Research Topics
Species | Arthur TzianabosSummaryAffiliation: Harvard University Country: USA Publications
Research Grants
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Detail Information
Publications
Protection against experimental intraabdominal sepsis by two polysaccharide immunomodulatorsA O Tzianabos
Channing Laboratory, Brigham and Women s Hospital, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
J Infect Dis 178:200-6. 1998....- Role of T cells in abscess formationArthur O Tzianabos
Channing Laboratory, Brigham and Women s Hospital, Departments of Medicine, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
Curr Opin Microbiol 5:92-6. 2002..This work describes how zwitterionic polysaccharides on the surface of these organisms interact with the host immune system in general, and with T cells in particular, to coordinate this pathobiologic response... 
Structural rationale for the modulation of abscess formation by Staphylococcus aureus capsular polysaccharidesA O Tzianabos
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 98:9365-70. 2001..These results provide a structure/function rationale for abscess formation by S. aureus and expand the sphere of encapsulated organisms that interact directly with T cells to regulate this host response to bacterial infection...- Bacterial pathogens induce abscess formation by CD4(+) T-cell activation via the CD28-B7-2 costimulatory pathwayA O Tzianabos
Channing Laboratory, Department of Medicine, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
Infect Immun 68:6650-5. 2000..These results demonstrate that abscess formation by pathogenic bacteria is under the control of a common effector mechanism that requires T-cell activation via the CD28-B7-2 pathway... - Polysaccharide immunomodulators as therapeutic agents: structural aspects and biologic functionA O Tzianabos
Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Clin Microbiol Rev 13:523-33. 2000..This review focuses on recent studies that illustrate the structural and biologic activities of specific polysaccharide immunomodulators and outlines their potential for clinical use... - T cells activated by zwitterionic molecules prevent abscesses induced by pathogenic bacteriaA O Tzianabos
Channing Laboratory, Brigham and Women s Hospital, Dana Farber Cancer Institute, Harvard Medical School Boston, Massachusetts 02115, USA
J Biol Chem 275:6733-40. 2000..These studies demonstrate that bacterial polysaccharides with a distinct charge motif activate T cells and that this activity confers immunity to a distinct pathologic response to bacterial infection... - Effect of surgical adhesion reduction devices on the propagation of experimental intra-abdominal infectionA O Tzianabos
Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
Arch Surg 134:1254-9. 1999..The use of certain surgical adhesion reduction devices where there is a risk of concomitant bacterial contamination potentiates intra-abdominal infection... - IL-2 mediates protection against abscess formation in an experimental model of sepsisA O Tzianabos
Department of Medicine, Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
J Immunol 163:893-7. 1999..These data demonstrate that PS A-mediated protection against abscess formation is dependent upon a CD4+ T cell-dependent response, and that IL-2 is essential to this immune mechanism... - Biological chemistry of immunomodulation by zwitterionic polysaccharidesArthur Tzianabos
Department of Medicine, Channing Laboratory, 181 Longwood Ave, Brigham and Women s Hospital, Boston, MA 02115, USA
Carbohydr Res 338:2531-8. 2003..This review will describe the biological and structural aspects of ZPSs that convey these activities... - CD4+ T cells mediate abscess formation in intra-abdominal sepsis by an IL-17-dependent mechanismDoo Ryeon Chung
Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
J Immunol 170:1958-63. 2003..These data delineate the specific T cell response necessary for the development of intra-abdominal abscesses and underscore the role of IL-17 in this disease process... 
A bacterial carbohydrate links innate and adaptive responses through Toll-like receptor 2Qun Wang
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, and Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA
J Exp Med 203:2853-63. 2006..fragilis. Commensal bacteria, using molecules like PSA, potentially modulate the Th1/Th2 cell balance and the response to infection by coordinating both the innate and adaptive pathways...- CD4+ T cells and CXC chemokines modulate the pathogenesis of Staphylococcus aureus wound infectionsRachel M McLoughlin
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 103:10408-13. 2006..aureus infections in controlling local CXC chemokine production, neutrophil recruitment to the site of infection, and subsequent bacterial replication... - Associations of cord blood fatty acids with lymphocyte proliferation, IL-13, and IFN-gammaDiane R Gold
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
J Allergy Clin Immunol 117:931-8. 2006..However, both n-3 eicosapentaenoic acid (EPA) and n-6 arachidonic acid (AA) are required for normal fetal development... - Cord blood cytokines and acute lower respiratory illnesses in the first year of lifeNgoc P Ly
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Pediatrics 119:e171-8. 2007..The purpose of this work was to examine the relation between cytokine secretions by cord blood mononuclear cells and acute lower respiratory illness in a birth cohort of 297 children... - Functional Th1 cells are required for surgical adhesion formation in a murine modelArthur O Tzianabos
Department of Medicine and Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
J Immunol 180:6970-6. 2008..These data demonstrate that the CD4(+) T cells orchestrating adhesion formation are of the Th1 phenotype and delineate the central role of T-bet, Tim-3, IFN-gamma, and IL-16 in mediating this pathogenic tissue response... - An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune systemSarkis K Mazmanian
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Cell 122:107-18. 2005..These findings provide a molecular basis for host-bacterial symbiosis and reveal the archetypal molecule of commensal bacteria that mediates development of the host immune system... - CD4+ T cells regulate surgical and postinfectious adhesion formationDoo Ryeon Chung
Channing Laboratory, Department of Medicine, 181 Longwood Avenue, Boston, MA 02115, USA
J Exp Med 195:1471-8. 2002.... - IFN-gamma regulated chemokine production determines the outcome of Staphylococcus aureus infectionRachel M McLoughlin
Department of Medicine, Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Immunol 181:1323-32. 2008..aureus pathogenesis by facilitating bacterial survival within the neutrophil. These findings suggest avenues for novel immunomodulatory approaches to control S. aureus infections... - Regulation of postsurgical fibrosis by the programmed death-1 inhibitory pathwayMatthew A Holsti
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Immunol 172:5774-81. 2004.... - Zwitterionic polysaccharides stimulate T cells by MHC class II-dependent interactionsWiltrud M Kalka-Moll
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Immunol 169:6149-53. 2002..These results indicate that MHC class II molecules expressing HLA-DR on professional APCs are required for ZPS-induced T cell activation. The implication is that binding of ZPS to HLA-DR may be required for T cell activation... - Antibody-independent, interleukin-17A-mediated, cross-serotype immunity to pneumococci in mice immunized intranasally with the cell wall polysaccharideRichard Malley
Division of Infectious Diseases, Children s Hospital, 300 Longwood Avenue, Boston, MA 02115, USA
Infect Immun 74:2187-95. 2006..C-Ps also protected in a model of fatal aspiration pneumonia by heavily capsulated serotype 3. These findings suggest a novel immunization strategy against S. pneumoniae... - Modulation of surgical fibrosis by microbial zwitterionic polysaccharidesBegonia Ruiz-Perez
Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 102:16753-8. 2005.... - Polysaccharide processing and presentation by the MHCII pathwayBrian A Cobb
Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA
Cell 117:677-87. 2004..Our observations begin to elucidate the mechanisms by which some carbohydrates induce important immunologic responses through T cell activation, suggesting a fundamental shift in the MHCII presentation paradigm... - A defined O-antigen polysaccharide mutant of Francisella tularensis live vaccine strain has attenuated virulence while retaining its protective capacityShite Sebastian
Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA
Infect Immun 75:2591-602. 2007..tularensis type B. Recognition and characterization of the pivotal role of O-PS in the virulence of this intracellular bacterial pathogen may have broad implications for the creation of a safe and efficacious vaccine... - Immunization with Porphyromonas gingivalis capsular polysaccharide prevents P. gingivalis-elicited oral bone loss in a murine modelDario Gonzalez
Department of Periodontology and Oral Biology, Goldman School of Dental Medicine, Boston, Massachusetts, USA
Infect Immun 71:2283-7. 2003..The mice immunized with P. gingivalis CPS were protected from P. gingivalis-elicited oral bone loss. These data demonstrate that P. gingivalis CPS is a vaccine candidate for prevention of P. gingivalis-elicited oral bone loss... - Cytokines, allergy, and asthmaP Ly Ngoc
Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA
Curr Opin Allergy Clin Immunol 5:161-6. 2005..Understanding early-life immune mechanisms responsible for atopic diseases, specifically how cytokines of T-regulatory cells act to balance the Th1 and Th2 immune response, continues to be a fruitful area of research... - Zwitterionic polysaccharides stimulate T cells with no preferential V beta usage and promote anergy, resulting in protection against experimental abscess formationFrancesca Stingele
Nestle Research Center, Vers chez les Blanc, Lausanne, Switzerland
J Immunol 172:1483-90. 2004..Taken together, the data show that this class of polysaccharides interacts directly with T cells in a nonbiased manner to elicit an IL-2-dependent anergic response that confers protection against abscess formation... - Effect of B7-2 and CD40 signals from activated antigen-presenting cells on the ability of zwitterionic polysaccharides to induce T-Cell stimulationTom Li Stephen
Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Medical Center, Goldenfelsstr. 19-21, 50935 Cologne, Germany
Infect Immun 73:2184-9. 2005..The implication is that activation of ZPS-specific T cells requires an orchestrated arrangement of both presenting and costimulatory molecules to form an immunological synapse... - Hyaluronic acid binding peptides prevent experimental staphylococcal wound infectionKathleen J Zaleski
Shire Pharmaceuticals, 700 Main Street, Cambridge, MA 02139, USA
Antimicrob Agents Chemother 50:3856-60. 2006..These data suggest a novel approach for the treatment and prophylaxis of staphylococcal wound infections in the clinical setting... - Thioredoxin reductase is essential for thiol/disulfide redox control and oxidative stress survival of the anaerobe Bacteroides fragilisEdson R Rocha
Department of Microbiology and Immunology, East Carolina University Brody School of Medicine, 600 Moye Blvd, Greenville, NC 27834, USA
J Bacteriol 189:8015-23. 2007..Taken together, these data strongly suggest that TrxB/Trx is the major, if not the sole, thiol/disulfide redox system in this anaerobe required for survival and abscess formation in a peritoneal cavity infection model...
Research Grants
- TEACHING BIOLOGY THROUGH IMMUNOLOGY FELLOWSHIPSArthur Tzianabos; Fiscal Year: 2007..Thus, we will also survey each teacher and school district previously in the program in order to determine the effect of the program on science education and student career choices. ..
- Host Response in S. aureus Infections: Role of T cellsArthur Tzianabos; Fiscal Year: 2006..aureus infections. This information may reveal new strategies for the prevention or treatment of S. aureus infections through immunomodulation of the host response to this organism. ..
- Surgical Adhesions: Role of T cells in PathogenesisArthur Tzianabos; Fiscal Year: 2005..abstract_text> ..
- FASEB Summer Conference on Microbial PolysaccharidesArthur Tzianabos; Fiscal Year: 2004..This meeting will provide a unique environment for scientific exchange between a diverse group of investigators in the area of microbial polysaccharides. ..