A Aria Tzika

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Functional MRI using robotic MRI compatible devices for monitoring rehabilitation from chronic stroke in the molecular medicine era (Review)
    Loukas G Astrakas
    Department of Surgery, NMR Surgical Laboratory, Massachusetts General Hospital and Shriners Burn Institute, Harvard Medical School, Boston, MA 02114, USA
    Int J Mol Med 29:963-73. 2012
  2. pmc Nuclear magnetic resonance in conjunction with functional genomics suggests mitochondrial dysfunction in a murine model of cancer cachexia
    Caterina Constantinou
    NMR Surgical Laboratory, Massachusetts General and Shriners Hospitals, Harvard Medical School, Boston, MA 02114, USA
    Int J Mol Med 27:15-24. 2011
  3. pmc High-resolution magic angle spinning magnetic resonance spectroscopy detects glycine as a biomarker in brain tumors
    Valeria Righi
    NMR Surgical Laboratory, Department of Surgery, Harvard Medical School and Massachusetts General Hospital, Boston, MA 02114, USA
    Int J Oncol 36:301-6. 2010
  4. pmc Functional MRI of Rehabilitation in Chronic Stroke Patients Using Novel MR-Compatible Hand Robots
    Dionyssios Mintzopoulos
    NMR Surgical Laboratory, Department of Surgery, Massachusetts General Hospital and Shriner s Burn Institute, Harvard Medical School, Boston, MA 02114, USA
    Open Neuroimag J 2:94-101. 2008
  5. pmc In vivo high-resolution magic angle spinning magnetic resonance spectroscopy of Drosophila melanogaster at 14.1 T shows trauma in aging and in innate immune-deficiency is linked to reduced insulin signaling
    Valeria Righi
    NMR Surgical Laboratory, Department of Surgery, Massachusetts General Hospital and Shriners Burn Institute, Harvard Medical School, Boston, MA 02114, USA
    Int J Mol Med 26:175-84. 2010
  6. pmc Diffusion tensor and volumetric magnetic resonance imaging using an MR-compatible hand-induced robotic device suggests training-induced neuroplasticity in patients with chronic stroke
    Asimina Lazaridou
    NMR Surgical Laboratory, Department of Surgery, Massachusetts General Hospital and Shriners Burn Institute, Harvard Medical School, Boston, MA, USA
    Int J Mol Med 32:995-1000. 2013
  7. pmc fMRI as a molecular imaging procedure for the functional reorganization of motor systems in chronic stroke
    Asimina Lazaridou
    NMR Surgical Laboratory, Massachusetts General Hospital and Shriners Burn Institute, Harvard Medical School, Boston, MA, USA
    Mol Med Rep 8:775-9. 2013
  8. pmc Microarray analysis suggests that burn injury results in mitochondrial dysfunction in human skeletal muscle
    A Aria Tzika
    NMR Surgical Laboratory, Department of Surgery, Massachusetts General and Shriners Hospitals, Harvard Medical School, Boston, MA 02114, USA
    Int J Mol Med 24:387-92. 2009
  9. ncbi request reprint Proton magnetic resonance spectroscopic imaging as a cancer biomarker for pediatric brain tumors (Review)
    A Aria Tzika
    NMR Surgical Laboratory, Department of Surgery, Massachusetts General Hospital and Shriner s Burn Institute, Harvard Medical School, Boston, MA 02114, USA
    Int J Oncol 32:517-26. 2008
  10. ncbi request reprint Combination of high-resolution magic angle spinning proton magnetic resonance spectroscopy and microscale genomics to type brain tumor biopsies
    A Aria Tzika
    NMR Surgical Laboratory, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Int J Mol Med 20:199-208. 2007

Collaborators

Detail Information

Publications34

  1. pmc Functional MRI using robotic MRI compatible devices for monitoring rehabilitation from chronic stroke in the molecular medicine era (Review)
    Loukas G Astrakas
    Department of Surgery, NMR Surgical Laboratory, Massachusetts General Hospital and Shriners Burn Institute, Harvard Medical School, Boston, MA 02114, USA
    Int J Mol Med 29:963-73. 2012
    ....
  2. pmc Nuclear magnetic resonance in conjunction with functional genomics suggests mitochondrial dysfunction in a murine model of cancer cachexia
    Caterina Constantinou
    NMR Surgical Laboratory, Massachusetts General and Shriners Hospitals, Harvard Medical School, Boston, MA 02114, USA
    Int J Mol Med 27:15-24. 2011
    ....
  3. pmc High-resolution magic angle spinning magnetic resonance spectroscopy detects glycine as a biomarker in brain tumors
    Valeria Righi
    NMR Surgical Laboratory, Department of Surgery, Harvard Medical School and Massachusetts General Hospital, Boston, MA 02114, USA
    Int J Oncol 36:301-6. 2010
    ..We conclude from these findings that Gly can serve as a biomarker for brain tumors and that the Gly:Myo ratio may be a useful index for brain tumor classification...
  4. pmc Functional MRI of Rehabilitation in Chronic Stroke Patients Using Novel MR-Compatible Hand Robots
    Dionyssios Mintzopoulos
    NMR Surgical Laboratory, Department of Surgery, Massachusetts General Hospital and Shriner s Burn Institute, Harvard Medical School, Boston, MA 02114, USA
    Open Neuroimag J 2:94-101. 2008
    ..The effect persisted four weeks after training completion, indicating the potential of rehabilitation in inducing cortical plasticity in chronic stroke patients...
  5. pmc In vivo high-resolution magic angle spinning magnetic resonance spectroscopy of Drosophila melanogaster at 14.1 T shows trauma in aging and in innate immune-deficiency is linked to reduced insulin signaling
    Valeria Righi
    NMR Surgical Laboratory, Department of Surgery, Massachusetts General Hospital and Shriners Burn Institute, Harvard Medical School, Boston, MA 02114, USA
    Int J Mol Med 26:175-84. 2010
    ..Our approach advances the development of novel in vivo non-destructive research approaches in Drosophila, suggests biomarkers for investigation of biomedical paradigms, and thus may contribute to novel therapeutic development...
  6. pmc Diffusion tensor and volumetric magnetic resonance imaging using an MR-compatible hand-induced robotic device suggests training-induced neuroplasticity in patients with chronic stroke
    Asimina Lazaridou
    NMR Surgical Laboratory, Department of Surgery, Massachusetts General Hospital and Shriners Burn Institute, Harvard Medical School, Boston, MA, USA
    Int J Mol Med 32:995-1000. 2013
    ..Our study is an example of personalized medicine using advanced neuroimaging methods in conjunction with robotics in the molecular medicine era...
  7. pmc fMRI as a molecular imaging procedure for the functional reorganization of motor systems in chronic stroke
    Asimina Lazaridou
    NMR Surgical Laboratory, Massachusetts General Hospital and Shriners Burn Institute, Harvard Medical School, Boston, MA, USA
    Mol Med Rep 8:775-9. 2013
    ..These results also indicate that connectivity alterations between motor areas might assist the counterbalance of a functionally abnormal M1 in chronic stroke survivors and possibly other patients with motor dysfunction...
  8. pmc Microarray analysis suggests that burn injury results in mitochondrial dysfunction in human skeletal muscle
    A Aria Tzika
    NMR Surgical Laboratory, Department of Surgery, Massachusetts General and Shriners Hospitals, Harvard Medical School, Boston, MA 02114, USA
    Int J Mol Med 24:387-92. 2009
    ..008). These results suggest that altered PPAR and mitochondrial gene expression soon after burn injury may lead to metabolic and mitochondrial dysfunction in human skeletal muscle...
  9. ncbi request reprint Proton magnetic resonance spectroscopic imaging as a cancer biomarker for pediatric brain tumors (Review)
    A Aria Tzika
    NMR Surgical Laboratory, Department of Surgery, Massachusetts General Hospital and Shriner s Burn Institute, Harvard Medical School, Boston, MA 02114, USA
    Int J Oncol 32:517-26. 2008
    ..We further focus on applying the MRS technology to pediatric brain tumors, the leading cause of pediatric cancer mortality...
  10. ncbi request reprint Combination of high-resolution magic angle spinning proton magnetic resonance spectroscopy and microscale genomics to type brain tumor biopsies
    A Aria Tzika
    NMR Surgical Laboratory, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Int J Mol Med 20:199-208. 2007
    ....
  11. ncbi request reprint Murine intramyocellular lipids quantified by NMR act as metabolic biomarkers in burn trauma
    A Aria Tzika
    NMR Surgical Laboratory, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Int J Mol Med 21:825-32. 2008
    ..We believe that IMCLs may therefore be useful biomarkers in predicting the therapeutic effectiveness of hypolipidemic agents for patients with severe burns...
  12. ncbi request reprint Reduced rate of adenosine triphosphate synthesis by in vivo 31P nuclear magnetic resonance spectroscopy and downregulation of PGC-1beta in distal skeletal muscle following burn
    A Aria Tzika
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Int J Mol Med 21:201-8. 2008
    ..That PGC-1beta is a highly inducible factor in most tissues and responds to common calcium and cyclic adenosine monophosphate (cAMP) signaling pathways strongly suggests that it may be possible to develop drugs that can induce PGC-1beta...
  13. pmc Connectivity alterations assessed by combining fMRI and MR-compatible hand robots in chronic stroke
    Dionyssios Mintzopoulos
    NMR Surgical Laboratory, Department of Surgery, Massachusetts General Hospital and Shriner s Burn Institute, Harvard Medical School, Boston, MA 02114, USA
    Neuroimage 47:T90-7. 2009
    ..Assessing changes in connectivity by means of fMRI and MR_CHIROD might be used in the future to further elucidate the neural network plasticity that underlies functional recovery in chronic stroke patients...
  14. ncbi request reprint Uncoupling protein 3 expression and intramyocellular lipid accumulation by NMR following local burn trauma
    Qunhao Zhang
    Department of Surgery, Massachusetts General Hospital, Shriners Burn Institute and Harvard Medical School, Boston, MA 02114, USA
    Int J Mol Med 18:1223-9. 2006
    ....
  15. doi request reprint Combining magnetic resonance spectroscopy and molecular genomics offers better accuracy in brain tumor typing and prediction of survival than either methodology alone
    Loukas Astrakas
    NMR Surgical Laboratory, Department of Surgery, Massachusetts General Hospital and Shriners Burn Institute, Harvard Medical School, Boston, MA 02114, USA
    Int J Oncol 38:1113-27. 2011
    ..It is an important step for novel drug development, it generates testable hypotheses regarding neoplasia and promises to guide human brain tumor therapy provided improved in vivo methods for monitoring response to therapy are developed...
  16. pmc Molecular classification of brain tumor biopsies using solid-state magic angle spinning proton magnetic resonance spectroscopy and robust classifiers
    Ovidiu C Andronesi
    NMR Surgical Laboratory, Department of Surgery, Harvard Medical School and Massachusetts General Hospital, Boston, MA 02114, USA
    Int J Oncol 33:1017-25. 2008
    ..We suggest that molecular characterization of brain tumors based on highly informative 2D MRS should enable us to type and prognose even inoperable patients with high accuracy in vivo...
  17. ncbi request reprint Noninvasive magnetic resonance spectroscopic imaging biomarkers to predict the clinical grade of pediatric brain tumors
    Loukas G Astrakas
    Nuclear Magnetic Resonance Surgical Laboratory, Department of Surgery, Massachusetts General Hospital, Shriners Burns Institute, Harvard Medical School, Boston, Massachusetts 02114, USA
    Clin Cancer Res 10:8220-8. 2004
    ..Proton magnetic resonance spectroscopic imaging, although not a proxy for histology, provides noninvasive, in vivo biomarkers for predicting clinical grades of pediatric brain tumors...
  18. ncbi request reprint Predicting survival of children with CNS tumors using proton magnetic resonance spectroscopic imaging biomarkers
    Karen J Marcus
    Department of Radiation Oncology, Children s Hospital Boston, 51 Blossom Street, Boston, MA 02114, USA
    Int J Oncol 30:651-7. 2007
    ..More accurate prediction using this non-invasive technique represents an important advance and may suggest more appropriate therapy, especially when diagnostic biopsy is not feasible...
  19. doi request reprint Skeletal muscle mitochondrial uncoupling in a murine cancer cachexia model
    A Aria Tzika
    NMR Surgical Laboratory, Department of Surgery, Massachusetts General Hospital and Shriners Burn Institute, Harvard Medical School, Boston, MA 02114, USA
    Int J Oncol 43:886-94. 2013
    ..These findings may prove relevant to elucidating the mechanisms underlying skeletal muscle wasting observed in other chronic diseases, as well as in aging...
  20. ncbi request reprint Proton NMR spectroscopy shows lipids accumulate in skeletal muscle in response to burn trauma-induced apoptosis
    Loukas G Astrakas
    Department of Surgery, Massachusetts General Hospital, Shriners Burns Institute and Harvard Medical School, Boston, Massachusetts 02114, USA
    FASEB J 19:1431-40. 2005
    ..Together, our results provide new insight into the local physiological changes that occur in skeletal muscle after severe burn trauma...
  21. pmc A small volatile bacterial molecule triggers mitochondrial dysfunction in murine skeletal muscle
    A Aria Tzika
    Department of Surgery, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, United States of America Athinoula A Martinos Center of Biomedical Imaging, Massachusetts General Hospital, Boston, Massachusetts, United States of America Shriners Hospitals for Children Boston, Boston, Massachusetts, United States of America
    PLoS ONE 8:e74528. 2013
    ..Reduced energy production and mitochondrial dysfunctional may further favor infection, and be an important step in the establishment of chronic and persistent infections. ..
  22. ncbi request reprint Local and distant burn injury alter immuno-inflammatory gene expression in skeletal muscle
    Katie E Padfield
    Department of Surgery, Massachusetts General Hospital, Shriners Burns, Institute and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Trauma 61:280-92. 2006
    ..We are investigating the immuno-inflammatory response by characterizing gene expression changes in skeletal muscle after local and distant burn injury...
  23. ncbi request reprint Spectroscopic and perfusion magnetic resonance imaging predictors of progression in pediatric brain tumors
    A Aria Tzika
    NMR Surgical Laboratory, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Cancer 100:1246-56. 2004
    ....
  24. pmc Burn injury causes mitochondrial dysfunction in skeletal muscle
    Katie E Padfield
    Department of Surgery, Harvard Medical School and Massachusetts General Hospital, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 102:5368-73. 2005
    ....
  25. ncbi request reprint Biochemical characterization of pediatric brain tumors by using in vivo and ex vivo magnetic resonance spectroscopy
    A Aria Tzika
    Department of Radiology, Massachusetts General Hospital, Harvard Medical School, and Shriners Burns Institute, Boston, 02114, USA
    J Neurosurg 96:1023-31. 2002
    ..Their hypothesis was that ex vivo MR spectroscopy provides a link between in vivo MR spectroscopy and neuropathological analysis...
  26. pmc Mitochondria-targeted antioxidant promotes recovery of skeletal muscle mitochondrial function after burn trauma assessed by in vivo 31P nuclear magnetic resonance and electron paramagnetic resonance spectroscopy
    Valeria Righi
    Nuclear Magnetic Resonance Surgical Laboratory, Department of Surgery, Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Shriners Burns Institute, Harvard Medical School, Boston, MA 02114, USA
    FASEB J 27:2521-30. 2013
    ..These findings suggest use of noninvasive in vivo NMR and complementary EPR offers an approach to monitor the effectiveness of mitochondrial protective agents in alleviating burn injury symptoms...
  27. pmc Molecular characterization and quantification using state of the art solid-state adiabatic TOBSY NMR in burn trauma
    Valeria Righi
    NMR Surgical Laboratory, Department of Surgery, Massachusetts General Hospital and Shriners Burn Institute, Harvard Medical School, Boston, MA 02114, USA
    Int J Mol Med 24:749-57. 2009
    ..Moreover, this method has applications that facilitate the development of novel therapeutic strategies...
  28. ncbi request reprint Solid-state NMR adiabatic TOBSY sequences provide enhanced sensitivity for multidimensional high-resolution magic-angle-spinning 1H MR spectroscopy
    Ovidiu C Andronesi
    NMR Surgical Laboratory, Department of Surgery, Massachusetts General Hospital and Shriner s Burn Institute, Harvard Medical School, 51 Blossom Street, Room 261, Boston, MA 02114, USA
    J Magn Reson 193:251-8. 2008
    ..This is the first demonstration of such a concept for HRMAS metabolic profiling of disease processes, including cancer, from biopsies requiring reduced sample degradation for further genomic analysis...
  29. ncbi request reprint In vivo high-resolution magic angle spinning proton NMR spectroscopy of Drosophila melanogaster flies as a model system to investigate mitochondrial dysfunction in Drosophila GST2 mutants
    Valeria Righi
    NMR Surgical Laboratory, Department of Surgery, Massachusetts General Hospital and Shriners Burn Institute, Harvard Medical School, Boston, MA 02114, USA
    Int J Mol Med 34:327-33. 2014
    ..These findings may thus be directly relevant to a wide range of metabolically disruptive conditions, such as trauma, aging and immune system deficiencies, that lead to increased susceptibility to infection...
  30. ncbi request reprint Prediction of adverse outcome with cerebral lactate level and apparent diffusion coefficient in infants with perinatal asphyxia
    Maria K Zarifi
    Departments of Radiology, Children s Hospital, Harvard Medical School, Boston, Mass 02114, USA
    Radiology 225:859-70. 2002
    ..To compare the predictive value for adverse outcome of quantitative cerebral lactate level and of apparent diffusion coefficient (ADC) in infants with perinatal asphyxia in the early postnatal period...
  31. ncbi request reprint MR_CHIROD v.2: magnetic resonance compatible smart hand rehabilitation device for brain imaging
    Azadeh Khanicheh
    Department of Mechanical and Industrial Engineering, Northeastern University, Boston, MA 02115, USA
    IEEE Trans Neural Syst Rehabil Eng 16:91-8. 2008
    ..The results are encouraging in jointly using MR_CHIROD v.2 and brain MR imaging to study motor performance and assess rehabilitation after neurological injuries such as stroke...
  32. pmc Inhibitors of pathogen intercellular signals as selective anti-infective compounds
    Biliana Lesic
    Department of Surgery, Microbiology and Molecular Genetics, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, USA
    PLoS Pathog 3:1229-39. 2007
    ..These compounds provide a starting point for the design and development of selective anti-infectives that restrict human P. aeruginosa pathogenesis, and possibly other clinically significant pathogens...
  33. ncbi request reprint Neuroimaging in pediatric brain tumors: Gd-DTPA-enhanced, hemodynamic, and diffusion MR imaging compared with MR spectroscopic imaging
    A Aria Tzika
    Department of Radiology, Children s Hospital, Harvard Medical School, Boston, MA 02114, USA
    AJNR Am J Neuroradiol 23:322-33. 2002
    ..Our aim was to improve conventional neuroimaging of pediatric brain tumors with hemodynamic, diffusion, and spectroscopic MR imaging...
  34. ncbi request reprint The clinical perspective of large scale projects: a case study of multiparametric MR imaging of pediatric brain tumors
    L Astrakas
    NMR Surgical Laboratory, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, 51 Blossom Street, Boston, MA 02114, USA
    Oncol Rep 15:1065-9. 2006
    ..At present, efforts to organize medical data locally and between different sites is limited by diversity, interoperability, security, and accountability difficulties...