Research Topics
| Sengwee TohSummaryAffiliation: Harvard University Country: USA Publications
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Detail Information
Publications
Prevalence and trends in the use of antipsychotic medications during pregnancy in the U.S., 2001-2007: a population-based study of 585,615 deliveriesSengwee Toh
Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA 02215, USA
Arch Womens Ment Health 16:149-57. 2013..Studies are needed to examine the comparative safety and effectiveness of these medications relative to other therapeutic options in pregnancy...- Comparative risk for angioedema associated with the use of drugs that target the renin-angiotensin-aldosterone systemSengwee Toh
Department of Population Medicine, Harvard Medical School, Boston, MA 02215, USA
Arch Intern Med 172:1582-9. 2012..We assessed the risk for angioedema associated with the use of angiotensin converting enzyme inhibitors (ACEIs), angiotensin receptor blockers (ARBs), and the direct renin inhibitor aliskiren... 
Comparative safety of infliximab and etanercept on the risk of serious infections: does the association vary by patient characteristics?Sengwee Toh
Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA 02215, USA
Pharmacoepidemiol Drug Saf 21:524-34. 2012..It is unclear whether the risk varies by patient characteristics. We conducted a study to address this question...- Analyzing partially missing confounder information in comparative effectiveness and safety research of therapeuticsSengwee Toh
Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA
Pharmacoepidemiol Drug Saf 21:13-20. 2012..Many databases now include additional confounder information in a subset of the study population through data linkage or data collection. We described and compared existing methods for analyzing such datasets... - Confounding adjustment via a semi-automated high-dimensional propensity score algorithm: an application to electronic medical recordsSengwee Toh
Department of Population Medicine, Harvard Medical School Harvard Pilgrim Health Care Institute, Boston, MA 02215, USA
Pharmacoepidemiol Drug Saf 20:849-57. 2011..A semi-automated high-dimensional propensity score (hd-PS) algorithm has been proposed to adjust for confounding in claims databases. The feasibility of using this algorithm in other types of healthcare databases is unknown... - Antibiotics and oral contraceptive failure - a case-crossover studySengwee Toh
Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA 02215, USA
Contraception 83:418-25. 2011..Evidence on the association between antibiotic use and combined oral contraceptive (COC) failure is controversial. We examined the effect of concomitant antibiotic treatment on the risk of breakthrough pregnancy among COC users... - Estimating absolute risks in the presence of nonadherence: an application to a follow-up study with baseline randomizationSengwee Toh
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02215, USA
Epidemiology 21:528-39. 2010..64; 95% CI = 1.24 to 2.18). The methods described here are also applicable to observational studies with time-varying treatments... - Coronary heart disease in postmenopausal recipients of estrogen plus progestin therapy: does the increased risk ever disappear? A randomized trialSengwee Toh
Department of Population Medicine, Harvard Medical School Harvard Pilgrim Health Care Institute, 133 Brookline Avenue, 6th Floor, Boston, MA 02215, USA
Ann Intern Med 152:211-7. 2010..Estrogen plus progestin therapy increases the risk for coronary heart disease (CHD) in postmenopausal women. However, this increased risk might be limited to the first years of use and to women who start therapy late in menopause... - Antidepressant use during pregnancy and the risk of preterm delivery and fetal growth restrictionSengwee Toh
Department of Population Medicine, Harvard Medical School Harvard Pilgrim Health Care Institute, 133 Brookline Ave 6th Floor, Boston, MA 02215, USA
J Clin Psychopharmacol 29:555-60. 2009..The associations between prenatal exposure to antidepressants and preterm delivery and fetal growth restriction are controversial and poorly understood. We studied the relation between antidepressant use and these outcomes... - Validity of health plan and birth certificate data for pregnancy researchSusan E Andrade
Meyers Primary Care Institute and University of Massachusetts Medical School, Worcester, MA, USA
Pharmacoepidemiol Drug Saf 22:7-15. 2013..To evaluate the validity of health plan and birth certificate data for pregnancy research... - Validation of acute myocardial infarction in the Food and Drug Administration's Mini-Sentinel programSarah L Cutrona
Meyers Primary Care Institute Fallon Community Health Plan, Reliant Medical Group, and University of Massachusetts Medical School, Worcester, MA, USA
Pharmacoepidemiol Drug Saf 22:40-54. 2013..To validate an algorithm based upon International Classification of Diseases, 9(th) revision, Clinical Modification (ICD-9-CM) codes for acute myocardial infarction (AMI) documented within the Mini-Sentinel Distributed Database (MSDD)... - Sensitivity and specificity of computerized algorithms to classify gestational periods in the absence of information on date of conceptionSengwee Toh
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
Am J Epidemiol 167:633-40. 2008..However, the sensitivity of this algorithm is lower for preterm deliveries, suggesting limited validity to assess drug safety for pregnancy outcomes associated with prematurity... - Selective serotonin reuptake inhibitor use and risk of gestational hypertensionSengwee Toh
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
Am J Psychiatry 166:320-8. 2009..The purpose of this study was to assess the effects of treatment with selective serotonin reuptake inhibitors (SSRIs) on the risks of gestational hypertension and preeclampsia... - Risk of pre-eclampsia in first and subsequent pregnancies: prospective cohort studySonia Hernandez-Diaz
Department of Epidemiology, Harvard School of Public Health, 677 Huntington Ave, Boston, MA 02115, USA
BMJ 338:b2255. 2009..To investigate whether pre-eclampsia is more common in first pregnancies solely because fewer affected women, who presumably have a higher risk of recurrence, go on to have subsequent pregnancies... 
Statins and fracture risk. A systematic reviewSengwee Toh
Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
Pharmacoepidemiol Drug Saf 16:627-40. 2007..To summarize current evidence on statin use and fracture risk and to explore potential sources of heterogeneity among study results...- Datapoints: trends in ADHD and stimulant use among children, 1993-2003Sengwee Toh
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
Psychiatr Serv 57:1091. 2006 - Design for validation of acute myocardial infarction cases in Mini-SentinelSarah L Cutrona
Fallon Community Health Plan and Fallon Clinic, Meyers Primary Care Institute, University of Massachusetts Medical School, Worcester, MA, USA
Pharmacoepidemiol Drug Saf 21:274-81. 2012..To describe the acute myocardial infarction (AMI) validation project, a test case for health outcome validation within the US Food and Drug Administration-funded Mini-Sentinel pilot program... - Validation of algorithms to ascertain clinical conditions and medical procedures used during pregnancySusan E Andrade
Meyers Primary Care Institute and University of Massachusetts Medical School, Worcester, MA, USA
Pharmacoepidemiol Drug Saf 20:1168-76. 2011..To evaluate the validity of health plan administrative and claims data to identify pre-gestational and gestational diabetes, obesity, and ultrasounds among pregnant women... - Use of antidepressants and risk of lung cancerSengwee Toh
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
Cancer Causes Control 18:1055-64. 2007..To evaluate the effect of antidepressant use on lung cancer risk...