L Tondo

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Bipolar disorders following initial depression: Modeling predictive clinical factors
    Leonardo Tondo
    International Consortium for Bipolar Disorder Research, Mailman Research Center, McLean Division of Massachusetts General Hospital, Boston, MA, USA Centro Lucio Bini Mood Disorders Center, Cagliari and Rome, Italy Electronic address
    J Affect Disord 167:44-9. 2014
  2. ncbi Options for pharmacological treatment of refractory bipolar depression
    Leonardo Tondo
    International Consortium for Bipolar and Psychotic Disorder Research, McLean Hospital, Belmont, MA, USA
    Curr Psychiatry Rep 16:431. 2014
  3. doi Clinical responses to antidepressants among 1036 acutely depressed patients with bipolar or unipolar major affective disorders
    L Tondo
    International Consortium for Bipolar Disorder Research, Mailman Research Center, McLean Division of Massachusetts General Hospital, Boston, MA, USA
    Acta Psychiatr Scand 127:355-64. 2013
  4. ncbi Suicide rates in relation to health care access in the United States: an ecological study
    Leonardo Tondo
    Department of Psychiatry and Neuroscience Program, Harvard Medical School, Boston, MA, USA
    J Clin Psychiatry 67:517-23. 2006
  5. ncbi Mania associated with antidepressant treatment: comprehensive meta-analytic review
    L Tondo
    Department of Psychiatry and Neuroscience Program, Harvard Medical School and McLean Division of Massachusetts General Hospital, Boston, MA, USA
    Acta Psychiatr Scand 121:404-14. 2010
  6. ncbi Latency and episodes before treatment: response to lithium maintenance in bipolar I and II disorders
    R J Baldessarini
    Consolidated Department of Psychiatry, Harvard Medical School and Bipolar and Psychotic Disorders Program, McLean Massachusetts General Hospitals, Boston, USA
    Bipolar Disord 1:91-7. 1999
  7. ncbi Age at onset in 3014 Sardinian bipolar and major depressive disorder patients
    L Tondo
    Department of Psychiatry, Harvard Medical School and International Consortium for Psychotic and Mood Disorders Research, McLean Division of Massachusetts General Hospital, Boston, MA, USA
    Acta Psychiatr Scand 121:446-52. 2010
  8. ncbi Suicidal status during antidepressant treatment in 789 Sardinian patients with major affective disorder
    L Tondo
    Department of Psychiatry and Neuroscience Program, Harvard Medical School and McLean Division of Massachusetts General Hospital, Boston, MA, USA
    Acta Psychiatr Scand 118:106-15. 2008
  9. ncbi Effects of rapid cycling on response to lithium maintenance treatment in 360 bipolar I and II disorder patients
    R J Baldessarini
    International Consortium for Bipolar Disorder Research, MA, Boston, USA
    J Affect Disord 61:13-22. 2000
  10. ncbi Suicide attempts in major affective disorder patients with comorbid substance use disorders
    L Tondo
    International Consortium for Research on Bipolar Disorders the Department of Psychiatry, Harvard Medical School, Boston, Mass, USA
    J Clin Psychiatry 60:63-9; discussion 75-6, 113-6. 1999

Collaborators

Detail Information

Publications46

  1. ncbi Bipolar disorders following initial depression: Modeling predictive clinical factors
    Leonardo Tondo
    International Consortium for Bipolar Disorder Research, Mailman Research Center, McLean Division of Massachusetts General Hospital, Boston, MA, USA Centro Lucio Bini Mood Disorders Center, Cagliari and Rome, Italy Electronic address
    J Affect Disord 167:44-9. 2014
    ..To support early differentiation, we tested several predictive factors for association with later diagnoses of bipolar disorder...
  2. ncbi Options for pharmacological treatment of refractory bipolar depression
    Leonardo Tondo
    International Consortium for Bipolar and Psychotic Disorder Research, McLean Hospital, Belmont, MA, USA
    Curr Psychiatry Rep 16:431. 2014
    ....
  3. doi Clinical responses to antidepressants among 1036 acutely depressed patients with bipolar or unipolar major affective disorders
    L Tondo
    International Consortium for Bipolar Disorder Research, Mailman Research Center, McLean Division of Massachusetts General Hospital, Boston, MA, USA
    Acta Psychiatr Scand 127:355-64. 2013
    ..Whether responses to antidepressants differ in bipolar and unipolar depression remains unresolved...
  4. ncbi Suicide rates in relation to health care access in the United States: an ecological study
    Leonardo Tondo
    Department of Psychiatry and Neuroscience Program, Harvard Medical School, Boston, MA, USA
    J Clin Psychiatry 67:517-23. 2006
    ..We tested the hypothesis that suicide rates in the United States are associated with indicators of access to health care services...
  5. ncbi Mania associated with antidepressant treatment: comprehensive meta-analytic review
    L Tondo
    Department of Psychiatry and Neuroscience Program, Harvard Medical School and McLean Division of Massachusetts General Hospital, Boston, MA, USA
    Acta Psychiatr Scand 121:404-14. 2010
    ..To review available data pertaining to risk of mania-hypomania among bipolar (BPD) and major depressive disorder (MDD) patients with vs. without exposure to antidepressant drugs (ADs) and consider effects of mood stabilizers...
  6. ncbi Latency and episodes before treatment: response to lithium maintenance in bipolar I and II disorders
    R J Baldessarini
    Consolidated Department of Psychiatry, Harvard Medical School and Bipolar and Psychotic Disorders Program, McLean Massachusetts General Hospitals, Boston, USA
    Bipolar Disord 1:91-7. 1999
    ..To test whether longer treatment-delays or more pretreatment illness episodes are followed by diminished response to lithium maintenance...
  7. ncbi Age at onset in 3014 Sardinian bipolar and major depressive disorder patients
    L Tondo
    Department of Psychiatry, Harvard Medical School and International Consortium for Psychotic and Mood Disorders Research, McLean Division of Massachusetts General Hospital, Boston, MA, USA
    Acta Psychiatr Scand 121:446-52. 2010
    ..To test if onset age in major affective illnesses is younger in bipolar disorder (BPD) than unipolar-major depressive disorder (UP-MDD), and is a useful measure...
  8. ncbi Suicidal status during antidepressant treatment in 789 Sardinian patients with major affective disorder
    L Tondo
    Department of Psychiatry and Neuroscience Program, Harvard Medical School and McLean Division of Massachusetts General Hospital, Boston, MA, USA
    Acta Psychiatr Scand 118:106-15. 2008
    ..Relationships between antidepressant treatment and suicidality remain uncertain in major depressive disorder (MDD), and rarely evaluated in bipolar disorder (BPD)...
  9. ncbi Effects of rapid cycling on response to lithium maintenance treatment in 360 bipolar I and II disorder patients
    R J Baldessarini
    International Consortium for Bipolar Disorder Research, MA, Boston, USA
    J Affect Disord 61:13-22. 2000
    ..Rapid cycling (RC) in bipolar disorders is widely believed to predict future morbidity and poor treatment response, although empirical testing of its predictive utility remains limited...
  10. ncbi Suicide attempts in major affective disorder patients with comorbid substance use disorders
    L Tondo
    International Consortium for Research on Bipolar Disorders the Department of Psychiatry, Harvard Medical School, Boston, Mass, USA
    J Clin Psychiatry 60:63-9; discussion 75-6, 113-6. 1999
    ..The widely accepted impression that substance abuse and dependence are associated with increased suicidal risk was evaluated by literature review and with new data...
  11. ncbi Discontinuing lithium maintenance treatment in bipolar disorders: risks and implications
    R J Baldessarini
    The International Consortium for Bipolar Disorders Research, Consolidated Department of Psychiatry and Neuroscience Program, Harvard Medical School, Boston, MA, USA
    Bipolar Disord 1:17-24. 1999
    ..To review research findings on clinical effects of discontinuing lithium maintenance treatment...
  12. ncbi Response to lithium maintenance treatment in bipolar disorders: comparison of women and men
    A C Viguera
    The International Consortium for Bipolar Disorder Research, Boston, Massachusetts, USA
    Bipolar Disord 3:245-52. 2001
    ..Since women with bipolar disorder reportedly have more features that may predict a poor prognosis (depression and rapid cycling), we tested the hypothesis that women respond less well to lithium maintenance treatment...
  13. ncbi Sex differences in response to lithium treatment
    A C Viguera
    Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Psychiatry 157:1509-11. 2000
    ..The authors' goal was to investigate whether there are differences between the sexes in response to lithium...
  14. ncbi Reduced morbidity after gradual discontinuation of lithium treatment for bipolar I and II disorders: a replication study
    R J Baldessarini
    International Consortium for Bipolar Disorder Research, MA, USA
    Am J Psychiatry 154:551-3. 1997
    ..The aim of this study was to verify reduction of early affective morbidity by gradual, rather than rapid, discontinuation of lithium treatment...
  15. ncbi Treating the suicidal patient with bipolar disorder. Reducing suicide risk with lithium
    R J Baldessarini
    Department of Psychiatry and Neuroscience Program, Harvard Medical School, and Bipolar and Psychotic Disorders Program, Mailman Research Center, McLean Division of Massachusetts General Hospital, Belmont, Massachusetts 02478, USA
    Ann N Y Acad Sci 932:24-38; discussion 39-43. 2001
    ..Studies of commonly used, but incompletely evaluated, alternative treatments are required, and further protection against premature mortality can be anticipated with better protection against bipolar depression...
  16. doi Reproduction among 1975 Sardinian women and men diagnosed with major mood disorders
    L Tondo
    International Consortium for Psychotic and Mood Disorder Research, McLean Hospital and Harvard Medical School, Boston, MA, USA
    Acta Psychiatr Scand 123:283-9. 2011
    ..It may include reproductive functioning, which has rarely been studied systematically...
  17. doi Predominant recurrence polarity among 928 adult international bipolar I disorder patients
    R J Baldessarini
    International Consortium for Bipolar Disorder Research, McLean Division of Massachusetts General Hospital, Belmont, USA
    Acta Psychiatr Scand 125:293-302. 2012
    ..To test the hypothesis that patients with bipolar disorder (BPD) differ demographically and clinically within subgroups based on the predominant-polarity of major recurrences...
  18. doi Onset-age of bipolar disorders at six international sites
    R J Baldessarini
    Department of Psychiatry and Neuroscience Program, Harvard Medical School, USA
    J Affect Disord 121:143-6. 2010
    ....
  19. ncbi Lower suicide risk with long-term lithium treatment in major affective illness: a meta-analysis
    L Tondo
    Consolidated Department of Psychiatry and Neuroscience Program, Harvard Medical School, Boston, Massachusetts, USA
    Acta Psychiatr Scand 104:163-72. 2001
    ..CONCLUSION: Suicide risk was consistently lower during long-term treatment of major affective illnesses with lithium in all studies in the meta-analysis, including the few involving treatment-randomization...
  20. ncbi Effects of treatment latency on response to maintenance treatment in manic-depressive disorders
    Ross J Baldessarini
    Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    Bipolar Disord 9:386-93. 2007
    ..To further test the hypothesis that past illness episodes and delay of long-term treatment do not limit maintenance treatment response among patients with manic-depressive illnesses (MDI)...
  21. ncbi Suicidal risks among 2826 Sardinian major affective disorder patients
    L Tondo
    Department of Psychiatry and Neuroscience Program, Harvard Medical School and McLean Division of Massachusetts General Hospital, Boston, MA, USA
    Acta Psychiatr Scand 116:419-28. 2007
    ..We estimated risks of suicidal behaviors in 2826 mood-disorder patients evaluated and followed in a Sardinian mood disorders research center over the past 30 years...
  22. ncbi Prophylaxis latency and outcome in bipolar disorders
    Christopher Baethge
    Consolidated Department of Psychiatry, Harvard Medical School, Bipolar and Psychotic Disorders Program, McLean Division of Massachusetts General Hospital, Belmont, Massachusetts, USA
    Can J Psychiatry 48:449-57. 2003
    ..To analyze new and reviewed findings to evaluate relations between treatment response and latency from onset of bipolar disorder (BD) to the start of mood-stabilizer prophylaxis...
  23. ncbi Comorbid substance-use in schizophrenia: relation to positive and negative symptoms
    A Talamo
    Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    Schizophr Res 86:251-5. 2006
    ..Comorbid SUD in schizophrenia patients was associated with male sex and higher PANSS positive to lower negative scores. Cause-effect relationships remain to be clarified...
  24. ncbi Long-term clinical effectiveness of lithium maintenance treatment in types I and II bipolar disorders
    L Tondo
    Department of Psychology, University of Cagliari, Sardinia, Italy and McLean Hospital, Department of Psychiatry, Harvard Medical School, Boston, USA
    Br J Psychiatry Suppl 41:s184-90. 2001
    ..The effectiveness of lithium is being questioned increasingly and requires clarification...
  25. ncbi First-episode types in bipolar disorder: predictive associations with later illness
    R J Baldessarini
    International Consortium for Bipolar Disorder Research, McLean Hospital, Belmont, MA, USA Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    Acta Psychiatr Scand 129:383-92. 2014
    ..Characteristics of initial illness in bipolar disorder (BD) may predict later morbidity...
  26. ncbi Course sequences in bipolar disorder: depressions preceding or following manias or hypomanias
    A Koukopoulos
    Lucio Bini Mood Disorder Centers, Rome and Cagliari, Italy
    J Affect Disord 151:105-10. 2013
    ..However, additional characteristics of BD course-patterns require further assessment...
  27. ncbi Suicide in bipolar disorder: Risks and management
    Ross J Baldessarini
    Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    CNS Spectr 11:465-71. 2006
    ..Applying available knowledge systematically, with close and sustained clinical supervision, can enhance management of suicidal risk in bipolar disorders patients...
  28. ncbi Correlation of initial wellness with long-term morbidity in recurrent major affective disorder patients as a test of survival analysis
    Ross J Baldessarini
    Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    J Clin Psychopharmacol 30:72-5. 2010
    ..These findings provide moderate support for a basic assumption underlying the use of survival analysis for psychopharmacology research and suggest that clinical outcomes might be predictable from initial wellness intervals...
  29. ncbi Is lithium still worth using? An update of selected recent research
    Ross J Baldessarini
    Department of Psychiatry, Harvard Medical School, Boston, Mass, USA
    Harv Rev Psychiatry 10:59-75. 2002
    ....
  30. doi Illness risk following rapid versus gradual discontinuation of antidepressants
    Ross J Baldessarini
    Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    Am J Psychiatry 167:934-41. 2010
    ..Recurrence occurs earlier after rapid than after gradual discontinuation with lithium and antipsychotics. The authors compared illness recurrence after rapid versus gradual discontinuation of antidepressants...
  31. ncbi Rapid-cycling bipolar disorder: effects of long-term treatments
    L Tondo
    Department of Psychiatry and Neuroscience Program, Harvard Medical School, USA
    Acta Psychiatr Scand 108:4-14. 2003
    ..To compare responses to long-term treatment of rapid-cycling (RC) vs. non-RC bipolar disorder patients and assess relative effectiveness of specific agents in RC patients...
  32. ncbi Lithium treatment and suicide risk in major affective disorders: update and new findings
    Ross J Baldessarini
    Department of Psychiatry and Neuroscience Program, Harvard Medical School, Boston, MA, USA
    J Clin Psychiatry 64:44-52. 2003
    ..An exception is growing evidence for such suicidal risk reduction with long-term lithium maintenance. This report updates and extends analyses of lithium treatment and suicides and attempts...
  33. ncbi Treatment-latency and previous episodes: relationships to pretreatment morbidity and response to maintenance treatment in bipolar I and II disorders
    Ross J Baldessarini
    Consolidated Department of Psychiatry, Harvard Medical School, Belmont, MA, USA
    Bipolar Disord 5:169-79. 2003
    ..To clarify relationships of treatment delay and pretreatment episode count with pretreatment morbidity and responses to maintenance treatments in bipolar disorders...
  34. ncbi Decreased risk of suicides and attempts during long-term lithium treatment: a meta-analytic review
    Ross J Baldessarini
    International Consortium for Research on Bipolar Disorders, Department of Psychiatry and Neuroscience Program, Harvard Medical School, Boston, MA, USA
    Bipolar Disord 8:625-39. 2006
    ..To update and extend comparisons of rates of suicides and suicide attempts among patients with major affective disorders with versus without long-term lithium treatment...
  35. ncbi Lithium treatment reduces suicide risk in recurrent major depressive disorder
    Francesca Guzzetta
    Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    J Clin Psychiatry 68:380-3. 2007
    ..Since lithium shows major antisuicidal effects in bipolar disorders and in heterogeneous mood disorder samples, we evaluated evidence of antisuicidal effects of lithium in patients with recurrent MDD...
  36. ncbi Pretreatment episode count and response to lithium treatment in manic-depressive illness
    Irene M Bratti
    Department of Psychiatry, Harvard Medical School, Belmont, MA, USA
    Harv Rev Psychiatry 11:245-56. 2003
    ....
  37. ncbi Suicide risk and treatments for patients with bipolar disorder
    Ross J Baldessarini
    JAMA 290:1517-9. 2003
  38. ncbi Relapse after antidepressant discontinuation
    Federico Soldani
    Am J Psychiatry 161:1312-3; author reply 1313. 2004
  39. doi Lithium and suicidal risk
    Ross J Baldessarini
    Bipolar Disord 10:114-5. 2008
  40. ncbi Suicidal behaviour in bipolar disorder: risk and prevention
    Leonardo Tondo
    Department of Psychology, University of Cagliari, Centro Lucio Bini Stanley Medical Research Institute Research Center, Cagliari, Sardinia, Italy
    CNS Drugs 17:491-511. 2003
    ....
  41. ncbi Suicidal risk in antidepressant drug trials
    Ross J Baldessarini
    Arch Gen Psychiatry 63:246-8. 2006
  42. ncbi Strategies to prevent suicide
    Leonardo Tondo
    JAMA 295:1515; author reply 1516. 2006
  43. ncbi Protective effect of pregnancy on the course of lithium-responsive bipolar I disorder
    Adele C Viguera
    J Affect Disord 72:107-8; author reply 103-5. 2002
  44. ncbi Longitudinal research on bipolar disorders
    Paola Salvatore
    Epidemiol Psichiatr Soc 16:109-17. 2007
    ..Project findings indicate that the course of bipolar I disorder is much less favorable than had been believed formerly, despite clinical treatment with modern mood-stabilizing and other treatments...
  45. doi Stargazin involvement with bipolar disorder and response to lithium treatment
    Gilad Silberberg
    Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Pharmacogenet Genomics 18:403-12. 2008
    ....
  46. ncbi TEMPS-A (Rome): psychometric validation of affective temperaments in clinically well subjects in mid- and south Italy
    Maurizio Pompili
    Department of Psychiatry, Sant Andrea Hospital, University of Rome La Sapienza, Rome, Italy
    J Affect Disord 107:63-75. 2008
    ..In Italian, the TEMPS has previously been validated in its original 32-item version, the TEMPS-I (Pisa), one which did not yet include an anxious subscale...