Research Topics
| Guillermo TearneySummaryAffiliation: Harvard University Country: USA Publications
Research Grants
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Detail Information
Publications
Miniature grating for spectrally-encoded endoscopyDongKyun Kang
Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
Lab Chip 13:1810-6. 2013..In addition to providing high quality imaging SEE optics, the soft lithography method allows cost-effective and reliable fabrication of these miniature endoscopes, which will facilitate the clinical translation of SEE technology...
Quantification of macrophage content in atherosclerotic plaques by optical coherence tomographyGuillermo J Tearney
Wellman Laboratories of Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, Mass 02114, USA
Circulation 107:113-9. 2003..The aim of this study was to investigate the use of OCT for identifying macrophages in fibrous caps...- Fluorescence interferometry: principles and applications in biologyAlberto Bilenca
Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, 50 Blossom St, BAR 720, Boston, Massachusetts 02114, USA
Ann N Y Acad Sci 1130:68-77. 2008..Finally, we point out future research directions in fluorescence interferometry, such as fluorescence tomography of whole organisms and the extension to molecular interferometry by means of quantum dots and bioluminescence... 
Measurement of fibrous cap thickness in atherosclerotic plaques by spatiotemporal analysis of laser speckle imagesSeemantini K Nadkarni
Massachusetts General Hospital, Harvard Medical School, Wellman Center for Photomedicine, Boston, Massachusetts 02114, USA
J Biomed Opt 11:021006. 2006..4). These results demonstrate that spatio-temporal LSI may allow the estimation of fibrous cap thickness in NCFAs, which is an important predictor of plaque stability...- Diagnostic accuracy of optical coherence tomography and integrated backscatter intravascular ultrasound images for tissue characterization of human coronary plaquesMasanori Kawasaki
Wellman Laboratories of Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
J Am Coll Cardiol 48:81-8. 2006.... - Differential near-field scanning optical microscopyAydogan Ozcan
Wellman Center for Photomedicine, Harvard Medical School, Boston, Massachusetts 02114, USA
Nano Lett 6:2609-16. 2006..Principles of DNSOM can also be extended to other aperture/detector geometries such as triangles and parallelograms... - In vivo association between positive coronary artery remodelling and coronary plaque characteristics assessed by intravascular optical coherence tomographyOwen Christopher Raffel
Cardiology Division, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, GRB 800, Boston, MA 02114, USA
Eur Heart J 29:1721-8. 2008..OCT is a unique imaging modality capable of characterizing these important morphological features of vulnerable plaque... - Identifying intestinal metaplasia at the squamocolumnar junction by using optical coherence tomographyJohn A Evans
Gastrointestinal Unit, Massachusetts General Hospital, Boston, Massachusetts, USA
Gastrointest Endosc 65:50-6. 2007..The accuracy of OCT for differentiating tissue types at the squamocolumnar junction (SCJ) has not been established... - Comprehensive esophageal microscopy by using optical frequency-domain imaging (with video)Benjamin J Vakoc
Wellman Center for Photomedicine, Department of Dermatology, Massachusetts General Hospital, Harvard MIT Division of Health Sciences and Technology, Boston, Massachusetts, USA
Gastrointest Endosc 65:898-905. 2007..However, the relatively slow image-acquisition rate of the present OCT systems inhibits wide-field imaging and limits the clinical utility of OCT for diagnostic imaging in patients with Barrett's esophagus... - Measurement of collagen and smooth muscle cell content in atherosclerotic plaques using polarization-sensitive optical coherence tomographySeemantini K Nadkarni
Department of Dermatology, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, USA
J Am Coll Cardiol 49:1474-81. 2007..The purpose of this study was to investigate the measurement of collagen and smooth muscle cell (SMC) content in atherosclerotic plaques using polarization-sensitive optical coherence tomography (PSOCT)... - Relationship between a systemic inflammatory marker, plaque inflammation, and plaque characteristics determined by intravascular optical coherence tomographyO Christopher Raffel
Cardiology Division, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
Arterioscler Thromb Vasc Biol 27:1820-7. 2007.... - Comparison of coronary plaque characteristics between diabetic and non-diabetic subjects: An in vivo optical coherence tomography studyStanley Chia
Cardiology Division, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street GRB 800, Boston, MA, United States
Diabetes Res Clin Pract 81:155-60. 2008..Using OCT imaging, we compared in vivo plaque characteristics between diabetic and non-diabetic subjects... - Speckle reduction in optical coherence tomography images using digital filteringAydogan Ozcan
Harvard Medical School, Massachusetts General Hospital, Boston 02114, USA
J Opt Soc Am A Opt Image Sci Vis 24:1901-10. 2007..Our results suggest that by using these digital filters, the number of individual angles required to attain a certain level of speckle reduction can be decreased... - Backscattering spectroscopic contrast with angle-resolved optical coherence tomographyAdrien E Desjardins
Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, Boston 02114, USA
Opt Lett 32:3158-60. 2007..High levels of speckle noise reduction achieved by angular compounding increased the spatial resolution at which backscattering spectra could be accurately differentiated... - Optical coherence tomography for imaging the vulnerable plaqueGuillermo J Tearney
Wellman Center for Photomedicine, Department of Pathology, Massachusetts General Hospital, 50 Blossom Street, BAR703, Boston, Massachusetts 02114, USA
J Biomed Opt 11:021002. 2006.... - Technology Insight: optical coherence tomography--current status and future developmentAdrian F Low
Cardiology Division at the Massachusetts General Hospital, Boston, MA 02114, USA
Nat Clin Pract Cardiovasc Med 3:154-62; quiz 172. 2006..Here, we discuss results from clinical studies which indicate that optical coherence tomography is a promising imaging technique for improved characterization of the coronary atherosclerotic plaque... - Fourier fluorescence spectrometer for excitation emission matrix measurementLeilei Peng
Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, 55 Fruit Street, BAR 708, Massachusetts 02114, USA
Opt Express 16:10493-500. 2008..The system provides a wide spectral range, adjustable spectral resolution, and fast EEM acquisition speed, which allows EEM's to be acquired in 40 seconds at a spectral resolution of 81-cm-1... - Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: comparison with intravascular ultrasoundIk Kyung Jang
Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Am Coll Cardiol 39:604-9. 2002..The aim of this study was to evaluate the feasibility and the ability of intravascular optical coherence tomography (OCT) to visualize the components of coronary plaques in living patients... - Characterization of human atherosclerosis by optical coherence tomographyHiroshi Yabushita
Cardiology Division, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
Circulation 106:1640-5. 2002..These results represent an important step in validating this new intravascular imaging modality and will provide a basis for the interpretation of intracoronary OCT images obtained from patients... - Improved signal-to-noise ratio in spectral-domain compared with time-domain optical coherence tomographyJohannes F de Boer
Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, 50 Blossom Street, BAR 724, Boston, Massachusetts 02114, USA
Opt Lett 28:2067-9. 2003..A significant SNR gain of several hundredfold is found for acquisition in the spectral domain. The SNR benefit is demonstrated experimentally in a hybrid time-domain-spectral-domain OCT system... - In vivo human retinal imaging by ultrahigh-speed spectral domain optical coherence tomographyNader Nassif
Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, 50 Blossom Street, BAR 724, Boston, Massachusetts 02114, USA
Opt Lett 29:480-2. 2004..In vivo images of the human retina are presented, demonstrating the ability to acquire high-quality structural images with an axial resolution of 6 microm at ultrahigh speed and with an ocular exposure level of less than 600 microW... - Focal and multi-focal plaque macrophage distributions in patients with acute and stable presentations of coronary artery diseaseBriain D Macneill
Cardiology Division, Harvard Medical School, Boston, Massachusetts, USA
J Am Coll Cardiol 44:972-9. 2004..By providing a means of detecting increases in plaque macrophage content before an acute event, this technique may aid in determining prognosis and guiding preventive therapy... - Mechanical analysis of atherosclerotic plaques based on optical coherence tomographyAlexandra H Chau
Department of Mechanical Engineering and Biological Engineering Division, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Ann Biomed Eng 32:1494-503. 2004..Our results indicate that vascular structure and composition determined by OCT provides an adequate basis for investigating the biomechanical factors relevant to atherosclerosis and acute myocardial infarction... - In vivo characterization of coronary atherosclerotic plaque by use of optical coherence tomographyIk Kyung Jang
Cardiology Division, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Circulation 111:1551-5. 2005..Optical coherence tomography (OCT) is a high-resolution ( approximately 10 microm), catheter-based imaging modality capable of investigating detailed coronary plaque morphology in vivo... - Optical coherence tomography as a tool for percutaneous coronary interventionsLarry J Diaz-Sandoval
Cardiology Division and Cardiovascular Clinical Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Catheter Cardiovasc Interv 65:492-6. 2005..This is the first report of the use of OCT to identify in vivo human intracoronary pathology after PCI... - Characterization of atherosclerotic plaques by laser speckle imagingSeemantini K Nadkarni
Department of Dermatology, Harvard Medical School, Wellman Center for Photomedicine, Massachusetts General Hospital, 40 Blossom St, BAR 718, Boston, MA 02114, USA
Circulation 112:885-92. 2005..In this article, we describe a new optical technique, laser speckle imaging (LSI), that measures an index of plaque viscoelasticity. We evaluate the potential of LSI for characterizing atherosclerotic plaque... - Intravascular optical coherence tomography: cellular imagingBriain D Macneill
Cardiology Division, Massachusetts General Hospital, Boston, MA 02114, USA
J Nucl Cardiol 12:460-5. 2005..Superimposed on this inflammatory background, local increases in macrophage content, particularly at the cap surface and at areas at high risk for rupture, further promote the instability of individual lesions... - Spectral- and frequency-encoded fluorescence imagingJason T Motz
Harvard Medical School and the Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Opt Lett 30:2760-2. 2005..This method is applicable for developing submillimeter diameter endoscopes. The principles of the technique are validated by imaging indocyanine green fluorescence in microfluidic channels... - Spectral domain optical coherence tomography: ultra-high speed, ultra-high resolution ophthalmic imagingTeresa C Chen
Department of Ophthalmology, Harvard Medical School, Boston, Mass, USA
Arch Ophthalmol 123:1715-20. 2005..To introduce a new ophthalmic optical coherence tomography technology that allows unprecedented simultaneous ultra-high speed and ultra-high resolution... - Automated algorithm for differentiation of human breast tissue using low coherence interferometry for fine needle aspiration biopsy guidanceBRIAN D GOLDBERG
Massachusetts General Hospital, Wellman Center for Photomedicine, 40 Blossom Street, Boston, Massachusetts 02114, USA
J Biomed Opt 13:014014. 2008..1% (89.7 to 99.9) sensitivity and 82.4% (65.5 to 93.2) specificity where the numbers in parentheses represent the 95% confidence intervals. These results suggest that LCI can be used to determine tissue type and guide FNAB of the breast... - Association of statin therapy with reduced coronary plaque rupture: an optical coherence tomography studyStanley Chia
Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Coron Artery Dis 19:237-42. 2008..We aimed to demonstrate the potential utility of OCT in evaluating coronary plaques in patients with or without statin therapy... - Multimodality optical imaging of embryonic heart microstructureRonit Yelin
Massachusetts General Hospital, Harvard Medical School and the Wellman Center for Photomedicine, 55 Fruit Street, BAR 703, Boston, Massachusetts 02114, USA
J Biomed Opt 12:064021. 2007..Microstructural abnormalities associated with high levels of ethanol exposure are observed, including compromised heart looping and loss of ventricular trabecular mass... - In-vivo comparison of coronary plaque characteristics using optical coherence tomography in women vs. men with acute coronary syndromeStanley Chia
Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
Coron Artery Dis 18:423-7. 2007..Intravascular optical coherence tomography (OCT) is a high-resolution imaging technique capable of in-vivo plaque characterization. The aim of this study was to compare culprit plaque characteristics in women and men presenting with ACS... - Real-time microscopic visualization of tissue response to laser thermal therapyBenjamin J Vakoc
Harvard Medical School and Massachusetts General Hospital, Wellman Center for Photomedicine, 55 Fruit Street, BAR 703, Boston, Massachusetts 02114, USA
J Biomed Opt 12:020501. 2007..Using porcine esophageal specimens ex vivo, we demonstrate that the extent and evolution of laser thermal damage can be assessed in real time... - Comprehensive volumetric optical microscopy in vivoSeok H Yun
Wellman Center for Photomedicine, 55 Fruit Street, Boston, Massachusetts 02114, USA
Nat Med 12:1429-33. 2006..Our pilot study results suggest that this technology may be a useful clinical tool for comprehensive diagnostic imaging for epithelial disease and for evaluating coronary pathology and iatrogenic effects... - Arterial wall imaging: evaluation with 16-section multidetector CT in blood vessel phantoms and ex vivo coronary arteriesMaros Ferencik
Department of Radiology, Wellman Laboratories of Photomedicine, Boston, MA 02114, USA
Radiology 240:708-16. 2006..001). CONCLUSION: Determination of composition of individual plaques from attenuation values can be more challenging because of overlapping values for different tissue types... - Optical coherence tomography to identify intramucosal carcinoma and high-grade dysplasia in Barrett's esophagusJohn A Evans
Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
Clin Gastroenterol Hepatol 4:38-43. 2006..The purpose of this study was to establish OCT image characteristics of IMC and HGD in Barrett's esophagus... - Optical coherence tomography of the biliary tree during ERCPJohn M Poneros
Gastrointestinal Unit, Wellman Laboratories of Photomedicine, Harvard Medical School, Boston, Massachusetts, USA
Gastrointest Endosc 55:84-8. 2002..There were no OCT-related complications. CONCLUSIONS: High-resolution OCT imaging of the biliary tree is feasible and may provide useful diagnostic information during ERCP...
Research Grants
- Chemical analysis of coronary atherosclerosis in patientsGuillermo Tearney; Fiscal Year: 2009..This study will provide insight on the clinical utility of this new method by comparing chemical and molecular information obtained from patients with different presentations of coronary artery disease. ..
- Chemical analysis of coronary atherosclerosis in patientsGuillermo J Tearney; Fiscal Year: 2010..This study will provide insight on the clinical utility of this new method by comparing chemical and molecular information obtained from patients with different presentations of coronary artery disease. ..
- Miniature Laser Therapy EndoscopeGuillermo Tearney; Fiscal Year: 2007..In addition to treatment of TTTS, this device can be used for endoscopically-guided therapy in other applications where ultraminiature instrumentation is critical for tissue access and patient safety. ..
- Comprehensive architectural and cellular endoscopic microscopyGuillermo Tearney; Fiscal Year: 2007....
- Improving screening & surveillance in Barrett's patientsGuillermo Tearney; Fiscal Year: 2007....
- Natural History of Vulnerable Coronary PlaquesGuillermo Tearney; Fiscal Year: 2007..abstract_text> ..
- Improving Screening and Surveillance in Barrett's PatientsGuillermo J Tearney; Fiscal Year: 2010..We will validate the accuracy of this device and will then compare it to endoscopy, the current standard of care, in a clinical study of 300 patients. ..