Arthur Tzianabos

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc CD4+ T cells regulate surgical and postinfectious adhesion formation
    Doo Ryeon Chung
    Channing Laboratory, Department of Medicine, 181 Longwood Avenue, Boston, MA 02115, USA
    J Exp Med 195:1471-8. 2002
  2. ncbi request reprint Protection against experimental intraabdominal sepsis by two polysaccharide immunomodulators
    A O Tzianabos
    Channing Laboratory, Brigham and Women s Hospital, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Infect Dis 178:200-6. 1998
  3. ncbi request reprint Biological chemistry of immunomodulation by zwitterionic polysaccharides
    Arthur Tzianabos
    Department of Medicine, Channing Laboratory, 181 Longwood Ave, Brigham and Women s Hospital, Boston, MA 02115, USA
    Carbohydr Res 338:2531-8. 2003
  4. ncbi request reprint Role of T cells in abscess formation
    Arthur O Tzianabos
    Channing Laboratory, Brigham and Women s Hospital, Departments of Medicine, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Curr Opin Microbiol 5:92-6. 2002
  5. pmc Structural rationale for the modulation of abscess formation by Staphylococcus aureus capsular polysaccharides
    A O Tzianabos
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 98:9365-70. 2001
  6. pmc Bacterial pathogens induce abscess formation by CD4(+) T-cell activation via the CD28-B7-2 costimulatory pathway
    A O Tzianabos
    Channing Laboratory, Department of Medicine, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Infect Immun 68:6650-5. 2000
  7. pmc Polysaccharide immunomodulators as therapeutic agents: structural aspects and biologic function
    A O Tzianabos
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Clin Microbiol Rev 13:523-33. 2000
  8. ncbi request reprint T cells activated by zwitterionic molecules prevent abscesses induced by pathogenic bacteria
    A O Tzianabos
    Channing Laboratory, Brigham and Women s Hospital, Dana Farber Cancer Institute, Harvard Medical School Boston, Massachusetts 02115, USA
    J Biol Chem 275:6733-40. 2000
  9. ncbi request reprint Effect of surgical adhesion reduction devices on the propagation of experimental intra-abdominal infection
    A O Tzianabos
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Arch Surg 134:1254-9. 1999
  10. ncbi request reprint IL-2 mediates protection against abscess formation in an experimental model of sepsis
    A O Tzianabos
    Department of Medicine, Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Immunol 163:893-7. 1999

Research Grants

  1. TEACHING BIOLOGY THROUGH IMMUNOLOGY FELLOWSHIPS
    Arthur Tzianabos; Fiscal Year: 2007
  2. Surgical Adhesions: Role of T cells in Pathogenesis
    Arthur Tzianabos; Fiscal Year: 2002
  3. Host Response in S. aureus Infections: Role of T cells
    Arthur Tzianabos; Fiscal Year: 2006
  4. Host Response in S. aureus Infections: Role of T cells
    Arthur Tzianabos; Fiscal Year: 2005
  5. Host Response in S. aureus Infections: Role of T cells
    Arthur Tzianabos; Fiscal Year: 2004
  6. Surgical Adhesions: Role of T cells in Pathogenesis
    Arthur Tzianabos; Fiscal Year: 2004
  7. Host Response in S. aureus Infections: Role of T cells
    Arthur Tzianabos; Fiscal Year: 2003
  8. Surgical Adhesions: Role of T cells in Pathogenesis
    Arthur Tzianabos; Fiscal Year: 2003
  9. Host Response in S. aureus Infections: Role of T cells
    Arthur Tzianabos; Fiscal Year: 2002
  10. FASEB Summer Conference on Microbial Polysaccharides
    Arthur Tzianabos; Fiscal Year: 2004

Collaborators

Detail Information

Publications30

  1. pmc CD4+ T cells regulate surgical and postinfectious adhesion formation
    Doo Ryeon Chung
    Channing Laboratory, Department of Medicine, 181 Longwood Avenue, Boston, MA 02115, USA
    J Exp Med 195:1471-8. 2002
    ....
  2. ncbi request reprint Protection against experimental intraabdominal sepsis by two polysaccharide immunomodulators
    A O Tzianabos
    Channing Laboratory, Brigham and Women s Hospital, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Infect Dis 178:200-6. 1998
    ....
  3. ncbi request reprint Biological chemistry of immunomodulation by zwitterionic polysaccharides
    Arthur Tzianabos
    Department of Medicine, Channing Laboratory, 181 Longwood Ave, Brigham and Women s Hospital, Boston, MA 02115, USA
    Carbohydr Res 338:2531-8. 2003
    ..This review will describe the biological and structural aspects of ZPSs that convey these activities...
  4. ncbi request reprint Role of T cells in abscess formation
    Arthur O Tzianabos
    Channing Laboratory, Brigham and Women s Hospital, Departments of Medicine, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Curr Opin Microbiol 5:92-6. 2002
    ..This work describes how zwitterionic polysaccharides on the surface of these organisms interact with the host immune system in general, and with T cells in particular, to coordinate this pathobiologic response...
  5. pmc Structural rationale for the modulation of abscess formation by Staphylococcus aureus capsular polysaccharides
    A O Tzianabos
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 98:9365-70. 2001
    ..These results provide a structure/function rationale for abscess formation by S. aureus and expand the sphere of encapsulated organisms that interact directly with T cells to regulate this host response to bacterial infection...
  6. pmc Bacterial pathogens induce abscess formation by CD4(+) T-cell activation via the CD28-B7-2 costimulatory pathway
    A O Tzianabos
    Channing Laboratory, Department of Medicine, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Infect Immun 68:6650-5. 2000
    ..These results demonstrate that abscess formation by pathogenic bacteria is under the control of a common effector mechanism that requires T-cell activation via the CD28-B7-2 pathway...
  7. pmc Polysaccharide immunomodulators as therapeutic agents: structural aspects and biologic function
    A O Tzianabos
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Clin Microbiol Rev 13:523-33. 2000
    ..This review focuses on recent studies that illustrate the structural and biologic activities of specific polysaccharide immunomodulators and outlines their potential for clinical use...
  8. ncbi request reprint T cells activated by zwitterionic molecules prevent abscesses induced by pathogenic bacteria
    A O Tzianabos
    Channing Laboratory, Brigham and Women s Hospital, Dana Farber Cancer Institute, Harvard Medical School Boston, Massachusetts 02115, USA
    J Biol Chem 275:6733-40. 2000
    ..These studies demonstrate that bacterial polysaccharides with a distinct charge motif activate T cells and that this activity confers immunity to a distinct pathologic response to bacterial infection...
  9. ncbi request reprint Effect of surgical adhesion reduction devices on the propagation of experimental intra-abdominal infection
    A O Tzianabos
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Arch Surg 134:1254-9. 1999
    ..The use of certain surgical adhesion reduction devices where there is a risk of concomitant bacterial contamination potentiates intra-abdominal infection...
  10. ncbi request reprint IL-2 mediates protection against abscess formation in an experimental model of sepsis
    A O Tzianabos
    Department of Medicine, Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Immunol 163:893-7. 1999
    ..These data demonstrate that PS A-mediated protection against abscess formation is dependent upon a CD4+ T cell-dependent response, and that IL-2 is essential to this immune mechanism...
  11. ncbi request reprint CD4+ T cells mediate abscess formation in intra-abdominal sepsis by an IL-17-dependent mechanism
    Doo Ryeon Chung
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 170:1958-63. 2003
    ..These data delineate the specific T cell response necessary for the development of intra-abdominal abscesses and underscore the role of IL-17 in this disease process...
  12. pmc A bacterial carbohydrate links innate and adaptive responses through Toll-like receptor 2
    Qun Wang
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, and Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 203:2853-63. 2006
    ..fragilis. Commensal bacteria, using molecules like PSA, potentially modulate the Th1/Th2 cell balance and the response to infection by coordinating both the innate and adaptive pathways...
  13. pmc CD4+ T cells and CXC chemokines modulate the pathogenesis of Staphylococcus aureus wound infections
    Rachel M McLoughlin
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 103:10408-13. 2006
    ..aureus infections in controlling local CXC chemokine production, neutrophil recruitment to the site of infection, and subsequent bacterial replication...
  14. pmc Antibody-independent, interleukin-17A-mediated, cross-serotype immunity to pneumococci in mice immunized intranasally with the cell wall polysaccharide
    Richard Malley
    Division of Infectious Diseases, Children s Hospital, 300 Longwood Avenue, Boston, MA 02115, USA
    Infect Immun 74:2187-95. 2006
    ..C-Ps also protected in a model of fatal aspiration pneumonia by heavily capsulated serotype 3. These findings suggest a novel immunization strategy against S. pneumoniae...
  15. pmc Associations of cord blood fatty acids with lymphocyte proliferation, IL-13, and IFN-gamma
    Diane R Gold
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    J Allergy Clin Immunol 117:931-8. 2006
    ..However, both n-3 eicosapentaenoic acid (EPA) and n-6 arachidonic acid (AA) are required for normal fetal development...
  16. pmc Cord blood cytokines and acute lower respiratory illnesses in the first year of life
    Ngoc P Ly
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Pediatrics 119:e171-8. 2007
    ..The purpose of this work was to examine the relation between cytokine secretions by cord blood mononuclear cells and acute lower respiratory illness in a birth cohort of 297 children...
  17. pmc Functional Th1 cells are required for surgical adhesion formation in a murine model
    Arthur O Tzianabos
    Department of Medicine and Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 180:6970-6. 2008
    ..These data demonstrate that the CD4(+) T cells orchestrating adhesion formation are of the Th1 phenotype and delineate the central role of T-bet, Tim-3, IFN-gamma, and IL-16 in mediating this pathogenic tissue response...
  18. ncbi request reprint An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system
    Sarkis K Mazmanian
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 122:107-18. 2005
    ..These findings provide a molecular basis for host-bacterial symbiosis and reveal the archetypal molecule of commensal bacteria that mediates development of the host immune system...
  19. ncbi request reprint IFN-gamma regulated chemokine production determines the outcome of Staphylococcus aureus infection
    Rachel M McLoughlin
    Department of Medicine, Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 181:1323-32. 2008
    ..aureus pathogenesis by facilitating bacterial survival within the neutrophil. These findings suggest avenues for novel immunomodulatory approaches to control S. aureus infections...
  20. ncbi request reprint Regulation of postsurgical fibrosis by the programmed death-1 inhibitory pathway
    Matthew A Holsti
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 172:5774-81. 2004
    ....
  21. ncbi request reprint Zwitterionic polysaccharides stimulate T cells by MHC class II-dependent interactions
    Wiltrud M Kalka-Moll
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 169:6149-53. 2002
    ..These results indicate that MHC class II molecules expressing HLA-DR on professional APCs are required for ZPS-induced T cell activation. The implication is that binding of ZPS to HLA-DR may be required for T cell activation...
  22. pmc Modulation of surgical fibrosis by microbial zwitterionic polysaccharides
    Begonia Ruiz-Perez
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 102:16753-8. 2005
    ....
  23. pmc Polysaccharide processing and presentation by the MHCII pathway
    Brian A Cobb
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Cell 117:677-87. 2004
    ..Our observations begin to elucidate the mechanisms by which some carbohydrates induce important immunologic responses through T cell activation, suggesting a fundamental shift in the MHCII presentation paradigm...
  24. ncbi request reprint Cytokines, allergy, and asthma
    P Ly Ngoc
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Curr Opin Allergy Clin Immunol 5:161-6. 2005
    ..This review examines recent articles on the relationship of cytokines to allergy and asthma with particular emphasis on immune mechanisms involved in disease development in early life...
  25. pmc A defined O-antigen polysaccharide mutant of Francisella tularensis live vaccine strain has attenuated virulence while retaining its protective capacity
    Shite Sebastian
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA
    Infect Immun 75:2591-602. 2007
    ..tularensis type B. Recognition and characterization of the pivotal role of O-PS in the virulence of this intracellular bacterial pathogen may have broad implications for the creation of a safe and efficacious vaccine...
  26. pmc Immunization with Porphyromonas gingivalis capsular polysaccharide prevents P. gingivalis-elicited oral bone loss in a murine model
    Dario Gonzalez
    Department of Periodontology and Oral Biology, Goldman School of Dental Medicine, Boston, Massachusetts, USA
    Infect Immun 71:2283-7. 2003
    ..The mice immunized with P. gingivalis CPS were protected from P. gingivalis-elicited oral bone loss. These data demonstrate that P. gingivalis CPS is a vaccine candidate for prevention of P. gingivalis-elicited oral bone loss...
  27. ncbi request reprint Zwitterionic polysaccharides stimulate T cells with no preferential V beta usage and promote anergy, resulting in protection against experimental abscess formation
    Francesca Stingele
    Nestle Research Center, Vers chez les Blanc, Lausanne, Switzerland
    J Immunol 172:1483-90. 2004
    ..Taken together, the data show that this class of polysaccharides interacts directly with T cells in a nonbiased manner to elicit an IL-2-dependent anergic response that confers protection against abscess formation...
  28. pmc Hyaluronic acid binding peptides prevent experimental staphylococcal wound infection
    Kathleen J Zaleski
    Shire Pharmaceuticals, 700 Main Street, Cambridge, MA 02139, USA
    Antimicrob Agents Chemother 50:3856-60. 2006
    ..These data suggest a novel approach for the treatment and prophylaxis of staphylococcal wound infections in the clinical setting...
  29. pmc Effect of B7-2 and CD40 signals from activated antigen-presenting cells on the ability of zwitterionic polysaccharides to induce T-Cell stimulation
    Tom Li Stephen
    Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Medical Center, Goldenfelsstr 19 21, 50935 Cologne, Germany
    Infect Immun 73:2184-9. 2005
    ..The implication is that activation of ZPS-specific T cells requires an orchestrated arrangement of both presenting and costimulatory molecules to form an immunological synapse...
  30. pmc Thioredoxin reductase is essential for thiol/disulfide redox control and oxidative stress survival of the anaerobe Bacteroides fragilis
    Edson R Rocha
    Department of Microbiology and Immunology, East Carolina University Brody School of Medicine, 600 Moye Blvd, Greenville, NC 27834, USA
    J Bacteriol 189:8015-23. 2007
    ..Taken together, these data strongly suggest that TrxB/Trx is the major, if not the sole, thiol/disulfide redox system in this anaerobe required for survival and abscess formation in a peritoneal cavity infection model...

Research Grants11

  1. TEACHING BIOLOGY THROUGH IMMUNOLOGY FELLOWSHIPS
    Arthur Tzianabos; Fiscal Year: 2007
    ..Thus, we will also survey each teacher and school district previously in the program in order to determine the effect of the program on science education and student career choices. ..
  2. Surgical Adhesions: Role of T cells in Pathogenesis
    Arthur Tzianabos; Fiscal Year: 2002
    ..abstract_text> ..
  3. Host Response in S. aureus Infections: Role of T cells
    Arthur Tzianabos; Fiscal Year: 2006
    ..aureus infections. This information may reveal new strategies for the prevention or treatment of S. aureus infections through immunomodulation of the host response to this organism. ..
  4. Host Response in S. aureus Infections: Role of T cells
    Arthur Tzianabos; Fiscal Year: 2005
    ..aureus infections. This information may reveal new strategies for the prevention or treatment of S. aureus infections through immunomodulation of the host response to this organism. ..
  5. Host Response in S. aureus Infections: Role of T cells
    Arthur Tzianabos; Fiscal Year: 2004
    ..aureus infections. This information may reveal new strategies for the prevention or treatment of S. aureus infections through immunomodulation of the host response to this organism. ..
  6. Surgical Adhesions: Role of T cells in Pathogenesis
    Arthur Tzianabos; Fiscal Year: 2004
    ..abstract_text> ..
  7. Host Response in S. aureus Infections: Role of T cells
    Arthur Tzianabos; Fiscal Year: 2003
    ..aureus infections. This information may reveal new strategies for the prevention or treatment of S. aureus infections through immunomodulation of the host response to this organism. ..
  8. Surgical Adhesions: Role of T cells in Pathogenesis
    Arthur Tzianabos; Fiscal Year: 2003
    ..abstract_text> ..
  9. Host Response in S. aureus Infections: Role of T cells
    Arthur Tzianabos; Fiscal Year: 2002
    ..aureus infections. This information may reveal new strategies for the prevention or treatment of S. aureus infections through immunomodulation of the host response to this organism. ..
  10. FASEB Summer Conference on Microbial Polysaccharides
    Arthur Tzianabos; Fiscal Year: 2004
    ..This meeting will provide a unique environment for scientific exchange between a diverse group of investigators in the area of microbial polysaccharides. ..
  11. Surgical Adhesions: Role of T cells in Pathogenesis
    Arthur Tzianabos; Fiscal Year: 2005
    ..abstract_text> ..