Affiliation: Harvard University
- SOD1 mutants linked to amyotrophic lateral sclerosis selectively inactivate a glial glutamate transporterD Trotti
Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Nat Neurosci 2:427-33. 1999..Because inactivation of GLT1 results in neuronal degeneration, we propose that toxic properties of SOD1 mutants lead to neuronal death via an excitotoxic mechanism in SOD1-linked FALS...
- Amyotrophic lateral sclerosis-linked glutamate transporter mutant has impaired glutamate clearance capacityD Trotti
Membrane Biology Program, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 276:576-82. 2001..The resulting alteration in glutamate clearance capacity likely contributes to excitotoxicity that participates in motor neuron degeneration in amyotrophic lateral sclerosis...
- Inhibition of the glutamate transporter EAAC1 expressed in Xenopus oocytes by phorbol estersD Trotti
Membrane Biology Program, Brigham and Women s Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
Brain Res 914:196-203. 2001..Because activation of PKC by phorbol esters leads to opposite effects on EAAC1 activity in different culture models, we conclude that the PKC-mediated regulation of EAAC1 is cell-type specific...
- Symmetry of H+ binding to the intra- and extracellular side of the H+-coupled oligopeptide cotransporter PepT1S Nussberger
Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 272:7777-85. 1997..This concept constitutes an important extension of previous kinetic models of ion-coupled solute transporters by including a more detailed description of intracellular events...
- Modulation of DMT1 activity by redox compoundsP Marciani
Institute of General Physiology and Biological Chemistry, Pharmacology Faculty, University of Milan, 20134 Milan, Italy
J Membr Biol 197:91-9. 2004..These findings may have a profound relevance from a physiological and pathophysiological standpoint...