Shelley Tworoger

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc A 20-year prospective study of plasma prolactin as a risk marker of breast cancer development
    Shelley S Tworoger
    Channing Division of Network Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Cancer Res 73:4810-9. 2013
  2. pmc Tubal ligation, hysterectomy and ovarian cancer: A meta-analysis
    Megan S Rice
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    J Ovarian Res 5:13. 2012
  3. pmc Insulin-like growth factor-1, insulin-like growth factor binding protein-3 and lobule type in the Nurses' Health Study II
    Megan S Rice
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Ave 3rd Floor, Boston, MA, 02115 USA
    Breast Cancer Res 14:R44. 2012
  4. pmc Genetic variability in IGF-1 and IGFBP-3 and body size in early life
    Elizabeth M Poole
    Department of Medicine, Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    BMC Public Health 12:659. 2012
  5. pmc Acrylamide hemoglobin adduct levels and ovarian cancer risk: a nested case-control study
    Jing Xie
    Channing Division of Network Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 22:653-60. 2013
  6. pmc The combined influence of multiple sex and growth hormones on risk of postmenopausal breast cancer: a nested case-control study
    Shelley S Tworoger
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Breast Cancer Res 13:R99. 2011
  7. pmc Risk factors for ductal and lobular breast cancer: results from the nurses' health study
    Joanne Kotsopoulos
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Breast Cancer Res 12:R106. 2010
  8. ncbi request reprint A prospective study of plasma prolactin concentrations and risk of premenopausal and postmenopausal breast cancer
    Shelley S Tworoger
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Clin Oncol 25:1482-8. 2007
  9. ncbi request reprint Plasma adiponectin concentrations and risk of incident breast cancer
    Shelley S Tworoger
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Third Floor, Boston, Massachusetts 02115, USA
    J Clin Endocrinol Metab 92:1510-6. 2007
  10. ncbi request reprint Birthweight and body size throughout life in relation to sex hormones and prolactin concentrations in premenopausal women
    Shelley S Tworoger
    Channing Laboratory, 181 Longwood Avenue, 3rd Floor, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 15:2494-501. 2006

Research Grants

Detail Information

Publications96

  1. pmc A 20-year prospective study of plasma prolactin as a risk marker of breast cancer development
    Shelley S Tworoger
    Channing Division of Network Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Cancer Res 73:4810-9. 2013
    ..This corresponds with biologic data that prolactin is etiologically important in tumor promotion...
  2. pmc Tubal ligation, hysterectomy and ovarian cancer: A meta-analysis
    Megan S Rice
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    J Ovarian Res 5:13. 2012
    ..abstract:..
  3. pmc Insulin-like growth factor-1, insulin-like growth factor binding protein-3 and lobule type in the Nurses' Health Study II
    Megan S Rice
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Ave 3rd Floor, Boston, MA, 02115 USA
    Breast Cancer Res 14:R44. 2012
    ..Studies in animal models suggest that insulin-like growth factor-1 (IGF-1) may inhibit involution of lobules in the breast; however, this has not been studied in humans...
  4. pmc Genetic variability in IGF-1 and IGFBP-3 and body size in early life
    Elizabeth M Poole
    Department of Medicine, Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    BMC Public Health 12:659. 2012
    ..Previous studies have examined the role of IGF-1 and IGFBP-3 genetic variation in relation to adult height and body size, but few studies have examined associations with birthweight and childhood size...
  5. pmc Acrylamide hemoglobin adduct levels and ovarian cancer risk: a nested case-control study
    Jing Xie
    Channing Division of Network Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 22:653-60. 2013
    ..Two large prospective cohort studies of dietary acrylamide intake and ovarian cancer risk observed a positive association, although two other studies reported no association...
  6. pmc The combined influence of multiple sex and growth hormones on risk of postmenopausal breast cancer: a nested case-control study
    Shelley S Tworoger
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Breast Cancer Res 13:R99. 2011
    ..Sex and growth hormones are positively associated with postmenopausal breast cancer risk. However, few studies have evaluated the influence of multiple hormones simultaneously...
  7. pmc Risk factors for ductal and lobular breast cancer: results from the nurses' health study
    Joanne Kotsopoulos
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Breast Cancer Res 12:R106. 2010
    ....
  8. ncbi request reprint A prospective study of plasma prolactin concentrations and risk of premenopausal and postmenopausal breast cancer
    Shelley S Tworoger
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Clin Oncol 25:1482-8. 2007
    ....
  9. ncbi request reprint Plasma adiponectin concentrations and risk of incident breast cancer
    Shelley S Tworoger
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Third Floor, Boston, Massachusetts 02115, USA
    J Clin Endocrinol Metab 92:1510-6. 2007
    ..Therefore, we conducted a prospective case-control study nested within the Nurses' Health Study (NHS) and NHSII cohorts examining the association between plasma adiponectin concentrations and breast cancer risk...
  10. ncbi request reprint Birthweight and body size throughout life in relation to sex hormones and prolactin concentrations in premenopausal women
    Shelley S Tworoger
    Channing Laboratory, 181 Longwood Avenue, 3rd Floor, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 15:2494-501. 2006
    ..Our results suggest that effects on premenopausal sex hormone levels may be one mechanism through which adult adiposity, but not birthweight or childhood body size, affects premenopausal breast cancer risk...
  11. ncbi request reprint The association of plasma DHEA and DHEA sulfate with breast cancer risk in predominantly premenopausal women
    Shelley S Tworoger
    Channing Laboratory, 181 Longwood Avenue, 3rd Floor, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 15:967-71. 2006
    ....
  12. ncbi request reprint Intake of folate and related nutrients in relation to risk of epithelial ovarian cancer
    Shelley S Tworoger
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Epidemiol 163:1101-11. 2006
    ..There was little evidence that folate, methionine, and vitamin B(6) are important in ovarian cancer risk, although dietary folate was inversely associated with risk in some analyses...
  13. ncbi request reprint Prolactin and breast cancer risk
    Shelley S Tworoger
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, 3rd Floor, Boston, MA 02115, USA
    Cancer Lett 243:160-9. 2006
    ..Future research directions include better characterizing the potential interplay between prolactin and estrogen and determining whether genetic variability in prolactin-related genes is associated with breast cancer risk...
  14. ncbi request reprint Plasma 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D and risk of incident ovarian cancer
    Shelley S Tworoger
    Channing Laboratory, Department of Medicine, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 16:783-8. 2007
    ..However, we observed significant associations in some subgroups, which should be evaluated further in other studies because increasing vitamin D intake is an easy preventive measure to adopt...
  15. ncbi request reprint Physical activity and inactivity in relation to sex hormone, prolactin, and insulin-like growth factor concentrations in premenopausal women - exercise and premenopausal hormones
    Shelley S Tworoger
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Ave, 3rd Floor, Boston, MA 02115, USA
    Cancer Causes Control 18:743-52. 2007
    ..These cross-sectional results suggest that physical activity and inactivity have limited associations with premenopausal sex hormone and growth factor levels, except possibly luteal estrogens...
  16. ncbi request reprint Association of oral contraceptive use, other contraceptive methods, and infertility with ovarian cancer risk
    Shelley S Tworoger
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Epidemiol 166:894-901. 2007
    ..Furthermore, tubal ligation, intrauterine device use, and infertility were associated with ovarian cancer risk...
  17. ncbi request reprint Relationship of plasma adiponectin with sex hormone and insulin-like growth factor levels
    Shelley S Tworoger
    Channing Laboratory, 181 Longwood Ave, 3rd Floor, Boston, MA 02115, USA
    Obesity (Silver Spring) 15:2217-24. 2007
    ....
  18. ncbi request reprint Plasma androgen concentrations and risk of incident ovarian cancer
    Shelley S Tworoger
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Am J Epidemiol 167:211-8. 2008
    ..bottom, relative risks were 0.65 and 0.70, respectively). Overall, these results do not support a positive association between circulating androgen levels and ovarian cancer risk...
  19. ncbi request reprint Caffeine, alcohol, smoking, and the risk of incident epithelial ovarian cancer
    Shelley S Tworoger
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Cancer 112:1169-77. 2008
    ..Therefore, the associations between these exposures and ovarian cancer risk were prospectively examined among 110,454 women in the Nurses' Health Study (NHS) for the smoking analyses and 80,253 women for the dietary analyses...
  20. ncbi request reprint Prolactin and breast cancer etiology: an epidemiologic perspective
    Shelley S Tworoger
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    J Mammary Gland Biol Neoplasia 13:41-53. 2008
    ..Overall, epidemiologic data suggest that prolactin is involved in breast cancer etiology. Further research to better elucidate these associations and their underlying mechanisms is warranted...
  21. ncbi request reprint Reproducibility of proteomic profiles over 3 years in postmenopausal women not taking postmenopausal hormones
    Shelley S Tworoger
    Channing Laboratory, 181 Longwood Avenue, 3rd Floor, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 17:1480-5. 2008
    ..40. Although we observed a large range of CVs and ICCs, sufficient numbers of peaks had reasonable ICCs to suggest that protein peak reproducibility over 3 years was reasonable among postmenopausal women not taking hormones...
  22. pmc Polymorphisms in the vitamin D receptor and risk of ovarian cancer in four studies
    Shelley S Tworoger
    Channing Laboratory, Boston, MA 02115, USA
    Cancer Res 69:1885-91. 2009
    ..34-1.28), and among women with the Ff or ff genotype the OR was 0.71 (95% CI, 0.43-1.18). Our results of an association with the Fok1 VDR polymorphism further support a role of the vitamin D pathway in ovarian carcinogenesis...
  23. ncbi request reprint The association of self-reported sleep duration, difficulty sleeping, and snoring with cognitive function in older women
    Shelley S Tworoger
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Alzheimer Dis Assoc Disord 20:41-8. 2006
    ..However, the lack of an association with prospective cognitive decline warrants further investigation...
  24. ncbi request reprint Association between plasma prolactin concentrations and risk of breast cancer among predominately premenopausal women
    Shelley S Tworoger
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Res 66:2476-82. 2006
    ..Our data suggest a modest positive association between prolactin and breast cancer risk among predominately premenopausal women; however, further follow-up is needed to increase power for subgroup analyses...
  25. ncbi request reprint Effect of a nighttime magnetic field exposure on sleep patterns in young women
    Shelley S Tworoger
    Channing Laboratory, Harvard Medical School and Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Epidemiol 160:224-9. 2004
    ..The intervention magnetic field had no effect on sleep patterns, suggesting that this exposure may not be an important factor in predicting sleep of young women who sleep at home...
  26. ncbi request reprint Factors associated with objective (actigraphic) and subjective sleep quality in young adult women
    Shelley S Tworoger
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Psychosom Res 59:11-9. 2005
    ..The aim of this study was to describe factors associated with actigraphic and subjective sleep quality in young women...
  27. ncbi request reprint Plasma prolactin concentrations and risk of postmenopausal breast cancer
    Shelley S Tworoger
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Cancer Res 64:6814-9. 2004
    ..Our prospective data suggest that plasma prolactin concentrations are associated with an increased risk of postmenopausal breast cancer, particularly for estrogen receptor+/progesterone receptor+ cancers, and independently of estradiol...
  28. ncbi request reprint Plasma sex hormone concentrations and subsequent risk of breast cancer among women using postmenopausal hormones
    Shelley S Tworoger
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Natl Cancer Inst 97:595-602. 2005
    ....
  29. pmc Common genetic variation in IGF1, IGFBP1 and IGFBP3 and ovarian cancer risk
    Kathryn L Terry
    Obstetrics and Gynecology Epidemiology Center, Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Carcinogenesis 30:2042-6. 2009
    ..Of particular interest was the IGFBP3 SNP rs2270628, which was associated with both increased IGF1 plasma levels and higher ovarian cancer risk...
  30. ncbi request reprint The effect of CYP19 and COMT polymorphisms on exercise-induced fat loss in postmenopausal women
    Shelley S Tworoger
    Channing Laboratory, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts, USA
    Obes Res 12:972-81. 2004
    ..These genes metabolize estrogens and androgens, which are important in body fat regulation...
  31. pmc Body fatness at young ages and risk of breast cancer throughout life
    Heather J Baer
    Brigham and Women s Hospital, Boston, Massachusetts 02120, USA
    Am J Epidemiol 171:1183-94. 2010
    ..86 and RR = 0.92, respectively; P(heterogeneity) = 0.03). Body fatness at young ages has a strong and independent inverse relation to breast cancer risk throughout life...
  32. ncbi request reprint Insulin-like growth factors and ovarian cancer risk: a nested case-control study in three cohorts
    Shelley S Tworoger
    Channing Laboratory, Department of Medicine, Harvard School of Public Health, 3rd Floor, 181 Longwood Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 16:1691-5. 2007
    ..Overall, our results do not support a positive association between IGF-related proteins and ovarian cancer risk. (Cancer Epidemiol Biomarkers Prev 2007;16(8):1691-5)...
  33. ncbi request reprint Specimen allocation in longitudinal biomarker studies: controlling subject-specific effects by design
    Shelley S Tworoger
    Channing Laboratory, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts, USA
    Cancer Epidemiol Biomarkers Prev 13:1257-60. 2004
    ..These results suggest that bias can be artificially introduced into intervention effect estimates of longitudinal studies if samples from a subject are not assayed in the same batch...
  34. pmc Energy balance, early life body size, and plasma prolactin levels in postmenopausal women
    Xuefen Su
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Ave, 3rd Floor, Boston, MA 02115, USA
    Cancer Causes Control 20:253-62. 2009
    ....
  35. pmc A prospective study of androgen levels, hormone-related genes and risk of rheumatoid arthritis
    Elizabeth W Karlson
    Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Arthritis Res Ther 11:R97. 2009
    ....
  36. pmc Coffee intake, variants in genes involved in caffeine metabolism, and the risk of epithelial ovarian cancer
    Joanne Kotsopoulos
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Cancer Causes Control 20:335-44. 2009
    ..Furthermore, we did not observe any clear gene-environment interactions between caffeine metabolizing genes and ovarian cancer. Future studies evaluating mechanisms by which coffee mediates this relationship are warranted...
  37. pmc +331G/A variant in the progesterone receptor gene, postmenopausal hormone use and risk of breast cancer
    Joanne Kotsopoulos
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Int J Cancer 125:1685-91. 2009
    ..This finding adds to the evidence that the PR has an important etiologic role in breast cancer and should be evaluated in future studies...
  38. ncbi request reprint Reproductive factors and family history of breast cancer in relation to plasma prolactin levels in premenopausal and postmenopausal women
    A Heather Eliassen
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Int J Cancer 120:1536-41. 2007
    ..9 ng/mL vs. 14.3 ng/mL, p=0.04) but not postmenopausal (p=0.73) women. In conclusion, the associations of parity and family history with breast cancer risk may be mediated, at least in part, by prolactin levels...
  39. pmc Risk factors for epithelial ovarian cancer by histologic subtype
    Margaret A Gates
    Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA
    Am J Epidemiol 171:45-53. 2010
    ..03). Results suggest that associations with several ovarian cancer risk factors vary by subtype, and these differences are consistent with known similarities between each major histologic subtype and its normal tissue counterpart...
  40. pmc Talc use, variants of the GSTM1, GSTT1, and NAT2 genes, and risk of epithelial ovarian cancer
    Margaret A Gates
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 17:2436-44. 2008
    ..These results suggest that women with certain genetic variants may have a higher risk of ovarian cancer associated with genital talc use. Additional research is needed on these interactions and the underlying biological mechanisms...
  41. pmc Rotating night shift work and risk of ovarian cancer
    Elizabeth M Poole
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 20:934-8. 2011
    ..Night shift work has been associated with higher risks of breast and endometrial cancer, but few studies have evaluated associations with other reproductive cancers...
  42. pmc Biomarkers of inflammation and development of rheumatoid arthritis in women from two prospective cohort studies
    Elizabeth W Karlson
    Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Arthritis Rheum 60:641-52. 2009
    ..To examine the association of biomarkers of inflammation with preclinical rheumatoid arthritis (RA)...
  43. pmc Circulating 2-hydroxy- and 16alpha-hydroxy estrone levels and risk of breast cancer among postmenopausal women
    A Heather Eliassen
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 17:2029-35. 2008
    ..The significant positive associations with 2-OH estrone and the 2-OH:16-OH estrone ratio among women with ER-negative/PR-negative tumors needs to be replicated in future studies...
  44. pmc Breast cancer susceptibility alleles and ovarian cancer risk in 2 study populations
    Margaret A Gates
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Int J Cancer 124:729-33. 2009
    ..16-1.18 per allele at the alpha=0.05 level in the pooled analysis. Our results do not provide strong support for an association between these breast cancer susceptibility alleles and epithelial ovarian cancer risk...
  45. pmc Validation of tissue microarray technology in ovarian cancer: results from the Nurses' Health Study
    Jonathan L Hecht
    Department of Pathology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    Cancer Epidemiol Biomarkers Prev 17:3043-50. 2008
    ..Tissue microarrays (TMAs) allow high-throughput evaluation of protein expression from archived tissue samples. We identified characteristics specific to ovarian cancer that may influence TMA interpretation...
  46. pmc Circulating 25-hydroxyvitamin D and risk of epithelial ovarian cancer: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers
    Wei Zheng
    Department of Medicine, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37203, USA
    Am J Epidemiol 172:70-80. 2010
    ..01). In conclusion, this large pooled analysis did not support an overall association between circulating 25(OH)D and ovarian cancer risk, except possibly among overweight women...
  47. pmc Analgesic use and sex steroid hormone concentrations in postmenopausal women
    Margaret A Gates
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 19:1033-41. 2010
    ..04). Among postmenopausal women, regular users of aspirin and other analgesics may have lower estrogen levels than nonusers, which could contribute to a decreased risk of breast or ovarian cancer among analgesic users...
  48. pmc ABO blood group and incidence of epithelial ovarian cancer
    Margaret A Gates
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Int J Cancer 128:482-6. 2011
    ..Additional studies are needed to confirm this association and to explore the mechanisms through which blood group may influence ovarian cancer risk...
  49. pmc Anthropometric measures and risk of epithelial ovarian cancer: results from the nurses' health study
    Joanne Kotsopoulos
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Obesity (Silver Spring) 18:1625-31. 2010
    ..The differential effect of hip circumference based on menopausal status requires further confirmation...
  50. pmc Relationship between caffeine intake and plasma sex hormone concentrations in premenopausal and postmenopausal women
    Joanne Kotsopoulos
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer 115:2765-74. 2009
    ..Caffeine intake may decrease risk of breast and ovarian cancer, although the data are not entirely consistent. Whether or not caffeine affects cancer risk by altering sex hormone levels is currently unknown...
  51. pmc Relationship between dietary and supplemental intake of folate, methionine, vitamin B6 and folate receptor alpha expression in ovarian tumors
    Joanne Kotsopoulos
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Int J Cancer 126:2191-8. 2010
    ..Our data do not support the hypothesis that the relationship between factors involved in one-carbon metabolism and ovarian cancer risk differs by FRalpha status of the tumor...
  52. pmc The association of plasma androgen levels with breast, ovarian and endometrial cancer risk factors among postmenopausal women
    Kim N Danforth
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Int J Cancer 126:199-207. 2010
    ..Future studies are needed to clarify further which lifestyle factors modulate androgen levels...
  53. pmc Relationship between epidemiologic risk factors and hormone receptor expression in ovarian cancer: results from the Nurses' Health Study
    Jonathan L Hecht
    Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Cancer Epidemiol Biomarkers Prev 18:1624-30. 2009
    ..Reproductive and hormonal risk factors are associated with subgroups of ovarian cancer defined by histologic subtype or ERalpha and PR status. These finding support specific models of hormone mediated triggers of ovarian cancer...
  54. pmc Use of nonsteroidal antiinflammatory agents and incidence of ovarian cancer in 2 large prospective cohorts
    Simone P Pinheiro
    Department of Medicine, Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Am J Epidemiol 169:1378-87. 2009
    ..In this large prospective study, the authors found no compelling evidence to support an association between regular use of aspirin, nonaspirin NSAIDs, or acetaminophen and ovarian cancer incidence...
  55. pmc Flavonoid intake and ovarian cancer risk in a population-based case-control study
    Margaret A Gates
    Department of Medicine, Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Int J Cancer 124:1918-25. 2009
    ..However, given the findings of previous studies and the biologic plausibility of this association, additional studies are warranted...
  56. pmc Reproducibility of plasma and urine biomarkers among premenopausal and postmenopausal women from the Nurses' Health Studies
    Joanne Kotsopoulos
    Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 19:938-46. 2010
    ..Temporal variability of biomarkers should be evaluated before their use in epidemiologic studies...
  57. ncbi request reprint Circulating insulin and c-peptide levels and risk of breast cancer among predominately premenopausal women
    A Heather Eliassen
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 16:161-4. 2007
    ..These associations did not differ by age, body mass index, or waist-to-hip ratio. Overall, higher levels of insulin and c-peptide were not associated with a higher risk of breast cancer among predominantly premenopausal women...
  58. ncbi request reprint The p53 Arg72Pro and MDM2 -309 polymorphisms and risk of breast cancer in the nurses' health studies
    David G Cox
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Cancer Causes Control 18:621-5. 2007
    ..Neither SNP is independently associated with overall breast cancer risk. Some indication of gene-by-gene interaction was observed; however, no consistent direction of interaction was apparent...
  59. ncbi request reprint Breastfeeding and risk of ovarian cancer in two prospective cohorts
    Kim N Danforth
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, 3rd Floor, Boston, MA 02115, USA
    Cancer Causes Control 18:517-23. 2007
    ..To describe the association between breastfeeding and ovarian cancer risk in two prospective cohorts...
  60. ncbi request reprint Effect of a 12-month randomized clinical trial of exercise on serum prolactin concentrations in postmenopausal women
    Shelley S Tworoger
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Harvard School of Public Health, Boston, Massachusetts, USA
    Cancer Epidemiol Biomarkers Prev 16:895-9. 2007
    ..Although the exercise intervention had little effect on prolactin concentrations overall, increasing physical fitness was associated with reduced prolactin concentrations among postmenopausal women...
  61. ncbi request reprint Endogenous steroid hormone concentrations and risk of breast cancer among premenopausal women
    A Heather Eliassen
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Ave, Boston, MA 02115, USA
    J Natl Cancer Inst 98:1406-15. 2006
    ..We prospectively evaluated associations between plasma sex hormone levels and breast cancer risk among premenopausal women in a case-control study nested within the Nurses' Health Study II...
  62. pmc Genetic variation in TYMS in the one-carbon transfer pathway is associated with ovarian carcinoma types in the Ovarian Cancer Association Consortium
    Linda E Kelemen
    Department of Population Health Research, Alberta Health Services Cancer Care, 1331 29th Street Northwest, Calgary, Alberta T2N4N2, Canada
    Cancer Epidemiol Biomarkers Prev 19:1822-30. 2010
    ....
  63. ncbi request reprint A prospective study on habitual duration of sleep and incidence of breast cancer in a large cohort of women
    Simone P Pinheiro
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Cancer Res 66:5521-5. 2006
    ..05). In this prospective study, we found no convincing evidence for an association between sleep duration and the incidence of breast cancer...
  64. ncbi request reprint Body shape throughout life and correlations with IGFs and GH
    Eva S Schernhammer
    Channing Laboratory, Department of Medicine, Harvard Medical School, Brigham and Women s Hospital, 181 Longwood Avenue, Boston 02115, Massachusetts, USA
    Endocr Relat Cancer 14:721-32. 2007
    ..Our results suggest that childhood and adult body size may affect premenopausal breast cancer risk differently than birth weight, through associations with IGF and GH levels...
  65. ncbi request reprint Endogenous steroid hormone concentrations and risk of breast cancer: does the association vary by a woman's predicted breast cancer risk?
    A Heather Eliassen
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Clin Oncol 24:1823-30. 2006
    ....
  66. doi request reprint Obstetric and perinatal complications in placentas with fetal thrombotic vasculopathy
    Aasia Saleemuddin
    Department of Pathology, Harvard Medical School, Boston, MA, USA
    Pediatr Dev Pathol 13:459-64. 2010
    ..This study points to abnormal fetal circulation, either in the form of congenital heart disease or oligohydramnios predisposing to cord compression, as a risk factor for FTV...
  67. pmc Epidemiologic correlates of ovarian cortical inclusion cysts (CICs) support a dual precursor pathway to pelvic epithelial cancer
    Ann K Folkins
    Divisionsof Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Gynecol Oncol 115:108-11. 2009
    ..Many ovarian carcinomas are presumed to arise within ovarian cortical inclusion cysts (CICs). This study examined the frequency of ovarian CICs in relation to epidemiologic risk factors in women with BRCA1 and BRCA2 (BRCA+) mutations...
  68. ncbi request reprint Plasma 25-hydroxyvitamin D levels and risk of incident hypertension
    John P Forman
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Hypertension 49:1063-9. 2007
    ..31 (95% CI: 2.03 to 2.63) in men and 1.57 (95% CI: 1.44 to 1.72) in women. Plasma 25(OH)D levels are inversely associated with risk of incident hypertension...
  69. ncbi request reprint Human plasma ghrelin levels increase during a one-year exercise program
    Karen E Foster-Schubert
    Department of Medicine, Division of Metabolism, University of Washington, Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA
    J Clin Endocrinol Metab 90:820-5. 2005
    ..In summary, ghrelin levels increase with weight loss achieved without reduced food intake, consistent with a role for ghrelin in the adaptive response constraining weight loss and, thus, in long-term body weight regulation...
  70. pmc Total and high-molecular-weight adiponectin and resistin in relation to the risk for type 2 diabetes in women
    Christin Heidemann
    Harvard School of Public Health, Massachusetts General Hospital, Brigham and Women s Hospital, and Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Ann Intern Med 149:307-16. 2008
    ..Adiponectin and resistin are recently discovered adipokines that may provide a molecular link between adiposity and type 2 diabetes...
  71. pmc MTHFR polymorphisms in relation to ovarian cancer risk
    Kathryn L Terry
    Ob Gyn Epidemiology Center, Brigham and Women s Hospital, Boston, MA 02115, USA
    Gynecol Oncol 119:319-24. 2010
    ..Thus, we examined ovarian cancer risk in relation to two functional polymorphisms (C677T and A1298C) in the MTHFR gene...
  72. ncbi request reprint A prospective study of dietary flavonoid intake and incidence of epithelial ovarian cancer
    Margaret A Gates
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA
    Int J Cancer 121:2225-32. 2007
    ..If confirmed, these results would provide an important target for ovarian cancer prevention...
  73. pmc Risk factors for a serous cancer precursor ("p53 signature") in women with inherited BRCA mutations
    Aasia Saleemuddin
    Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Boston, MA, USA
    Gynecol Oncol 111:226-32. 2008
    ..This study examined the relationship of putative ovarian cancer risk factors with the presence of p53 signatures in women with BRCA mutations (BRCA+)...
  74. ncbi request reprint Associations between reproductive and menstrual factors and postmenopausal androgen concentrations
    Jessica Chubak
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Womens Health (Larchmt) 14:704-12. 2005
    ....
  75. ncbi request reprint Effect of exercise on serum estrogens in postmenopausal women: a 12-month randomized clinical trial
    Anne McTiernan
    Cancer Prevention Research Program, The Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Cancer Res 64:2923-8. 2004
    ..The association between increased physical activity and reduced risk for postmenopausal breast cancer may be partly explained by effects on serum estrogens...
  76. ncbi request reprint Mailing strategies and recruitment into an intervention trial of the exercise effect on breast cancer biomarkers
    Shelley S Tworoger
    Cancer Prevention Research Program, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 11:73-7. 2002
    ..Our study indicates that bulk mail may be more cost-effective than first-class mail for recruitment into intervention trials and that older women are willing to participate in such studies...
  77. ncbi request reprint Influence of demographic, physiologic, and psychosocial variables on adherence to a yearlong moderate-intensity exercise trial in postmenopausal women
    Melinda L Irwin
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520 8034, USA
    Prev Med 39:1080-6. 2004
    ..We examined the patterns of adherence to a yearlong exercise intervention and the influence of demographic, physiologic, and psychosocial variables on patterns of adherence among 173 sedentary, overweight, postmenopausal women...
  78. ncbi request reprint Association of CYP17, CYP19, CYP1B1, and COMT polymorphisms with serum and urinary sex hormone concentrations in postmenopausal women
    Shelley S Tworoger
    The Fred Hutchinson Cancer Research Center, Cancer Prevention Research Program, Seattle, Washington, USA
    Cancer Epidemiol Biomarkers Prev 13:94-101. 2004
    ..This study provides further evidence that genetic variation may appreciably alter sex hormone concentrations in postmenopausal women not taking hormone therapy...
  79. ncbi request reprint Effects of a yearlong moderate-intensity exercise and a stretching intervention on sleep quality in postmenopausal women
    Shelley S Tworoger
    The Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Cancer Prevention Research Program, Seattle, Wash 98109 1024, USA
    Sleep 26:830-6. 2003
    ....
  80. pmc Adiposity and sex hormones in postmenopausal breast cancer survivors
    Anne McTiernan
    Cancer Prevention Research Program, MP 900, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
    J Clin Oncol 21:1961-6. 2003
    ..This study examined the association between adiposity and concentrations of estrogens, androgens, and sex hormone-binding globulin (SHBG) in a population-based sample of postmenopausal women with breast cancer...
  81. ncbi request reprint Stability of Wertheimer-Leeper wire codes as a measure of exposure to residential magnetic fields over a 9- to 11-year interval
    Shelley S Tworoger
    Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Expo Anal Environ Epidemiol 12:448-54. 2002
    ..Although the wire code detected less than half of electrical configuration changes, misclassification of exposure over time may change odds ratios and mask possible dose-response relationships...
  82. ncbi request reprint Effect of a yearlong, moderate-intensity exercise intervention on the occurrence and severity of menopause symptoms in postmenopausal women
    Erin J Aiello
    Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Cancer Prevention Research Program, Seattle, WA 98109, USA
    Menopause 11:382-8. 2004
    ..To evaluate the effect of moderate-intensity exercise on the occurrence and severity of menopause symptoms...
  83. ncbi request reprint Associations among circulating sex hormones, insulin-like growth factor, lipids, and mammographic density in postmenopausal women
    Erin J Aiello
    Center for Health Studies, Group Health Cooperative, Seattle, Washington, USA
    Cancer Epidemiol Biomarkers Prev 14:1411-7. 2005
    ..Therefore, we evaluated the relationship of endogenous sex hormones, insulin-like growth factor (IGF), and lipids with mammographic density in 88 overweight, postmenopausal women not taking hormone therapy...
  84. ncbi request reprint Effect of exercise on serum androgens in postmenopausal women: a 12-month randomized clinical trial
    Anne McTiernan
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, and Department of Epidemiology, School of Public Health, University of Washington, Seattle, USA
    Cancer Epidemiol Biomarkers Prev 13:1099-105. 2004
    ..The association between exercise and breast cancer risk may be partly explained by the effects of exercise on these hormones...
  85. pmc Consortium analysis of 7 candidate SNPs for ovarian cancer
    Susan J Ramus
    Translational Research Laboratory, University College London EGA Institute for Women s Health, London, United Kingdom
    Int J Cancer 123:380-8. 2008
    ..These null results for SNPs identified from relatively large initial studies shows the importance of replicating associations by a consortium approach...
  86. ncbi request reprint Serum steroid hormones, sex hormone-binding globulin concentrations, and urinary hydroxylated estrogen metabolites in post-menopausal women in relation to daidzein-metabolizing phenotypes
    Cara L Frankenfeld
    Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, 1100 Fairview Ave N, PO Box 19024, M4 B402, Seattle, WA 98109 1024, USA
    J Steroid Biochem Mol Biol 88:399-408. 2004
    ..These results suggest that interindividual variability in intestinal bacteria may be related to differences in products of hormone metabolism in post-menopausal women...
  87. ncbi request reprint Effects of an exercise intervention on other health behaviors in overweight/obese post-menopausal women
    Isaac Rhew
    Fred Hutchinson Cancer Research Center, Cancer Prevention Program, University of Washington, School of Public Health and Community Medicine, Department of Epidemiology, Seattle, WA, 98109 1024, United States
    Contemp Clin Trials 28:472-81. 2007
    ..If other behaviors do change with increasing physical activity, this would complicate interpretation of differences in study outcomes in exercise intervention trials...
  88. ncbi request reprint Effects of a moderate intensity exercise intervention on estrogen metabolism in postmenopausal women
    Charlotte Atkinson
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, P O Box 19024, Seattle, WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 13:868-74. 2004
    ..Thus, this 12-month moderate intensity exercise intervention did not significantly alter urinary excretion of 2-OH E(1), 16alpha-OH E(1), or their ratio in this population of women...
  89. ncbi request reprint No effect of exercise on insulin-like growth factor 1 and insulin-like growth factor binding protein 3 in postmenopausal women: a 12-month randomized clinical trial
    Anne McTiernan
    Cancer Prevention Research Program, The Fred Hutchinson Cancer Research Center, P O Box 19024, M4 B402, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 14:1020-1. 2005
  90. pmc Associations between the CYP17, CYPIB1, COMT and SHBG polymorphisms and serum sex hormones in post-menopausal breast cancer survivors
    Page E Abrahamson
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, M4 B402, Seattle, WA, 98109 1024, USA
    Breast Cancer Res Treat 105:45-54. 2007
    ..These results provide little evidence that the CYP17, CYP1B1, and COMT polymorphisms are associated with different sex hormone levels in post-menopausal breast cancer survivors...
  91. pmc UDP-glucuronosyltransferase and sulfotransferase polymorphisms, sex hormone concentrations, and tumor receptor status in breast cancer patients
    Rachel Sparks
    Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Breast Cancer Res 6:R488-98. 2004
    ....
  92. ncbi request reprint Associations between reproductive and menstrual factors and postmenopausal sex hormone concentrations
    Jessica Chubak
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, P O Box 19024, M4 B402, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 13:1296-301. 2004
    ....
  93. ncbi request reprint Effects of exercise on metabolic risk variables in overweight postmenopausal women: a randomized clinical trial
    Laura Lewis Frank
    Fred Hutchinson Cancer Research Center, Cancer Prevention, Seattle, WA 98109 1024, USA
    Obes Res 13:615-25. 2005
    ..This study examined the effects of exercise on metabolic risk variables insulin, leptin, glucose, and triglycerides in overweight/obese postmenopausal women...
  94. ncbi request reprint Collection, processing, and storage of biological samples in epidemiologic studies: sex hormones, carotenoids, inflammatory markers, and proteomics as examples
    Shelley S Tworoger
    Channing Laboratory, 181 Longwood Avenue, 3rd Floor, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 15:1578-81. 2006
    ..Finally, decisions about these issues depend primarily on the scientific questions of most interest, cost, flexibility, and resources...
  95. ncbi request reprint Effect of exercise on bone mineral density and lean mass in postmenopausal women
    Jessica Chubak
    Fred Hutchinson Cancer Research Center, Cancer Prevention Research Program, and University of Washington, School of Public Health and Community Medicine, Department of Epidemiology, Seattle, WA 98109 1024, USA
    Med Sci Sports Exerc 38:1236-44. 2006
    ..To evaluate the effects of physical activity on bone mineral density, bone mineral content, and lean mass in postmenopausal, overweight/obese women...
  96. ncbi request reprint Serum lipoproteins in overweight/obese postmenopausal women: a one-year exercise trial
    Manish Mohanka
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Med Sci Sports Exerc 38:231-9. 2006
    ..This analysis was conducted to study the effect of a 1-yr moderate-intensity aerobic exercise program on serum lipoproteins among overweight/obese postmenopausal women...

Research Grants4

  1. The Role of Prolactin in the Etiology of Postmenopausal Breast Cancer
    Shelley Tworoger; Fiscal Year: 2006
    ..This potentially may affect public health by increasing our understanding of how breast cancer develops, which in turn can lead to a better understanding of how to prevent this disease. ..
  2. The Role of Prolactin in the Etiology of Postmenopausal Breast Cancer
    Shelley Tworoger; Fiscal Year: 2007
    ..This potentially may affect public health by increasing our understanding of how breast cancer develops, which in turn can lead to a better understanding of how to prevent this disease. ..
  3. Growth Hormones and Breast Cancer Risk
    Shelley S Tworoger; Fiscal Year: 2010
    ....