M T Tsuang
Affiliation: Harvard University
- Genes, environment and schizophreniaM T Tsuang
Harvard Medical School, Department of Psychiatry at Massachusetts Mental Health Center, 74 Fenwood Road, Boston, MA 02115, USA
Br J Psychiatry Suppl 40:s18-24. 2001..Nevertheless, it remains clear that environmental factors both add to and interact with genetic factors to produce the disorder...
- Diagnostic accuracy and linkage analysis: how useful are schizophrenia spectrum phenotypes?S V Faraone
Harvard Medical School Department of Psychiatry, Massachusetts Mental Health Center, Boston, USA
Am J Psychiatry 152:1286-90. 1995..However, most of these studies do not address a key measurement question: does the diagnostic accuracy of these spectrum classifications warrant their use in genetic linkage studies of schizophrenia?..
- Impact of genetic vulnerability and hypoxia on overall intelligence by age 7 in offspring at high risk for schizophrenia compared with affective psychosesJ M Goldstein
Department of Psychiatry at Massachusetts Mental Health Center, Boston 02115, USA
Schizophr Bull 26:323-34. 2000..Specificity of the effects for schizophrenia compared with affective psychoses and sex effects were also tested. Low IQ at age 7 was significantly associated with genetic vulnerability to psychoses, in particular with schizophrenia...
- Reduced subcortical brain volumes in nonpsychotic siblings of schizophrenic patients: a pilot magnetic resonance imaging studyL J Seidman
Department of Psychiatry at Massachusetts Mental Health Center, Harvard Medical School, Boston 02115, USA
Am J Med Genet 74:507-14. 1997..If replicated in a larger sample including both sexes, these results would suggest that the genetic liability to schizophrenia is also expressed as structural brain abnormalities...
- Association of neuropsychological vulnerability markers in relatives of schizophrenic patientsR Toomey
Harvard Institute of Psychiatric Epidemiology and Genetics, Boston, MA, USA
Schizophr Res 31:89-98. 1998..We discuss how the use of multiple risk indicators may help us better identify those relatives that carry the schizophrenia genotype...
- The genetics of schizophreniaM T Tsuang
Harvard Medical School, Department of Psychiatry at the Massachusetts Mental Health Center, 74 Fenwood Road, Boston, MA 02115, USA
Curr Psychiatry Rep 1:20-4. 1999..The potential importance of schizotaxia, or similar concepts, for use in genetic studies, is discussed...
- Neuropsychological performance and family history in children at age 7 who develop adult schizophrenia or bipolar psychosis in the New England Family StudiesL J Seidman
Department of Psychiatry, Harvard Medical School, Massachusetts Mental Health Center Division of Public Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA
Psychol Med 43:119-31. 2013..We evaluated the specificity and impact of family history (FH) of psychosis on pre-morbid neuropsychological functioning...
- The relationship of prenatal and perinatal complications to cognitive functioning at age 7 in the New England Cohorts of the National Collaborative Perinatal ProjectL J Seidman
Harvard Medical School, Department of Psychiatry at Massachusetts Mental Health Center, Boston 02115, USA
Schizophr Bull 26:309-21. 2000..Future studies will evaluate the effects of specific PPCs and genetic risk factors for psychosis on cognitive functioning in childhood...
- The Harvard Twin Study of Substance Abuse: what we have learnedM T Tsuang
Harvard Institute of Psychiatric Epidemiology and Genetics, Boston, MA 02115, USA
Harv Rev Psychiatry 9:267-79. 2001..Our results, thus far, indicate a complex pattern of genetic and environmental influences on substance use and abuse...
- Prenatal maternal immune disruption and sex-dependent risk for psychosesJ M Goldstein
Connors Center for Women s Health and Gender Biology, Brigham and Women s Hospital, Boston, MA, USA
Psychol Med 44:3249-61. 2014..Previous studies suggest that abnormalities in maternal immune activity during pregnancy alter the offspring's brain development and are associated with increased risk for schizophrenia (SCZ) dependent on sex...
- Concurrent validation of schizotaxia: a pilot studyW S Stone
Department of Psychiatry at Massachusetts Mental Health Center, Harvard Medical School, 74 Fenwood Road, Boston, MA 02115, USA
Biol Psychiatry 50:434-40. 2001....
- Normal sexual dimorphism of the adult human brain assessed by in vivo magnetic resonance imagingJ M Goldstein
Harvard Medical School Department of Psychiatry at Massachusetts Mental Health Center, Boston, MA 02115, USA
Cereb Cortex 11:490-7. 2001..These findings have implications for developmental studies that would directly test hypotheses about mechanisms relating sex steroid hormones to sexual dimorphisms in humans...
- Genetic association analysis of behavioral inhibition using candidate loci from mouse modelsJ W Smoller
Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Am J Med Genet 105:226-35. 2001..This study illustrates the potential utility of using candidate genes derived from mouse models to dissect the genetic basis of BI, a possible intermediate phenotype for panic and phobic disorders...
- A functional magnetic resonance imaging study of auditory vigilance with low and high information processing demandsL J Seidman
Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
Neuropsychology 12:505-18. 1998..Performance and degree of activation was associated with an estimate of IQ. Further research should clarify the contributions of working memory and interference filtering to the activated network...
- Meta-analysis identifies an association between the dopamine D2 receptor gene and schizophreniaS J Glatt
Department of Psychiatry, Harvard Medical School at Massachusetts Mental Health Center, Boston, MA 02115, USA
Mol Psychiatry 8:911-5. 2003..Although more family-based studies are needed to confirm this relation, our results provide strong evidence that DRD2 influences susceptibility to schizophrenia...
- Neuropsychological consequences of regular marijuana use: a twin studyM J Lyons
Psychology Department, Boston University, Boston, MA 02215, USA
Psychol Med 34:1239-50. 2004..A major methodological limitation of prior studies is the inability to determine whether differences between users and non-users are due to differences in genetic vulnerability preceding drug use or due to the effects of the drug...
- Genome scan of European-American schizophrenia pedigrees: results of the NIMH Genetics Initiative and Millennium ConsortiumS V Faraone
Department of Psychiatry, Harvard Medical School at Massachusetts Mental Health Center, Boston, USA
Am J Med Genet 81:290-5. 1998..4, P = .0004) and its neighbor, D10S582 (NPL Z = 3.2, P = .0006)...