Sengwee Toh

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Confounding adjustment in comparative effectiveness research conducted within distributed research networks
    Sengwee Toh
    Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA 02215, USA
    Med Care 51:S4-10. 2013
  2. pmc Prevalence and trends in the use of antipsychotic medications during pregnancy in the U.S., 2001-2007: a population-based study of 585,615 deliveries
    Sengwee Toh
    Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA 02215, USA
    Arch Womens Ment Health 16:149-57. 2013
  3. doi Comparative risk for angioedema associated with the use of drugs that target the renin-angiotensin-aldosterone system
    Sengwee Toh
    Department of Population Medicine, Harvard Medical School, Boston, MA 02215, USA
    Arch Intern Med 172:1582-9. 2012
  4. pmc Comparative safety of infliximab and etanercept on the risk of serious infections: does the association vary by patient characteristics?
    Sengwee Toh
    Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA 02215, USA
    Pharmacoepidemiol Drug Saf 21:524-34. 2012
  5. pmc Analyzing partially missing confounder information in comparative effectiveness and safety research of therapeutics
    Sengwee Toh
    Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA
    Pharmacoepidemiol Drug Saf 21:13-20. 2012
  6. pmc Antibiotics and oral contraceptive failure - a case-crossover study
    Sengwee Toh
    Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA 02215, USA
    Contraception 83:418-25. 2011
  7. pmc Confounding adjustment via a semi-automated high-dimensional propensity score algorithm: an application to electronic medical records
    Sengwee Toh
    Department of Population Medicine, Harvard Medical School Harvard Pilgrim Health Care Institute, Boston, MA 02215, USA
    Pharmacoepidemiol Drug Saf 20:849-57. 2011
  8. pmc Estimating absolute risks in the presence of nonadherence: an application to a follow-up study with baseline randomization
    Sengwee Toh
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02215, USA
    Epidemiology 21:528-39. 2010
  9. pmc Coronary heart disease in postmenopausal recipients of estrogen plus progestin therapy: does the increased risk ever disappear? A randomized trial
    Sengwee Toh
    Department of Population Medicine, Harvard Medical School Harvard Pilgrim Health Care Institute, 133 Brookline Avenue, 6th Floor, Boston, MA 02215, USA
    Ann Intern Med 152:211-7. 2010
  10. pmc Antidepressant use during pregnancy and the risk of preterm delivery and fetal growth restriction
    Sengwee Toh
    Department of Population Medicine, Harvard Medical School Harvard Pilgrim Health Care Institute, 133 Brookline Ave 6th Floor, Boston, MA 02215, USA
    J Clin Psychopharmacol 29:555-60. 2009

Detail Information

Publications28

  1. ncbi Confounding adjustment in comparative effectiveness research conducted within distributed research networks
    Sengwee Toh
    Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA 02215, USA
    Med Care 51:S4-10. 2013
    ..An essential component of a fully functional DRN is the capability to perform robust statistical analyses to produce valid, actionable evidence without compromising patient privacy, data security, or proprietary interests...
  2. pmc Prevalence and trends in the use of antipsychotic medications during pregnancy in the U.S., 2001-2007: a population-based study of 585,615 deliveries
    Sengwee Toh
    Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA 02215, USA
    Arch Womens Ment Health 16:149-57. 2013
    ..Studies are needed to examine the comparative safety and effectiveness of these medications relative to other therapeutic options in pregnancy...
  3. doi Comparative risk for angioedema associated with the use of drugs that target the renin-angiotensin-aldosterone system
    Sengwee Toh
    Department of Population Medicine, Harvard Medical School, Boston, MA 02215, USA
    Arch Intern Med 172:1582-9. 2012
    ..We assessed the risk for angioedema associated with the use of angiotensin converting enzyme inhibitors (ACEIs), angiotensin receptor blockers (ARBs), and the direct renin inhibitor aliskiren...
  4. pmc Comparative safety of infliximab and etanercept on the risk of serious infections: does the association vary by patient characteristics?
    Sengwee Toh
    Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA 02215, USA
    Pharmacoepidemiol Drug Saf 21:524-34. 2012
    ..It is unclear whether the risk varies by patient characteristics. We conducted a study to address this question...
  5. pmc Analyzing partially missing confounder information in comparative effectiveness and safety research of therapeutics
    Sengwee Toh
    Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA
    Pharmacoepidemiol Drug Saf 21:13-20. 2012
    ..Many databases now include additional confounder information in a subset of the study population through data linkage or data collection. We described and compared existing methods for analyzing such datasets...
  6. pmc Antibiotics and oral contraceptive failure - a case-crossover study
    Sengwee Toh
    Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA 02215, USA
    Contraception 83:418-25. 2011
    ..Evidence on the association between antibiotic use and combined oral contraceptive (COC) failure is controversial. We examined the effect of concomitant antibiotic treatment on the risk of breakthrough pregnancy among COC users...
  7. pmc Confounding adjustment via a semi-automated high-dimensional propensity score algorithm: an application to electronic medical records
    Sengwee Toh
    Department of Population Medicine, Harvard Medical School Harvard Pilgrim Health Care Institute, Boston, MA 02215, USA
    Pharmacoepidemiol Drug Saf 20:849-57. 2011
    ..A semi-automated high-dimensional propensity score (hd-PS) algorithm has been proposed to adjust for confounding in claims databases. The feasibility of using this algorithm in other types of healthcare databases is unknown...
  8. pmc Estimating absolute risks in the presence of nonadherence: an application to a follow-up study with baseline randomization
    Sengwee Toh
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02215, USA
    Epidemiology 21:528-39. 2010
    ..64; 95% CI = 1.24 to 2.18). The methods described here are also applicable to observational studies with time-varying treatments...
  9. pmc Coronary heart disease in postmenopausal recipients of estrogen plus progestin therapy: does the increased risk ever disappear? A randomized trial
    Sengwee Toh
    Department of Population Medicine, Harvard Medical School Harvard Pilgrim Health Care Institute, 133 Brookline Avenue, 6th Floor, Boston, MA 02215, USA
    Ann Intern Med 152:211-7. 2010
    ..Estrogen plus progestin therapy increases the risk for coronary heart disease (CHD) in postmenopausal women. However, this increased risk might be limited to the first years of use and to women who start therapy late in menopause...
  10. pmc Antidepressant use during pregnancy and the risk of preterm delivery and fetal growth restriction
    Sengwee Toh
    Department of Population Medicine, Harvard Medical School Harvard Pilgrim Health Care Institute, 133 Brookline Ave 6th Floor, Boston, MA 02215, USA
    J Clin Psychopharmacol 29:555-60. 2009
    ..The associations between prenatal exposure to antidepressants and preterm delivery and fetal growth restriction are controversial and poorly understood. We studied the relation between antidepressant use and these outcomes...
  11. pmc Validation of an algorithm to estimate gestational age in electronic health plan databases
    Qian Li
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Pharmacoepidemiol Drug Saf 22:524-32. 2013
    ..To validate an algorithm that uses delivery date and diagnosis codes to define gestational age at birth in electronic health plan databases...
  12. pmc Validity of health plan and birth certificate data for pregnancy research
    Susan E Andrade
    Meyers Primary Care Institute and University of Massachusetts Medical School, Worcester, MA, USA
    Pharmacoepidemiol Drug Saf 22:7-15. 2013
    ..To evaluate the validity of health plan and birth certificate data for pregnancy research...
  13. pmc Validation of acute myocardial infarction in the Food and Drug Administration's Mini-Sentinel program
    Sarah L Cutrona
    Meyers Primary Care Institute Fallon Community Health Plan, Reliant Medical Group, and University of Massachusetts Medical School, Worcester, MA, USA
    Pharmacoepidemiol Drug Saf 22:40-54. 2013
    ..To validate an algorithm based upon International Classification of Diseases, 9(th) revision, Clinical Modification (ICD-9-CM) codes for acute myocardial infarction (AMI) documented within the Mini-Sentinel Distributed Database (MSDD)...
  14. ncbi Multivariable confounding adjustment in distributed data networks without sharing of patient-level data
    Sengwee Toh
    Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA
    Pharmacoepidemiol Drug Saf 22:1171-7. 2013
    ..We describe and compare two approaches that do not require sharing of patient-level information to adjust for confounding in multi-site studies...
  15. pmc Design for validation of acute myocardial infarction cases in Mini-Sentinel
    Sarah L Cutrona
    Fallon Community Health Plan and Fallon Clinic, Meyers Primary Care Institute, University of Massachusetts Medical School, Worcester, MA, USA
    Pharmacoepidemiol Drug Saf 21:274-81. 2012
    ..To describe the acute myocardial infarction (AMI) validation project, a test case for health outcome validation within the US Food and Drug Administration-funded Mini-Sentinel pilot program...
  16. pmc Selective serotonin reuptake inhibitor use and risk of gestational hypertension
    Sengwee Toh
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Psychiatry 166:320-8. 2009
    ..The purpose of this study was to assess the effects of treatment with selective serotonin reuptake inhibitors (SSRIs) on the risks of gestational hypertension and preeclampsia...
  17. ncbi Design considerations in an active medical product safety monitoring system
    Joshua J Gagne
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02120, USA
    Pharmacoepidemiol Drug Saf 21:32-40. 2012
    ..The cohort approach generally is preferred in other situations and particularly when timing of exposure or outcome is uncertain because cohort approaches are less vulnerable to biases resulting from misclassification...
  18. doi Sensitivity and specificity of computerized algorithms to classify gestational periods in the absence of information on date of conception
    Sengwee Toh
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Epidemiol 167:633-40. 2008
    ..However, the sensitivity of this algorithm is lower for preterm deliveries, suggesting limited validity to assess drug safety for pregnancy outcomes associated with prematurity...
  19. pmc Validation of claims-based algorithms for identification of high-grade cervical dysplasia and cervical cancer
    Seoyoung C Kim
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital Harvard Medical School, Boston, MA, USA Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, MA, USA
    Pharmacoepidemiol Drug Saf 22:1239-44. 2013
    ..High-grade cervical dysplasia or cervical intraepithelial neoplasia grade 2 or worse has been widely used as a surrogate endpoint in cervical cancer screening or prevention trials...
  20. pmc Risk of pre-eclampsia in first and subsequent pregnancies: prospective cohort study
    Sonia Hernandez-Diaz
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Ave, Boston, MA 02115, USA
    BMJ 338:b2255. 2009
    ..To investigate whether pre-eclampsia is more common in first pregnancies solely because fewer affected women, who presumably have a higher risk of recurrence, go on to have subsequent pregnancies...
  21. ncbi Statins and fracture risk. A systematic review
    Sengwee Toh
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Pharmacoepidemiol Drug Saf 16:627-40. 2007
    ..To summarize current evidence on statin use and fracture risk and to explore potential sources of heterogeneity among study results...
  22. ncbi Datapoints: trends in ADHD and stimulant use among children, 1993-2003
    Sengwee Toh
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Psychiatr Serv 57:1091. 2006
  23. doi Re-using Mini-Sentinel data following rapid assessments of potential safety signals via modular analytic programs
    Sengwee Toh
    Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA
    Pharmacoepidemiol Drug Saf 22:1036-45. 2013
    ..The committee also discussed how this general framework may apply to two completed rapid assessments of dabigatran and bleeding risk and of olmesartan and celiac disease risk...
  24. doi Validation of algorithms to ascertain clinical conditions and medical procedures used during pregnancy
    Susan E Andrade
    Meyers Primary Care Institute and University of Massachusetts Medical School, Worcester, MA, USA
    Pharmacoepidemiol Drug Saf 20:1168-76. 2011
    ..To evaluate the validity of health plan administrative and claims data to identify pre-gestational and gestational diabetes, obesity, and ultrasounds among pregnant women...
  25. pmc A critical review of methods to evaluate the impact of FDA regulatory actions
    Becky A Briesacher
    Division of Geriatric Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Pharmacoepidemiol Drug Saf 22:986-94. 2013
    ..To conduct a synthesis of the literature on methods to evaluate the impacts of FDA regulatory actions and identify best practices for future evaluations...
  26. ncbi Data quality assessment for comparative effectiveness research in distributed data networks
    Jeffrey S Brown
    Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA 02215, USA
    Med Care 51:S22-9. 2013
    ..Often, distributed networks that combine information from multiple sources are needed to generate this real-world evidence...
  27. ncbi Use of antidepressants and risk of lung cancer
    Sengwee Toh
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Cancer Causes Control 18:1055-64. 2007
    ..To evaluate the effect of antidepressant use on lung cancer risk...
  28. ncbi The U.S. Food and Drug Administration's Mini-Sentinel program: status and direction
    Richard Platt
    Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA
    Pharmacoepidemiol Drug Saf 21:1-8. 2012
    ....