Research Topics
Species | DALE UMETSUSummaryAffiliation: Harvard University Country: USA Publications
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Publications
Early exposure to germs and the Hygiene HypothesisDale T Umetsu
Division of Immunology, Karp Laboratories, Rm 10127, Children s Hospital Boston, Harvard Medical School, One Blackfan Circle, Boston, MA 02115, USA
Cell Res 22:1210-1. 2012..Such a scenario could explain the Hygiene Hypothesis, which has been a puzzle for decades...
Immune dysregulation in asthmaDale T Umetsu
Division of Immunology, Children s Hospital Boston, Harvard Medical School, Karp Laboratories, Rm 10127, One Blackfan Circle, Boston, MA 02115, USA
Curr Opin Immunol 18:727-32. 2006..Impaired expansion of regulatory T cells is hypothesized to lead to the development of allergy and asthma, and treatment to induce allergen-specific regulatory T cells could provide curative therapies for these problems...- TIM gene family and their role in atopic diseasesD T Umetsu
Harvard Medical School, Division of Immunology and Allergy, Children s Hospital, Boston, MA 02115, USA
Curr Top Microbiol Immunol 321:201-15. 2008..These studies together suggest that the TIM gene family evolved to regulate immune responses by managing survival and cell death of hematopoetic cells... - 99th Dahlem conference on infection, inflammation and chronic inflammatory disorders: microbes, apoptosis and TIM-1 in the development of asthmaD T Umetsu
Harvard Medical School, Children s Hospital Boston, One Blackfan Circle, Boston, MA 02115, USA
Clin Exp Immunol 160:125-9. 2010.... - Natural killer T cells are important in the pathogenesis of asthma: the many pathways to asthmaDale T Umetsu
Division of Immunology and Allergy, Children s Hospital Boston, Harvard Medical School, Boston, MA, USA
J Allergy Clin Immunol 125:975-9. 2010..These studies of NKT cells greatly expand our understanding of possible mechanisms that drive the development of asthma, particularly in the case of asthma associated with neutrophils, viral infection, and air pollution... - The regulation of allergy and asthmaDale T Umetsu
Division of Immunology, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
Immunol Rev 212:238-55. 2006..Impaired expansion of natural and/or adaptive Tregs is hypothesized to lead to the development of allergy and asthma, and treatment to induce allergen-specific Tregs could provide curative therapies for these problems... 
The regulatory role of natural killer T cells in the airwaysDale T Umetsu
Division of Immunology, Children s Hospital Boston, Harvard Medical School, Boston, MA 02459, United States
Int J Biochem Cell Biol 42:529-34. 2010..In this review, we discuss the data that support the notion that NKT cells critically regulate the development of asthma...- A role for natural killer T cells in asthmaDale T Umetsu
Division of Immunology, Children s Hospital Boston, Department of Pediatrics, Harvard Medical School, 1 Blackfan Circle, Boston, Massachusetts 02115, USA
Nat Rev Immunol 6:953-8. 2006.... - Antigen-specific regulatory T cells develop via the ICOS-ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivityOmid Akbari
Division of Immunology and Allergy, Department of Pediatrics, School of Medicine, Stanford University, Stanford, California, USA
Nat Med 8:1024-32. 2002..These studies demonstrate that T(R) cells and the ICOS-ICOS-ligand signaling pathway are critically involved in respiratory tolerance and in downregulating pulmonary inflammation in asthma... - Regulation of tolerance in the respiratory tract: TIM-1, hygiene, and the environmentDale T Umetsu
Department of Pediatrics, Rm G309, Stanford University, Stanford, CA 94305 5208, USA
Ann N Y Acad Sci 1029:88-93. 2004..Finally, we will discuss the association in humans of TIM-1 and atopy, and the relationship between TIM1, hygiene, and the environment... - Glycolipid activation of invariant T cell receptor+ NK T cells is sufficient to induce airway hyperreactivity independent of conventional CD4+ T cellsEverett H Meyer
Division of Immunology, Children s Hospital, Harvard Medical School, One Blackfan Circle, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 103:2782-7. 2006.... - Regulatory T cells control the development of allergic disease and asthmaDale T Umetsu
Division of Immunology and Allergy, Department of Pediatrics, Room G309, Stanford University, Stanford, CA 94305-5208, USA
J Allergy Clin Immunol 112:480-7; quiz 488. 2003..A spectrum of CD4+ T cells, including T(H)1 cells, T(H)3 cells, regulatory T cells, CD25+ T cells, and natural killer T cells might play a critical role in regulating these diseases and are discussed in this review... - Role of regulatory dendritic cells in allergy and asthmaOmid Akbari
Department of Pediatrics, Stanford University, Rm G309, 300 Pasteur Drive, Stanford, CA 94305-5208, USA
Curr Allergy Asthma Rep 5:56-61. 2005..Subsets of DCs regulate the induction of a variety of T-cell subtypes, which suppress the development of allergy and asthma, thus providing anti-inflammatory responses and protective immunity... - Ozone exposure in a mouse model induces airway hyperreactivity that requires the presence of natural killer T cells and IL-17Muriel Pichavant
Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
J Exp Med 205:385-93. 2008.... - TIM-1 and TIM-4 glycoproteins bind phosphatidylserine and mediate uptake of apoptotic cellsNorimoto Kobayashi
Department of Medical Oncology, Dana Farber Cancer Institute, 44 Binney Street, Harvard Medical School, Boston, MA 02115, USA
Immunity 27:927-40. 2007..These results show that TIM-4 and TIM-1 are immunologically restricted members of the group of receptors whose recognition of PS is critical for the efficient clearance of apoptotic cells and prevention of autoimmunity... - TNF receptor-associated factor 1 expressed in resident lung cells is required for the development of allergic lung inflammationMichiko K Oyoshi
CBR Institute for Biomedical Research, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Immunol 180:1878-85. 2008..Finally, we demonstrate that T cell-transfused TRAF1(-/-) recipient mice demonstrated impaired up-regulation of ICAM-1 expression on lung cells in response to OVA exposure... - CD4 T-helper cells engineered to produce IL-10 prevent allergen-induced airway hyperreactivity and inflammationJae-Won Oh
Division of Immunology and Allergy, Department of Pediatrics, Stanford University, CA 94305, USA
J Allergy Clin Immunol 110:460-8. 2002.... - Differential engagement of Tim-1 during activation can positively or negatively costimulate T cell expansion and effector functionSheng Xiao
Center for Neurologic Diseases, Brigham and Women s Hospital and Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
J Exp Med 204:1691-702. 2007..These data indicate that Tim-1 regulates T cell responses and that Tim-1 engagement can alter T cell function depending on the affinity/avidity with which it is engaged... - Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivityOmid Akbari
Division of Immunology and Allergy, Department of Pediatrics, Stanford University, Stanford, California, USA
Nat Med 9:582-8. 2003..Therapies that target V(alpha)14i NKT cells may be clinically effective in limiting the development of AHR and asthma... - Mucosal tolerance and immunity: regulating the development of allergic disease and asthmaOmid Akbari
Division of Immunology and Allergy, Department of Pediatrics, Stanford University, Stanford, CA 94305-5208, USA
Int Arch Allergy Immunol 130:108-18. 2003.... - Immunology: hepatitis A virus link to atopic diseaseJennifer J McIntire
Division of Immunology and Allergy, Department of Pediatrics, Stanford University, Stanford, California 94305-5208, USA
Nature 425:576. 2003 - Allergen-specific MHC class II tetramer+ cells are detectable in allergic, but not in nonallergic, individualsClaudia Macaubas
Department of Pediatrics, Stanford University, CA 94305, USA
J Immunol 176:5069-77. 2006..Thus, analysis using DRB1*0401 tetramers loaded with a major epitope of Lol p 1 indicates that allergen-specific CD4+ T cells in nonallergic individuals are distinct from those in allergic subjects... - CD4+ invariant T-cell-receptor+ natural killer T cells in bronchial asthmaOmid Akbari
Division of Immunology, Children's Hospital Boston, Boston, MA 02115, USA
N Engl J Med 354:1117-29. 2006.... - Natural killer T cells regulate the development of asthmaDale T Umetsu
Division of Immunology, Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
Int Rev Immunol 26:121-40. 2007 - ICOS/ICOSL interaction is required for CD4+ invariant NKT cell function and homeostatic survivalOmid Akbari
Division of Immunology, Children s Hospital, Harvard Medical School, Boston, MA, 02115, USA
J Immunol 180:5448-56. 2008..These results indicate that ICOS costimulation plays a major role in induction of AHR by iNKT cells and is required for CD4(+) iNKT cell function, homeostasis, and survival in the periphery... - CD1d restricted natural killer T cells are not required for allergic skin inflammationAbdallah Elkhal
Division of Immunology, Children's Hospital, Boston. MA 02115, USA
J Allergy Clin Immunol 118:1363-8. 2006..CLINICAL IMPLICATIONS: Understanding the potential role of iNKT cells in AD will allow us to have a more specific target for therapeutic use... - Exaggerated IL-17 response to epicutaneous sensitization mediates airway inflammation in the absence of IL-4 and IL-13Rui He
Division of Immunology, Children s Hospital, and the Department of Pediatrics, Harvard Medical School, Boston, Mass, USA
J Allergy Clin Immunol 124:761-70.e1. 2009..Atopic dermatitis (AD) is characterized by local and systemic T(H)2 responses to cutaneously introduced allergens and is a risk factor for asthma. Blockade of T(H)2 cytokines has been suggested as therapy for AD... - The TIM gene family: emerging roles in immunity and diseaseVijay K Kuchroo
Center for Neurologic Diseases, Brigham and Women s Hospital, Dana Farber Cancer Institute, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
Nat Rev Immunol 3:454-62. 2003..Here, we describe the various TIM-family members in mice and humans, and discuss the genetic and functional evidence for their role in regulating autoimmune and allergic diseases... - Apoptotic cells activate NKT cells through T cell Ig-like mucin-like-1 resulting in airway hyperreactivityHyun Hee Lee
Division of Immunology and Allergy, Department of Pediatrics, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
J Immunol 185:5225-35. 2010..Furthermore, these results provide evidence for a novel innate pathway that results in airway hyperreactivity and may help to explain how TIM-1 and NKT cells regulate asthma... - TIM genes: a family of cell surface phosphatidylserine receptors that regulate innate and adaptive immunityGordon J Freeman
Department of Medical Oncology, Dana Farber Cancer Institute, and Department of Medicine, Harvard Medical School, Boston, MA, USA
Immunol Rev 235:172-89. 2010.... - Natural killer T cells regulate the development of asthmaMuriel Pichavant
Division of Immunology and Allergy, Harvard Medical School, Children s Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA
Expert Rev Clin Immunol 5:251-60. 2009..Together, these studies suggest that iNK T cells, which can interact with many other cell types including Th2 cells, eosinophils and neutrophils, provide a unifying pathogenic mechanism for many distinct forms of asthma... - Role of regulatory dendritic cells in allergy and asthmaOmid Akbari
Division of Immunology and Allergy, Department of Pediatrics, Stanford University, Stanford, California 94305-5208, USA
Curr Opin Allergy Clin Immunol 4:533-8. 2004..SUMMARY: Subsets of dendritic cells regulate the induction of a variety of T-cell subtypes, which suppress the development of allergy and asthma, thus providing antiinflammatory responses and protective immunity... - Respiratory tolerance is inhibited by the administration of corticosteroidsPhilippe Stock
Division of Immunology, Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
J Immunol 175:7380-7. 2005.... - TIM-1 induces T cell activation and inhibits the development of peripheral toleranceSarah E Umetsu
Department of Pediatrics, Stanford University, Stanford, California 94305, USA
Nat Immunol 6:447-54. 2005..Our studies suggest that immunotherapies that regulate TIM-1 function may downmodulate allergic inflammatory diseases... - CD8(+) T cells regulate immune responses in a murine model of allergen-induced sensitization and airway inflammationPhilippe Stock
Department of Pediatrics, Stanford University, Stanford, CA 94305 5208, USA
Eur J Immunol 34:1817-27. 2004..These data demonstrate protective effects of CD8(+)T cells against the induction of immune responses and show a functional diversity of CD8(+) T cells in different compartments of sensitized mice... - The costimulatory role of TIM moleculesROSELYNN RODRIGUEZ-MANZANET
Department of Neurology, Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Immunol Rev 229:259-70. 2009..The TIM molecules thus have surprisingly broad activities affecting multiple aspects of immunology... - The many paths to asthma: phenotype shaped by innate and adaptive immunityHye Young Kim
Division of Immunology and Allergy, Children s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Nat Immunol 11:577-84. 2010..Further study of these many pathways to asthma will greatly increase understanding of the distinct asthma phenotypes, and such studies may lead to new therapies for this important public health problem... - Role of regulatory T cells in allergy and asthmaOmid Akbari
Division of Immunology and Allergy, Department of Pediatrics, Stanford University, Stanford, CA 94305-5208, USA
Curr Opin Immunol 15:627-33. 2003..A better understanding of the role of regulatory cells in allergic diseases may lead to the identification of novel therapeutic targets... - Critical role of B cells in the development of T cell tolerance to aeroallergensDaphne C Tsitoura
Division of Immunology and Allergy, Department of Pediatrics, Stanford University, Stanford, CA 94305 5208, USA
Int Immunol 14:659-67. 2002..Our data indicate that B cells critically influence the immune response to inhaled allergens and are required for the development of allergen-specific T cell unresponsiveness induced by respiratory allergen... - Asthma: an epidemic of dysregulated immunityDale T Umetsu
Division of Immunology and Allergy, Department of Pediatrics, Stanford University, Stanford, CA 94305 5208, USA
Nat Immunol 3:715-20. 2002..In the absence of such infections, T(H)2 cells--which are developmentally related to T(R) cells--develop instead and coordinate the development of asthmatic inflammation... - TIM-1, a novel allergy and asthma susceptibility geneJennifer J McIntire
Division of Allergy and Immunology, Department of Pediatrics, Stanford University, CA 94305 5208, USA
Springer Semin Immunopathol 25:335-48. 2004.... - Animal models of airway sensitizationMuriel Pichavant
Children s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Curr Protoc Immunol . 2007..In this unit we discuss the induction and measurement of AHR and the two most common methodologies: noninvasive measurement using a whole-body plethysmograph (WBP) and invasive measurement of lung resistance and dynamic compliance... - T cell/transmembrane, Ig, and mucin-3 allelic variants differentially recognize phosphatidylserine and mediate phagocytosis of apoptotic cellsRosemarie H DeKruyff
Division of Immunology, Children s Hospital Boston, E, Boston, MA, USA
J Immunol 184:1918-30. 2010..These findings establish a new paradigm for TIM proteins as PtdSer receptors and unify the function of the TIM gene family, which has been associated with asthma and autoimmunity and shown to modulate peripheral tolerance... - The development of airway hyperreactivity in T-bet-deficient mice requires CD1d-restricted NKT cellsHye Young Kim
Division of Immunology and Allergy, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
J Immunol 182:3252-61. 2009..We conclude therefore that the AHR that develops in T-bet(-/-) mice is dependent on the presence of iNKT cells, and that whereas T-bet(-/-) have reduced numbers of iNKT cells, these are sufficient for the development of AHR... - Tim-1 signaling substitutes for conventional signal 1 and requires costimulation to induce T cell proliferationChristophe Mariat
Division of Transplant Immunology and Transplant Research Center, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
J Immunol 182:1379-85. 2009.... - TIM-4 is the ligand for TIM-1, and the TIM-1-TIM-4 interaction regulates T cell proliferationJennifer Hartt Meyers
Department of Neurology, Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Nat Immunol 6:455-64. 2005..These data suggest that the TIM-1-TIM-4 interaction is involved in regulating T cell proliferation... - Respiratory tolerance in the protection against asthmaClaudia Macaubas
Division of Immunology and Allergy, Department of Pediatrics, Stanford University, Stanford, CA 94305 5208, USA
Curr Drug Targets Inflamm Allergy 2:175-86. 2003..Strategies to further improve mucosal immunotherapy include the use of modified allergen derived peptides, and adjuvants like CpG motifs... - iNKT cells require CCR4 to localize to the airways and to induce airway hyperreactivityEverett H Meyer
Division of Immunology, Karp Laboratories, Children s Hospital, Boston, MA 02115, USA
J Immunol 179:4661-71. 2007..These results establish for the first time that the pulmonary localization of iNKT cells critical for the induction of AHR requires CCR4 expression by iNKT cells... - Induction of T helper type 1-like regulatory cells that express Foxp3 and protect against airway hyper-reactivityPhilippe Stock
Division of Immunology and Allergy, Department of Pediatrics, Stanford University, Stanford, California 94305-5208, USA
Nat Immunol 5:1149-56. 2004..Thus, adaptive T(R) cells are heterogeneous and comprise T(H)1-like T(R) cells as well as previously described T(H)2-like T(R) cells, which express Foxp3 and are induced during the development of respiratory tolerance by CD8alpha(-) DCs... - Revising the immunological theories of asthma and allergyDale T Umetsu
Department of Pediatrics, Stanford University, CA 94305, USA
Lancet 365:98-100. 2005 - TIM family of genes in immunity and toleranceVijay K Kuchroo
Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
Adv Immunol 91:227-49. 2006.... - Activation of nonclassical CD1d-restricted NK T cells induces airway hyperreactivity in beta 2-microglobulin-deficient miceYoungil I Koh
Division of Immunology and Allergy, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
J Immunol 181:4560-9. 2008.... - Immunostimulatory Tim-1-specific antibody deprograms Tregs and prevents transplant tolerance in miceNicolas Degauque
Division of Transplant Immunology and Transplant Research Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
J Clin Invest 118:735-41. 2008..The reciprocal effects of agonist Tim-1-specific mAbs upon effector T cells and Tregs serve to prevent allogeneic transplant tolerance... - In vivo regulation of the allergic response by the IL-4 receptor alpha chain immunoreceptor tyrosine-based inhibitory motifRaffi Tachdjian
Division of Immunology, Allergy and Rheumatology, The Department of Pediatrics, The David Geffen School of Medicine at the University of California at Los Angeles, CA 90095 1752, USA
J Allergy Clin Immunol 125:1128-1136.e8. 2010..The function of the ITIM in the in vivo regulation of IL-4 receptor signaling remains unknown... - Clinical efficacy of microencapsulated timothy grass pollen extract in grass-allergic individualsElizabeth C TePas
Division of Immunology and Allergy, Department of Pediatrics, Stanford University, Stanford, California, USA
Ann Allergy Asthma Immunol 92:25-31. 2004..It differs from other pharmacotherapies in that it can induce long-term clinical remission of these diseases. However, it requires years of treatment and is associated with serious allergic reactions... - Lack of iNKT cells in patients with combined immune deficiency due to hypomorphic RAG mutationsPonpan Matangkasombut
Division of Immunology, Children s Hospital Boston, Harvard Medical School, Boston, MA, USA
Blood 111:271-4. 2008..These findings suggest that lack of this important immunoregulatory cell population may contribute to the pathophysiology of Omenn syndrome... - Effectiveness of a multicomponent self-management program in at-risk, school-aged children with asthmaRichard S Shames
Department of Pediatrics, Stanford University School of Medicine, Stanford, California 94305, USA
Ann Allergy Asthma Immunol 92:611-8. 2004..We developed a novel multiple-component intervention that included the use of an asthma education video game intended to promote adoption of asthma self-management behaviors and appropriate asthma care... - Critical role of CD81 in cognate T-B cell interactions leading to Th2 responsesJun Deng
Division of Oncology, Department of Medicine, Stanford University Medical Center, CA 94305, USA
Int Immunol 14:513-23. 2002..Taken together, these results indicate that CD81 expression by T cells greatly enhances cognate T-B cell interactions and greatly augments intracellular activation pathways leading to Th2 polarization... - Inhibition of the allergic response by regulatory T cellsPhilippe Stock
Department of Pediatric Pneumology and Immunology, University Hospital Charit, Berlin, Germany
Curr Opin Allergy Clin Immunol 6:12-6. 2006..SUMMARY: Allergen-specific regulatory T cells play an important role in controlling the development of allergy and asthma... - Immunoglobulin A (IgA) is a natural ligand of hepatitis A virus cellular receptor 1 (HAVCR1), and the association of IgA with HAVCR1 enhances virus-receptor interactionsCecilia Tami
Laboratory of Hepatitis and Related Emerging Agents, CBER, Food and Drug Administration, Bethesda, MD 20892, USA
J Virol 81:3437-46. 2007..IgA enhanced significantly the neutralization of HAV by HAVCR1/TIM1 Fc. Our results indicate that IgA1lambda is a specific ligand of HAVCR1/TIM1 and that their association has a synergistic effect in virus-receptor interactions... - TIM-1 and TIM-3 enhancement of Th2 cytokine production by mast cellsSusumu Nakae
Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
Blood 110:2565-8. 2007..These observations suggest that TIM-1 and TIM-3 may be able to influence T-cell-mediated immune responses in part through effects on mast cells... - Invariant natural killer T cells in obstructive pulmonary diseasesOmid Akbari
N Engl J Med 357:193-4; author reply 194-5. 2007 - Direct activation of natural killer T cells induces airway hyperreactivity in nonhuman primatesPonpan Matangkasombut
J Allergy Clin Immunol 121:1287-9. 2008 - T cells and NKT cells in the pathogenesis of asthmaEverett H Meyer
Immunology Program, Stanford University, Stanford, California 94305, USA
Annu Rev Med 59:281-92. 2008..We hypothesize that Th2 cells and iNKT cells interact synergistically to induce asthma but that different forms of asthma result from distinct roles of CD4(+) iNKT cells versus Th2 cells... - TIM-1, hepatitis A virus and the hygiene theory of atopy: association of TIM-1 with atopyDale T Umetsu
Stanford University, Stanford, California, USA
J Pediatr Gastroenterol Nutr 40:S43. 2005 - Flu strikes the hygiene hypothesisDale T Umetsu
Nat Med 10:232-4. 2004 - Editorial overview: novel concepts in the pathogenesis and therapy of allergy and asthmaDale T Umetsu
Springer Semin Immunopathol 25:231-6. 2004 - Agreement among measures of asthma status: a prospective study of low-income children with moderate to severe asthmaPaul J Sharek
Division of General Pediatrics, Stanford University School of Medicine, Palo Alto, California, USA
Pediatrics 110:797-804. 2002..Understanding the relationship between these measures may facilitate more parsimonious and valid evaluation strategies without loss of information...
Research Grants
- Oral Tolerance Induced by Encapsulated AllergenDALE UMETSU; Fiscal Year: 2004..These studies therefore, are likely to lead to better methods and therapies that will induce protective immunity and allergen-specific tolerance, which will potentially cure patients with asthma and allergic diseases. ..
- Heterogeneity Among Human CD4 LymphocytesDALE UMETSU; Fiscal Year: 2005..These studies therefore, are likely to lead to greatly improved therapies that protect against and potentially cure asthma and allergic diseases. ..
- Mechanisms by which Influenza A Protects Against AsthmaDALE UMETSU; Fiscal Year: 2007..We will also learn more about regulatory mechanisms that affect airway inflammation, and how viral infections and the environment affect the development of asthma. ..
- Role of Th Cell Subsets in Allergic Lung InflammationDALE UMETSU; Fiscal Year: 2007..These studies will ascertain the precise role of NK T cells in the development of asthma, and greatly enhance our understanding of pathogenic and protective mechanisms in asthma. ..
- Role of Tim Family Genes in Asthma and Allergic DiseasesDALE UMETSU; Fiscal Year: 2007..These studies of Tim genes will characterize a very important human asthma susceptibility gene, and provide extraordinary insight into genetic, immunologic and environmental pathways involved in asthma pathogenesis. ..
- THE ROLE OF TH CELL SUBSETS AND ALLERGIC LUNG INFLAMMATIDALE UMETSU; Fiscal Year: 2002..They will provide the basis for development of new disease-modifying strategies to treat and potentially cure patients with allergy and asthma. ..
- HETEROGENEITY AMONG HUMAN CD4+ T LYMPHOCYTESDALE UMETSU; Fiscal Year: 1993....
- HETEROGENEITY AMONG HUMAN CD4+T CELL CLONESDALE UMETSU; Fiscal Year: 1991....
- HETEROGENEITY AMONG HUMAN CD4+ T LYMPHOCYTESDALE UMETSU; Fiscal Year: 2000..Such an understanding will be key in the design of novel immunotherapies for allergic disease. ..
- Heterogeneity among human CD4 T lymphocytesDale T Umetsu; Fiscal Year: 2010..We are proposing new paradigms for the pathogenesis of asthma, and these new paradigms should lead to an improved understanding of asthma and to important novel therapies for asthma and allergy. ..