Youren Tong

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway
    Youren Tong
    Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital, Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA
    Mol Neurodegener 7:2. 2012
  2. pmc Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice
    Youren Tong
    Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital, Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:9879-84. 2010
  3. pmc Absence of nigral degeneration in aged parkin/DJ-1/PINK1 triple knockout mice
    Tohru Kitada
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusets, USA
    J Neurochem 111:696-702. 2009
  4. pmc alpha-synuclein and LRRK2: partners in crime
    Youren Tong
    Center for Neurologic Diseases, Brigham and Women s Hospital, Program in Neuroscience, Harvard Medical School, Boston, MA, 02115, USA
    Neuron 64:771-3. 2009
  5. ncbi request reprint Genetic analysis of Parkinson's disease-linked leucine-rich repeat kinase 2
    Youren Tong
    Center for Neurologic Diseases, Brigham and Women s Hospital, Program in Neuroscience, Harvard Medical School, Boston, MA 02115, U S A
    Biochem Soc Trans 40:1042-6. 2012
  6. doi request reprint A trojan horse for Parkinson's disease
    Yi Hu
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, 65 Landsdowne Street, Cambridge, MA 02139, USA
    Sci Signal 3:pe13. 2010
  7. pmc R1441C mutation in LRRK2 impairs dopaminergic neurotransmission in mice
    Youren Tong
    Center for Neurologic Diseases, Brigham and Women s Hospital, Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 106:14622-7. 2009

Detail Information

Publications7

  1. pmc Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway
    Youren Tong
    Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital, Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA
    Mol Neurodegener 7:2. 2012
    ..We previously reported that loss of LRRK2 causes impairment of protein degradation pathways as well as increases of apoptotic cell death and inflammatory responses in the kidney of aged mice...
  2. pmc Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice
    Youren Tong
    Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital, Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:9879-84. 2010
    ....
  3. pmc Absence of nigral degeneration in aged parkin/DJ-1/PINK1 triple knockout mice
    Tohru Kitada
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusets, USA
    J Neurochem 111:696-702. 2009
    ..These findings also support the notion that mammalian Parkin and PINK1 may function in the same genetic pathway as in Drosophila...
  4. pmc alpha-synuclein and LRRK2: partners in crime
    Youren Tong
    Center for Neurologic Diseases, Brigham and Women s Hospital, Program in Neuroscience, Harvard Medical School, Boston, MA, 02115, USA
    Neuron 64:771-3. 2009
    ..The results reveal an interesting interaction between alpha-synuclein and LRRK2, two gene products linked to dominantly inherited Parkinson's disease...
  5. ncbi request reprint Genetic analysis of Parkinson's disease-linked leucine-rich repeat kinase 2
    Youren Tong
    Center for Neurologic Diseases, Brigham and Women s Hospital, Program in Neuroscience, Harvard Medical School, Boston, MA 02115, U S A
    Biochem Soc Trans 40:1042-6. 2012
    ..We conclude that pathogenic mutations in LRRK2 impair the nigrostriatal dopaminergic pathway, and LRRK2 plays an essential role in the dynamic regulation of autophagy function in vivo...
  6. doi request reprint A trojan horse for Parkinson's disease
    Yi Hu
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, 65 Landsdowne Street, Cambridge, MA 02139, USA
    Sci Signal 3:pe13. 2010
    ..Thus, the intrinsic kinase activity of LRRK2 appears to be a Trojan horse for PD, and inhibition of its kinase activity could potentially be therapeutically beneficial...
  7. pmc R1441C mutation in LRRK2 impairs dopaminergic neurotransmission in mice
    Youren Tong
    Center for Neurologic Diseases, Brigham and Women s Hospital, Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 106:14622-7. 2009
    ..Together, our data suggest that the R1441C mutation in LRRK2 impairs stimulated dopamine neurotransmission and D2 receptor function, which may represent pathogenic precursors preceding dopaminergic degeneration in PD brains...