Giuseppina Tesco

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Growth properties and growth factor responsiveness in skin fibroblasts from centenarians
    G Tesco
    Department of Neurological and Psychiatric Sciences, University of Florence, Italy
    Biochem Biophys Res Commun 244:912-6. 1998
  2. pmc Depletion of GGA3 stabilizes BACE and enhances beta-secretase activity
    Giuseppina Tesco
    Genetics and Aging Research Unit, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Neuron 54:721-37. 2007
  3. ncbi request reprint Ubiquilin 1 modulates amyloid precursor protein trafficking and Abeta secretion
    Mikko Hiltunen
    Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Charlestown, MA 02129, USA
    J Biol Chem 281:32240-53. 2006
  4. ncbi request reprint Hypocapnia induces caspase-3 activation and increases Abeta production
    Zhongcong Xie
    Genetics and Aging Research Unit, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown 02129 4404, USA
    Neurodegener Dis 1:29-37. 2004
  5. ncbi request reprint BACE is degraded via the lysosomal pathway
    Young Ho Koh
    Genetics and Aging Research Unit, Massachusetts General Hospital, Charlestown, 02129, USA
    J Biol Chem 280:32499-504. 2005
  6. pmc Reduced amyloidogenic processing of the amyloid beta-protein precursor by the small-molecule Differentiation Inducing Factor-1
    Michael A Myre
    Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Cell Signal 21:567-76. 2009
  7. ncbi request reprint APP substitutions V715F and L720P alter PS1 conformation and differentially affect Abeta and AICD generation
    Giuseppina Tesco
    Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Charlestown, Massachusetts 02129 4404, USA
    J Neurochem 95:446-56. 2005
  8. ncbi request reprint Generation of the beta-amyloid peptide and the amyloid precursor protein C-terminal fragment gamma are potentiated by FE65L1
    Yang Chang
    Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129 4404, USA
    J Biol Chem 278:51100-7. 2003
  9. pmc Potential late-onset Alzheimer's disease-associated mutations in the ADAM10 gene attenuate {alpha}-secretase activity
    Minji Kim
    MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Hum Mol Genet 18:3987-96. 2009
  10. pmc Age-dependent effect of apolipoprotein E4 on functional outcome after controlled cortical impact in mice
    Rebekah C Mannix
    Division of Emergency Medicine, Department of Medicine, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Cereb Blood Flow Metab 31:351-61. 2011

Research Grants

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Growth properties and growth factor responsiveness in skin fibroblasts from centenarians
    G Tesco
    Department of Neurological and Psychiatric Sciences, University of Florence, Italy
    Biochem Biophys Res Commun 244:912-6. 1998
    ..On the whole, our data challenge the tenet of a simple and strict relationship between in vivo aging and in vitro proliferative capability of human fibroblasts, at least at the individual level...
  2. pmc Depletion of GGA3 stabilizes BACE and enhances beta-secretase activity
    Giuseppina Tesco
    Genetics and Aging Research Unit, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Neuron 54:721-37. 2007
    ..In summary, we have elucidated a GGA3-dependent mechanism regulating BACE levels and beta-secretase activity. This mechanism may explain increased cerebral levels of BACE and Abeta following cerebral ischemia and existing in AD...
  3. ncbi request reprint Ubiquilin 1 modulates amyloid precursor protein trafficking and Abeta secretion
    Mikko Hiltunen
    Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Charlestown, MA 02129, USA
    J Biol Chem 281:32240-53. 2006
    ..These findings suggest that changes in UBQLN1 steady-state levels affect APP trafficking and processing, thereby influencing the generation of Abeta...
  4. ncbi request reprint Hypocapnia induces caspase-3 activation and increases Abeta production
    Zhongcong Xie
    Genetics and Aging Research Unit, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown 02129 4404, USA
    Neurodegener Dis 1:29-37. 2004
    ..Mutant forms of PS1 have been shown to sensitize cells to apoptotic cell death...
  5. ncbi request reprint BACE is degraded via the lysosomal pathway
    Young Ho Koh
    Genetics and Aging Research Unit, Massachusetts General Hospital, Charlestown, 02129, USA
    J Biol Chem 280:32499-504. 2005
    ..Collectively, our data indicate that BACE is transported to the late endosomal/lysosomal compartments where it is degraded via the lysosomal pathway and that the di-leucine motif plays a role in sorting BACE to lysosomes...
  6. pmc Reduced amyloidogenic processing of the amyloid beta-protein precursor by the small-molecule Differentiation Inducing Factor-1
    Michael A Myre
    Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Cell Signal 21:567-76. 2009
    ..Our findings suggest that DIF-1 affects G0/G1-associated amyloidogenic processing of APP by a gamma-secretase-, proteasome- and calpain-insensitive pathway, and that this effect requires the presence of residue Thr668...
  7. ncbi request reprint APP substitutions V715F and L720P alter PS1 conformation and differentially affect Abeta and AICD generation
    Giuseppina Tesco
    Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Charlestown, Massachusetts 02129 4404, USA
    J Neurochem 95:446-56. 2005
    ..In conclusion, both APPV715F and APPL720P change PS1 conformation with differential effects on Abeta and AICD production...
  8. ncbi request reprint Generation of the beta-amyloid peptide and the amyloid precursor protein C-terminal fragment gamma are potentiated by FE65L1
    Yang Chang
    Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129 4404, USA
    J Biol Chem 278:51100-7. 2003
    ..Finally, although FE65L1 increases APP C-terminal domain production, it does not mediate the APP-dependent transcriptional activation observed with FE65...
  9. pmc Potential late-onset Alzheimer's disease-associated mutations in the ADAM10 gene attenuate {alpha}-secretase activity
    Minji Kim
    MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Hum Mol Genet 18:3987-96. 2009
    ..5-3.5-fold) in cell-based studies. In summary, we provide the first evidence of ADAM10 as a candidate AD susceptibility gene, and report two potentially pathogenic mutations with incomplete penetrance for late-onset familial AD...
  10. pmc Age-dependent effect of apolipoprotein E4 on functional outcome after controlled cortical impact in mice
    Rebekah C Mannix
    Division of Emergency Medicine, Department of Medicine, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Cereb Blood Flow Metab 31:351-61. 2011
    ..The data suggest age-dependent effects of APOE4 on cognitive outcome after TBI, and that therapies targeting APOE4 may be more effective in adults versus children with TBI...
  11. ncbi request reprint Caspase activation increases beta-amyloid generation independently of caspase cleavage of the beta-amyloid precursor protein (APP)
    Giuseppina Tesco
    Genetics and Aging Research Unit, Center for Aging, Genetics and Neurodegeneration, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachussetts 02129, USA
    J Biol Chem 278:46074-80. 2003
    ..These findings indicate that the enhanced Abeta generation associated with apoptosis does not require cleavage of APP at its C-terminal (Asp720) and/or N-terminal caspase sites...

Research Grants1

  1. Role of BACE stabilization in Alzheimer's Disease (AD)
    Giuseppina Tesco; Fiscal Year: 2007
    ..abstract_text> ..