Research Topics
| L TondoSummaryAffiliation: Harvard University Country: USA Publications
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Publications
Suicide rates in relation to health care access in the United States: an ecological studyLeonardo Tondo
Department of Psychiatry and Neuroscience Program, Harvard Medical School, Boston, MA, USA
J Clin Psychiatry 67:517-23. 2006..We tested the hypothesis that suicide rates in the United States are associated with indicators of access to health care services...
Mania associated with antidepressant treatment: comprehensive meta-analytic reviewL Tondo
Department of Psychiatry and Neuroscience Program, Harvard Medical School and McLean Division of Massachusetts General Hospital, Boston, MA, USA
Acta Psychiatr Scand 121:404-14. 2010..To review available data pertaining to risk of mania-hypomania among bipolar (BPD) and major depressive disorder (MDD) patients with vs. without exposure to antidepressant drugs (ADs) and consider effects of mood stabilizers...- Latency and episodes before treatment: response to lithium maintenance in bipolar I and II disordersR J Baldessarini
Consolidated Department of Psychiatry, Harvard Medical School and Bipolar and Psychotic Disorders Program, McLean Massachusetts General Hospitals, Boston, USA
Bipolar Disord 1:91-7. 1999..To test whether longer treatment-delays or more pretreatment illness episodes are followed by diminished response to lithium maintenance... - Age at onset in 3014 Sardinian bipolar and major depressive disorder patientsL Tondo
Department of Psychiatry, Harvard Medical School and International Consortium for Psychotic and Mood Disorders Research, McLean Division of Massachusetts General Hospital, Boston, MA, USA
Acta Psychiatr Scand 121:446-52. 2010..To test if onset age in major affective illnesses is younger in bipolar disorder (BPD) than unipolar-major depressive disorder (UP-MDD), and is a useful measure... - Discontinuing lithium maintenance treatment in bipolar disorders: risks and implicationsR J Baldessarini
The International Consortium for Bipolar Disorders Research, Consolidated Department of Psychiatry and Neuroscience Program, Harvard Medical School, Boston, MA, USA
Bipolar Disord 1:17-24. 1999..To review research findings on clinical effects of discontinuing lithium maintenance treatment... - Suicide attempts in major affective disorder patients with comorbid substance use disordersL Tondo
International Consortium for Research on Bipolar Disorders the Department of Psychiatry, Harvard Medical School, Boston, Mass, USA
J Clin Psychiatry 60:63-9; discussion 75-6, 113-6. 1999..The widely accepted impression that substance abuse and dependence are associated with increased suicidal risk was evaluated by literature review and with new data... - Effects of rapid cycling on response to lithium maintenance treatment in 360 bipolar I and II disorder patientsR J Baldessarini
International Consortium for Bipolar Disorder Research, MA, Boston, USA
J Affect Disord 61:13-22. 2000..Rapid cycling (RC) in bipolar disorders is widely believed to predict future morbidity and poor treatment response, although empirical testing of its predictive utility remains limited... - Response to lithium maintenance treatment in bipolar disorders: comparison of women and menA C Viguera
The International Consortium for Bipolar Disorder Research, Boston, Massachusetts, USA
Bipolar Disord 3:245-52. 2001..Since women with bipolar disorder reportedly have more features that may predict a poor prognosis (depression and rapid cycling), we tested the hypothesis that women respond less well to lithium maintenance treatment... - Suicidal status during antidepressant treatment in 789 Sardinian patients with major affective disorderL Tondo
Department of Psychiatry and Neuroscience Program, Harvard Medical School and McLean Division of Massachusetts General Hospital, Boston, MA, USA
Acta Psychiatr Scand 118:106-15. 2008..Relationships between antidepressant treatment and suicidality remain uncertain in major depressive disorder (MDD), and rarely evaluated in bipolar disorder (BPD)... - Treating the suicidal patient with bipolar disorder. Reducing suicide risk with lithiumR J Baldessarini
Department of Psychiatry and Neuroscience Program, Harvard Medical School, and Bipolar and Psychotic Disorders Program, Mailman Research Center, McLean Division of Massachusetts General Hospital, Belmont, Massachusetts 02478, USA
Ann N Y Acad Sci 932:24-38; discussion 39-43. 2001..Studies of commonly used, but incompletely evaluated, alternative treatments are required, and further protection against premature mortality can be anticipated with better protection against bipolar depression... - Reproduction among 1975 Sardinian women and men diagnosed with major mood disordersL Tondo
International Consortium for Psychotic and Mood Disorder Research, McLean Hospital and Harvard Medical School, Boston, MA, USA
Acta Psychiatr Scand 123:283-9. 2011..It may include reproductive functioning, which has rarely been studied systematically... - Reduced morbidity after gradual discontinuation of lithium treatment for bipolar I and II disorders: a replication studyR J Baldessarini
International Consortium for Bipolar Disorder Research, MA, USA
Am J Psychiatry 154:551-3. 1997..The aim of this study was to verify reduction of early affective morbidity by gradual, rather than rapid, discontinuation of lithium treatment... - Sex differences in response to lithium treatmentA C Viguera
Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
Am J Psychiatry 157:1509-11. 2000..The authors' goal was to investigate whether there are differences between the sexes in response to lithium... - Onset-age of bipolar disorders at six international sitesR J Baldessarini
Department of Psychiatry and Neuroscience Program, Harvard Medical School, USA
J Affect Disord 121:143-6. 2010.... - Lower suicide risk with long-term lithium treatment in major affective illness: a meta-analysisL Tondo
Consolidated Department of Psychiatry and Neuroscience Program, Harvard Medical School, Boston, Massachusetts, USA
Acta Psychiatr Scand 104:163-72. 2001..CONCLUSION: Suicide risk was consistently lower during long-term treatment of major affective illnesses with lithium in all studies in the meta-analysis, including the few involving treatment-randomization... - Effects of treatment latency on response to maintenance treatment in manic-depressive disordersRoss J Baldessarini
Department of Psychiatry, Harvard Medical School, Boston, MA, USA
Bipolar Disord 9:386-93. 2007..To further test the hypothesis that past illness episodes and delay of long-term treatment do not limit maintenance treatment response among patients with manic-depressive illnesses (MDI)... - Prophylaxis latency and outcome in bipolar disordersChristopher Baethge
Consolidated Department of Psychiatry, Harvard Medical School, Bipolar and Psychotic Disorders Program, McLean Division of Massachusetts General Hospital, Belmont, Massachusetts, USA
Can J Psychiatry 48:449-57. 2003..To analyze new and reviewed findings to evaluate relations between treatment response and latency from onset of bipolar disorder (BD) to the start of mood-stabilizer prophylaxis... - Clinical responses to antidepressants among 1036 acutely depressed patients with bipolar or unipolar major affective disordersL Tondo
International Consortium for Bipolar Disorder Research, Mailman Research Center, McLean Division of Massachusetts General Hospital, Boston, MA, USA Centro Lucio Bini Mood Disorders Center, Cagliari, Italy
Acta Psychiatr Scand 127:355-64. 2013..Whether responses to antidepressants differ in bipolar and unipolar depression remains unresolved... - Suicidal risks among 2826 Sardinian major affective disorder patientsL Tondo
Department of Psychiatry and Neuroscience Program, Harvard Medical School and McLean Division of Massachusetts General Hospital, Boston, MA, USA
Acta Psychiatr Scand 116:419-28. 2007..We estimated risks of suicidal behaviors in 2826 mood-disorder patients evaluated and followed in a Sardinian mood disorders research center over the past 30 years... - Comorbid substance-use in schizophrenia: relation to positive and negative symptomsA Talamo
Department of Psychiatry, Harvard Medical School, Boston, MA, USA
Schizophr Res 86:251-5. 2006..Comorbid SUD in schizophrenia patients was associated with male sex and higher PANSS positive to lower negative scores. Cause-effect relationships remain to be clarified... - Long-term clinical effectiveness of lithium maintenance treatment in types I and II bipolar disordersL Tondo
Department of Psychology, University of Cagliari, Sardinia, Italy and McLean Hospital, Department of Psychiatry, Harvard Medical School, Boston, USA
Br J Psychiatry Suppl 41:s184-90. 2001..The effectiveness of lithium is being questioned increasingly and requires clarification... - Illness risk following rapid versus gradual discontinuation of antidepressantsRoss J Baldessarini
Department of Psychiatry, Harvard Medical School, Boston, MA, USA
Am J Psychiatry 167:934-41. 2010..Recurrence occurs earlier after rapid than after gradual discontinuation with lithium and antipsychotics. The authors compared illness recurrence after rapid versus gradual discontinuation of antidepressants... - Correlation of initial wellness with long-term morbidity in recurrent major affective disorder patients as a test of survival analysisRoss J Baldessarini
Department of Psychiatry, Harvard Medical School, Boston, MA, USA
J Clin Psychopharmacol 30:72-5. 2010..These findings provide moderate support for a basic assumption underlying the use of survival analysis for psychopharmacology research and suggest that clinical outcomes might be predictable from initial wellness intervals... - Suicide in bipolar disorder: Risks and managementRoss J Baldessarini
Department of Psychiatry, Harvard Medical School, Boston, MA, USA
CNS Spectr 11:465-71. 2006..Applying available knowledge systematically, with close and sustained clinical supervision, can enhance management of suicidal risk in bipolar disorders patients... - Is lithium still worth using? An update of selected recent researchRoss J Baldessarini
Department of Psychiatry, Harvard Medical School, Boston, Mass, USA
Harv Rev Psychiatry 10:59-75. 2002.... - Rapid-cycling bipolar disorder: effects of long-term treatmentsL Tondo
Department of Psychiatry and Neuroscience Program, Harvard Medical School, USA
Acta Psychiatr Scand 108:4-14. 2003..Additional long-term studies comparing RC/non-RC patients randomized to specific treatments are required... - Decreased risk of suicides and attempts during long-term lithium treatment: a meta-analytic reviewRoss J Baldessarini
International Consortium for Research on Bipolar Disorders, Department of Psychiatry and Neuroscience Program, Harvard Medical School, Boston, MA, USA
Bipolar Disord 8:625-39. 2006..To update and extend comparisons of rates of suicides and suicide attempts among patients with major affective disorders with versus without long-term lithium treatment... - Treatment-latency and previous episodes: relationships to pretreatment morbidity and response to maintenance treatment in bipolar I and II disordersRoss J Baldessarini
Consolidated Department of Psychiatry, Harvard Medical School, Belmont, MA, USA
Bipolar Disord 5:169-79. 2003..To clarify relationships of treatment delay and pretreatment episode count with pretreatment morbidity and responses to maintenance treatments in bipolar disorders... - Lithium treatment and suicide risk in major affective disorders: update and new findingsRoss J Baldessarini
Department of Psychiatry and Neuroscience Program, Harvard Medical School, Boston, MA, USA
J Clin Psychiatry 64:44-52. 2003..An exception is growing evidence for such suicidal risk reduction with long-term lithium maintenance. This report updates and extends analyses of lithium treatment and suicides and attempts... - Pretreatment episode count and response to lithium treatment in manic-depressive illnessIrene M Bratti
Department of Psychiatry, Harvard Medical School, Belmont, MA, USA
Harv Rev Psychiatry 11:245-56. 2003.... - Lithium treatment reduces suicide risk in recurrent major depressive disorderFrancesca Guzzetta
Department of Psychiatry, Harvard Medical School, Boston, MA, USA
J Clin Psychiatry 68:380-3. 2007..Since lithium shows major antisuicidal effects in bipolar disorders and in heterogeneous mood disorder samples, we evaluated evidence of antisuicidal effects of lithium in patients with recurrent MDD... - Relapse after antidepressant discontinuationFederico Soldani
Am J Psychiatry 161:1312-3; author reply 1313. 2004 - Suicide risk and treatments for patients with bipolar disorderRoss J Baldessarini
JAMA 290:1517-9. 2003 - Strategies to prevent suicideLeonardo Tondo
JAMA 295:1515; author reply 1516. 2006 - Suicidal risk in antidepressant drug trialsRoss J Baldessarini
Arch Gen Psychiatry 63:246-8. 2006 - Suicidal behaviour in bipolar disorder: risk and preventionLeonardo Tondo
Department of Psychology, University of Cagliari, Centro Lucio Bini Stanley Medical Research Institute Research Center, Cagliari, Sardinia, Italy
CNS Drugs 17:491-511. 2003.... - Protective effect of pregnancy on the course of lithium-responsive bipolar I disorderAdele C Viguera
J Affect Disord 72:107-8; author reply 103-5. 2002 - Stargazin involvement with bipolar disorder and response to lithium treatmentGilad Silberberg
Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
Pharmacogenet Genomics 18:403-12. 2008.... - Longitudinal research on bipolar disordersPaola Salvatore
Epidemiol Psichiatr Soc 16:109-17. 2007..Project findings indicate that the course of bipolar I disorder is much less favorable than had been believed formerly, despite clinical treatment with modern mood-stabilizing and other treatments... - Lithium and suicidal riskRoss J Baldessarini
Bipolar Disord 10:114-5. 2008 - TEMPS-A (Rome): psychometric validation of affective temperaments in clinically well subjects in mid- and south ItalyMaurizio Pompili
Department of Psychiatry, Sant Andrea Hospital, University of Rome La Sapienza, Rome, Italy
J Affect Disord 107:63-75. 2008..In Italian, the TEMPS has previously been validated in its original 32-item version, the TEMPS-I (Pisa), one which did not yet include an anxious subscale...