Yu Hua Tseng

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Brown-fat paucity due to impaired BMP signalling induces compensatory browning of white fat
    Tim J Schulz
    Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 495:379-83. 2013
  2. pmc Cellular bioenergetics as a target for obesity therapy
    Yu Hua Tseng
    Joslin Diabetes Center, Harvard Medical School, One Joslin Place, Boston, Massachusetts 02215, USA
    Nat Rev Drug Discov 9:465-82. 2010
  3. pmc New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure
    Yu Hua Tseng
    Section on Obesity and Hormone Action, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 454:1000-4. 2008
  4. pmc Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat
    Aaron M Cypess
    Section of Integrative Physiology and Metabolism, Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 19:635-9. 2013
  5. pmc Insulin/IGF-I regulation of necdin and brown adipocyte differentiation via CREB- and FoxO1-associated pathways
    Aaron M Cypess
    Research Division, Joslin Diabetes Center, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    Endocrinology 152:3680-9. 2011
  6. ncbi request reprint Differential roles of insulin receptor substrates in the anti-apoptotic function of insulin-like growth factor-1 and insulin
    Yu Hua Tseng
    Research Division, Joslin Diabetes Center, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 277:31601-11. 2002
  7. ncbi request reprint Prediction of preadipocyte differentiation by gene expression reveals role of insulin receptor substrates and necdin
    Yu Hua Tseng
    Research Division, Joslin Diabetes Center, Children s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Nat Cell Biol 7:601-11. 2005
  8. pmc Insulin and insulin-like growth factor-1 receptors act as ligand-specific amplitude modulators of a common pathway regulating gene transcription
    Jeremie Boucher
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Joslin Diabetes Center, Boston, Massachusetts 02215, USA
    J Biol Chem 285:17235-45. 2010
  9. pmc Differential roles of insulin receptor substrates in brown adipocyte differentiation
    Yu Hua Tseng
    Research Division, Joslin Diabetes Center, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    Mol Cell Biol 24:1918-29. 2004
  10. pmc Bone morphogenetic protein 7 (BMP7) reverses obesity and regulates appetite through a central mTOR pathway
    Kristy L Townsend
    Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    FASEB J 26:2187-96. 2012

Collaborators

Detail Information

Publications30

  1. pmc Brown-fat paucity due to impaired BMP signalling induces compensatory browning of white fat
    Tim J Schulz
    Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 495:379-83. 2013
    ..This sophisticated regulatory mechanism of body temperature may participate in the control of energy balance and metabolic disease...
  2. pmc Cellular bioenergetics as a target for obesity therapy
    Yu Hua Tseng
    Joslin Diabetes Center, Harvard Medical School, One Joslin Place, Boston, Massachusetts 02215, USA
    Nat Rev Drug Discov 9:465-82. 2010
    ..In this article, we integrate these developments in relation to the classical understandings of cellular bioenergetics to explore the potential for developing novel anti-obesity therapies that target cellular energy expenditure...
  3. pmc New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure
    Yu Hua Tseng
    Section on Obesity and Hormone Action, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 454:1000-4. 2008
    ..These data reveal an important role of BMP7 in promoting brown adipocyte differentiation and thermogenesis in vivo and in vitro, and provide a potential new therapeutic approach for the treatment of obesity...
  4. pmc Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat
    Aaron M Cypess
    Section of Integrative Physiology and Metabolism, Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 19:635-9. 2013
    ..Although the properties of human neck fat vary substantially between individuals, some human samples share many similarities with classical, also called constitutive, rodent BAT...
  5. pmc Insulin/IGF-I regulation of necdin and brown adipocyte differentiation via CREB- and FoxO1-associated pathways
    Aaron M Cypess
    Research Division, Joslin Diabetes Center, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    Endocrinology 152:3680-9. 2011
    ..These two pathways combine to decrease necdin levels and permit the clonal expansion and coordinated gene expression necessary to complete brown adipocyte differentiation...
  6. ncbi request reprint Differential roles of insulin receptor substrates in the anti-apoptotic function of insulin-like growth factor-1 and insulin
    Yu Hua Tseng
    Research Division, Joslin Diabetes Center, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 277:31601-11. 2002
    ....
  7. ncbi request reprint Prediction of preadipocyte differentiation by gene expression reveals role of insulin receptor substrates and necdin
    Yu Hua Tseng
    Research Division, Joslin Diabetes Center, Children s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Nat Cell Biol 7:601-11. 2005
    ..Together these define a key signalling network that is involved in brown preadipocyte determination...
  8. pmc Insulin and insulin-like growth factor-1 receptors act as ligand-specific amplitude modulators of a common pathway regulating gene transcription
    Jeremie Boucher
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Joslin Diabetes Center, Boston, Massachusetts 02215, USA
    J Biol Chem 285:17235-45. 2010
    ..Thus, IR and IGF1R act as identical portals to the regulation of gene expression, with differences between insulin and IGF-1 effects due to a modulation of the amplitude of the signal created by the specific ligand-receptor interaction...
  9. pmc Differential roles of insulin receptor substrates in brown adipocyte differentiation
    Yu Hua Tseng
    Research Division, Joslin Diabetes Center, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    Mol Cell Biol 24:1918-29. 2004
    ..Although IRS-4 is not essential for the process, overexpression of IRS-4 can compensate for the deficiency in differentiation in IRS-1 KO cells...
  10. pmc Bone morphogenetic protein 7 (BMP7) reverses obesity and regulates appetite through a central mTOR pathway
    Kristy L Townsend
    Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    FASEB J 26:2187-96. 2012
    ..Together, these results underscore the importance of BMP7 in regulating both food intake and energy expenditure, and suggest new therapeutic approaches for obesity and its comorbidities...
  11. pmc Identification of inducible brown adipocyte progenitors residing in skeletal muscle and white fat
    Tim J Schulz
    the Joslin Diabetes Center, Harvard Medical School, and Harvard Stem Cell Institute, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 108:143-8. 2011
    ..These data establish the molecular characteristics of tissue-resident adipose progenitors and demonstrate a dynamic interplay between these progenitors and inductive signals that act in concert to specify brown adipocyte development...
  12. pmc Increased mitochondrial activity in BMP7-treated brown adipocytes, due to increased CPT1- and CD36-mediated fatty acid uptake
    Kristy L Townsend
    Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Antioxid Redox Signal 19:243-57. 2013
    ..To determine if BMP7 is able to affect the mitochondrial activity of mature brown adipocytes, independent of the differentiation process, we delivered BMP7 to mature brown adipocytes and measured mitochondrial activity...
  13. pmc Cross talk between insulin and bone morphogenetic protein signaling systems in brown adipogenesis
    Hongbin Zhang
    Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA
    Mol Cell Biol 30:4224-33. 2010
    ..Together, these data suggest cross talk between the insulin and BMP signaling systems by which BMP7 can rescue brown adipogenesis in cells with insulin resistance...
  14. pmc Intrinsic differences in adipocyte precursor cells from different white fat depots
    Yazmin Macotela
    Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 61:1691-9. 2012
    ..Regulation of these populations may provide a new target for the treatment and prevention of obesity and its metabolic complications...
  15. ncbi request reprint Quantification of human and rodent brown adipose tissue function using 99mTc-methoxyisobutylisonitrile SPECT/CT and 18F-FDG PET/CT
    Aaron M Cypess
    Section of Integrative Physiology and Metabolism, Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts
    J Nucl Med 54:1896-901. 2013
    ..Here we used a combination of human and rodent models to assess changes in BAT blood flow and glucose utilization...
  16. pmc Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival
    Kohjiro Ueki
    Research Division, Joslin Diabetes Center, Harvard Medical School Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Mol Cell Biol 22:965-77. 2002
    ..Thus, a reduction in p85alpha represents a novel therapeutic target for enhancing IGF-1/insulin signaling, prolongation of cell survival, and protection against apoptosis...
  17. ncbi request reprint Developmental origin of fat: tracking obesity to its source
    Stephane Gesta
    Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    Cell 131:242-56. 2007
    ..In this Review, we consider how the developmental origins of fat contribute to its physiological, cellular, and molecular heterogeneity and explore how these factors may play a role in the growing epidemic of obesity...
  18. pmc Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouse
    Kohjiro Ueki
    Research Division, Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 101:10422-7. 2004
    ..Thus, SOCS proteins play an important role in pathogenesis of the metabolic syndrome by concordantly modulating insulin signaling and cytokine signaling...
  19. pmc Ablation of TRIP-Br2, a regulator of fat lipolysis, thermogenesis and oxidative metabolism, prevents diet-induced obesity and insulin resistance
    Chong Wee Liew
    Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 19:217-26. 2013
    ....
  20. pmc Substance P as a novel anti-obesity target
    Iordanes Karagiannides
    Gastrointestinal Neuropeptide Center, Gastroenterology Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Gastroenterology 134:747-55. 2008
    ..Its presence in the hypothalamus and other areas of the brain that regulate feeding as well as in the stomach and small intestine prompted us to investigate its role on appetite control and energy balance...
  21. pmc Brown adipose tissue regulates glucose homeostasis and insulin sensitivity
    Kristin I Stanford
    Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 123:215-23. 2013
    ..These findings reveal a previously under-appreciated role for BAT in glucose metabolism...
  22. pmc Anti-melanin-concentrating hormone treatment attenuates chronic experimental colitis and fibrosis
    Dimitrios C Ziogas
    Beth Israel Deaconess Medical Center, Dana 501, 330 Brookline Ave, Boston, MA 02215, USA
    Am J Physiol Gastrointest Liver Physiol 304:G876-84. 2013
    ..Thus, by virtue of combined anti-inflammatory and anti-fibrotic effects, blocking MCH might represent a compelling approach for treating IBD...
  23. pmc Emerging role of bone morphogenetic proteins in adipogenesis and energy metabolism
    Tim J Schulz
    Joslin Diabetes Center, One Joslin Place, and Harvard Medical School, Boston, MA 02215, USA
    Cytokine Growth Factor Rev 20:523-31. 2009
    ..These findings have opened up exciting opportunities for developing new therapeutic approaches for the treatment of obesity and its many associated metabolic disorders...
  24. doi request reprint Lung stem cell differentiation in mice directed by endothelial cells via a BMP4-NFATc1-thrombospondin-1 axis
    Joo Hyeon Lee
    Stem Cell Program, Boston Children s Hospital, Boston, MA 02115, USA Harvard Stem Cell Institute, Cambridge, MA 02138, USA Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Cell 156:440-55. 2014
    ..These findings elucidate a pathway that may be a critical target in lung diseases and provide tools to understand the mechanisms of respiratory diseases at the single-cell level. ..
  25. ncbi request reprint Intramuscular adipogenesis is inhibited by myo-endothelial progenitors with functioning Bmpr1a signalling
    Ping Huang
    Division of Genetics, Boston Children s Hospital, Boston, Massachusetts 02115, USA
    Nat Commun 5:4063. 2014
    ....
  26. ncbi request reprint Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes
    Jenny E Gunton
    Joslin Diabetes Center and Harvard Medical School, 1 Joslin Place, Boston, Massachusetts 02215, USA
    Cell 122:337-49. 2005
    ..Together, these data suggest an important role for decreased ARNT and altered gene expression in the impaired islet function of human type 2 diabetes...
  27. ncbi request reprint Brown fat fuel utilization and thermogenesis
    Kristy L Townsend
    Joslin Diabetes Center and Harvard Medical School, One Joslin Place, Boston, MA 02215, USA
    Trends Endocrinol Metab 25:168-77. 2014
    ..Recent research has provided a better understanding of the processes of fuel utilization carried out by brown adipocytes, which is the focus of the current review. ..
  28. ncbi request reprint Insulin-like growth factor-1 induces adhesion and migration in human multiple myeloma cells via activation of beta1-integrin and phosphatidylinositol 3'-kinase/AKT signaling
    Yu Tzu Tai
    The Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Cancer Res 63:5850-8. 2003
    ..Moreover, they define the functional association of IGF-IR and beta1 integrin in mediating MM cell homing, providing the preclinical rationale for novel treatment strategies targeting IGF-I/IGF-IR in MM...
  29. pmc Identification and importance of brown adipose tissue in adult humans
    Aaron M Cypess
    Research Division, Joslin Diabetes Center, Boston, MA 02215, USA
    N Engl J Med 360:1509-17. 2009
    ....

Research Grants8

  1. Role of BMPs in Adipogenesis, Mitochondrial Function and Energy Homeostasis
    Yu Hua Tseng; Fiscal Year: 2010
    ..These studies will increase our understanding of adipocyte differentiation, energy balance, and BMP actions, and may help to develop potential therapeutic approaches for obesity and related diseases. ..
  2. Role of BMPs on Brown Adipogenesis and Thermogenesis
    Yu Hua Tseng; Fiscal Year: 2006
    ..abstract_text> ..
  3. Role of BMPs in Adipogenesis, Mitochondrial Function and Energy Homeostasis
    Yu Hua Tseng; Fiscal Year: 2010
    ..These studies will increase our understanding of adipocyte differentiation, energy balance, and BMP actions, and may help to develop potential therapeutic approaches for obesity and related diseases. ..
  4. Role of BMPs in Adipogenesis, Mitochondrial Function and Energy Homeostasis
    Yu Hua Tseng; Fiscal Year: 2007
    ..These studies will increase our understanding of adipocyte differentiation, energy balance, and BMP actions, and may help to develop potential therapeutic approaches for obesity and related diseases. ..
  5. Role of BMPs in Adipogenesis, Mitochondrial Function and Energy Homeostasis
    Yu Hua Tseng; Fiscal Year: 2009
    ..These studies will increase our understanding of adipocyte differentiation, energy balance, and BMP actions, and may help to develop potential therapeutic approaches for obesity and related diseases. ..
  6. ROLE OF INSULIN AND IGF-1 ON BROWN ADIPOCYTES
    Yu Hua Tseng; Fiscal Year: 2003
    ..Accomplishment of the proposed studies will further our understanding on hormonal controls of metabolism and survival of brown adipocytes. ..
  7. Role of BMPs in Adipogenesis, Mitochondrial Function and Energy Homeostasis
    Yu Hua Tseng; Fiscal Year: 2009
    ..These studies will increase our understanding of adipocyte differentiation, energy balance, and BMP actions, and may help to develop potential therapeutic approaches for obesity and related diseases. ..