Affiliation: Harvard University
Thomsen M, Wess J, Fulton B, Fink Jensen A, Caine S. Modulation of prepulse inhibition through both M(1) and M (4) muscarinic receptors in mice. Psychopharmacology (Berl). 2010;208:401-16 pubmed publisher
..Finally, our results do not support a role of M(1)/M(4) receptors in mediating antipsychotic-like effects of clozapine. ..
Thomsen M, Ralph R, Caine S. Psychomotor stimulation by dopamine D?-like but not D?-like agonists in most mouse strains. Exp Clin Psychopharmacol. 2011;19:342-60 pubmed publisher
..These results should aid in the selection of mouse strains for future studies in which D? or D? responsiveness is a necessary consideration in the experimental design. ..
Thomsen M, Caine S. Effects of dopamine D1-like and D2-like antagonists on cocaine discrimination in muscarinic receptor knockout mice. Eur J Pharmacol. 2016;776:71-80 pubmed publisher
Thomsen M, Woldbye D, Wortwein G, Fink Jensen A, Wess J, Caine S. Reduced cocaine self-administration in muscarinic M5 acetylcholine receptor-deficient mice. J Neurosci. 2005;25:8141-9 pubmed
..Our results indicate that M5 receptor deletion diminished the reinforcing effects of low doses of cocaine and identified specific conditions under which this may be observed. ..
Thomsen M, Wortwein G, Fink Jensen A, Woldbye D, Wess J, Caine S. Decreased prepulse inhibition and increased sensitivity to muscarinic, but not dopaminergic drugs in M5 muscarinic acetylcholine receptor knockout mice. Psychopharmacology (Berl). 2007;192:97-110 pubmed
Thomsen M, Hall F, Uhl G, Caine S. Dramatically decreased cocaine self-administration in dopamine but not serotonin transporter knock-out mice. J Neurosci. 2009;29:1087-92 pubmed publisher
..These findings support the notion that the DAT, but not the SERT, is critical in mediating the reinforcing effects of cocaine. ..
Joseph L, Thomsen M. Effects of muscarinic receptor antagonists on cocaine discrimination in wild-type mice and in muscarinic receptor M1, M2, and M4 receptor knockout mice. Behav Brain Res. 2017;329:75-83 pubmed publisher
Thomsen M, Barrett A, Butler P, Negus S, Caine S. Effects of Acute and Chronic Treatments with Dopamine D2 and D3 Receptor Ligands on Cocaine versus Food Choice in Rats. J Pharmacol Exp Ther. 2017;362:161-176 pubmed publisher
..With the possible exception of the D3 antagonist PG01037, no ligand was promising in terms of cocaine addiction treatment. ..
Dall C, Weikop P, Dencker D, Molander A, WÃ¶rtwein G, Conn P, et al
. Muscarinic receptor M4 positive allosteric modulators attenuate central effects of cocaine. Drug Alcohol Depend. 2017;176:154-161 pubmed publisher