Claudio R Thoma

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. doi request reprint Mechanisms of aneuploidy and its suppression by tumour suppressor proteins
    Claudio R Thoma
    Institute of Cell Biology, ETH Zurich, Switzerland
    Swiss Med Wkly 141:w13170. 2011
  2. doi request reprint miR-28-5p promotes chromosomal instability in VHL-associated cancers by inhibiting Mad2 translation
    Michael P Hell
    Authors Affiliations Institute of Molecular Health Sciences and Rodent Center HCI, ETH Zurich, Zurich, Switzerland
    Cancer Res 74:2432-43. 2014
  3. doi request reprint Genetic deletion of the long isoform of the von Hippel-Lindau tumour suppressor gene product alters microtubule dynamics
    Ian J Frew
    Institute of Molecular Health Sciences, ETH Zurich, Zurich, Switzerland
    Eur J Cancer 49:2433-40. 2013
  4. doi request reprint VHL loss causes spindle misorientation and chromosome instability
    Claudio R Thoma
    Institute of Cell Biology, ETH Zurich, 8093 Zurich, Switzerland
    Nat Cell Biol 11:994-1001. 2009
  5. pmc Quantitative image analysis identifies pVHL as a key regulator of microtubule dynamic instability
    Claudio R Thoma
    Institute of Cell Biology, Swiss Federal Institute of Technology ETH Zurich, 8093 Zurich, Switzerland
    J Cell Biol 190:991-1003. 2010
  6. doi request reprint A high-throughput-compatible 3D microtissue co-culture system for phenotypic RNAi screening applications
    Claudio R Thoma
    1Institute of Molecular Health Sciences, ETH Zurich, Zurich, Switzerland
    J Biomol Screen 18:1330-7. 2013

Collaborators

Detail Information

Publications6

  1. doi request reprint Mechanisms of aneuploidy and its suppression by tumour suppressor proteins
    Claudio R Thoma
    Institute of Cell Biology, ETH Zurich, Switzerland
    Swiss Med Wkly 141:w13170. 2011
    ..The prospects that these findings offer for understanding the role of aneuploidy in cancer are discussed in this review...
  2. doi request reprint miR-28-5p promotes chromosomal instability in VHL-associated cancers by inhibiting Mad2 translation
    Michael P Hell
    Authors Affiliations Institute of Molecular Health Sciences and Rodent Center HCI, ETH Zurich, Zurich, Switzerland
    Cancer Res 74:2432-43. 2014
    ..By identifying a potential mediator of chromosomal instability in VHL-associated cancers, our work also suggests a novel microRNA-based therapeutic strategy to target aneuploid cells in VHL-associated cancers...
  3. doi request reprint Genetic deletion of the long isoform of the von Hippel-Lindau tumour suppressor gene product alters microtubule dynamics
    Ian J Frew
    Institute of Molecular Health Sciences, ETH Zurich, Zurich, Switzerland
    Eur J Cancer 49:2433-40. 2013
    ..We conclude that the microtubule-regulating function and the HIF╬▒-regulating function of pVHL are separable activities mediated by different protein isoforms...
  4. doi request reprint VHL loss causes spindle misorientation and chromosome instability
    Claudio R Thoma
    Institute of Cell Biology, ETH Zurich, 8093 Zurich, Switzerland
    Nat Cell Biol 11:994-1001. 2009
    ....
  5. pmc Quantitative image analysis identifies pVHL as a key regulator of microtubule dynamic instability
    Claudio R Thoma
    Institute of Cell Biology, Swiss Federal Institute of Technology ETH Zurich, 8093 Zurich, Switzerland
    J Cell Biol 190:991-1003. 2010
    ..Thus, single cell-level analysis of pVHL MT regulatory function allows new predictions for genotype to phenotype associations that deviate from the coarser clinically defined mutant classifications...
  6. doi request reprint A high-throughput-compatible 3D microtissue co-culture system for phenotypic RNAi screening applications
    Claudio R Thoma
    1Institute of Molecular Health Sciences, ETH Zurich, Zurich, Switzerland
    J Biomol Screen 18:1330-7. 2013
    ..Moreover, they denote that the high-throughput-compatible, hanging drop technology-based 3D co-culture model will enable the discovery, characterization, and validation of gene functions in key biological and pathological processes. ..