A Thomas Look

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. Zimmerman M, Liu Y, He S, Durbin A, Abraham B, Easton J, et al. MYC Drives a Subset of High-Risk Pediatric Neuroblastomas and Is Activated through Mechanisms Including Enhancer Hijacking and Focal Enhancer Amplification. Cancer Discov. 2018;8:320-335 pubmed publisher
    ..i>Cancer Discov; 8(3); 320-35. ©2017 AACR.This article is highlighted in the In This Issue feature, p. 253. ..
  2. Mansour M, Abraham B, Anders L, Berezovskaya A, Gutierrez A, Durbin A, et al. Oncogene regulation. An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element. Science. 2014;346:1373-7 pubmed publisher
    ..Thus, this study identifies a genetic mechanism responsible for the generation of oncogenic super-enhancers in malignant cells. ..
  3. Li Z, He S, Look A. The MCL1-specific inhibitor S63845 acts synergistically with venetoclax/ABT-199 to induce apoptosis in T-cell acute lymphoblastic leukemia cells. Leukemia. 2019;33:262-266 pubmed publisher
  4. Durbin A, Zimmerman M, Dharia N, Abraham B, Iniguez A, Weichert Leahey N, et al. Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry. Nat Genet. 2018;50:1240-1246 pubmed publisher
    ..This study defines a set of critical dependency genes in MYCN-amplified neuroblastoma that are essential for cell state and survival in this tumor. ..
  5. Mansour M, He S, Li Z, Lobbardi R, Abraham B, Hug C, et al. JDP2: An oncogenic bZIP transcription factor in T cell acute lymphoblastic leukemia. J Exp Med. 2018;215:1929-1945 pubmed publisher
    ..These studies establish JDP2 as a novel oncogene in high-risk T-ALL and implicate overexpression of MCL1 as a mechanism of steroid resistance in JDP2-overexpressing cells. ..
  6. Zhu S, Thomas Look A. Neuroblastoma and Its Zebrafish Model. Adv Exp Med Biol. 2016;916:451-78 pubmed publisher
  7. Durbin A, Ki D, He S, Look A. Malignant Peripheral Nerve Sheath Tumors. Adv Exp Med Biol. 2016;916:495-530 pubmed publisher
  8. Gjini E, Mansour M, Sander J, Moritz N, Nguyen A, Kesarsing M, et al. A zebrafish model of myelodysplastic syndrome produced through tet2 genomic editing. Mol Cell Biol. 2015;35:789-804 pubmed publisher
    ..tet2(m/m) zebrafish are viable and fertile, providing an ideal model to dissect altered pathways in hematopoietic cells and, for small-molecule screens in embryos, to identify compounds with specific activity against tet2 mutant cells. ..
  9. Zhu S, Zhang X, Weichert Leahey N, Dong Z, Zhang C, Lopez G, et al. LMO1 Synergizes with MYCN to Promote Neuroblastoma Initiation and Metastasis. Cancer Cell. 2017;32:310-323.e5 pubmed publisher
    ..Our results provide in vivo validation of LMO1 as an important oncogene that promotes neuroblastoma initiation, progression, and widespread metastatic dissemination. ..