Ming T Tsuang

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Schizophrenia is not associated with the functional candidate gene ERBB3: results from a case-control study
    Tetsufumi Kanazawa
    Department of Psychiatry, Center for Behavioral Genomics, University of California, San Diego, La Jolla, California 92093, USA
    Am J Med Genet B Neuropsychiatr Genet 144:113-6. 2007
  2. ncbi request reprint Toward reformulating the diagnosis of schizophrenia
    M T Tsuang
    Harvard Medical School Department of Psychiatry, Massachusetts Mental Health Center, Boston 02115, USA
    Am J Psychiatry 157:1041-50. 2000
  3. ncbi request reprint An overview of the genetics of psychotic mood disorders
    Ming T Tsuang
    Harvard Medical School Department of Psychiatry at the Massachusetts Mental Health Center, 74 Fenwood Road, Boston, MA, USA
    J Psychiatr Res 38:3-15. 2004
  4. ncbi request reprint Understanding predisposition to schizophrenia: toward intervention and prevention
    Ming T Tsuang
    Harvard Medical School Department of Psychiatry, Massachusetts Mental Health Center, 74 Fenwood Rd, Boston, MA 02115, USA
    Can J Psychiatry 47:518-26. 2002
  5. ncbi request reprint Schizotaxia: current status and future directions
    Ming T Tsuang
    Department of Psychiatry at the Massachusetts Mental Health Center, Harvard Medical School, 74 Fernwood Road, Boston, MA 02115, USA
    Curr Psychiatry Rep 5:128-34. 2003
  6. ncbi request reprint Pilot study of spirituality and mental health in twins
    Ming T Tsuang
    Harvard Institute of Psychiatric Epidemiology and Genetics, Harvard Medical School Department of Psychiatry, Massachusetts Mental Health Center, Boston, 02115, USA
    Am J Psychiatry 159:486-8. 2002
  7. ncbi request reprint An integration of schizophrenia with schizotypy: identification of schizotaxia and implications for research on treatment and prevention
    Ming T Tsuang
    Department of Psychiatry, Harvard Medical School, Massachusetts Mental Health Center MMHC, 74 Fenwood Road, Boston, MA 02115, USA
    Schizophr Res 54:169-75. 2002
  8. ncbi request reprint The Harvard Twin Study of Substance Abuse: what we have learned
    M T Tsuang
    Harvard Institute of Psychiatric Epidemiology and Genetics, Boston, MA 02115, USA
    Harv Rev Psychiatry 9:267-79. 2001
  9. ncbi request reprint Department of Veterans Affairs Cooperative Studies Program genetic linkage study of schizophrenia: ascertainment methods and sample description
    M T Tsuang
    Brockton West Roxbury VA Medical Center, MA, USA
    Am J Med Genet 96:342-7. 2000
  10. ncbi request reprint Treatment of nonpsychotic relatives of patients with schizophrenia: six case studies
    Ming T Tsuang
    Harvard Medical School, Department of Psychiatry at Massachusetts Mental Health Center, Boston 02115, USA
    Am J Med Genet 114:943-8. 2002

Detail Information

Publications111 found, 100 shown here

  1. ncbi request reprint Schizophrenia is not associated with the functional candidate gene ERBB3: results from a case-control study
    Tetsufumi Kanazawa
    Department of Psychiatry, Center for Behavioral Genomics, University of California, San Diego, La Jolla, California 92093, USA
    Am J Med Genet B Neuropsychiatr Genet 144:113-6. 2007
    ..However, our failure to find genetic association suggests that the differential expression of ERBB3 in schizophrenia may be environmentally driven, or involve cis- or trans-acting genetic factors beyond the boundaries of the gene itself...
  2. ncbi request reprint Toward reformulating the diagnosis of schizophrenia
    M T Tsuang
    Harvard Medical School Department of Psychiatry, Massachusetts Mental Health Center, Boston 02115, USA
    Am J Psychiatry 157:1041-50. 2000
    ..The authors then discuss alternative conceptions of schizophrenia that take into account recent data concerning its genetic and neurodevelopmental origins and its pathophysiological substrates...
  3. ncbi request reprint An overview of the genetics of psychotic mood disorders
    Ming T Tsuang
    Harvard Medical School Department of Psychiatry at the Massachusetts Mental Health Center, 74 Fenwood Road, Boston, MA, USA
    J Psychiatr Res 38:3-15. 2004
    ..Future research should continue to examine psychotic forms of mood disorder using both epidemiological and molecular approaches...
  4. ncbi request reprint Understanding predisposition to schizophrenia: toward intervention and prevention
    Ming T Tsuang
    Harvard Medical School Department of Psychiatry, Massachusetts Mental Health Center, 74 Fenwood Rd, Boston, MA 02115, USA
    Can J Psychiatry 47:518-26. 2002
    ..In this paper, we consider some of the major obstacles that must be studied before prevention strategies become feasible...
  5. ncbi request reprint Schizotaxia: current status and future directions
    Ming T Tsuang
    Department of Psychiatry at the Massachusetts Mental Health Center, Harvard Medical School, 74 Fernwood Road, Boston, MA 02115, USA
    Curr Psychiatry Rep 5:128-34. 2003
    ..In this review, the authors update the conceptual basis of schizotaxia, consider evidence for its validity, and look toward its likely evolution in the future...
  6. ncbi request reprint Pilot study of spirituality and mental health in twins
    Ming T Tsuang
    Harvard Institute of Psychiatric Epidemiology and Genetics, Harvard Medical School Department of Psychiatry, Massachusetts Mental Health Center, Boston, 02115, USA
    Am J Psychiatry 159:486-8. 2002
    ..The goal of this study was to investigate associations between empirically defined dimensions of spirituality, personality variables, and psychiatric disorders in Vietnam era veterans...
  7. ncbi request reprint An integration of schizophrenia with schizotypy: identification of schizotaxia and implications for research on treatment and prevention
    Ming T Tsuang
    Department of Psychiatry, Harvard Medical School, Massachusetts Mental Health Center MMHC, 74 Fenwood Road, Boston, MA 02115, USA
    Schizophr Res 54:169-75. 2002
    ..25-2.0 mg). Thus, clinical deficits in schizotaxia may be identifiable, and to a significant extent, reversible. Implications for the conception of schizotypy and the prevention of schizophrenia will be discussed...
  8. ncbi request reprint The Harvard Twin Study of Substance Abuse: what we have learned
    M T Tsuang
    Harvard Institute of Psychiatric Epidemiology and Genetics, Boston, MA 02115, USA
    Harv Rev Psychiatry 9:267-79. 2001
    ..Our results, thus far, indicate a complex pattern of genetic and environmental influences on substance use and abuse...
  9. ncbi request reprint Department of Veterans Affairs Cooperative Studies Program genetic linkage study of schizophrenia: ascertainment methods and sample description
    M T Tsuang
    Brockton West Roxbury VA Medical Center, MA, USA
    Am J Med Genet 96:342-7. 2000
    ..There was a total of 216 affected sib-pairs in these families. Using the n-1 rule, these families contain 188 independent affected sib-pairs...
  10. ncbi request reprint Treatment of nonpsychotic relatives of patients with schizophrenia: six case studies
    Ming T Tsuang
    Harvard Medical School, Department of Psychiatry at Massachusetts Mental Health Center, Boston 02115, USA
    Am J Med Genet 114:943-8. 2002
  11. pmc Preliminary evidence of ethnic divergence in associations of putative genetic variants for methamphetamine dependence
    Chad A Bousman
    Department of Psychiatry, University of California San Diego, La Jolla, CA 92103, USA
    Psychiatry Res 178:295-8. 2010
    ..Results provide preliminary support for further exploration and validation of candidate single nucleotide polymorphisms (SNPs) for methamphetamine (METH) dependence reported among Asian populations across other ethnic/ancestral groups...
  12. pmc Auditory working memory impairments in individuals at familial high risk for schizophrenia
    Larry J Seidman
    Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA, USA
    Neuropsychology 26:288-303. 2012
    ..The goal of these studies was to develop new auditory continuous performance tests (ACPTs) and evaluate their effects in individuals with schizophrenia and their relatives...
  13. ncbi request reprint A review and new report of medial temporal lobe dysfunction as a vulnerability indicator for schizophrenia: a magnetic resonance imaging morphometric family study of the parahippocampal gyrus
    Larry J Seidman
    Commonwealth Research Center, Harvard Medical School, Department of Psychiatry, Massachusetts Mental Health Center, Boston, MA, USA
    Schizophr Bull 29:803-30. 2003
    ..Implications of genetic risk studies for prodromal research are discussed...
  14. pmc Hypomethylation of MB-COMT promoter is a major risk factor for schizophrenia and bipolar disorder
    Hamid Mostafavi Abdolmaleky
    Department of Psychiatry at Massachusetts Mental Health Center and Harvard Institute of Psychiatric Epidemiology and Genetics, Harvard Medical School, Boston, MA, USA
    Hum Mol Genet 15:3132-45. 2006
    ....
  15. doi request reprint Group and site differences on the California Verbal Learning Test in persons with schizophrenia and their first-degree relatives: findings from the Consortium on the Genetics of Schizophrenia (COGS)
    William S Stone
    Massachusetts Mental Health Center Public Psychiatry Division of the Beth Israel Deaconess Medical Center, Harvard Medical School Department of Psychiatry, Boston, MA 02215, USA
    Schizophr Res 128:102-10. 2011
    ....
  16. pmc Neuroanatomic substrates of sex differences in language dysfunction in schizophrenia: a pilot study
    Deborah J Walder
    Psychiatric Neuroscience Division, Harvard Medical School Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02120, USA
    Schizophr Res 90:295-301. 2007
    ....
  17. ncbi request reprint The corticotropin-releasing hormone gene and behavioral inhibition in children at risk for panic disorder
    Jordan W Smoller
    Department of Psychiatry, Massachusetts General Hospital, Boston 02114, USA
    Biol Psychiatry 57:1485-92. 2005
    ..To evaluate this further, we genotyped additional families for this marker and a panel of markers encompassing the CRH locus...
  18. pmc Common genetic liability to major depression and posttraumatic stress disorder in men
    Karestan C Koenen
    Department of Society, Human Development, and Health, Harvard School of Public Health, Boston, MA 02115, United States
    J Affect Disord 105:109-15. 2008
    ..The degree to which a common genetic liability explains the etiology of the MD-PTSD association has not been quantified and has important implications for research and prevention...
  19. doi request reprint Genome-wide linkage analyses of 12 endophenotypes for schizophrenia from the Consortium on the Genetics of Schizophrenia
    Tiffany A Greenwood
    Department of Psychiatry, University of California San Diego, La Jolla, Calif, USA
    Am J Psychiatry 170:521-32. 2013
    ..The authors previously demonstrated the heritability of these endophenotypes; in the present study, genetic linkage was evaluated...
  20. pmc Genetic and environmental influences of white and gray matter signal contrast: a new phenotype for imaging genetics?
    Matthew S Panizzon
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
    Neuroimage 60:1686-95. 2012
    ..The lack of significant genetic correlations with cortical thickness suggests that this measure potentially represents a unique source of genetic variance, one that has yet to be explored by the field of imaging genetics...
  21. pmc Neuropsychology of the prodrome to psychosis in the NAPLS consortium: relationship to family history and conversion to psychosis
    Larry J Seidman
    Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Arch Gen Psychiatry 67:578-88. 2010
    ..Early detection and prospective evaluation of clinical high-risk (CHR) individuals who may develop schizophrenia or other psychotic disorders is critical for predicting psychosis onset and for testing preventive interventions...
  22. ncbi request reprint Initial heritability analyses of endophenotypic measures for schizophrenia: the consortium on the genetics of schizophrenia
    Tiffany A Greenwood
    Department of Psychiatry, University of California San Diego, La Jolla, USA
    Arch Gen Psychiatry 64:1242-50. 2007
    ..Exploration of the genetic architecture of specific endophenotypes may be a powerful strategy for understanding the genetic basis of schizophrenia...
  23. doi request reprint Emotion-cognition interaction in people at familial high risk for schizophrenia: the impact of sex differences
    Laura K Phillips
    Harvard Medical School, Harvard University, USA
    J Abnorm Psychol 120:993-8. 2011
    ..Additional research with larger samples of men and women is needed to test these preliminary findings...
  24. ncbi request reprint Hypothalamic abnormalities in schizophrenia: sex effects and genetic vulnerability
    Jill M Goldstein
    Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
    Biol Psychiatry 61:935-45. 2007
    ..We tested the hypothesis that normal hypothalamic sexual dimorphism is disrupted in schizophrenia...
  25. pmc Abnormal auditory N100 amplitude: a heritable endophenotype in first-degree relatives of schizophrenia probands
    Bruce I Turetsky
    Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biol Psychiatry 64:1051-9. 2008
    ..We report initial results from the COGS dataset of auditory N100 amplitude and gating as candidate endophenotypes...
  26. ncbi request reprint Co-occurrence of binge eating disorder with psychiatric and medical disorders
    Kristin N Javaras
    Department of Biostatistics, Harvard School of Public Health, Boston, Mass, USA
    J Clin Psychiatry 69:266-73. 2008
    ..We used data from that type of study to assess the co-occurrence of various psychiatric and medical disorders with DSM-IV BED and with subthreshold BED...
  27. ncbi request reprint Elaborative verbal encoding and altered anterior parahippocampal activation in adolescents and young adults at genetic risk for schizophrenia using FMRI
    Heidi W Thermenos
    Harvard Medical School, Massachusetts Mental Health Center in the Division of Public Psychiatry, Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, USA
    Biol Psychiatry 61:564-74. 2007
    ..We used functional magnetic resonance imaging (fMRI) to assess brain activity in the MTL during novel and repeated word-pair encoding...
  28. ncbi request reprint Spiritual well-being and health
    Ming T Tsuang
    Department of Psychiatry, Center for Behavioral Genomics, University of California, San Diego 92037, and Massachusetts General Hospital, Boston, Massachusetts, USA
    J Nerv Ment Dis 195:673-80. 2007
    ..quot; We concluded that studies of SWB and health should continue to distinguish between explicitly religious variables and others that more closely approximate the psychological construct of personal well-being...
  29. ncbi request reprint A discordant twin study of premorbid cognitive ability in schizophrenia
    William S Kremen
    Institute of Behavioral Genomics, Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive, La Jolla, 92093 0603, USA
    J Clin Exp Neuropsychol 28:208-24. 2006
    ..Educational advancement may be slightly slowed by this familial vulnerability, but results were equivocal with regard to attenuation of one's ultimate educational attainment...
  30. pmc Inhibition of the P50 cerebral evoked response to repeated auditory stimuli: results from the Consortium on Genetics of Schizophrenia
    Ann Olincy
    Department of Psychiatry, Veterans Affairs Denver Medical Center VISN 19 MIRECC, CO 80045, USA
    Schizophr Res 119:175-82. 2010
    ....
  31. pmc Regional prefrontal cortex gray matter volumes in youth at familial risk for schizophrenia from the Harvard Adolescent High Risk Study
    Isabelle M Rosso
    Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    Schizophr Res 123:15-21. 2010
    ..We conducted a region-of-interest morphometric study of prefrontal subregions in adolescent and young adult relatives of schizophrenia patients...
  32. pmc A comparison of heritability maps of cortical surface area and thickness and the influence of adjustment for whole brain measures: a magnetic resonance imaging twin study
    Lisa T Eyler
    Department of Psychiatry, University of California San Diego, La Jolla, CA, USA
    Twin Res Hum Genet 15:304-14. 2012
    ..Implications regarding brain phenotypes for future genetic association studies are discussed...
  33. pmc Evidence for genetic association of RORB with bipolar disorder
    Casey L McGrath
    Department of Psychiatry, Laboratory of Neurophenomics, Indiana University School of Medicine, Indianapolis, IN, USA
    BMC Psychiatry 9:70. 2009
    ..Here we report association studies between bipolar disorder and single-nucleotide polymorphisms (SNPs) in RORA and RORB...
  34. doi request reprint A functional MRI study of working memory in adolescents and young adults at genetic risk for bipolar disorder: preliminary findings
    Heidi W Thermenos
    Division of Public Psychiatry, Department of Psychiatry, Massachusetts Mental Health Center, Beth Israel Deaconess Medical Center, Boston, USA
    Bipolar Disord 13:272-86. 2011
    ....
  35. pmc Specificity of familial transmission of schizophrenia psychosis spectrum and affective psychoses in the New England family study's high-risk design
    Jill M Goldstein
    Division of Women s Health, Mary Horrigan Connors Center for Women s Health and Gender Biology, and Department of Psychiatry, Brigham and Women s Hospital, Boston, Massachusetts 02120, USA
    Arch Gen Psychiatry 67:458-67. 2010
    ..However, few studies have investigated the specificity of the transmission of schizophrenia-psychosis spectrum (SPS) disorders and affective psychoses (APs) or observed high-risk offspring into mid-adulthood...
  36. ncbi request reprint Evidence for linkage between regulatory enzymes in glycolysis and schizophrenia in a multiplex sample
    William S Stone
    Harvard Medical School Department of Psychiatry at Massachusetts Mental Health Center, Boston, Massachusetts 02115, USA
    Am J Med Genet B Neuropsychiatr Genet 127:5-10. 2004
    ..More generally, they support the view that relationships between glucose dysregulation and schizophrenia are inherent to the disorder, and are not merely epiphenomena related to medication or other treatment factors...
  37. pmc Posttraumatic stress disorder and the genetic structure of comorbidity
    Erika J Wolf
    National Center for PTSD, VA Boston Healthcare System and Department of Psychology, Boston University, Boston, MA, USA
    J Abnorm Psychol 119:320-30. 2010
    ..Shared genetic variance across the 2 dimensions explained 67% of their phenotypic correlation (r = .52). These findings have implications for conceptualizations of the etiology of PTSD and its location in an empirically based nosology...
  38. doi request reprint Positive symptoms of psychosis correlate with expression of ubiquitin proteasome genes in peripheral blood
    Chad A Bousman
    Department of Psychiatry, University of California, San Diego, California, USA
    Am J Med Genet B Neuropsychiatr Genet 153:1336-41. 2010
    ..Our findings suggest that dysregulation of the UPS, specifically ubiquitin conjugation and deubiquitination, may point to a possible underlying biological mechanism for severity of positive but not negative symptoms...
  39. ncbi request reprint Family-based association study of the NOTCH4 gene in schizophrenia using Japanese and Chinese samples
    Sakae Takahashi
    Department of Psychiatry, Massachusetts Mental Health Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    Biol Psychiatry 54:129-35. 2003
    ..A family based association study in a British sample found the NOTCH4 gene to be associated with schizophrenia; however, all six replication studies failed to confirm the finding...
  40. ncbi request reprint Hypermethylation of the reelin (RELN) promoter in the brain of schizophrenic patients: a preliminary report
    Hamid Mostafavi Abdolmaleky
    Department of Psychiatry, Harvard Medical School at Massachusetts Mental Health Center, Boston, Massachusetts, USA
    Am J Med Genet B Neuropsychiatr Genet 134:60-6. 2005
    ..Further studies with a larger sample set would be required to validate these preliminary observations...
  41. pmc Hierarchical genetic organization of human cortical surface area
    Chi Hua Chen
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
    Science 335:1634-6. 2012
    ..We also found that the results were consistent with human-specific regions being subdivisions of previously described, genetically based lobar regionalization patterns...
  42. pmc Children of parents with affective and nonaffective psychoses: a longitudinal study of behavior problems
    Jo Ann L Donatelli
    Department of Psychiatry, Community Health, Brown University, Providence, RI 02903, USA
    Am J Psychiatry 167:1331-8. 2010
    ..g., schizophrenia, other nonaffective psychoses, and affective psychoses) have distinct forms of behavioral problems (i.e., internalizing and externalizing)...
  43. ncbi request reprint Shared genetic risk of major depression, alcohol dependence, and marijuana dependence: contribution of antisocial personality disorder in men
    Qiang Fu
    Missouri Alcoholism Research Center at Washington University, Department of Psychiatry, Washington University School of Medicine, 40 N Kingshighway Blvd, Suite 2, St Louis, MO 63108, USA
    Arch Gen Psychiatry 59:1125-32. 2002
    ..We examined the contribution of genetic effects associated with ASPD to the comorbidity of MD and substance use disorders...
  44. ncbi request reprint A twin study of the neuropsychological consequences of stimulant abuse
    Rosemary Toomey
    Department of Psychiatry, Massachusetts Mental Health Center, Harvard Medical School, 02129, USA
    Arch Gen Psychiatry 60:303-10. 2003
    ..Previous studies document neuropsychological deficits associated with stimulant abuse, but findings are inconsistent...
  45. ncbi request reprint Left hippocampal volume as a vulnerability indicator for schizophrenia: a magnetic resonance imaging morphometric study of nonpsychotic first-degree relatives
    Larry J Seidman
    Neuropsychology Laboratory, Massachusetts Mental Health Center, 74 Fenwood Rd, Boston, MA 02115, USA
    Arch Gen Psychiatry 59:839-49. 2002
    ....
  46. ncbi request reprint Meta-analysis of the association between two polymorphisms in the serotonin transporter gene and affective disorders
    Jessica A Lasky-Su
    Department of Psychiatry, Harvard Medical School at the Massachusetts Mental Health Center, Boston, Massachusetts, USA
    Am J Med Genet B Neuropsychiatr Genet 133:110-5. 2005
    ..The small but significant effects of the 44-bp insertion/deletion polymorphism for BP is consistent with being one of many genes that contributes to the multi-factorial nature of these psychiatric disorders...
  47. ncbi request reprint Altered brain activation in dorsolateral prefrontal cortex in adolescents and young adults at genetic risk for schizophrenia: an fMRI study of working memory
    Larry J Seidman
    Harvard Medical School, Department of Psychiatry, Massachusetts Mental Health Center Public Psychiatry Division, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    Schizophr Res 85:58-72. 2006
    ..Because substantially less is known about these phenotypes in adolescent subjects we sought to demonstrate that young relatives of persons with schizophrenia manifest impaired WM and altered prefrontal activation...
  48. pmc Factor structure of planning and problem-solving: a behavioral genetic analysis of the Tower of London task in middle-aged twins
    William S Kremen
    Department of Psychiatry, Center for Behavioral Genomics, University of California, San Diego, La Jolla, CA 92093 0738, USA
    Behav Genet 39:133-44. 2009
    ..The different phenotypic and genetic factor results suggest that relying solely on the former could obscure genetic associations...
  49. pmc Validity of the prodromal risk syndrome for first psychosis: findings from the North American Prodrome Longitudinal Study
    Scott W Woods
    PRIME Prodromal Research Clinic, Department of Psychiatry, Yale University School of Medicine, 34 Park Street, New Haven, CT 06519, USA
    Schizophr Bull 35:894-908. 2009
    ..The strong evidence of diagnostic validity for the prodromal risk syndrome for first psychosis raises the question of its evaluation for inclusion in Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition)...
  50. ncbi request reprint Genome scan of Han Chinese schizophrenia families from Taiwan: confirmation of linkage to 10q22.3
    Stephen V Faraone
    Department of Psychiatry, SUNY Upstate Medical University, 750 East Adams St, Syracuse, NY 13210, USA
    Am J Psychiatry 163:1760-6. 2006
    ..To address this issue, the authors ascertained 606 Han Chinese families comprising 1,234 affected members...
  51. pmc Genetic and environmental contributions to regional cortical surface area in humans: a magnetic resonance imaging twin study
    Lisa T Eyler
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
    Cereb Cortex 21:2313-21. 2011
    ....
  52. pmc Genetic influences on hippocampal volume differ as a function of testosterone level in middle-aged men
    Matthew S Panizzon
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
    Neuroimage 59:1123-31. 2012
    ..To the best of our knowledge, this is the first study to demonstrate that the heritability of a brain structure in adults may be modified by an endogenous biological factor...
  53. pmc Heritability of brain ventricle volume: converging evidence from inconsistent results
    William S Kremen
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
    Neurobiol Aging 33:1-8. 2012
    ..These conclusions have implications for the basic understanding of the genetic and environmental underpinnings of normative and pathological brain aging...
  54. pmc Presence of ApoE ε4 allele associated with thinner frontal cortex in middle age
    Christine Fennema-Notestine
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093 0738, USA
    J Alzheimers Dis 26:49-60. 2011
    ..Ongoing follow-up of the VETSA sample may shed light on the potential for age- and disease-related mediation of the influence of ApoE allele status...
  55. pmc A twin study of spatial and non-spatial delayed response performance in middle age
    William S Kremen
    Department of Psychiatry, Center for Behavioral Genomics, University of California, San Diego, La Jolla, CA 92093 0738, USA
    Brain Cogn 76:43-51. 2011
    ..Compared with findings from small, selected control samples, high "failure" rates in this community-based sample raise concerns about interpretation of brain dysfunction in elderly or patient samples...
  56. pmc Multi-site studies of acoustic startle and prepulse inhibition in humans: initial experience and methodological considerations based on studies by the Consortium on the Genetics of Schizophrenia
    Neal R Swerdlow
    Department of Psychiatry, University of California San Diego, San Diego, California, USA
    Schizophr Res 92:237-51. 2007
    ..Genetic studies now often employ multiple, geographically dispersed test sites to accommodate the need for large and complex study samples. Here, we assessed the feasibility of using PPI in multi-site studies...
  57. ncbi request reprint Structural brain abnormalities among relatives of patients with schizophrenia: implications for linkage studies
    Stephen V Faraone
    Harvard Medical School Department of Psychiatry at the Massachusetts Mental Health Center, Boston, MA, USA
    Schizophr Res 60:125-40. 2003
    ....
  58. ncbi request reprint Adolescent alcohol use is a risk factor for adult alcohol and drug dependence: evidence from a twin design
    Julia D Grant
    Department of Psychiatry, Midwest Alcoholism Research Center, Washington University School of Medicine, St Louis, MO 63110, USA
    Psychol Med 36:109-18. 2006
    ..Early alcohol use is associated with abuse and dependence of licit and illicit substances later in life. The role of genetic and environmental factors in this association is not conclusive...
  59. pmc Neuropsychological functioning in adolescents and young adults at genetic risk for schizophrenia and affective psychoses: results from the Harvard and Hillside Adolescent High Risk Studies
    Larry J Seidman
    Department of Psychiatry, Harvard Medical School, Massachusetts Mental Health Center, Division of Public Psychiatry, Beth Israel Deaconess Medical Center, Boston, USA
    Schizophr Bull 32:507-24. 2006
    ..Ascertainment criteria for controls may markedly influence results and interpretation of group differences...
  60. ncbi request reprint Three potential susceptibility loci shown by a genome-wide scan for regions influencing the age at onset of mania
    Stephen V Faraone
    Department of Psychiatry, Harvard Medical School, Boston, USA
    Am J Psychiatry 161:625-30. 2004
    ..Because age at onset may have utility in resolving the complexity and heterogeneity of the disorder, the authors sought to identify chromosomal loci that harbor the genes influencing this trait...
  61. ncbi request reprint Is there heterogeneity among syndromes of substance use disorder for illicit drugs?
    Cheryl Beseler
    Center for Behavioral Genomics, Department of Psychiatry, University of California, 9500 Gilman Drive, Mail Code 0603, La Jolla, San Diego, CA 92093, and Veterans Medical Research Foundation, La Jolla 92161, USA
    Addict Behav 31:929-47. 2006
    ....
  62. pmc Analysis of 94 candidate genes and 12 endophenotypes for schizophrenia from the Consortium on the Genetics of Schizophrenia
    Tiffany A Greenwood
    Department of Psychiatry, University of California at San Diego, La Jolla, CA 92093 0804, USA
    Am J Psychiatry 168:930-46. 2011
    ....
  63. ncbi request reprint Genetics of verbal working memory processes: a twin study of middle-aged men
    William S Kremen
    Department of Psychiatry, Center for Behavioral Genomics, University of California, San Diego, CA 92093 0738, USA
    Neuropsychology 21:569-80. 2007
    ..The genetic influences that were specific to reading span were concluded to most likely reflect an executive function component. Implications for genetic studies of aging and prefrontal brain function are discussed...
  64. ncbi request reprint Co-twin control study of relationships among combat exposure, combat-related PTSD, and other mental disorders
    Karestan C Koenen
    Women s Health Sciences Division, National Center for PTSD, VA Boston Healthcare System, Boston, Massachusetts 02114, USA
    J Trauma Stress 16:433-8. 2003
    ..We conclude C-PTSD comorbidity persists after controlling for shared vulnerability. Combat exposure is directly and indirectly, through C-PTSD, associated with increased risk for other mental disorders...
  65. doi request reprint A twin study of smoking, nicotine dependence, and major depression in men
    Michael Lyons
    Department of Psychology, Boston University, Boston, MA 02215, USA
    Nicotine Tob Res 10:97-108. 2008
    ..Findings extend Kendler and colleague's (1993) study of female twins by demonstrating in men that shared genetic factors predispose not only to major depression and daily smoking but also to major depression and nicotine dependence...
  66. doi request reprint IQ decline in cross-sectional studies of schizophrenia: methodology and interpretation
    William S Kremen
    Department of Psychiatry, Center for Behavioral Genomics, University of California, San Diego School of Medicine, 9500 Gilman Drive MC 0738, La Jolla, CA 92093 0738, USA
    Psychiatry Res 158:181-94. 2008
    ..Overall, these results strongly suggest that differences in current neuropsychological function in schizophrenia are attributable primarily to current IQ instead of to IQ trajectory over time...
  67. pmc An fMRI study of working memory in persons with bipolar disorder or at genetic risk for bipolar disorder
    Heidi W Thermenos
    Department of Psychiatry, Harvard Medical School, Massachusetts Mental Health Center Division of Public Psychiatry, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Am J Med Genet B Neuropsychiatr Genet 153:120-31. 2010
    ..Persons with BD and RELs exhibit altered activity in the frontopolar cortex and insula, which may represent biomarkers of genetic risk for BD...
  68. doi request reprint Preliminary evidence of ubiquitin proteasome system dysregulation in schizophrenia and bipolar disorder: convergent pathway analysis findings from two independent samples
    Chad A Bousman
    Center for Behavioral Genomics, Department of Psychiatry, University of California, San Diego, La Jolla, CA 92039, USA
    Am J Med Genet B Neuropsychiatr Genet 153:494-502. 2010
    ..Findings provide preliminary evidence of UPS dysregulation in BPD and psychosis as well as support further investigation of the UPS and other molecular and cellular pathways for potential biomarkers for SCZ, BPD, and/or psychosis...
  69. ncbi request reprint A novel permutation testing method implicates sixteen nicotinic acetylcholine receptor genes as risk factors for smoking in schizophrenia families
    Stephen V Faraone
    Department of Psychiatry at Massachusetts General Hospital, Harvard Medical School, 37 Shields Avenue, Boston, MA 02301, USA
    Hum Hered 57:59-68. 2004
    ..Such findings help prioritize genes for future case control studies. In addition, we provide a novel permutation method that is useful in future analyses involving a single hypothesis, with multiple candidate genes...
  70. ncbi request reprint Intellectual decline in schizophrenia: evidence from a prospective birth cohort 28 year follow-up study
    Larry J Seidman
    Department of Psychiatry at Massachusetts Mental Health Center, Harvard Medical School, Boston, USA
    J Clin Exp Neuropsychol 28:225-42. 2006
    ..Future research on this sample will evaluate the prospective roles of family history and perinatal complications on cognition, and assess the specificity of these findings...
  71. pmc White matter volume abnormalities and associations with symptomatology in schizophrenia
    Nikolaos Makris
    Athinoula A Martinos Imaging Center, Department of Neurology, Center for Morphometric Analysis, Massachusetts General Hospital, Boston, MA, United States
    Psychiatry Res 183:21-9. 2010
    ..These observations suggest a pattern of volume WM alterations associated with symptomatology in schizophrenia that may be related in part to predisposition to schizophrenia...
  72. ncbi request reprint Psychopathology, personality traits and social development of young first-degree relatives of patients with schizophrenia
    Stephen J Glatt
    Center for Behavioral Genomics, Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 920923, USA
    Br J Psychiatry 189:337-45. 2006
    ..Evaluation of individuals at high genetic risk of schizophrenia is a powerful method for identifying precursors of the illness...
  73. doi request reprint Salivary cortisol and prefrontal cortical thickness in middle-aged men: A twin study
    William S Kremen
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
    Neuroimage 53:1093-102. 2010
    ..Longitudinal assessments are underway to elucidate the direction of the associations and the genetic underpinnings of longitudinal phenotypes for changes in cortisol and brain morphology...
  74. ncbi request reprint Association of a genetic marker at the corticotropin-releasing hormone locus with behavioral inhibition
    Jordan W Smoller
    Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Biol Psychiatry 54:1376-81. 2003
    ..Transgenic mice overexpressing CRH exhibit BI-like behaviors, implicating this gene in the development of the phenotype...
  75. ncbi request reprint Sex differences in language dysfunction in schizophrenia
    Deborah J Walder
    Department of Psychiatry, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Am J Psychiatry 163:470-7. 2006
    ..The current study investigated this issue in the domains of phonology, semantics, and grammar, which have been closely linked with neuroanatomic regions for which sex differences have been identified...
  76. ncbi request reprint Family-based association study of markers on chromosome 22 in schizophrenia using African-American, European-American, and Chinese families
    Sakae Takahashi
    Department of Psychiatry, Massachusetts Mental Health Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Med Genet B Neuropsychiatr Genet 120:11-7. 2003
    ..However, we found no significant association for the African-American sample. In conclusion, our data provide further support for the idea that the region around D22S683 contains a susceptibility gene for schizophrenia...
  77. ncbi request reprint Is there disproportionate impairment in semantic or phonemic fluency in schizophrenia?
    William S Kremen
    Department of Psychiatry, University of California, Davis School of Medicine, 2230 Stockton Blvd, Sacramento, CA 95817, USA
    J Int Neuropsychol Soc 9:79-88. 2003
    ..48 < rs < .79). These results mirror a literature that overall suggests a small degree of disproportionate semantic fluency impairment in schizophrenia, but also some heterogeneity in fluency deficits...
  78. ncbi request reprint The genetics of pediatric-onset bipolar disorder
    Stephen V Faraone
    Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Biol Psychiatry 53:970-7. 2003
    ....
  79. ncbi request reprint Early onset bipolar disorder: possible linkage to chromosome 9q34
    Stephen V Faraone
    Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA
    Bipolar Disord 8:144-51. 2006
    ..We hypothesized that using age at onset to look at subsets of BD families in a genetic linkage analysis would prove useful in separating etiologically homogeneous BD sub-groups and subsequently identifying genetic susceptibility regions...
  80. doi request reprint The utility of SELENBP1 gene expression as a biomarker for major psychotic disorders: replication in schizophrenia and extension to bipolar disorder with psychosis
    Tetsufumi Kanazawa
    Department of Psychiatry, University of California, San Diego, La Jolla, California 92093 0603, USA
    Am J Med Genet B Neuropsychiatr Genet 147:686-9. 2008
    ..Future studies should exploit DNA-based methods and molecular investigations on the role of SELENBP1 in order to gain insights into the nature of its influence on schizophrenia and psychotic symptoms...
  81. ncbi request reprint Genome-wide scan of homogeneous subtypes of NIMH genetics initiative schizophrenia families
    Sakae Takahashi
    Department of Psychiatry, Harvard Medical School, Massachusetts Mental Health Center, Boston, MA, USA
    Psychiatry Res 133:111-22. 2005
    ..32) using a recessive parametric model. Although this work should be interpreted cautiously and requires replication, these results suggest that schizophrenia may be linked to chromosomal regions 8p23.1 and 22q12.3-q13.32...
  82. ncbi request reprint Meta-analysis of association between the T102C polymorphism of the 5HT2a receptor gene and schizophrenia
    Hamid Mostafavi Abdolmaleky
    Department of Psychiatry, Harvard Medical School, Massachusetts Mental Health Center, Boston, MA 02115, USA
    Schizophr Res 67:53-62. 2004
    ..The effects of other genes, environmental effects on DNA methylation, or different methods of classification may be the causes for such heterogeneity, but more study in this area is needed...
  83. ncbi request reprint Organizational and visual memory deficits in schizophrenia and bipolar psychoses using the Rey-Osterrieth complex figure: effects of duration of illness
    Larry J Seidman
    Harvard Medical, School Department of Psychiatry at Massachusetts Mental Health Center, Harvard Institute of Psychiatric Epidemiology and Genetics, Boston, MA 02115, USA
    J Clin Exp Neuropsychol 25:949-64. 2003
    ..Further research is required to determine whether similar mechanisms underlie the neurocognitive deficits in these psychotic disorders...
  84. ncbi request reprint Association between a functional catechol O-methyltransferase gene polymorphism and schizophrenia: meta-analysis of case-control and family-based studies
    Stephen J Glatt
    Department of Psychiatry, Harvard Medical School at Massachusetts Mental Health Center and Massachusetts General Hospital, Boston 02115, USA
    Am J Psychiatry 160:469-76. 2003
    ..The authors' goal was to evaluate the collective evidence for an association between the Val158/108Met polymorphism of the catechol O-methyltransferase (COMT) gene and schizophrenia...
  85. ncbi request reprint Family study of affective spectrum disorder
    James I Hudson
    Department of Psychiatry, Harvard Medical School, Boston, Mass, USA
    Arch Gen Psychiatry 60:170-7. 2003
    ..Two predictions of the ASD hypothesis were tested: that ASD, taken as a single entity, would aggregate in families and that MDD would coaggregate with other forms of ASD in families...
  86. ncbi request reprint Family, twin, and adoption studies of bipolar disease
    Levi Taylor
    Harvard Medical School, Department of Psychiatry at the Massachusetts Mental Health Center, 74 Fenwood Road, Boston, MA 02115, USA
    Curr Psychiatry Rep 4:130-3. 2002
    ..In addition, adoption studies have demonstrated that biological relatives of bipolar patients are substantially more likely to have the disorder than are adoptive relatives...
  87. ncbi request reprint Impact of normal sexual dimorphisms on sex differences in structural brain abnormalities in schizophrenia assessed by magnetic resonance imaging
    Jill M Goldstein
    Massachusetts Mental Health Center, Harvard Institute of Psychiatric Epidemiology and Genetics, 74 Fenwood Rd, Boston, MA 02115, USA
    Arch Gen Psychiatry 59:154-64. 2002
    ....
  88. ncbi request reprint The molecular genetics of schizophrenia: an emerging consensus
    Stephen V Faraone
    Harvard Medical School Dept of Psychiatry at the Massachusetts Mental Health Center and Brockton West Roxbury Veterans Affairs Medical Center, 74 Fenwood Rd, Boston, MA 02115, USA
    Expert Rev Mol Med 4:1-13. 2002
    ..Molecular genetic studies of specific candidate genes are then reviewed. Some controversies within the literature are examined and possible directions for future research are discussed...
  89. ncbi request reprint The application of a random effects model to censored twin data
    I Chao Liu
    Department of Psychiatry, Cardinal Tien Hospital and Fu Jen Medical School, Taipei, Taiwan
    Behav Genet 35:781-9. 2005
    ..Our results show genetic factors contribute about one third of twin similarity in the age of onset of alcohol abuse in male twins. The application of this model to twin data is discussed...
  90. ncbi request reprint Decreased volume of left and total anterior insular lobule in schizophrenia
    Nikos Makris
    Athinoula A Martinos Center, Harvard Medical School Department of Neurology, Massachusetts General Hospital, Boston, MA 02129, United States
    Schizophr Res 83:155-71. 2006
    ....
  91. ncbi request reprint Auditory verbal working memory load and thalamic activation in nonpsychotic relatives of persons with schizophrenia: an fMRI replication
    Larry J Seidman
    Division of Public Psychiatry, Harvard Medical School Massachusetts Mental Health Center, Beth Israel Deaconess Medical Center, MA 02215, USA
    Neuropsychology 21:599-610. 2007
    ..This replication suggests that altered thalamic activation is a feature of neurobiological risk for schizophrenia...
  92. ncbi request reprint Validating schizotaxia and its place in studies of preventing schizophrenia by psychopharmacological intervention
    Ming T Tsuang
    Department of Psychiatry, University of California, San Diego, USA
    Essent Psychopharmacol 6:91-103. 2005
    ..These may represent special vulnerability to schizophrenia. Five areas of deficit are enumerated and suggestions as to the potential value of pre-illness interventions are discussed...
  93. pmc Longitudinal study of the diagnosis of components of the metabolic syndrome in individuals with binge-eating disorder
    James I Hudson
    McLean Hospital, Belmont, MA 02478, USA
    Am J Clin Nutr 91:1568-73. 2010
    ..Binge-eating disorder may represent a risk factor for the metabolic syndrome...
  94. ncbi request reprint A genome-wide scan of symptom dimensions in bipolar disorder pedigrees of adult probands
    Stephen V Faraone
    Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA
    J Affect Disord 82:S71-8. 2004
    ....
  95. pmc The Consortium on the Genetics of Endophenotypes in Schizophrenia: model recruitment, assessment, and endophenotyping methods for a multisite collaboration
    Monica E Calkins
    Neuropsychiatry Section, Department of Psychiatry, University of Pennsylvania, 10 Gates, 3400 Spruce St, Philadelphia, PA 19104, USA
    Schizophr Bull 33:33-48. 2007
    ..The purpose of this article is to provide a description of the COGS structure and methods, including participant recruitment and assessment...
  96. ncbi request reprint Genetic and environmental contributions to age of onset of alcohol dependence symptoms in male twins
    I Chao Liu
    Department of Psychiatry, Cardinal Tien Hospital, Taipei, Taiwan
    Addiction 99:1403-9. 2004
    ..To investigate genetic and environmental influences on the development of specific alcohol dependence symptoms...
  97. ncbi request reprint The retrospective measurement of prenatal and perinatal events: accuracy of maternal recall
    Stephen L Buka
    Department of Epidemiology, Human Development and Health, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Schizophr Res 71:417-26. 2004
    ....
  98. ncbi request reprint Evaluation of RGS4 as a candidate gene for schizophrenia
    Yu Li Liu
    Department of Psychiatry, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    Am J Med Genet B Neuropsychiatr Genet 141:418-20. 2006
    ..Our results fail to support the RGS4 as a candidate gene for schizophrenia when evaluated from these three SNP markers...
  99. ncbi request reprint Pretrauma cognitive ability and risk for posttraumatic stress disorder: a twin study
    William S Kremen
    Department of Psychiatry and Center for Behavioral Genomics, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Arch Gen Psychiatry 64:361-8. 2007
    ..Cognitive deficits are associated with posttraumatic stress disorder (PTSD), but whether such deficits reflect sequelae or risk factors is not fully resolved...
  100. pmc Common genetic risk of major depression and nicotine dependence: the contribution of antisocial traits in a United States veteran male twin cohort
    Qiang Fu
    Department of Community Health, St Louis University School of Public Health, St Louis, Missouri 63104, United States of America
    Twin Res Hum Genet 10:470-8. 2007
    ....
  101. ncbi request reprint Genome-wide linkage scan of schizophrenia: a cross-isolate study
    Kazima B Bulayeva
    N I Vavilov Institute of General Genetics, Russian Academy of Sciences, Gubkin Street 3, Moscow 117809, Russia
    Genomics 89:167-77. 2007
    ..A study at higher genotyping density across the regions of interest and fluorescence in situ hybridization analyses are currently underway...