Tami
    Laboratory of Hepatitis and Related Emerging Agents, CBER, Food and Drug Administration, Bethesda, MD 20892, USA
    J Virol 81:3437-46. 2007
    ..IgA enhanced significantly the neutralization of HAV by HAVCR1/TIM1 Fc. Our results indicate that IgA1lambda is a specific ligand of HAVCR1/TIM1 and that their association has a synergistic effect in virus-receptor interactions...
  66. pmc TIM-1 and TIM-3 enhancement of Th2 cytokine production by mast cells
    Susumu Nakae
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Blood 110:2565-8. 2007
    ..These observations suggest that TIM-1 and TIM-3 may be able to influence T-cell-mediated immune responses in part through effects on mast cells...
  67. ncbi request reprint Invariant natural killer T cells in obstructive pulmonary diseases
    Omid Akbari
    N Engl J Med 357:193-4; author reply 194-5. 2007
  68. ncbi request reprint T cells and NKT cells in the pathogenesis of asthma
    Everett H Meyer
    Immunology Program, Stanford University, Stanford, California 94305, USA
    Annu Rev Med 59:281-92. 2008
    ..We hypothesize that Th2 cells and iNKT cells interact synergistically to induce asthma but that different forms of asthma result from distinct roles of CD4(+) iNKT cells versus Th2 cells...
  69. ncbi request reprint Agreement among measures of asthma status: a prospective study of low-income children with moderate to severe asthma
    Paul J Sharek
    Division of General Pediatrics, Stanford University School of Medicine, Palo Alto, California, USA
    Pediatrics 110:797-804. 2002
    ..Understanding the relationship between these measures may facilitate more parsimonious and valid evaluation strategies without loss of information...
  70. ncbi request reprint Editorial overview: novel concepts in the pathogenesis and therapy of allergy and asthma
    Dale T Umetsu
    Springer Semin Immunopathol 25:231-6. 2004
  71. ncbi request reprint Flu strikes the hygiene hypothesis
    Dale T Umetsu
    Nat Med 10:232-4. 2004

Research Grants37

  1. Role of Th Cell Subsets in Allergic Lung Inflammation
    DALE UMETSU; Fiscal Year: 2004
    ..These studies will ascertain the precise role of NK T cells in the development of asthma, and greatly enhance our understanding of pathogenic and protective mechanisms in asthma. ..
  2. HETEROGENEITY AMONG HUMAN CD4+ T LYMPHOCYTES
    DALE UMETSU; Fiscal Year: 2000
    ..Such an understanding will be key in the design of novel immunotherapies for allergic disease. ..
  3. HETEROGENEITY AMONG HUMAN CD4+ T LYMPHOCYTES
    DALE UMETSU; Fiscal Year: 1999
    ..Such an understanding will be key in the design of novel immunotherapies for allergic disease. ..
  4. Mechanisms by which Influenza A Protects Against Asthma
    DALE UMETSU; Fiscal Year: 2005
    ..We will also learn more about regulatory mechanisms that affect airway inflammation, and how viral infections and the environment affect the development of asthma. ..
  5. Heterogeneity Among Human CD4 Lymphocytes
    DALE UMETSU; Fiscal Year: 2004
    ..These studies therefore, are likely to lead to greatly improved therapies that protect against and potentially cure asthma and allergic diseases. ..
  6. Role of Th Cell Subsets in Allergic Lung Inflammation
    DALE UMETSU; Fiscal Year: 2005
    ..These studies will ascertain the precise role of NK T cells in the development of asthma, and greatly enhance our understanding of pathogenic and protective mechanisms in asthma. ..
  7. Oral Tolerance Induced by Encapsulated Allergen
    DALE UMETSU; Fiscal Year: 2004
    ..These studies therefore, are likely to lead to better methods and therapies that will induce protective immunity and allergen-specific tolerance, which will potentially cure patients with asthma and allergic diseases. ..
  8. Heterogeneity Among Human CD4 Lymphocytes
    DALE UMETSU; Fiscal Year: 2004
    ..These studies therefore, are likely to lead to greatly improved therapies that protect against and potentially cure asthma and allergic diseases. ..
  9. Oral Tolerance Induced by Encapsulated Allergen
    DALE UMETSU; Fiscal Year: 2004
    ..These studies therefore, are likely to lead to better methods and therapies that will induce protective immunity and allergen-specific tolerance, which will potentially cure patients with asthma and allergic diseases. ..
  10. Heterogeneity Among Human CD4 Lymphocytes
    DALE UMETSU; Fiscal Year: 2005
    ..These studies therefore, are likely to lead to greatly improved therapies that protect against and potentially cure asthma and allergic diseases. ..
  11. Mechanisms by which Influenza A Protects Against Asthma
    DALE UMETSU; Fiscal Year: 2006
    ..We will also learn more about regulatory mechanisms that affect airway inflammation, and how viral infections and the environment affect the development of asthma. ..
  12. Role of Th Cell Subsets in Allergic Lung Inflammation
    DALE UMETSU; Fiscal Year: 2006
    ..These studies will ascertain the precise role of NK T cells in the development of asthma, and greatly enhance our understanding of pathogenic and protective mechanisms in asthma. ..
  13. Mechanisms by which Influenza A Protects Against Asthma
    DALE UMETSU; Fiscal Year: 2007
    ..We will also learn more about regulatory mechanisms that affect airway inflammation, and how viral infections and the environment affect the development of asthma. ..
  14. Role of Th Cell Subsets in Allergic Lung Inflammation
    DALE UMETSU; Fiscal Year: 2007
    ..These studies will ascertain the precise role of NK T cells in the development of asthma, and greatly enhance our understanding of pathogenic and protective mechanisms in asthma. ..
  15. Role of Tim Family Genes in Asthma and Allergic Diseases
    DALE UMETSU; Fiscal Year: 2007
    ..These studies of Tim genes will characterize a very important human asthma susceptibility gene, and provide extraordinary insight into genetic, immunologic and environmental pathways involved in asthma pathogenesis. ..
  16. Heterogeneity among human CD4 T lymphocytes
    DALE UMETSU; Fiscal Year: 2009
    ..We are proposing new paradigms for the pathogenesis of asthma, and these new paradigms should lead to an improved understanding of asthma and to important novel therapies for asthma and allergy. ..
  17. Oral Tolerance Induced by Encapsulated Allergen
    DALE UMETSU; Fiscal Year: 2003
    ..These studies therefore, are likely to lead to better methods and therapies that will induce protective immunity and allergen-specific tolerance, which will potentially cure patients with asthma and allergic diseases. ..
  18. Heterogeneity Among Human CD4 Lymphocytes
    DALE UMETSU; Fiscal Year: 2003
    ..These studies therefore, are likely to lead to greatly improved therapies that protect against and potentially cure asthma and allergic diseases. ..
  19. Role of Th Cell Subsets in Allergic Lung Inflammation
    DALE UMETSU; Fiscal Year: 2003
    ..These studies will ascertain the precise role of NK T cells in the development of asthma, and greatly enhance our understanding of pathogenic and protective mechanisms in asthma. ..
  20. TH CELL SUBSETS AND ALLERGIC LUNG INFLAMMATION
    DALE UMETSU; Fiscal Year: 1999
    ..They will provide the basis for development of new disease-modifying strategies to treat and potentially cure patients with allergy and asthma. ..
  21. HETEROGENEITY AMONG HUMAN CD4+ T LYMPHOCYTES
    DALE UMETSU; Fiscal Year: 1993
    ....
  22. HETEROGENEITY AMONG HUMAN CD4+T CELL CLONES
    DALE UMETSU; Fiscal Year: 1990
    ....
  23. HETEROGENEITY AMONG HUMAN CD4+T CELL CLONES
    DALE UMETSU; Fiscal Year: 1991
    ....
  24. THE ROLE OF TH CELL SUBSETS AND ALLERGIC LUNG INFLAMMATI
    DALE UMETSU; Fiscal Year: 2000
    ..They will provide the basis for development of new disease-modifying strategies to treat and potentially cure patients with allergy and asthma. ..
  25. Heterogeneity Among Human CD4 Lymphocytes
    DALE UMETSU; Fiscal Year: 2001
    ..These studies therefore, are likely to lead to greatly improved therapies that protect against and potentially cure asthma and allergic diseases. ..
  26. THE ROLE OF TH CELL SUBSETS AND ALLERGIC LUNG INFLAMMATI
    DALE UMETSU; Fiscal Year: 2001
    ..They will provide the basis for development of new disease-modifying strategies to treat and potentially cure patients with allergy and asthma. ..
  27. Heterogeneity Among Human CD4 Lymphocytes
    DALE UMETSU; Fiscal Year: 2002
    ..These studies therefore, are likely to lead to greatly improved therapies that protect against and potentially cure asthma and allergic diseases. ..
  28. Oral Tolerance Induced by Encapsulated Allergen
    DALE UMETSU; Fiscal Year: 2002
    ..These studies therefore, are likely to lead to better methods and therapies that will induce protective immunity and allergen-specific tolerance, which will potentially cure patients with asthma and allergic diseases. ..
  29. THE ROLE OF TH CELL SUBSETS AND ALLERGIC LUNG INFLAMMATI
    DALE UMETSU; Fiscal Year: 2002
    ..They will provide the basis for development of new disease-modifying strategies to treat and potentially cure patients with allergy and asthma. ..
  30. Heterogeneity among human CD4 T lymphocytes
    Dale T Umetsu; Fiscal Year: 2010
    ..We are proposing new paradigms for the pathogenesis of asthma, and these new paradigms should lead to an improved understanding of asthma and to important novel therapies for asthma and allergy. ..