Sheila Thomas

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Cellular functions regulated by Src family kinases
    S M Thomas
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    Annu Rev Cell Dev Biol 13:513-609. 1997
  2. ncbi Characterization of a focal adhesion protein, Hic-5, that shares extensive homology with paxillin
    S M Thomas
    Department of Medicine, Cancer Biology Program, Beth Israel Deaconess Medical Center Harvard Medical School, Boston, MA 02215, USA
    J Cell Sci 112:181-90. 1999
  3. ncbi N-WASP deficiency reveals distinct pathways for cell surface projections and microbial actin-based motility
    S B Snapper
    Center for Blood Research, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nat Cell Biol 3:897-904. 2001
  4. ncbi The cytoplasmic domain of the integrin alpha9 subunit requires the adaptor protein paxillin to inhibit cell spreading but promotes cell migration in a paxillin-independent manner
    B A Young
    Lung Biology Center, Department of Medicine, University of California, San Francisco, 94110, USA
    Mol Biol Cell 12:3214-25. 2001
  5. ncbi Regulation of early events in integrin signaling by protein tyrosine phosphatase SHP-2
    E S Oh
    Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Mol Cell Biol 19:3205-15. 1999
  6. ncbi An Shp2/SFK/Ras/Erk signaling pathway controls trophoblast stem cell survival
    Wentian Yang
    Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    Dev Cell 10:317-27. 2006
  7. ncbi Role of phosphoinositide 3-kinase regulatory isoforms in development and actin rearrangement
    Saskia M Brachmann
    Beth Israel Hospital, NRB, Division of Signal Transduction, Department of Systems Biology, 10th Floor, 330 Brookline, MA 02215, USA
    Mol Cell Biol 25:2593-606. 2005
  8. ncbi FAK-Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly
    Donna J Webb
    Department of Cell Biology, UVA School of Medicine, P O Box 800732, Charlottesville, Virginia 22908 0732, USA
    Nat Cell Biol 6:154-61. 2004
  9. ncbi RNF5, a RING finger protein that regulates cell motility by targeting paxillin ubiquitination and altered localization
    Christine Didier
    Ruttenberg Cancer Center, Mount Sinai School of Medicine, New York, NY 10029, USA
    Mol Cell Biol 23:5331-45. 2003
  10. ncbi The multiple LIM domain-containing adaptor protein Hic-5 synaptically colocalizes and interacts with the dopamine transporter
    Ana M Carneiro
    Howard Hughes Medical Institute, Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci 22:7045-54. 2002

Research Grants

  1. SIGNALING THROUGH THE CYTOSKELETAL PROTEIN, PAXILLIN
    Sheila Thomas; Fiscal Year: 2001

Collaborators

Detail Information

Publications16

  1. ncbi Cellular functions regulated by Src family kinases
    S M Thomas
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    Annu Rev Cell Dev Biol 13:513-609. 1997
    ....
  2. ncbi Characterization of a focal adhesion protein, Hic-5, that shares extensive homology with paxillin
    S M Thomas
    Department of Medicine, Cancer Biology Program, Beth Israel Deaconess Medical Center Harvard Medical School, Boston, MA 02215, USA
    J Cell Sci 112:181-90. 1999
    ....
  3. ncbi N-WASP deficiency reveals distinct pathways for cell surface projections and microbial actin-based motility
    S B Snapper
    Center for Blood Research, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nat Cell Biol 3:897-904. 2001
    ..These results imply a crucial and non-redundant role for N-WASP in murine embryogenesis and in the actin-based motility of certain pathogens but not in the general formation of actin-containing structures...
  4. ncbi The cytoplasmic domain of the integrin alpha9 subunit requires the adaptor protein paxillin to inhibit cell spreading but promotes cell migration in a paxillin-independent manner
    B A Young
    Lung Biology Center, Department of Medicine, University of California, San Francisco, 94110, USA
    Mol Biol Cell 12:3214-25. 2001
    ....
  5. ncbi Regulation of early events in integrin signaling by protein tyrosine phosphatase SHP-2
    E S Oh
    Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Mol Cell Biol 19:3205-15. 1999
    ....
  6. ncbi An Shp2/SFK/Ras/Erk signaling pathway controls trophoblast stem cell survival
    Wentian Yang
    Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    Dev Cell 10:317-27. 2006
    ..Bim depletion substantially blocks apoptosis and significantly restores Shp2 null TS cell proliferation, thereby establishing a key mechanism by which FGF4 controls stem cell survival...
  7. ncbi Role of phosphoinositide 3-kinase regulatory isoforms in development and actin rearrangement
    Saskia M Brachmann
    Beth Israel Hospital, NRB, Division of Signal Transduction, Department of Systems Biology, 10th Floor, 330 Brookline, MA 02215, USA
    Mol Cell Biol 25:2593-606. 2005
    ..These results indicate that class Ia PI3K is critical for PDGF-dependent actin rearrangement but that the SH3 domain and the Rho/Rac/Cdc42-interacting domain of p85, which lacks p50alpha, are not required for this response...
  8. ncbi FAK-Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly
    Donna J Webb
    Department of Cell Biology, UVA School of Medicine, P O Box 800732, Charlottesville, Virginia 22908 0732, USA
    Nat Cell Biol 6:154-61. 2004
    ....
  9. ncbi RNF5, a RING finger protein that regulates cell motility by targeting paxillin ubiquitination and altered localization
    Christine Didier
    Ruttenberg Cancer Center, Mount Sinai School of Medicine, New York, NY 10029, USA
    Mol Cell Biol 23:5331-45. 2003
    ..Concomitantly, RNF5 expression results in inhibition of cell motility. Via targeting of paxillin ubiquitination, which alters its localization, RNF5 emerges as a novel regulator of cell motility...
  10. ncbi The multiple LIM domain-containing adaptor protein Hic-5 synaptically colocalizes and interacts with the dopamine transporter
    Ana M Carneiro
    Howard Hughes Medical Institute, Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci 22:7045-54. 2002
    ....
  11. ncbi The adaptor protein paxillin is essential for normal development in the mouse and is a critical transducer of fibronectin signaling
    Margit Hagel
    Beth Israel Deaconess Medical Center Harvard Medical School, Vascular Research Division, Department of Pathology, Brigham and Women s Hospital Harvard Medical School, Boston, Massachusetts, USA
    Mol Cell Biol 22:901-15. 2002
    ....
  12. ncbi Cortactin regulates cell migration through activation of N-WASP
    Jennifer R Kowalski
    Biological and Biomedical Sciences Program, Harvard Medical School, Boston, MA 02215, USA
    J Cell Sci 118:79-87. 2005
    ..Thus, our results suggest that cortactin has multiple mechanisms by which it can recruit and modulate the actin machinery and ultimately regulate cell migration...
  13. ncbi Regulation of Rho and Rac signaling to the actin cytoskeleton by paxillin during Drosophila development
    Guang Chao Chen
    Massachusetts General Hospital Cancer Center and Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    Mol Cell Biol 25:979-87. 2005
    ..Taken together, these data indicate the importance of paxillin modulation of Rho family GTPases during development and identify the LIMK pathway as a critical target of paxillin-mediated Rho regulation...
  14. ncbi Endothelial cell cortactin phosphorylation by Src contributes to polymorphonuclear leukocyte transmigration in vitro
    Lin Yang
    Center for Excellence in Vascular Biology, Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Circ Res 98:394-402. 2006
    ..Moreover, expression of cortactin3F alone partially blocked PMN transmigration. These data suggest a model whereby tyrosine phosphorylation of cortactin by Src family kinases regulates PMN transmigration...
  15. ncbi Endothelial cell cortactin coordinates intercellular adhesion molecule-1 clustering and actin cytoskeleton remodeling during polymorphonuclear leukocyte adhesion and transmigration
    Lin Yang
    Center for Excellence in Vascular Biology, Departments of Pathology, Brigham and Women s Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    J Immunol 177:6440-9. 2006
    ..Our data suggest a model in which tyrosine phosphorylation of cortactin dynamically links ICAM-1 to the actin cytoskeleton, enabling ICAM-1 to form clusters and facilitate leukocyte transmigration...
  16. ncbi Genetic interactions between Drosophila melanogaster Atg1 and paxillin reveal a role for paxillin in autophagosome formation
    Guang Chao Chen
    Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan
    Autophagy 4:37-45. 2008
    ..Together, these findings reveal a novel evolutionarily conserved role for paxillin in autophagy...

Research Grants5

  1. SIGNALING THROUGH THE CYTOSKELETAL PROTEIN, PAXILLIN
    Sheila Thomas; Fiscal Year: 2001
    ....