Research Topics
| D S TuchSummaryAffiliation: Harvard University Country: USA Publications
Research Grants
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Detail Information
Publications
Three-dimensional wound surface area calculations with a CAD surface element modelD S Tuch
Massachusetts General Hospital, Nuclear Magnetic Resonance Center, Charlestown, MA 02129, USA
IEEE Trans Biomed Eng 45:1397-400. 1998..The alternative method of direct summation over surface element space is shown to result in significant fringe error along the wound boundary...
Choice reaction time performance correlates with diffusion anisotropy in white matter pathways supporting visuospatial attentionDavid S Tuch
Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th Street, Room 2301, Charlestown, MA 02129, USA
Proc Natl Acad Sci U S A 102:12212-7. 2005....- Q-ball imaging of macaque white matter architectureDavid S Tuch
Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA
Philos Trans R Soc Lond B Biol Sci 360:869-79. 2005..The paper concludes by reviewing remaining challenges for the diffusion tractography project... - Q-ball imagingDavid S Tuch
Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown 02129, USA
Magn Reson Med 52:1358-72. 2004..Open aspects of the q-ball reconstruction algorithm are discussed... - Age-related changes in prefrontal white matter measured by diffusion tensor imagingD H Salat
MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, MGH Department of Radiology, Building 149, 13th Street, Mail Code 149 2301, Charlestown, MA 02129 2060, USA
Ann N Y Acad Sci 1064:37-49. 2005..This evidence of widespread and regionally accelerated alterations in prefrontal WM with aging illustrates FA's potential as a microstructural index of volumetric measures... - Neuroimaging H.M.: a 10-year follow-up examinationD H Salat
MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129 2060, USA
Hippocampus 16:936-45. 2006..Most of these alterations were not apparent in his prior scans, suggesting that they are of recent origin. Advanced age and hypertension likely contributed to these new findings... - White matter pathology isolates the hippocampal formation in Alzheimer's diseaseD H Salat
MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129 2060, United States
Neurobiol Aging 31:244-56. 2010..These results demonstrate that deterioration of neocortical connections to the hippocampal formation results in part from the degeneration of critical MTL and associated fiber pathways... - Boosting the sampling efficiency of q-Ball imaging using multiple wavevector fusionMark H Khachaturian
Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
Magn Reson Med 57:289-96. 2007..In human WM, MWF reveals more detailed WM architecture than QBI as measured by the IPCM for all sampling schemes presented... - Reduced microstructural integrity of the white matter underlying anterior cingulate cortex is associated with increased saccadic latency in schizophreniaDara S Manoach
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02215, USA
Neuroimage 37:599-610. 2007..Moreover, they suggest that anterior cingulate white matter abnormalities contribute to slower performance of volitional saccades and to inter-individual variability of saccadic latency in chronic, medicated schizophrenia... - Frontal connections and cognitive changes in normal aging rhesus monkeys: a DTI studyNikos Makris
Harvard Medical School Department of Neurology, Center for Morphometric Analysis, Massachusetts General Hospital, Boston, MA 02129, United States
Neurobiol Aging 28:1556-67. 2007..To our knowledge this is the first investigation reporting such alterations in the aging monkey... - Response monitoring, repetitive behaviour and anterior cingulate abnormalities in autism spectrum disorders (ASD)Katharine N Thakkar
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02215, USA
Brain 131:2464-78. 2008..Illuminating the mechanisms and clinical significance of abnormal response monitoring in ASD represents a fruitful avenue for further research... - White matter abnormalities in dystonia normalize after botulinum toxin treatmentAnne J Blood
Department of Neurology, Massachusetts General Hospital, Charlestown 02129, and Harvard Medical School, Boston, Massachusetts, USA
Neuroreport 17:1251-5. 2006..This raises the possibility that we have observed activity-dependent white matter plasticity in the adult human brain... - Focal reversible deactivation of cerebral metabolism affects water diffusionMark H Khachaturian
Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
Magn Reson Med 60:1178-89. 2008..In future experiments, we will apply this methodology to quantify the effect of reversible deactivation on neural activity as measured by the hemodynamic response and compare water diffusion changes with hemodynamic changes... - White matter alterations in cerebral amyloid angiopathy measured by diffusion tensor imagingDavid H Salat
Massachusetts General Hospital Massachusetts Institute of Technology Harvard Medical School, Athinoula A Martinos Center for Biomedical Imaging, Charlestown, Mass 02129 2060, USA
Stroke 37:1759-64. 2006..We used diffusion tensor imaging to evaluate the anatomic distribution of white matter degeneration in participants diagnosed with advanced CAA... - Diffusion tensor imaging in presymptomatic and early Huntington's disease: Selective white matter pathology and its relationship to clinical measuresH Diana Rosas
Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
Mov Disord 21:1317-25. 2006.... - Automatic segmentation of thalamic nuclei from diffusion tensor magnetic resonance imagingMette R Wiegell
Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th Street, Room 2301, Charlestown, MA 02129, USA
Neuroimage 19:391-401. 2003..The ability to resolve thalamic nuclei with DTI will allow for morphometric analysis of specific nuclei and improved anatomical localization of functional activation in the thalamus... - Age-related alterations in white matter microstructure measured by diffusion tensor imagingD H Salat
MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129 2060, USA
Neurobiol Aging 26:1215-27. 2005..These findings suggest that WM alterations are variable throughout the brain and that particular fiber populations within prefrontal region and PLIC are most vulnerable to age-related degeneration... - Conductivity tensor mapping of the human brain using diffusion tensor MRID S Tuch
Massachusetts General Hospital, NMR Center, 149 13th Street, Charlestown, MA 02129, USA
Proc Natl Acad Sci U S A 98:11697-701. 2001..844 +/- 0.0545 S small middle dots/mm(3), r(2) = 0.945). The extension to other biological transport phenomena is also discussed... - A non-invasive method to relate the timing of neural activity to white matter microstructural integritySteven M Stufflebeam
Department of Radiology at the Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
Neuroimage 42:710-6. 2008..This preliminary report demonstrates a non-invasive, unbiased method to relate the timing information from evoked-response experiments to the biophysical properties of white matter measured with DTI... - High angular resolution diffusion imaging reveals intravoxel white matter fiber heterogeneityDavid S Tuch
Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown 02129, USA
Magn Reson Med 48:577-82. 2002..The multitensor reconstruction resolved multiple intravoxel fiber populations corresponding to known fiber anatomy. Ma.. - Interictal alterations of the trigeminal somatosensory pathway and periaqueductal gray matter in migraineAlexandre F M DaSilva
Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
Neuroreport 18:301-5. 2007..Our results indicate the presence of permanent interictal changes in migraineurs, pointing to an effect of migraine on the trigeminal somatosensory and modulatory pain systems... 
Anatomical alterations of the visual motion processing network in migraine with and without auraCristina Granziera
Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, United States of America
PLoS Med 3:e402. 2006..In addition, these experimental data may provide clinicians and researchers with a noninvasively acquirable migraine biomarker...- A primer on diffusion tensor imaging of anatomical substructuresAlexandre F M DaSilva
Martinos Center for Biomedical Imaging, Massachusetts General Hospital, NMR Center, Harvard Medical School, Charlestown, Massachusetts 02129, USA
Neurosurg Focus 15:E4. 2003..The authors illustrate how DT imaging can resolve individual pathways in the brainstem as well as individual nuclei of the thalamus and conclude by describing potential applications in neurosurgery... - Diffusion MRI of complex neural architectureDavid S Tuch
Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th Street, Room 2301, Charlestown, MA 02129, USA
Neuron 40:885-95. 2003..The ability of q-ball imaging to resolve complex intravoxel fiber architecture eliminates a key obstacle to mapping neural connectivity in the human brain noninvasively... - Statistical group comparison of diffusion tensors via multivariate hypothesis testingBrandon Whitcher
Clinical Imaging Centre, GlaxoSmithKline, Hammersmith Hospital, London, UK
Magn Reson Med 57:1065-74. 2007..When applying the Cramér test of the diffusion tensor in a clinical population with a history of migraine, a 169% increase was observed in the volume of a significant cluster compared to the univariate FA test... - Using the wild bootstrap to quantify uncertainty in diffusion tensor imagingBrandon Whitcher
Clinical Imaging Centre, GlaxoSmithKline, Hammersmith Hospital, London, UK
Hum Brain Mapp 29:346-62. 2008..The wild bootstrap method can provide empirical distributions for tensor-derived quantities, such as fractional anisotropy and principal eigenvector direction, even when the exact distributions are not easily derived... - Influence of anisotropic conductivity on EEG source reconstruction: investigations in a rabbit modelDaniel Güllmar
Biomagnetic Center, Department of Neurology, Jena, Germany
IEEE Trans Biomed Eng 53:1841-50. 2006..In contrast, dipole orientation and dipole strength are influenced significantly by the anisotropy. We conclude that the inclusion of tissue anisotropy information improves source estimation procedures...
Research Grants
- Mapping the Cortical Connectivity of Macaque With MRIDavid Tuch; Fiscal Year: 2005..We will then apply the optimized diffusion imaging method to test a series of hypotheses on the cortical connectivity of macaque visual system. ..