Claudio R Thoma

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. doi request reprint Mechanisms of aneuploidy and its suppression by tumour suppressor proteins
    Claudio R Thoma
    Institute of Cell Biology, ETH Zurich, Switzerland
    Swiss Med Wkly 141:w13170. 2011
  2. doi request reprint Genetic deletion of the long isoform of the von Hippel-Lindau tumour suppressor gene product alters microtubule dynamics
    Ian J Frew
    Institute of Molecular Health Sciences, ETH Zurich, Zurich, Switzerland
    Eur J Cancer 49:2433-40. 2013
  3. ncbi request reprint miR-28-5p promotes chromosomal instability in VHL-associated cancers by inhibiting Mad2 translation
    Michael P Hell
    Authors Affiliations Institute of Molecular Health Sciences and Rodent Center HCI, ETH Zurich, Zurich, Switzerland
    Cancer Res 74:2432-43. 2014
  4. ncbi request reprint VHL loss causes spindle misorientation and chromosome instability
    Claudio R Thoma
    Institute of Cell Biology, ETH Zurich, 8093 Zurich, Switzerland
    Nat Cell Biol 11:994-1001. 2009
  5. pmc Quantitative image analysis identifies pVHL as a key regulator of microtubule dynamic instability
    Claudio R Thoma
    Institute of Cell Biology, Swiss Federal Institute of Technology ETH Zurich, 8093 Zurich, Switzerland
    J Cell Biol 190:991-1003. 2010
  6. ncbi request reprint A high-throughput-compatible 3D microtissue co-culture system for phenotypic RNAi screening applications
    Claudio R Thoma
    1Institute of Molecular Health Sciences, ETH Zurich, Zurich, Switzerland
    J Biomol Screen 18:1330-7. 2013

Collaborators

Detail Information

Publications6

  1. doi request reprint Mechanisms of aneuploidy and its suppression by tumour suppressor proteins
    Claudio R Thoma
    Institute of Cell Biology, ETH Zurich, Switzerland
    Swiss Med Wkly 141:w13170. 2011
    ..The prospects that these findings offer for understanding the role of aneuploidy in cancer are discussed in this review...
  2. doi request reprint Genetic deletion of the long isoform of the von Hippel-Lindau tumour suppressor gene product alters microtubule dynamics
    Ian J Frew
    Institute of Molecular Health Sciences, ETH Zurich, Zurich, Switzerland
    Eur J Cancer 49:2433-40. 2013
    ..We conclude that the microtubule-regulating function and the HIF╬▒-regulating function of pVHL are separable activities mediated by different protein isoforms...
  3. ncbi request reprint miR-28-5p promotes chromosomal instability in VHL-associated cancers by inhibiting Mad2 translation
    Michael P Hell
    Authors Affiliations Institute of Molecular Health Sciences and Rodent Center HCI, ETH Zurich, Zurich, Switzerland
    Cancer Res 74:2432-43. 2014
    ..By identifying a potential mediator of chromosomal instability in VHL-associated cancers, our work also suggests a novel microRNA-based therapeutic strategy to target aneuploid cells in VHL-associated cancers...
  4. ncbi request reprint VHL loss causes spindle misorientation and chromosome instability
    Claudio R Thoma
    Institute of Cell Biology, ETH Zurich, 8093 Zurich, Switzerland
    Nat Cell Biol 11:994-1001. 2009
    ....
  5. pmc Quantitative image analysis identifies pVHL as a key regulator of microtubule dynamic instability
    Claudio R Thoma
    Institute of Cell Biology, Swiss Federal Institute of Technology ETH Zurich, 8093 Zurich, Switzerland
    J Cell Biol 190:991-1003. 2010
    ..Thus, single cell-level analysis of pVHL MT regulatory function allows new predictions for genotype to phenotype associations that deviate from the coarser clinically defined mutant classifications...
  6. ncbi request reprint A high-throughput-compatible 3D microtissue co-culture system for phenotypic RNAi screening applications
    Claudio R Thoma
    1Institute of Molecular Health Sciences, ETH Zurich, Zurich, Switzerland
    J Biomol Screen 18:1330-7. 2013
    ..Moreover, they denote that the high-throughput-compatible, hanging drop technology-based 3D co-culture model will enable the discovery, characterization, and validation of gene functions in key biological and pathological processes. ..