RAVI I THADHANI

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Case records of the Massachusetts General Hospital. Case 38-2005. A 29-year-old pregnant woman with the nephrotic syndrome and hypertension
    Winfred W Williams
    Division of Nephrology, Department of Medicine, Massachusetts General Hospital, USA
    N Engl J Med 353:2590-600. 2005
  2. doi request reprint Vitamin D therapy and cardiac structure and function in patients with chronic kidney disease: the PRIMO randomized controlled trial
    Ravi Thadhani
    Division of Nephrology, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA
    JAMA 307:674-84. 2012
  3. ncbi request reprint Pulse pressure and risk of preeclampsia: a prospective study
    R Thadhani
    Renal Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA
    Obstet Gynecol 97:515-20. 2001
  4. ncbi request reprint Insulin resistance and alterations in angiogenesis: additive insults that may lead to preeclampsia
    Ravi Thadhani
    Renal Unit, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
    Hypertension 43:988-92. 2004
  5. ncbi request reprint First trimester placental growth factor and soluble fms-like tyrosine kinase 1 and risk for preeclampsia
    Ravi Thadhani
    Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 89:770-5. 2004
  6. ncbi request reprint First-trimester sex hormone binding globulin and subsequent gestational diabetes mellitus
    Ravi Thadhani
    Departments of Medicine and Obstetrics and Gynecology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Am J Obstet Gynecol 189:171-6. 2003
  7. pmc Early outcomes among those initiating chronic dialysis in the United States
    Kevin E Chan
    Fresenius Medical Care North America, Waltham, Massachusetts, USA
    Clin J Am Soc Nephrol 6:2642-9. 2011
  8. doi request reprint Vitamin D receptor activation and left ventricular hypertrophy in advanced kidney disease
    Ravi Thadhani
    Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Boston, USA
    Am J Nephrol 33:139-49. 2011
  9. doi request reprint Pilot study of extracorporeal removal of soluble fms-like tyrosine kinase 1 in preeclampsia
    Ravi Thadhani
    Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Circulation 124:940-50. 2011
  10. ncbi request reprint Patients with Fabry disease on dialysis in the United States
    Ravi Thadhani
    Renal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Kidney Int 61:249-55. 2002

Detail Information

Publications72

  1. ncbi request reprint Case records of the Massachusetts General Hospital. Case 38-2005. A 29-year-old pregnant woman with the nephrotic syndrome and hypertension
    Winfred W Williams
    Division of Nephrology, Department of Medicine, Massachusetts General Hospital, USA
    N Engl J Med 353:2590-600. 2005
  2. doi request reprint Vitamin D therapy and cardiac structure and function in patients with chronic kidney disease: the PRIMO randomized controlled trial
    Ravi Thadhani
    Division of Nephrology, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA
    JAMA 307:674-84. 2012
    ..Vitamin D is associated with decreased cardiovascular-related morbidity and mortality, possibly by modifying cardiac structure and function, yet firm evidence for either remains lacking...
  3. ncbi request reprint Pulse pressure and risk of preeclampsia: a prospective study
    R Thadhani
    Renal Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA
    Obstet Gynecol 97:515-20. 2001
    ..To find whether pulse pressure, a measure of arterial compliance, is associated early in pregnancy with increased risk of developing preeclampsia...
  4. ncbi request reprint Insulin resistance and alterations in angiogenesis: additive insults that may lead to preeclampsia
    Ravi Thadhani
    Renal Unit, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
    Hypertension 43:988-92. 2004
    ..1, 95% CI 1.7 to 134.9; high PlGF and low SHBG, OR 4.1, 95% CI 0.45 to 38.2; low PlGF and high SHBG, OR 8.7, 95% CI 1.2 to 60.3. Altered angiogenesis and insulin resistance are additive insults that lead to preeclampsia...
  5. ncbi request reprint First trimester placental growth factor and soluble fms-like tyrosine kinase 1 and risk for preeclampsia
    Ravi Thadhani
    Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 89:770-5. 2004
    ..7-fold (95% confidence interval, 2.3-351.0) in the third (<12 pg/ml) compared with the first (>39 pg/ml) PlGF tertile. First trimester serum levels of PlGF and sFlt1 may identify women at high risk for PE...
  6. ncbi request reprint First-trimester sex hormone binding globulin and subsequent gestational diabetes mellitus
    Ravi Thadhani
    Departments of Medicine and Obstetrics and Gynecology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Am J Obstet Gynecol 189:171-6. 2003
    ..We sought to examine the association between early pregnancy levels of sex hormone binding globulin and subsequent gestational diabetes mellitus, an association that has not been studied previously...
  7. pmc Early outcomes among those initiating chronic dialysis in the United States
    Kevin E Chan
    Fresenius Medical Care North America, Waltham, Massachusetts, USA
    Clin J Am Soc Nephrol 6:2642-9. 2011
    ..S. Renal Data System was 19.6% in 2007. This estimate has historically excluded the first 90 days of chronic dialysis...
  8. doi request reprint Vitamin D receptor activation and left ventricular hypertrophy in advanced kidney disease
    Ravi Thadhani
    Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Boston, USA
    Am J Nephrol 33:139-49. 2011
    ..In chronic kidney disease (CKD), left ventricular hypertrophy (LVH) is prevalent and is associated with increased cardiovascular morbidity and mortality. Vitamin D receptor (VDR) activation attenuates LVH progression in animal models...
  9. doi request reprint Pilot study of extracorporeal removal of soluble fms-like tyrosine kinase 1 in preeclampsia
    Ravi Thadhani
    Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Circulation 124:940-50. 2011
    ..Removing sFlt-1 may benefit women with very preterm (<32 weeks) preeclampsia...
  10. ncbi request reprint Patients with Fabry disease on dialysis in the United States
    Ravi Thadhani
    Renal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Kidney Int 61:249-55. 2002
    ..Little is known about the characteristics of patients with Fabry disease that initiate dialysis in the United States, although data from Europe suggests these individuals have a poor survival...
  11. ncbi request reprint Insulin resistance but not inflammation is associated with gestational hypertension
    Myles Wolf
    Renal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Mass 02114, USA
    Hypertension 40:886-91. 2002
    ..Furthermore, important mechanistic differences exist in the pathogenesis of gestational hypertension comparing nulliparous and multiparous women...
  12. ncbi request reprint Predicting gestational diabetes: choosing the optimal early serum marker
    Karen V Smirnakis
    Renal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Am J Obstet Gynecol 196:410.e1-6; discussion 410.e6-7. 2007
    ..To select an optimal early (<20 weeks) marker, we prospectively compared 3 serum markers examined simultaneously in a single cohort...
  13. pmc Bioavailable vitamin D is more tightly linked to mineral metabolism than total vitamin D in incident hemodialysis patients
    Ishir Bhan
    Division of Nephrology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Kidney Int 82:84-9. 2012
    ..Hence, bioavailable vitamin D levels are better correlated with measures of mineral metabolism than total levels in patients on hemodialysis...
  14. doi request reprint Does vitamin D modulate blood pressure?
    Hector Tamez
    Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA
    Curr Opin Nephrol Hypertens 22:204-9. 2013
    ..This article provides an overview of the data, with special emphasis on the work published in the last 2 years...
  15. pmc Carbamylation of serum albumin and erythropoietin resistance in end stage kidney disease
    Sahir Kalim
    Department of Medicine, Division of Nephrology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, Department of Pathology, Division of Clinical Chemistry and, Department of Medicine, Division of Nephrology and Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts
    Clin J Am Soc Nephrol 8:1927-34. 2013
    ..The hypothesis of this study is that carbamylation burden is independently associated with erythropoietin resistance...
  16. ncbi request reprint Preeclampsia and future cardiovascular disease: potential role of altered angiogenesis and insulin resistance
    Myles Wolf
    Renal Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 89:6239-43. 2004
    ..Women with a history of preeclampsia demonstrate altered expression of angiogenesis-related proteins and increased HOMA(IR) more than 1 yr postpartum. These factors may contribute to their risk of future CVD...
  17. pmc Clinical measures identify vitamin D deficiency in dialysis
    Ishir Bhan
    Department of Medicine, Massachusetts General Hospital, 50 Staniford Street, Suite 750, Boston, MA 02114, USA
    Clin J Am Soc Nephrol 5:460-7. 2010
    ..This study was conducted to determine whether routinely measured clinical and demographic parameters could identify dialysis patients who are vitamin D deficient...
  18. pmc First trimester vitamin D, vitamin D binding protein, and subsequent preeclampsia
    Camille E Powe
    Division of Nephrology, Massachusetts General Hospital and Harvard Medical School, Boston, Mass 02114, USA
    Hypertension 56:758-63. 2010
    ..These data suggest that first trimester total and free 25(OH)D levels are not independently associated with first trimester blood pressure or subsequent preeclampsia...
  19. doi request reprint Vitamin D and hypertension: an update and review
    Hector Tamez
    Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Curr Opin Nephrol Hypertens 21:492-9. 2012
    ..Vitamin D deficiency and hypertension are highly prevalent. This review will discuss the association between vitamin D deficiency and blood pressure...
  20. pmc Vitamin D therapy in chronic kidney disease and end stage renal disease
    Michal L Melamed
    Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Clin J Am Soc Nephrol 7:358-65. 2012
    ..This review discusses observational and available clinical trial evidence about the effects of both calcitriol and vitamin D analogs (active) and ergocalciferol and cholecalciferol (nutritional) vitamin D in patients with CKD and ESRD...
  21. pmc Chronic kidney disease, hypovitaminosis D, and mortality in the United States
    Rajnish Mehrotra
    Division of Nephrology and Hypertension, Department of Medicine, Los Angeles Biomedical Research Institute, Torrance, California 90502, USA
    Kidney Int 76:977-83. 2009
    ..Randomized, controlled trials are needed to conclusively determine whether vitamin D supplementation reduces mortality...
  22. ncbi request reprint First trimester insulin resistance and subsequent preeclampsia: a prospective study
    Myles Wolf
    Renal Unit, Departments of Medicine and Obstetrics and Gynecology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 87:1563-8. 2002
    ..First trimester SHBG levels may be a useful biomarker for preeclampsia, especially among lean women who otherwise would be perceived to be at low risk...
  23. pmc Fibroblast growth factor 23 and mortality among patients undergoing hemodialysis
    ORLANDO M GUTIERREZ
    Renal Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    N Engl J Med 359:584-92. 2008
    ..Hyperphosphatemia and low 1,25-dihydroxyvitamin D levels are associated with mortality among patients with chronic kidney disease, but the effect of the level of FGF-23 on mortality is unknown...
  24. doi request reprint Vitamin D status of newborns in New Zealand
    Carlos A Camargo
    Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, 326 Cambridge Street, Suite 410, Boston, MA 02114, USA
    Br J Nutr 104:1051-7. 2010
    ..Although the optimal timing and dosage of vitamin D supplementation require further study, our findings may assist future efforts to correct low levels of 25(OH)D among New Zealand mothers and their newborn children...
  25. ncbi request reprint Inflammation and glucose intolerance: a prospective study of gestational diabetes mellitus
    Myles Wolf
    Renal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Diabetes Care 27:21-7. 2004
    ..Although gestational diabetes mellitus (GDM) and type 2 diabetes share certain pathophysiological mechanisms, few studies have examined inflammation and risk of GDM...
  26. pmc Impact of activated vitamin D and race on survival among hemodialysis patients
    Myles Wolf
    Renal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Am Soc Nephrol 19:1379-88. 2008
    ..Further studies should determine whether treatment differences based on biologic differences contribute to disparities in other conditions...
  27. ncbi request reprint Moderate alcohol consumption and lower levels of inflammatory markers in US men and women
    Jennifer K Pai
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Atherosclerosis 186:113-20. 2006
    ..Moderate alcohol consumption is associated with substantially lower risk of cardiovascular disease (CVD). We assessed the relationship between alcohol intake and inflammatory markers to partially explain this beneficial effect...
  28. pmc Modeling the 4D Study: statins and cardiovascular outcomes in long-term hemodialysis patients with diabetes
    Kevin E Chan
    Fresenius Medical Care North America, Waltham, Massachusetts, USA
    Clin J Am Soc Nephrol 5:856-66. 2010
    ....
  29. doi request reprint Dietary vitamin D intake in advanced CKD/ESRD
    Ishir Bhan
    Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA
    Semin Dial 23:407-10. 2010
    ..This article reviews vitamin D metabolism, emerging new roles for vitamin D, and data surrounding the potential importance of nutritional sources of vitamin D in the management of patients with CKD...
  30. ncbi request reprint First-trimester C-reactive protein and subsequent gestational diabetes
    Myles Wolf
    Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Diabetes Care 26:819-24. 2003
    ..We tested the hypothesis that increased inflammation, measured early in pregnancy, is associated with the subsequent development of gestational diabetes mellitus (GDM), a precursor of type 2 diabetes...
  31. doi request reprint Targeted ablation of the vitamin D 1alpha-hydroxylase gene: getting to the heart of the matter
    Ravi Thadhani
    Renal Unit and the Center for D Receptor Activation Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Kidney Int 74:141-3. 2008
    ..In a study by Zhou et al., ablation of the 1alpha-hydroxylase gene led to hypertension, cardiac hypertrophy, and systolic dysfunction, and this cardiac phenotype was rescued with exogenous 1,25-dihydroxyvitamin D administration...
  32. doi request reprint Activated vitamin D sterols in kidney disease
    Ravi Thadhani
    Renal Unit and Center for D Receptor Activation Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Lancet 371:542-4. 2008
  33. ncbi request reprint Early pregnancy insulin resistance and subsequent gestational diabetes mellitus
    Karen V Smirnakis
    GRB 1003, Renal Unit, Department of Medicine, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA
    Diabetes Care 28:1207-8. 2005
  34. ncbi request reprint Postpartum diabetes screening in women with a history of gestational diabetes
    Karen V Smirnakis
    Renal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Obstet Gynecol 106:1297-303. 2005
    ..We sought to examine postpartum glycemic testing in women diagnosed with GDM...
  35. pmc Plasma gelsolin and circulating actin correlate with hemodialysis mortality
    Po Shun Lee
    Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Am Soc Nephrol 20:1140-8. 2009
    ..9 to 33.5). Worsening renal function correlated with pGSN decline in 53 subjects with CKD not on dialysis. In summary, low pGSN and detectable circulating actin identify chronic hemodialysis patients at highest risk for 1-yr mortality...
  36. ncbi request reprint Differential risk of hypertensive disorders of pregnancy among Hispanic women
    Myles Wolf
    Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Am Soc Nephrol 15:1330-8. 2004
    ..The initial presentation of hypertension during pregnancy in Hispanic women most likely represents early preeclampsia...
  37. ncbi request reprint Prevalence of cardiovascular risk factors and the serum levels of 25-hydroxyvitamin D in the United States: data from the Third National Health and Nutrition Examination Survey
    David Martins
    Department of Medicine, Charles R Drew University of Medicine and Science, Los Angeles, Calif, 90262, USA
    Arch Intern Med 167:1159-65. 2007
    ..Results of several epidemiologic and clinical studies have suggested that there is an excess risk of hypertension and diabetes mellitus in persons with suboptimal intake of vitamin D...
  38. pmc Plasma concentrations of soluble endoglin versus standard evaluation in patients with suspected preeclampsia
    Sarosh Rana
    Division of Maternal Fetal Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    PLoS ONE 7:e48259. 2012
    ....
  39. pmc Conversion of peripheral blood NK cells to a decidual NK-like phenotype by a cocktail of defined factors
    Ana Sofia Cerdeira
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Immunol 190:3939-48. 2013
    ..These findings have potential therapeutic applications for placental disorders associated with altered NK cell biology...
  40. pmc First-trimester follistatin-like-3 levels in pregnancies complicated by subsequent gestational diabetes mellitus
    Ravi Thadhani
    Division of Nephrology, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts, USA
    Diabetes Care 33:664-9. 2010
    ..30, P < 0.001). CONCLUSIONS First-trimester FSTL3 levels are associated with glucose intolerance and GDM later in pregnancy...
  41. pmc Metabolite profiling identifies markers of uremia
    Eugene P Rhee
    Massachusetts General Hospital, 149 13th Street, 8th Floor, Boston, MA, USA
    J Am Soc Nephrol 21:1041-1051. 2010
    ..In summary, this study demonstrates the application of metabolite profiling to identify markers of ESRD, provide perspective on uremic dyslipidemia, and broaden our understanding of the biochemical effects of hemodialysis...
  42. ncbi request reprint Beyond minerals and parathyroid hormone: role of active vitamin D in end-stage renal disease
    Myles Wolf
    Renal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Semin Dial 18:302-6. 2005
    ..Several of these nontraditional actions are reviewed with an emphasis on those that might impact hemodialysis outcomes...
  43. ncbi request reprint Circulating levels of the antiangiogenic marker sFLT-1 are increased in first versus second pregnancies
    Myles Wolf
    Renal Unit, Department of Medicine, Massachusetts General Hospital and the Renal Division, Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston 02114, USA
    Am J Obstet Gynecol 193:16-22. 2005
    ..Additional studies are needed to verify these findings and to further examine ethnic differences in angiogenesis factors and their potential impact on the incidence of preeclampsia...
  44. ncbi request reprint End-stage renal disease in patients with Fabry disease
    Gregorio T Obrador
    Division of Nephrology, New England Medical Center, Boston, Massachusetts, USA
    J Am Soc Nephrol 13:S144-6. 2002
  45. doi request reprint Low plasma level of cathelicidin antimicrobial peptide (hCAP18) predicts increased infectious disease mortality in patients undergoing hemodialysis
    Adrian F Gombart
    Department of Medicine, Division of Hematology Oncology, Cedars Sinai Medical Center, David Geffen School of Medicine at Univeristy of California, Los Angeles, USA
    Clin Infect Dis 48:418-24. 2009
    ....
  46. ncbi request reprint Soluble Fms-like tyrosine kinase 1 and endothelial dysfunction in the pathogenesis of preeclampsia
    Sharon E Maynard
    Department of Medicine, University of Massachusetts Medical School, Worcester 01655, USA
    Pediatr Res 57:1R-7R. 2005
    ....
  47. pmc Anticoagulant and antiplatelet usage associates with mortality among hemodialysis patients
    Kevin E Chan
    Fresenius Medical Care NA, Waltham, Massachusetts, USA
    J Am Soc Nephrol 20:872-81. 2009
    ..Given the possibility of confounding by indication, randomized trials are needed to determine definitively the risk and benefit of these medications...
  48. ncbi request reprint Activated injectable vitamin D and hemodialysis survival: a historical cohort study
    Ming Teng
    Fresenius Medical Care North America, Lexington, Massachusetts, USA
    J Am Soc Nephrol 16:1115-25. 2005
    ..Randomized clinical trials would permit definitive conclusions...
  49. ncbi request reprint Prospective study of moderate alcohol consumption and risk of hypertension in young women
    Ravi Thadhani
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, 181 Longwood Ave, Boston, MA 02115, USA
    Arch Intern Med 162:569-74. 2002
    ..However, the effect of moderate alcohol consumption; the specific effects of wine, beer, and liquor; and the pattern of drinking in relation to risk of hypertension among young women are unclear...
  50. doi request reprint The potential role of plasma gelsolin in dialysis-related protein-energy wasting
    Po Shun Lee
    Brigham and Women s Hospital, Boston, Mass, USA
    Blood Purif 29:99-101. 2010
    ..Therefore, pGSN deficiency appears to be a powerful biomarker and a potential therapeutic target in CKD patients...
  51. doi request reprint Early-pregnancy soluble Fas levels in idiopathic small-for-gestational-age pregnancies
    Guy Steinberg
    Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Am J Obstet Gynecol 202:299.e1-7. 2010
    ..We sought to determine first- and second-trimester serum soluble Fas (sFas) and placental growth factor (PlGF) levels in idiopathic small-for-gestational-age (SGA) pregnancies...
  52. pmc Soluble erythropoietin receptor contributes to erythropoietin resistance in end-stage renal disease
    Eliyahu V Khankin
    Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 5:e9246. 2010
    ..Erythropoietin acts through the erythropoietin receptor (EpoR) present in erythroblasts. Alternative mRNA splicing produces a soluble form of EpoR (sEpoR) found in human blood, however its role in anemia is not known...
  53. ncbi request reprint Cohort studies: marching forward
    Ravi Thadhani
    Renal Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Clin J Am Soc Nephrol 1:1117-23. 2006
  54. doi request reprint Vascular calcification and ESRD: a hard target
    Ishir Bhan
    Department of Medicine, Massachusetts General Hospital, Bullfinch 127, Boston, MA 02114, USA
    Clin J Am Soc Nephrol 4:S102-5. 2009
    ..Reviewed here is the current state of research on the biology and the significance of vascular calcification in ESRD, the role of vitamin D therapy in its development, and options for management...
  55. doi request reprint N-terminal pro-B-type natriuretic peptide (NT-proBNP) concentrations in hemodialysis patients: prognostic value of baseline and follow-up measurements
    ORLANDO M GUTIERREZ
    Nephrology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Clin Chem 54:1339-48. 2008
    ..Previous studies focused on prevalent dialysis patients and examined single measurements of NT-proBNP in time...
  56. doi request reprint Vitamin D therapy for chronic kidney disease
    Ishir Bhan
    Department of Medicine, Renal Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Semin Nephrol 29:85-93. 2009
    ..This article reviews the role of vitamin D therapy in CKD and looks to the answers that future research may bring...
  57. pmc Phosphorus binders and survival on hemodialysis
    Tamara Isakova
    Renal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Am Soc Nephrol 20:388-96. 2009
    ..Although confirmatory studies are needed in the dialysis setting, future placebo-controlled, randomized trials of phosphorus binders might focus on predialysis patients with chronic kidney disease and normal serum phosphate levels...
  58. ncbi request reprint Effects of short daily versus conventional hemodialysis on left ventricular hypertrophy and inflammatory markers: a prospective, controlled study
    Juan Carlos Ayus
    Division of Nephrology, Texas Diabetes Institute, University of Texas Health Science Center San Antonio, San Antonio, TX 78229 3900, USA
    J Am Soc Nephrol 16:2778-88. 2005
    ..Future trials are needed to determine whether short daily hemodialysis can reduce morbidity and mortality in this high-risk population...
  59. doi request reprint Shining light on vitamin D trials in chronic kidney disease
    Sagar U Nigwekar
    Division of Nephrology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Kidney Int 83:198-200. 2013
    ..However, recent randomized controlled trials have tempered enthusiasm. We appraise a trial by de Boer et al. that addresses effects of paricalcitol on glucose metabolism in CKD, and offer perspectives on future trials...
  60. pmc Shorter dialysis times are associated with higher mortality among incident hemodialysis patients
    Steven M Brunelli
    Renal Division, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Kidney Int 77:630-6. 2010
    ..Further studies are needed to confirm these findings and determine causality...
  61. ncbi request reprint Prediction of diabetic nephropathy using urine proteomic profiling 10 years prior to development of nephropathy
    Hasan H Otu
    Genomics Center and DF HCC Cancer Proteomics Core, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes Care 30:638-43. 2007
    ..We examined whether proteomic technologies identify novel urine proteins associated with subsequent development of diabetic nephropathy in subjects with type 2 diabetes before evidence of microalbuminuria...
  62. doi request reprint Second trimester insulin resistance, early pregnancy body mass index and gestational weight gain
    Alison M Stuebe
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Boston, MA, USA
    Matern Child Health J 14:254-60. 2010
    ..Because prior work suggests an association between high insulin concentrations in early pregnancy and excess gestational weight gain, we examined such associations in a prospective cohort...
  63. pmc Activated vitamin D attenuates left ventricular abnormalities induced by dietary sodium in Dahl salt-sensitive animals
    Natalya Bodyak
    Cardiovascular Division and Division of Nephrology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 104:16810-5. 2007
    ..In summary, PC attenuates the development of LV alterations in DSS rats, and these effects should be examined in human clinical trials...
  64. doi request reprint Risk for developing gestational diabetes in women with twin pregnancies
    Jose A Rauh-Hain
    Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Matern Fetal Neonatal Med 22:293-9. 2009
    ..To examine the risk of developing gestational diabetes mellitus (GDM) in women with twin compared with singleton pregnancies...
  65. ncbi request reprint Vitamin D in patients with kidney disease: cautiously optimistic
    Ravi Thadhani
    Center for D receptor Activation Research and Renal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Adv Chronic Kidney Dis 14:22-6. 2007
    ..If consistent with the recent observations, these studies may provide nephrologists with an intervention to alter the otherwise poor outcomes in patients with kidney disease...
  66. pmc Vitamin D in patients with renal failure: a summary of observational mortality studies and steps moving forward
    Myles Wolf
    Renal Unit, Department of Medicine, Massachusetts General Hospital Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
    J Steroid Biochem Mol Biol 103:487-90. 2007
    ..Potential steps moving forward in light of these observational studies are subsequently discussed...
  67. ncbi request reprint Fabry disease in genetic counseling practice: recommendations of the National Society of Genetic Counselors
    Robin L Bennett
    Department of Medicine, Division of Medical Genetics, University of Washington Medical Center, Box 357720, Seatlle, Washington 98195 7720, USA
    J Genet Couns 11:121-46. 2002
    ..The professional judgment of a healthcare provider, familiar with the facts and circumstances of a specific case, will always supersede these recommendations...
  68. pmc Klotho variants and chronic hemodialysis mortality
    David J Friedman
    Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
    J Bone Miner Res 24:1847-55. 2009
    ..Our data suggest that a specific Klotho variant (rs577912) is linked to survival in ESRD patients initiating chronic hemodialysis and that therapy with activated vitamin D may modify this risk...
  69. ncbi request reprint Kidney Injury Molecule-1 (KIM-1): a novel biomarker for human renal proximal tubule injury
    Won K Han
    Medical Services, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA
    Kidney Int 62:237-44. 2002
    ..The ectodomain of KIM-1 is shed from cells. The current studies were carried out to evaluate whether KIM-1 is present in human acute renal failure and might serve as a urinary marker of acute renal tubular injury...
  70. pmc Human kidney injury molecule-1 is a tissue and urinary tumor marker of renal cell carcinoma
    Won K Han
    Renal Division, Brigham and Women s Hospital, Medical Service, Massachusetts General Hospital, Boston, USA
    J Am Soc Nephrol 16:1126-34. 2005
    ..In conclusion, the cleaved ectodomain of hKIM-1 can be detected in the urine of patients with RCC and may serve as a new biomarker for early detection of RCC...
  71. doi request reprint Association between long-term blood pressure variability and mortality among incident hemodialysis patients
    Steven M Brunelli
    Renal, Electrolyte, and Hypertension Division, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Am J Kidney Dis 52:716-26. 2008
    ..The purposes of this study are to identify a suitable metric of long-term BPV in this population and determine whether an association between BPV and all-cause mortality exists...
  72. ncbi request reprint Hypertension during pregnancy: a disorder begging for pathophysiological support
    RAVI I THADHANI
    Hypertension 46:1250-1. 2005