A Thomas Look
Affiliation: Harvard University
Zimmerman M, Liu Y, He S, Durbin A, Abraham B, Easton J, et al
. MYC Drives a Subset of High-Risk Pediatric Neuroblastomas and Is Activated through Mechanisms Including Enhancer Hijacking and Focal Enhancer Amplification. Cancer Discov. 2018;8:320-335 pubmed publisher
..i>Cancer Discov; 8(3); 320-35. Â©2017 AACR.This article is highlighted in the In This Issue feature, p. 253. ..
Mansour M, Abraham B, Anders L, Berezovskaya A, Gutierrez A, Durbin A, et al
. Oncogene regulation. An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element. Science. 2014;346:1373-7 pubmed publisher
..Thus, this study identifies a genetic mechanism responsible for the generation of oncogenic super-enhancers in malignant cells. ..
Li Z, He S, Look A. The MCL1-specific inhibitor S63845 acts synergistically with venetoclax/ABT-199 to induce apoptosis in T-cell acute lymphoblastic leukemia cells. Leukemia. 2019;33:262-266 pubmed publisher
Durbin A, Zimmerman M, Dharia N, Abraham B, Iniguez A, Weichert Leahey N, et al
. Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry. Nat Genet. 2018;50:1240-1246 pubmed publisher
..This study defines a set of critical dependency genes in MYCN-amplified neuroblastoma that are essential for cell state and survival in this tumor. ..
Mansour M, He S, Li Z, Lobbardi R, Abraham B, Hug C, et al
. JDP2: An oncogenic bZIP transcription factor in T cell acute lymphoblastic leukemia. J Exp Med. 2018;215:1929-1945 pubmed publisher
..These studies establish JDP2 as a novel oncogene in high-risk T-ALL and implicate overexpression of MCL1 as a mechanism of steroid resistance in JDP2-overexpressing cells. ..
Zhu S, Thomas Look A. Neuroblastoma and Its Zebrafish Model. Adv Exp Med Biol. 2016;916:451-78 pubmed publisher
Durbin A, Ki D, He S, Look A. Malignant Peripheral Nerve Sheath Tumors. Adv Exp Med Biol. 2016;916:495-530 pubmed publisher
Gjini E, Mansour M, Sander J, Moritz N, Nguyen A, Kesarsing M, et al
. A zebrafish model of myelodysplastic syndrome produced through tet2 genomic editing. Mol Cell Biol. 2015;35:789-804 pubmed publisher
..tet2(m/m) zebrafish are viable and fertile, providing an ideal model to dissect altered pathways in hematopoietic cells and, for small-molecule screens in embryos, to identify compounds with specific activity against tet2 mutant cells. ..
Zhu S, Zhang X, Weichert Leahey N, Dong Z, Zhang C, Lopez G, et al
. LMO1 Synergizes with MYCN to Promote Neuroblastoma Initiation and Metastasis. Cancer Cell. 2017;32:310-323.e5 pubmed publisher
..Our results provide in vivo validation of LMO1 as an important oncogene that promotes neuroblastoma initiation, progression, and widespread metastatic dissemination. ..