D Trotti

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi SOD1 mutants linked to amyotrophic lateral sclerosis selectively inactivate a glial glutamate transporter
    D Trotti
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Neurosci 2:427-33. 1999
  2. ncbi Amyotrophic lateral sclerosis-linked glutamate transporter mutant has impaired glutamate clearance capacity
    D Trotti
    Membrane Biology Program, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 276:576-82. 2001
  3. ncbi Inhibition of the glutamate transporter EAAC1 expressed in Xenopus oocytes by phorbol esters
    D Trotti
    Membrane Biology Program, Brigham and Women s Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Brain Res 914:196-203. 2001
  4. ncbi Symmetry of H+ binding to the intra- and extracellular side of the H+-coupled oligopeptide cotransporter PepT1
    S Nussberger
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 272:7777-85. 1997
  5. ncbi Modulation of DMT1 activity by redox compounds
    P Marciani
    Institute of General Physiology and Biological Chemistry, Pharmacology Faculty, University of Milan, 20134 Milan, Italy
    J Membr Biol 197:91-9. 2004

Collaborators

Detail Information

Publications5

  1. ncbi SOD1 mutants linked to amyotrophic lateral sclerosis selectively inactivate a glial glutamate transporter
    D Trotti
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Neurosci 2:427-33. 1999
    ..Because inactivation of GLT1 results in neuronal degeneration, we propose that toxic properties of SOD1 mutants lead to neuronal death via an excitotoxic mechanism in SOD1-linked FALS...
  2. ncbi Amyotrophic lateral sclerosis-linked glutamate transporter mutant has impaired glutamate clearance capacity
    D Trotti
    Membrane Biology Program, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 276:576-82. 2001
    ..The resulting alteration in glutamate clearance capacity likely contributes to excitotoxicity that participates in motor neuron degeneration in amyotrophic lateral sclerosis...
  3. ncbi Inhibition of the glutamate transporter EAAC1 expressed in Xenopus oocytes by phorbol esters
    D Trotti
    Membrane Biology Program, Brigham and Women s Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Brain Res 914:196-203. 2001
    ..Because activation of PKC by phorbol esters leads to opposite effects on EAAC1 activity in different culture models, we conclude that the PKC-mediated regulation of EAAC1 is cell-type specific...
  4. ncbi Symmetry of H+ binding to the intra- and extracellular side of the H+-coupled oligopeptide cotransporter PepT1
    S Nussberger
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 272:7777-85. 1997
    ..This concept constitutes an important extension of previous kinetic models of ion-coupled solute transporters by including a more detailed description of intracellular events...
  5. ncbi Modulation of DMT1 activity by redox compounds
    P Marciani
    Institute of General Physiology and Biological Chemistry, Pharmacology Faculty, University of Milan, 20134 Milan, Italy
    J Membr Biol 197:91-9. 2004
    ..These findings may have a profound relevance from a physiological and pathophysiological standpoint...