D S Tuch

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Three-dimensional wound surface area calculations with a CAD surface element model
    D S Tuch
    Massachusetts General Hospital, Nuclear Magnetic Resonance Center, Charlestown, MA 02129, USA
    IEEE Trans Biomed Eng 45:1397-400. 1998
  2. pmc Choice reaction time performance correlates with diffusion anisotropy in white matter pathways supporting visuospatial attention
    David S Tuch
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th Street, Room 2301, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 102:12212-7. 2005
  3. pmc Q-ball imaging of macaque white matter architecture
    David S Tuch
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA
    Philos Trans R Soc Lond B Biol Sci 360:869-79. 2005
  4. ncbi request reprint Q-ball imaging
    David S Tuch
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown 02129, USA
    Magn Reson Med 52:1358-72. 2004
  5. ncbi request reprint Age-related changes in prefrontal white matter measured by diffusion tensor imaging
    D H Salat
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, MGH Department of Radiology, Building 149, 13th Street, Mail Code 149 2301, Charlestown, MA 02129 2060, USA
    Ann N Y Acad Sci 1064:37-49. 2005
  6. ncbi request reprint Neuroimaging H.M.: a 10-year follow-up examination
    D H Salat
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129 2060, USA
    Hippocampus 16:936-45. 2006
  7. pmc White matter pathology isolates the hippocampal formation in Alzheimer's disease
    D H Salat
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129 2060, United States
    Neurobiol Aging 31:244-56. 2010
  8. ncbi request reprint Boosting the sampling efficiency of q-Ball imaging using multiple wavevector fusion
    Mark H Khachaturian
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Magn Reson Med 57:289-96. 2007
  9. ncbi request reprint Reduced microstructural integrity of the white matter underlying anterior cingulate cortex is associated with increased saccadic latency in schizophrenia
    Dara S Manoach
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02215, USA
    Neuroimage 37:599-610. 2007
  10. ncbi request reprint Frontal connections and cognitive changes in normal aging rhesus monkeys: a DTI study
    Nikos Makris
    Harvard Medical School Department of Neurology, Center for Morphometric Analysis, Massachusetts General Hospital, Boston, MA 02129, United States
    Neurobiol Aging 28:1556-67. 2007

Research Grants

Detail Information

Publications27

  1. ncbi request reprint Three-dimensional wound surface area calculations with a CAD surface element model
    D S Tuch
    Massachusetts General Hospital, Nuclear Magnetic Resonance Center, Charlestown, MA 02129, USA
    IEEE Trans Biomed Eng 45:1397-400. 1998
    ..The alternative method of direct summation over surface element space is shown to result in significant fringe error along the wound boundary...
  2. pmc Choice reaction time performance correlates with diffusion anisotropy in white matter pathways supporting visuospatial attention
    David S Tuch
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th Street, Room 2301, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 102:12212-7. 2005
    ....
  3. pmc Q-ball imaging of macaque white matter architecture
    David S Tuch
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA
    Philos Trans R Soc Lond B Biol Sci 360:869-79. 2005
    ..The paper concludes by reviewing remaining challenges for the diffusion tractography project...
  4. ncbi request reprint Q-ball imaging
    David S Tuch
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown 02129, USA
    Magn Reson Med 52:1358-72. 2004
    ..Open aspects of the q-ball reconstruction algorithm are discussed...
  5. ncbi request reprint Age-related changes in prefrontal white matter measured by diffusion tensor imaging
    D H Salat
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, MGH Department of Radiology, Building 149, 13th Street, Mail Code 149 2301, Charlestown, MA 02129 2060, USA
    Ann N Y Acad Sci 1064:37-49. 2005
    ..This evidence of widespread and regionally accelerated alterations in prefrontal WM with aging illustrates FA's potential as a microstructural index of volumetric measures...
  6. ncbi request reprint Neuroimaging H.M.: a 10-year follow-up examination
    D H Salat
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129 2060, USA
    Hippocampus 16:936-45. 2006
    ..Most of these alterations were not apparent in his prior scans, suggesting that they are of recent origin. Advanced age and hypertension likely contributed to these new findings...
  7. pmc White matter pathology isolates the hippocampal formation in Alzheimer's disease
    D H Salat
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129 2060, United States
    Neurobiol Aging 31:244-56. 2010
    ..These results demonstrate that deterioration of neocortical connections to the hippocampal formation results in part from the degeneration of critical MTL and associated fiber pathways...
  8. ncbi request reprint Boosting the sampling efficiency of q-Ball imaging using multiple wavevector fusion
    Mark H Khachaturian
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Magn Reson Med 57:289-96. 2007
    ..In human WM, MWF reveals more detailed WM architecture than QBI as measured by the IPCM for all sampling schemes presented...
  9. ncbi request reprint Reduced microstructural integrity of the white matter underlying anterior cingulate cortex is associated with increased saccadic latency in schizophrenia
    Dara S Manoach
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02215, USA
    Neuroimage 37:599-610. 2007
    ..Moreover, they suggest that anterior cingulate white matter abnormalities contribute to slower performance of volitional saccades and to inter-individual variability of saccadic latency in chronic, medicated schizophrenia...
  10. ncbi request reprint Frontal connections and cognitive changes in normal aging rhesus monkeys: a DTI study
    Nikos Makris
    Harvard Medical School Department of Neurology, Center for Morphometric Analysis, Massachusetts General Hospital, Boston, MA 02129, United States
    Neurobiol Aging 28:1556-67. 2007
    ..To our knowledge this is the first investigation reporting such alterations in the aging monkey...
  11. pmc Response monitoring, repetitive behaviour and anterior cingulate abnormalities in autism spectrum disorders (ASD)
    Katharine N Thakkar
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02215, USA
    Brain 131:2464-78. 2008
    ..Illuminating the mechanisms and clinical significance of abnormal response monitoring in ASD represents a fruitful avenue for further research...
  12. pmc White matter abnormalities in dystonia normalize after botulinum toxin treatment
    Anne J Blood
    Department of Neurology, Massachusetts General Hospital, Charlestown 02129, and Harvard Medical School, Boston, Massachusetts, USA
    Neuroreport 17:1251-5. 2006
    ..This raises the possibility that we have observed activity-dependent white matter plasticity in the adult human brain...
  13. pmc Focal reversible deactivation of cerebral metabolism affects water diffusion
    Mark H Khachaturian
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Magn Reson Med 60:1178-89. 2008
    ..In future experiments, we will apply this methodology to quantify the effect of reversible deactivation on neural activity as measured by the hemodynamic response and compare water diffusion changes with hemodynamic changes...
  14. ncbi request reprint White matter alterations in cerebral amyloid angiopathy measured by diffusion tensor imaging
    David H Salat
    Massachusetts General Hospital Massachusetts Institute of Technology Harvard Medical School, Athinoula A Martinos Center for Biomedical Imaging, Charlestown, Mass 02129 2060, USA
    Stroke 37:1759-64. 2006
    ..We used diffusion tensor imaging to evaluate the anatomic distribution of white matter degeneration in participants diagnosed with advanced CAA...
  15. ncbi request reprint Diffusion tensor imaging in presymptomatic and early Huntington's disease: Selective white matter pathology and its relationship to clinical measures
    H Diana Rosas
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Mov Disord 21:1317-25. 2006
    ....
  16. ncbi request reprint Automatic segmentation of thalamic nuclei from diffusion tensor magnetic resonance imaging
    Mette R Wiegell
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th Street, Room 2301, Charlestown, MA 02129, USA
    Neuroimage 19:391-401. 2003
    ..The ability to resolve thalamic nuclei with DTI will allow for morphometric analysis of specific nuclei and improved anatomical localization of functional activation in the thalamus...
  17. ncbi request reprint Age-related alterations in white matter microstructure measured by diffusion tensor imaging
    D H Salat
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129 2060, USA
    Neurobiol Aging 26:1215-27. 2005
    ..These findings suggest that WM alterations are variable throughout the brain and that particular fiber populations within prefrontal region and PLIC are most vulnerable to age-related degeneration...
  18. pmc Conductivity tensor mapping of the human brain using diffusion tensor MRI
    D S Tuch
    Massachusetts General Hospital, NMR Center, 149 13th Street, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 98:11697-701. 2001
    ..844 +/- 0.0545 S small middle dots/mm(3), r(2) = 0.945). The extension to other biological transport phenomena is also discussed...
  19. pmc A non-invasive method to relate the timing of neural activity to white matter microstructural integrity
    Steven M Stufflebeam
    Department of Radiology at the Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Neuroimage 42:710-6. 2008
    ..This preliminary report demonstrates a non-invasive, unbiased method to relate the timing information from evoked-response experiments to the biophysical properties of white matter measured with DTI...
  20. ncbi request reprint High angular resolution diffusion imaging reveals intravoxel white matter fiber heterogeneity
    David S Tuch
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown 02129, USA
    Magn Reson Med 48:577-82. 2002
    ..The multitensor reconstruction resolved multiple intravoxel fiber populations corresponding to known fiber anatomy. Ma..
  21. pmc Interictal alterations of the trigeminal somatosensory pathway and periaqueductal gray matter in migraine
    Alexandre F M DaSilva
    Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Neuroreport 18:301-5. 2007
    ..Our results indicate the presence of permanent interictal changes in migraineurs, pointing to an effect of migraine on the trigeminal somatosensory and modulatory pain systems...
  22. pmc Anatomical alterations of the visual motion processing network in migraine with and without aura
    Cristina Granziera
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, United States of America
    PLoS Med 3:e402. 2006
    ..Moreover, the diagnosis of migraine relies on patient's history, and finding differences in the brain of migraineurs might help to contribute to basic research aimed at better understanding the pathophysiology of migraine...
  23. ncbi request reprint A primer on diffusion tensor imaging of anatomical substructures
    Alexandre F M DaSilva
    Martinos Center for Biomedical Imaging, Massachusetts General Hospital, NMR Center, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Neurosurg Focus 15:E4. 2003
    ..The authors illustrate how DT imaging can resolve individual pathways in the brainstem as well as individual nuclei of the thalamus and conclude by describing potential applications in neurosurgery...
  24. ncbi request reprint Diffusion MRI of complex neural architecture
    David S Tuch
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th Street, Room 2301, Charlestown, MA 02129, USA
    Neuron 40:885-95. 2003
    ..The ability of q-ball imaging to resolve complex intravoxel fiber architecture eliminates a key obstacle to mapping neural connectivity in the human brain noninvasively...
  25. pmc Statistical group comparison of diffusion tensors via multivariate hypothesis testing
    Brandon Whitcher
    Clinical Imaging Centre, GlaxoSmithKline, Hammersmith Hospital, London, UK
    Magn Reson Med 57:1065-74. 2007
    ..When applying the Cramér test of the diffusion tensor in a clinical population with a history of migraine, a 169% increase was observed in the volume of a significant cluster compared to the univariate FA test...
  26. ncbi request reprint Using the wild bootstrap to quantify uncertainty in diffusion tensor imaging
    Brandon Whitcher
    Clinical Imaging Centre, GlaxoSmithKline, Hammersmith Hospital, London, UK
    Hum Brain Mapp 29:346-62. 2008
    ..The wild bootstrap method can provide empirical distributions for tensor-derived quantities, such as fractional anisotropy and principal eigenvector direction, even when the exact distributions are not easily derived...
  27. ncbi request reprint Influence of anisotropic conductivity on EEG source reconstruction: investigations in a rabbit model
    Daniel Güllmar
    Biomagnetic Center, Department of Neurology, Jena, Germany
    IEEE Trans Biomed Eng 53:1841-50. 2006
    ..In contrast, dipole orientation and dipole strength are influenced significantly by the anisotropy. We conclude that the inclusion of tissue anisotropy information improves source estimation procedures...

Research Grants1

  1. Mapping the Cortical Connectivity of Macaque With MRI
    David Tuch; Fiscal Year: 2005
    ..We will then apply the optimized diffusion imaging method to test a series of hypotheses on the cortical connectivity of macaque visual system. ..