Genomes and Genes
J N Topper
Affiliation: Harvard University
- Vascular MADs: two novel MAD-related genes selectively inducible by flow in human vascular endotheliumJ N Topper
Vascular Research Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 94:9314-9. 1997....
- CREB binding protein is a required coactivator for Smad-dependent, transforming growth factor beta transcriptional responses in endothelial cellsJ N Topper
Vascular Research Division, Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 95:9506-11. 1998..Thus, functional Smad-coactivator interactions may be an important locus of signal integration in endothelial cells...
- MEKK-1, a component of the stress (stress-activated protein kinase/c-Jun N-terminal kinase) pathway, can selectively activate Smad2-mediated transcriptional activation in endothelial cellsJ D Brown
Vascular Research Division, Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 274:8797-805. 1999..These data demonstrate a novel mechanism for activation of Smad protein-mediated signaling in endothelial cells and suggest that Smad2 may act as an integrator of diverse stimuli in these cells...
- Transforming growth factor-beta 1 inhibits cytokine-mediated induction of human metalloelastase in macrophagesM W Feinberg
Program of Developmental Cardiovascular Biology, The Department of Medicine, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
J Biol Chem 275:25766-73. 2000..Taken together, MMP-12 is induced by several factors implicated in atherosclerosis. The inhibition of MMP-12 expression by TGF-beta1 suggests that TGF-beta1, acting via Smad3, may promote plaque stability...
- Endothelial dysfunction, hemodynamic forces, and atherogenesisM A Gimbrone
Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115 5817, USA
Ann N Y Acad Sci 902:230-9; discussion 239-40. 2000....
- Human prostaglandin transporter gene (hPGT) is regulated by fluid mechanical stimuli in cultured endothelial cells and expressed in vascular endothelium in vivoJ N Topper
Vascular Research Division, Department of Pathology, and the Cardiovascular Division Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Circulation 98:2396-403. 1998..This process is thought to involve the regulation of vascular gene expression by physiological fluid mechanical stimuli such as fluid shear stresses...
- Epidermal growth factor induces Egr-1 promoter activity in hepatocytes in vitro and in vivoJ C Tsai
Department of Molecular Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
Am J Physiol Gastrointest Liver Physiol 281:G1271-8. 2001..Together, these results suggest that the 1,200-bp promoter contains information for EGF response in hepatocytes both in vitro and in intact animals...
- Gene program for cardiac cell survival induced by transient ischemia in conscious pigsC Depre
Cardiovascular Research Institute, Department of Medicine, University of Medicine and Dentistry New Jersey, New Jersey Medical School, Newark, NJ 07103, USA
Proc Natl Acad Sci U S A 98:9336-41. 2001..Understanding the genes up-regulated during myocardial stunning, including those not previously described in the heart, and developing strategies that activate this program may open new avenues for therapy in ischemic heart disease...
- TGF-beta in the cardiovascular system: molecular mechanisms of a context-specific growth factorJ N Topper
Cardiovascular Division, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA
Trends Cardiovasc Med 10:132-7. 2000..These findings are beginning to provide a mechanistic framework with which to understand the complex and pleiotropic actions of these factors on cells and tissues of the cardiovascular system...
- The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signalingH Hayashi
Division of Gastroenterology, The Hospital for Sick Children, Toronto, Ontario, Canada
Cell 89:1165-73. 1997..These studies thus define a novel function for MAD-related proteins as intracellular antagonists of the type I kinase domain of TGFbeta family receptors...