Genomes and Genes
Affiliation: Harvard University
- Cellular functions regulated by Src family kinasesS M Thomas
Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
Annu Rev Cell Dev Biol 13:513-609. 1997....
- Characterization of a focal adhesion protein, Hic-5, that shares extensive homology with paxillinS M Thomas
Department of Medicine, Cancer Biology Program, Beth Israel Deaconess Medical Center Harvard Medical School, Boston, MA 02215, USA
J Cell Sci 112:181-90. 1999....
- N-WASP deficiency reveals distinct pathways for cell surface projections and microbial actin-based motilityS B Snapper
Center for Blood Research, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
Nat Cell Biol 3:897-904. 2001..These results imply a crucial and non-redundant role for N-WASP in murine embryogenesis and in the actin-based motility of certain pathogens but not in the general formation of actin-containing structures...
- The cytoplasmic domain of the integrin alpha9 subunit requires the adaptor protein paxillin to inhibit cell spreading but promotes cell migration in a paxillin-independent mannerB A Young
Lung Biology Center, Department of Medicine, University of California, San Francisco, 94110, USA
Mol Biol Cell 12:3214-25. 2001....
- Regulation of early events in integrin signaling by protein tyrosine phosphatase SHP-2E S Oh
Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
Mol Cell Biol 19:3205-15. 1999....
- An Shp2/SFK/Ras/Erk signaling pathway controls trophoblast stem cell survivalWentian Yang
Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
Dev Cell 10:317-27. 2006..Bim depletion substantially blocks apoptosis and significantly restores Shp2 null TS cell proliferation, thereby establishing a key mechanism by which FGF4 controls stem cell survival...
- Role of phosphoinositide 3-kinase regulatory isoforms in development and actin rearrangementSaskia M Brachmann
Beth Israel Hospital, NRB, Division of Signal Transduction, Department of Systems Biology, 10th Floor, 330 Brookline, MA 02215, USA
Mol Cell Biol 25:2593-606. 2005..These results indicate that class Ia PI3K is critical for PDGF-dependent actin rearrangement but that the SH3 domain and the Rho/Rac/Cdc42-interacting domain of p85, which lacks p50alpha, are not required for this response...
- FAK-Src signalling through paxillin, ERK and MLCK regulates adhesion disassemblyDonna J Webb
Department of Cell Biology, UVA School of Medicine, P O Box 800732, Charlottesville, Virginia 22908 0732, USA
Nat Cell Biol 6:154-61. 2004....
- RNF5, a RING finger protein that regulates cell motility by targeting paxillin ubiquitination and altered localizationChristine Didier
Ruttenberg Cancer Center, Mount Sinai School of Medicine, New York, NY 10029, USA
Mol Cell Biol 23:5331-45. 2003..Concomitantly, RNF5 expression results in inhibition of cell motility. Via targeting of paxillin ubiquitination, which alters its localization, RNF5 emerges as a novel regulator of cell motility...
- The multiple LIM domain-containing adaptor protein Hic-5 synaptically colocalizes and interacts with the dopamine transporterAna M Carneiro
Howard Hughes Medical Institute, Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
J Neurosci 22:7045-54. 2002....
- The adaptor protein paxillin is essential for normal development in the mouse and is a critical transducer of fibronectin signalingMargit Hagel
Beth Israel Deaconess Medical Center Harvard Medical School, Vascular Research Division, Department of Pathology, Brigham and Women s Hospital Harvard Medical School, Boston, Massachusetts, USA
Mol Cell Biol 22:901-15. 2002....
- Cortactin regulates cell migration through activation of N-WASPJennifer R Kowalski
Biological and Biomedical Sciences Program, Harvard Medical School, Boston, MA 02215, USA
J Cell Sci 118:79-87. 2005..Thus, our results suggest that cortactin has multiple mechanisms by which it can recruit and modulate the actin machinery and ultimately regulate cell migration...
- Regulation of Rho and Rac signaling to the actin cytoskeleton by paxillin during Drosophila developmentGuang Chao Chen
Massachusetts General Hospital Cancer Center and Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
Mol Cell Biol 25:979-87. 2005..Taken together, these data indicate the importance of paxillin modulation of Rho family GTPases during development and identify the LIMK pathway as a critical target of paxillin-mediated Rho regulation...
- Endothelial cell cortactin phosphorylation by Src contributes to polymorphonuclear leukocyte transmigration in vitroLin Yang
Center for Excellence in Vascular Biology, Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Circ Res 98:394-402. 2006..Moreover, expression of cortactin3F alone partially blocked PMN transmigration. These data suggest a model whereby tyrosine phosphorylation of cortactin by Src family kinases regulates PMN transmigration...
- Endothelial cell cortactin coordinates intercellular adhesion molecule-1 clustering and actin cytoskeleton remodeling during polymorphonuclear leukocyte adhesion and transmigrationLin Yang
Center for Excellence in Vascular Biology, Departments of Pathology, Brigham and Women s Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
J Immunol 177:6440-9. 2006..Our data suggest a model in which tyrosine phosphorylation of cortactin dynamically links ICAM-1 to the actin cytoskeleton, enabling ICAM-1 to form clusters and facilitate leukocyte transmigration...
- Genetic interactions between Drosophila melanogaster Atg1 and paxillin reveal a role for paxillin in autophagosome formationGuang Chao Chen
Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan
Autophagy 4:37-45. 2008..Together, these findings reveal a novel evolutionarily conserved role for paxillin in autophagy...
- SIGNALING THROUGH THE CYTOSKELETAL PROTEIN, PAXILLINSheila Thomas; Fiscal Year: 2001....