Research Topics
| Ching Hsuan TungSummaryAffiliation: Harvard University Country: USA Publications
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Detail Information
Publications
Arthritis imaging using a near-infrared fluorescence folate-targeted probeWei-Tsung Chen
Center of Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA
Arthritis Res Ther 7:R310-7. 2005..This receptor-targeted imaging method may facilitate improved arthritis diagnosis and early assessment of the disease progress by providing an in vivo characterization of active macrophage status in inflammatory joint diseases...- Preparation of a cathepsin D sensitive near-infrared fluorescence probe for imagingC H Tung
Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, 149, 13th Street, Room 5406, Boston, Massachusetts 02129 2060, USA
Bioconjug Chem 10:892-6. 1999..This sequence but not a scrambled control sequence showed enzyme specificity in vitro. We conclude that activatable NIRF optical probes can be synthesized to potentially probe for specific enzymes in living organisms... - Novel branching membrane translocational peptide as gene delivery vectorChing Hsuan Tung
Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
Bioorg Med Chem 10:3609-14. 2002..Using rhodamine labeled plasmid and eight tat-peptide complex, we were also able to demonstrate intracellular delivery of the complex by fluorescence microscopy... - Arginine containing peptides as delivery vectorsChing Hsuan Tung
Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, 149 13th St, Rm 5406, Charlestown, MA 02129, USA
Adv Drug Deliv Rev 55:281-94. 2003..In this review, we specifically focus on arginine-containing MTS, and their properties, characteristics, in vitro and in vivo applications are discussed in detail... - Novel factor XIII probes for blood coagulation imagingChing-Hsuan Tung
Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
Chembiochem 4:897-9. 2003 - In vivo imaging of beta-galactosidase activity using far red fluorescent switchChing Hsuan Tung
Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
Cancer Res 64:1579-83. 2004..The results indicated that in vivo real-time detection of beta-gal activity is possible by fluorescence imaging technology... - Fluorescent peptide probes for in vivo diagnostic imagingChing Hsuan Tung
Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
Biopolymers 76:391-403. 2004..Several of them have been tested in various in vitro and in vivo models, and the obtained imaging information has been applied to disease detection, medical diagnosis, and drug evaluations... - A receptor-targeted near-infrared fluorescence probe for in vivo tumor imagingChing-Hsuan Tung
Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
Chembiochem 3:784-6. 2002 - Optical visualization of cathepsin K activity in atherosclerosis with a novel, protease-activatable fluorescence sensorFarouc A Jaffer
Center for Molecular Imaging Research, Massachusetts General Hospital, Boston, MA 02129, USA
Circulation 115:2292-8. 2007..To assess better the biology of CatK activity in vivo, we developed a novel near-infrared fluorescence (NIRF) probe for imaging of CatK and evaluated it in mouse and human atherosclerosis... - Molecular imaging of factor XIIIa activity in thrombosis using a novel, near-infrared fluorescent contrast agent that covalently links to thrombiFarouc A Jaffer
Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, USA
Circulation 110:170-6. 2004..In vivo imaging of FXIIIa activity could further elucidate the role of this molecule in thrombosis and other biological processes and aid in the clinical detection of acute thrombi... - In vivo imaging of thrombin activity in experimental thrombi with thrombin-sensitive near-infrared molecular probeFarouc A Jaffer
Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown 02129, USA
Arterioscler Thromb Vasc Biol 22:1929-35. 2002..In this study, we investigated the ability of a novel thrombin-activatable molecular probe to provide in vivo images of thrombin activity in experimental thrombi... - In vivo imaging of proteolytic activity in atherosclerosisJiqiu Chen
Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, USA
Circulation 105:2766-71. 2002..On the basis of the hypothesis that the inflammatory response and proteolysis lead to plaque rupture, we have examined the role of cathepsin B as a model proteolytic enzyme... - In vivo imaging of HIV protease activity in amplicon vector-transduced gliomasKhalid Shah
Center for Molecular Imaging Research, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA
Cancer Res 64:273-8. 2004..These findings may be directly applicable in using viral protease expression as a transgene marker in tumor therapy and may have implications in testing the efficacy of HIV-1PR inhibitors in vivo... - A novel near-infrared fluorescence sensor for detection of thrombin activation in bloodChing Hsuan Tung
Center for Molecular Imaging Research, Massachusetts General Hospital, 149 13th Street, Room 5406, Charlestown, MA 02129, USA
Chembiochem 3:207-11. 2002..In addition to potentially furthering our understanding of thrombin regulation in vivo, the thrombin-activated near-infrared probe may have broad clinical application to the diagnosis of arterial and venous thrombosis... - Feasibility of in vivo multichannel optical imaging of gene expression: experimental study in miceUmar Mahmood
Center for Molecular Imaging Research, CNY149 5403, Department of Radiology, Massachusetts General Hospital, Bldg 149, 13th St, Charlestown, MA 02129, USA
Radiology 224:446-51. 2002..To develop and test a multichannel reflectance imaging system for small animals on the basis of a previously developed single-channel setup... - Inflammation in atherosclerosis: visualizing matrix metalloproteinase action in macrophages in vivoJun o Deguchi
Donald W Reynolds Cardiovascular Clinical Research Center, Harvard Medical School, Boston, Massachusetts, USA
Circulation 114:55-62. 2006..Matrix metalloproteinases (MMPs) in inflamed atherosclerotic plaques may contribute to extracellular matrix remodeling and the onset of acute thrombotic complications... - Detection of dysplastic intestinal adenomas using a fluorescent folate imaging probeWei Tsung Chen
Center for Molecular Imaging Research, Harvard Medical School, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 92129, USA
Mol Imaging 4:67-74. 2005..2.2%), and confirmed the source of FFP-positive cells to be primarily an F4/80-positive macrophage subpopulation. Taken together, these results indicate that probe potentially can be used to image dysplastic intestinal adenomas in vivo... - Imaging of differential protease expression in breast cancers for detection of aggressive tumor phenotypesChristoph Bremer
Center for Molecular Imaging Research, Massachusetts General Hospital and Harvard Medical School, Boston, USA
Radiology 222:814-8. 2002..To determine if different expression levels of tumor cathepsin-B activity in well differentiated and undifferentiated breast cancers could be revealed in vivo with optical imaging... - Inducible release of TRAIL fusion proteins from a proapoptotic form for tumor therapyKhalid Shah
Molecular Neurogenetics Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
Cancer Res 64:3236-42. 2004..This study serves as a template for design of recombinant proteins to enhance and control apoptosis of tumor cells via specific viral proteases and for use of viral proteases as in vivo reporters for cancer therapy... - Fluorescence molecular tomography resolves protease activity in vivoVasilis Ntziachristos
Center for Molecular Imaging Research, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, USA
Nat Med 8:757-60. 2002.... - A self-immolative reporter for beta-galactosidase sensingNan Hui Ho
Center of Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Room 5406, Charlestown, MA 02129, USA
Chembiochem 8:560-6. 2007..The beta-galactosidase activity was assayed by monitoring the absorbance at 630 nm and fluorescence at 670 nm... - Protease-sensitive fluorescent nanofibersBenedict Law
Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
Bioconjug Chem 18:1701-4. 2007..These protease-sensitive nanofibers may have considerable biomedical applications as diagnostic sensors or for protease-assisted drug deliveries... - Selective fluorescence probes for dipeptidyl peptidase activity-fibroblast activation protein and dipeptidyl peptidase IVKoon Siew Lai
Center of Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
Bioconjug Chem 18:1246-50. 2007..Furthermore, the novel probes can differentiate between FAP and DPP-IV proteolytic activities in cellular assay. Potentially, this assay platform is immediately useful for novel drug discovery... - Molecular imaging of MMP expression and therapeutic MMP inhibitionChristoph Bremer
Center for Molecular Imaging Research, Massachusetts General Hospital, Charlestown, USA
Acad Radiol 9:S314-5. 2002 - Membrane permeable esterase-activated fluorescent imaging probeYoungmi Kim
Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
Bioorg Med Chem Lett 17:5054-7. 2007..Permeation of probe 2 into cells and subsequent hydrolytic activation by cellular esterases result in a bright fluorescent intracellular signal... - In vivo imaging of S-TRAIL-mediated tumor regression and apoptosisKhalid Shah
Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Mol Ther 11:926-31. 2005..The use of S-TRAIL as a therapeutic protein and the ability to image noninvasively both apoptosis and any other cellular events in real time have important clinical implications... - Near-infrared fluorescent imaging of cerebral thrombi and blood-brain barrier disruption in a mouse model of cerebral venous sinus thrombosisDong-Eog Kim
Department of Radiology, Center for Molecular Imaging Research [corrected] Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
J Cereb Blood Flow Metab 25:226-33. 2005..This demonstrates the feasibility of simultaneous in vivo monitoring of thrombus and BBB permeability in an animal model of cerebral venous thrombosis... - Design, synthesis, and characterization of urokinase plasminogen-activator-sensitive near-infrared reporterBenedict Law
Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
Chem Biol 11:99-106. 2004..No activation with negative control compounds and uPA inhibitors could be measured. These data indicate that the optimized preparation should be useful for imaging uPA in cancer... - Enhanced tumor detection using a folate receptor-targeted near-infrared fluorochrome conjugateWoo Kyung Moon
Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
Bioconjug Chem 14:539-45. 2003..These results indicate that folate-modified NIR fluorochrome conjugate can be used for improved detection of FR-positive tumors... - Structural modification of protease inducible preprogrammed nanofiber precursorBenedict Law
Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
Biomacromolecules 9:421-5. 2008.... - A branched fluorescent peptide probe for imaging of activated plateletsChing-Hsuan Tung
Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
Mol Pharm 2:92-5. 2005..2PF fluorescence was also found 5.5-fold higher than that of the control probe, 2CF. Overall, our results suggest that 2PF binds tightly to GP-IIb/IIIa and potentially can be used for in vivo imaging of thrombosis... - Synthesis and properties of sulfhydryl-reactive near-infrared cyanine fluorochromes for fluorescence imagingYuhui Lin
Harvard Medical School, MA, USA
Mol Imaging 2:87-92. 2003..Each fluorochrome was designed to contain an iodoacetamido group that reacts specifically with sulfhydryl-containing molecules. The synthesized fluorochromes were used to label model peptides and sulfhydryl-containing biomolecules... - Near-infrared fluorescent imaging of matrix metalloproteinase activity after myocardial infarctionJiqiu Chen
Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital and Harvard Medical School, Charlestown, Mass 02129, USA
Circulation 111:1800-5. 2005..CONCLUSIONS: This study demonstrates that the activity of MMPs in the myocardium may be imaged by use of specific activity-dependent molecular probes... - Developing a peptide-based near-infrared molecular probe for protease sensingWellington Pham
Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
Bioconjug Chem 15:1403-7. 2004..The described synthetic strategy should have wide application for other NIR probe preparations... - A mitochondrial targeted fusion peptide exhibits remarkable cytotoxicityBenedict Law
Center for Molecular Imaging Research, Massachusetts General Hospital, 149 13th Street, Room 5406, Charlestown, 02129, USA
Mol Cancer Ther 5:1944-9. 2006..Our results suggested that r7-kla is an apoptosis inducer and can be potentially used as an antitumor agent, especially when combined with the appropriate systemic delivery systems... - Non-invasive optical detection of cathepsin K-mediated fluorescence reveals osteoclast activity in vitro and in vivoKenneth M Kozloff
Center for Molecular Imaging Research, Harvard Medical School, Massachusetts General Hospital, 149 13th Street, Room 5406, Charlestown, MA 02129 2060, USA
Bone 44:190-8. 2009.... - Transglutaminase activity in acute infarcts predicts healing outcome and left ventricular remodelling: implications for FXIII therapy and antithrombin use in myocardial infarctionMatthias Nahrendorf
Center for Molecular Imaging Research, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, Room 5406, Charlestown, MA 02129, USA
Eur Heart J 29:445-54. 2008..Here we assess the impact of transglutaminase-modulating therapies on healing and evolution of heart failure using a novel, non-invasive molecular imaging technique... - Novel near-infrared cyanine fluorochromes: synthesis, properties, and bioconjugationYuhui Lin
Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown 02129, USA
Bioconjug Chem 13:605-10. 2002..When multiple fluorochromes were attached to a single macromolecule, fluorescence quenching was observed. On the basis of this property, a novel autoquenched enzyme sensitive NIR fluorescence probe was prepared... - Fluorescence probe with a pH-sensitive triggerAmit K Galande
Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
Bioconjug Chem 17:255-7. 2006..This self-quenched probe is weakly fluorescent at a physiological pH of 7.4 but shows more than 3-fold fluorescence enhancement at pH 4.5... - Early diagnosis of osteoarthritis using cathepsin B sensitive near-infrared fluorescent probesWen-Fu T Lai
Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
Osteoarthritis Cartilage 12:239-44. 2004.... - A novel method for imaging apoptosis using a caspase-1 near-infrared fluorescent probeShanta M Messerli
Departments of Neurology and Radiology, Massachusetts General Hospital and Neuroscience Program, Harvard Medical School, Boston, MA 02115, USA
Neoplasia 6:95-105. 2004..This novel ICE-NIRF probe should prove useful in monitoring endogenous and vector-expressed caspase-1 activity, and potentially apoptosis in cell culture and in vivo... - Detection of dysplastic intestinal adenomas using enzyme-sensing molecular beacons in miceKatharina Marten
Center for Molecular Imaging Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
Gastroenterology 122:406-14. 2002..This detection technology can be adapted to endoscopy or tomographic optical imaging methods for screening of suspicious lesions and potentially for molecular profiling in vivo... - Enzyme-targeted fluorescent imaging probes on a multiple antigenic peptide coreAmit K Galande
Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
J Med Chem 49:4715-20. 2006..Upon proteolytic activation with cathepsin S (EC 3.4.22.27), CyPEG-2 showed greater than 70-fold increase and more than 95% recovery in fluorescence emission... - Selective antitumor effect of novel protease-mediated photodynamic agentYongdoo Choi
Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
Cancer Res 66:7225-9. 2006..A single low dose of PDT (0.125 mg Ce6 equivalent/kg) was sufficient to suppress tumor growth by >50%. Activatable singlet oxygen generation agents provide increased efficacy with reduced toxicity, and it could become a powerful PDT... - An azulene dimer as a near-infrared quencherWellington Pham
Center for Molecular Imaging Research Massachusetts General Hospital 149 13th Street, Room 5406, Charlestown, MA 02129, USA
Angew Chem Int Ed Engl 41:3659-62, 3519. 2002 - Enhancing membrane permeability by fatty acylation of oligoarginine peptidesWellington Pham
Center for Molecular Imaging Research, Massachusetts General Hospital, 149, 13th Street, Room 5406, Charlestown, MA 02129, USA
Chembiochem 5:1148-51. 2004 - Peptide-based biomaterials for protease-enhanced drug deliveryBenedict Law
Center of Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
Biomacromolecules 7:1261-5. 2006..Our results suggest that this type of material may have far-reaching applications for functionally targeted drug delivery... - In vivo imaging of protease activity in arthritis: a novel approach for monitoring treatment responseAndreas Wunder
Massachusets General Hospital, Harvard Medical School, Charlestown 02129, USA
Arthritis Rheum 50:2459-65. 2004..CONCLUSION: Protease-activated NIRF probes are sensitive means of imaging the presence of target enzymes in arthritic joints and can be used for early monitoring of treatment response to antirheumatic drugs such as MTX... - High efficiency synthesis of a bioconjugatable near-infrared fluorochromeWellington Pham
Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
Bioconjug Chem 14:1048-51. 2003..NIR820 is chemically stable and can be directly coupled to peptides during the solid-phase synthesis. In addition, NIR820 is also suitable for conjugation to proteins and other affinity molecules in aqueous buffer... - Optical zymography for specific detection of urokinase plasminogen activator activity in biological samplesBenedict Law
Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
Anal Biochem 338:151-8. 2005..We were able to directly measure uPA activities in different cancer cell lines. This newly developed technique could be expanded to nearly all proteases, including the ones that cannot be analyzed by traditional zymography... - Protease sensors for bioimagingMartin Funovics
Center for Molecular Imaging Research, Harvard Medical School, Rm. 5406, 149 13th St, Charlestown, MA 02129, USA
Anal Bioanal Chem 377:956-63. 2003..These agents are designed to be biocompatible, highly activatible, and able to produce bright NIRF following protease cleavage... - Mechanism-based fluorescent reporter for protein kinase A detectionBenedict Law
Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
Chembiochem 6:1361-7. 2005..The remaining peptide sequence, which acts as an inhibitor, is attached covalently to the enzyme. Our results suggest that this type of sensors could have far-reaching applications in the molecular sensing of enzymes... - Monofunctional near-infrared fluorochromes for imaging applicationsScott A Hilderbrand
Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Room 5406, 149 13th Street, Charlestown, Massachusetts 02129, USA
Bioconjug Chem 16:1275-81. 2005..Endothelial cell internalization of the VCAM-1 targeted phage was monitored via near-infrared fluorescence microscopy... - Conjugation of a photosensitizer to an oligoarginine-based cell-penetrating peptide increases the efficacy of photodynamic therapyYongdoo Choi
Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, 149 13th St, Rm. 5406, Charlestown, MA 02129, USA
ChemMedChem 1:458-63. 2006..Tumor cells mainly underwent apoptosis at lower concentrations of the photosensitizer-polyarginine conjugate, whereas necrotic cell damage became prevalent at higher concentrations... - Development of a dual fluorogenic and chromogenic dipeptidyl peptidase IV substrateNan-Hui Ho
Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
Bioorg Med Chem Lett 16:2599-602. 2006..Proteolysis of GPGP-2SBPO was assayed by monitoring the absorbance and fluorescence signals from the released fluorochrome, 2SBPO, at 625 and 670nm, respectively... - A fluorescent nanosensor for apoptotic cellsLuisa Quinti
Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, 02129, USA
Nano Lett 6:488-90. 2006..The described nanomaterials should be useful for a variety of biomedical applications including in vivo imaging of apoptosis... - Imaging reactive oxygen species in arthritisWei-Tsung Chen
Harvard Medical School, USA
Mol Imaging 3:159-62. 2004..In vivo chemiluminescence imaging is expected to become a useful modality to elucidate the role of ROS in the pathogenesis of arthritides and in determining therapeutic efficacy of protective therapies... - In-vivo imaging of tumor associated urokinase-type plasminogen activator activityJong-Kai Hsiao
Massachusetts General Hospital, Harvard Medical School, Center for Molecular Imaging Research, Charlestown, 02129, USA
J Biomed Opt 11:34013. 2006..Our results suggest a direct detection method for uPA activity in vivo and the approach can be used for monitoring tumor growth and development... - Factor XIII deficiency causes cardiac rupture, impairs wound healing, and aggravates cardiac remodeling in mice with myocardial infarctionMatthias Nahrendorf
Medizinische Klinik und Poliklinik I, Universitat Wurzburg, Wurzburg, Germany
Circulation 113:1196-202. 2006..We hypothesized that clotting factor XIII (FXIII), a transglutaminase involved in wound healing, may play an important role in MI given prior clinical and mouse model data... - Tissue inhibitor of metalloproteinase-3 expression from an oncolytic adenovirus inhibits matrix metalloproteinase activity in vivo without affecting antitumor efficacy in malignant gliomaMartine L M Lamfers
Department of Neurosurgery, Division of Gene Therapy, VU University Medical Center, Amsterdam, The Netherlands
Cancer Res 65:9398-405. 2005..However, expression of TIMP-3 in the context of AdDelta24 did not significantly affect the antitumor efficacy of this oncolytic agent... - Coxiella burnetii survival in THP-1 monocytes involves the impairment of phagosome maturation: IFN-gamma mediates its restoration and bacterial killingEric Ghigo
Unite des Rickettsies, Faculte de Medecine, Centre National de la Recherche Scientifique Unité Mixte de Recherche 6020, Institut Federatif de Recherche 48, Faculte de Medecine, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 5, France
J Immunol 169:4488-95. 2002..burnetii killing via two distinct mechanisms, phagosome maturation, and phagosome alkalinization. Thus, the tuning of vacuole biogenesis is likely a key part of C. burnetii survival and the pathophysiology of Q fever... - Construction of a novel chimera consisting of a chelator-containing Tat peptide conjugated to a morpholino antisense oligomer for technetium-99m labeling and accelerating cellular kineticsYu Min Zhang
Division of Nuclear Medicine, Department of Radiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
Nucl Med Biol 33:263-9. 2006.... - Survival of Tropheryma whipplei, the agent of Whipple's disease, requires phagosome acidificationEric Ghigo
, CNRS UMR 6020, , , 13385 Marseille Cedex 5, France
Infect Immun 70:1501-6. 2002..Our results suggest that manipulating the intravacuolar pH may provide a new approach for the treatment of Whipple's disease...