Research Topics
Genomes and GenesSpecies | Giuseppina TescoSummaryAffiliation: Harvard University Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Growth properties and growth factor responsiveness in skin fibroblasts from centenariansG Tesco
Department of Neurological and Psychiatric Sciences, University of Florence, Italy
Biochem Biophys Res Commun 244:912-6. 1998..On the whole, our data challenge the tenet of a simple and strict relationship between in vivo aging and in vitro proliferative capability of human fibroblasts, at least at the individual level...
Depletion of GGA3 stabilizes BACE and enhances beta-secretase activityGiuseppina Tesco
Genetics and Aging Research Unit, Massachusetts General Hospital, Charlestown, MA 02129, USA
Neuron 54:721-37. 2007..In summary, we have elucidated a GGA3-dependent mechanism regulating BACE levels and beta-secretase activity. This mechanism may explain increased cerebral levels of BACE and Abeta following cerebral ischemia and existing in AD...- Ubiquilin 1 modulates amyloid precursor protein trafficking and Abeta secretionMikko Hiltunen
Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Charlestown, MA 02129, USA
J Biol Chem 281:32240-53. 2006..These findings suggest that changes in UBQLN1 steady-state levels affect APP trafficking and processing, thereby influencing the generation of Abeta... 
Reduced amyloidogenic processing of the amyloid beta-protein precursor by the small-molecule Differentiation Inducing Factor-1Michael A Myre
Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Cell Signal 21:567-76. 2009..Our findings suggest that DIF-1 affects G0/G1-associated amyloidogenic processing of APP by a gamma-secretase-, proteasome- and calpain-insensitive pathway, and that this effect requires the presence of residue Thr668...- Hypocapnia induces caspase-3 activation and increases Abeta productionZhongcong Xie
Genetics and Aging Research Unit, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown 02129-4404, USA
Neurodegener Dis 1:29-37. 2004..Hypocapnia (5 and 20 mm Hg CO2 for 6 h) also led to an increased Abeta production. CONCLUSION: The findings suggest that hypocapnia (e.g. during general anesthesia) could exacerbate AD neuropathogenesis... - BACE is degraded via the lysosomal pathwayYoung Ho Koh
Genetics and Aging Research Unit, Massachusetts General Hospital, Charlestown, 02129, USA
J Biol Chem 280:32499-504. 2005..Collectively, our data indicate that BACE is transported to the late endosomal/lysosomal compartments where it is degraded via the lysosomal pathway and that the di-leucine motif plays a role in sorting BACE to lysosomes... - APP substitutions V715F and L720P alter PS1 conformation and differentially affect Abeta and AICD generationGiuseppina Tesco
Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Charlestown, Massachusetts 02129-4404, USA
J Neurochem 95:446-56. 2005..In conclusion, both APPV715F and APPL720P change PS1 conformation with differential effects on Abeta and AICD production... - Generation of the beta-amyloid peptide and the amyloid precursor protein C-terminal fragment gamma are potentiated by FE65L1Yang Chang
Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129 4404, USA
J Biol Chem 278:51100-7. 2003..Finally, although FE65L1 increases APP C-terminal domain production, it does not mediate the APP-dependent transcriptional activation observed with FE65... - Potential late-onset Alzheimer's disease-associated mutations in the ADAM10 gene attenuate {alpha}-secretase activityMinji Kim
MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
Hum Mol Genet 18:3987-96. 2009..5-3.5-fold) in cell-based studies. In summary, we provide the first evidence of ADAM10 as a candidate AD susceptibility gene, and report two potentially pathogenic mutations with incomplete penetrance for late-onset familial AD... - Age-dependent effect of apolipoprotein E4 on functional outcome after controlled cortical impact in miceRebekah C Mannix
Division of Emergency Medicine, Department of Medicine, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
J Cereb Blood Flow Metab 31:351-61. 2011..The data suggest age-dependent effects of APOE4 on cognitive outcome after TBI, and that therapies targeting APOE4 may be more effective in adults versus children with TBI... - Caspase activation increases beta-amyloid generation independently of caspase cleavage of the beta-amyloid precursor protein (APP)Giuseppina Tesco
Genetics and Aging Research Unit, Center for Aging, Genetics and Neurodegeneration, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachussetts 02129, USA
J Biol Chem 278:46074-80. 2003..These findings indicate that the enhanced Abeta generation associated with apoptosis does not require cleavage of APP at its C-terminal (Asp720) and/or N-terminal caspase sites...
Research Grants
- Role of BACE stabilization in Alzheimer's Disease (AD)Giuseppina Tesco; Fiscal Year: 2007..abstract_text> ..