Guillermo Tearney

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Miniature grating for spectrally-encoded endoscopy
    DongKyun Kang
    Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Lab Chip 13:1810-6. 2013
  2. ncbi request reprint Quantification of macrophage content in atherosclerotic plaques by optical coherence tomography
    Guillermo J Tearney
    Wellman Laboratories of Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, Mass 02114, USA
    Circulation 107:113-9. 2003
  3. doi request reprint Fluorescence interferometry: principles and applications in biology
    Alberto Bilenca
    Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, 50 Blossom St, BAR 720, Boston, Massachusetts 02114, USA
    Ann N Y Acad Sci 1130:68-77. 2008
  4. pmc Measurement of fibrous cap thickness in atherosclerotic plaques by spatiotemporal analysis of laser speckle images
    Seemantini K Nadkarni
    Massachusetts General Hospital, Harvard Medical School, Wellman Center for Photomedicine, Boston, Massachusetts 02114, USA
    J Biomed Opt 11:021006. 2006
  5. ncbi request reprint Diagnostic accuracy of optical coherence tomography and integrated backscatter intravascular ultrasound images for tissue characterization of human coronary plaques
    Masanori Kawasaki
    Wellman Laboratories of Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Am Coll Cardiol 48:81-8. 2006
  6. ncbi request reprint Differential near-field scanning optical microscopy
    Aydogan Ozcan
    Wellman Center for Photomedicine, Harvard Medical School, Boston, Massachusetts 02114, USA
    Nano Lett 6:2609-16. 2006
  7. pmc In vivo association between positive coronary artery remodelling and coronary plaque characteristics assessed by intravascular optical coherence tomography
    Owen Christopher Raffel
    Cardiology Division, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, GRB 800, Boston, MA 02114, USA
    Eur Heart J 29:1721-8. 2008
  8. pmc Identifying intestinal metaplasia at the squamocolumnar junction by using optical coherence tomography
    John A Evans
    Gastrointestinal Unit, Massachusetts General Hospital, Boston, Massachusetts, USA
    Gastrointest Endosc 65:50-6. 2007
  9. pmc Comprehensive esophageal microscopy by using optical frequency-domain imaging (with video)
    Benjamin J Vakoc
    Wellman Center for Photomedicine, Department of Dermatology, Massachusetts General Hospital, Harvard MIT Division of Health Sciences and Technology, Boston, Massachusetts, USA
    Gastrointest Endosc 65:898-905. 2007
  10. pmc Measurement of collagen and smooth muscle cell content in atherosclerotic plaques using polarization-sensitive optical coherence tomography
    Seemantini K Nadkarni
    Department of Dermatology, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, USA
    J Am Coll Cardiol 49:1474-81. 2007

Research Grants

  1. Improving screening & surveillance in Barrett's patients
    Guillermo Tearney; Fiscal Year: 2003
  2. Chemical analysis of coronary atherosclerosis in patients
    Guillermo Tearney; Fiscal Year: 2009
  3. Chemical analysis of coronary atherosclerosis in patients
    Guillermo J Tearney; Fiscal Year: 2010
  4. Chemical analysis of coronary atherosclerosis in patients
    Guillermo Tearney; Fiscal Year: 2009
  5. Miniature Laser Therapy Endoscope
    Guillermo Tearney; Fiscal Year: 2007
  6. Comprehensive architectural and cellular endoscopic microscopy
    Guillermo Tearney; Fiscal Year: 2007
  7. Improving screening & surveillance in Barrett's patients
    Guillermo Tearney; Fiscal Year: 2007
  8. Natural History of Vulnerable Coronary Plaques
    Guillermo Tearney; Fiscal Year: 2007
  9. Improving screening & surveillance in Barrett's patients
    Guillermo Tearney; Fiscal Year: 2006
  10. Natural History of Vulnerable Coronary Plaques
    Guillermo Tearney; Fiscal Year: 2006

Collaborators

Detail Information

Publications38

  1. pmc Miniature grating for spectrally-encoded endoscopy
    DongKyun Kang
    Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Lab Chip 13:1810-6. 2013
    ..In addition to providing high quality imaging SEE optics, the soft lithography method allows cost-effective and reliable fabrication of these miniature endoscopes, which will facilitate the clinical translation of SEE technology...
  2. ncbi request reprint Quantification of macrophage content in atherosclerotic plaques by optical coherence tomography
    Guillermo J Tearney
    Wellman Laboratories of Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, Mass 02114, USA
    Circulation 107:113-9. 2003
    ..The aim of this study was to investigate the use of OCT for identifying macrophages in fibrous caps...
  3. doi request reprint Fluorescence interferometry: principles and applications in biology
    Alberto Bilenca
    Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, 50 Blossom St, BAR 720, Boston, Massachusetts 02114, USA
    Ann N Y Acad Sci 1130:68-77. 2008
    ..Finally, we point out future research directions in fluorescence interferometry, such as fluorescence tomography of whole organisms and the extension to molecular interferometry by means of quantum dots and bioluminescence...
  4. pmc Measurement of fibrous cap thickness in atherosclerotic plaques by spatiotemporal analysis of laser speckle images
    Seemantini K Nadkarni
    Massachusetts General Hospital, Harvard Medical School, Wellman Center for Photomedicine, Boston, Massachusetts 02114, USA
    J Biomed Opt 11:021006. 2006
    ..4). These results demonstrate that spatio-temporal LSI may allow the estimation of fibrous cap thickness in NCFAs, which is an important predictor of plaque stability...
  5. ncbi request reprint Diagnostic accuracy of optical coherence tomography and integrated backscatter intravascular ultrasound images for tissue characterization of human coronary plaques
    Masanori Kawasaki
    Wellman Laboratories of Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Am Coll Cardiol 48:81-8. 2006
    ....
  6. ncbi request reprint Differential near-field scanning optical microscopy
    Aydogan Ozcan
    Wellman Center for Photomedicine, Harvard Medical School, Boston, Massachusetts 02114, USA
    Nano Lett 6:2609-16. 2006
    ..Principles of DNSOM can also be extended to other aperture/detector geometries such as triangles and parallelograms...
  7. pmc In vivo association between positive coronary artery remodelling and coronary plaque characteristics assessed by intravascular optical coherence tomography
    Owen Christopher Raffel
    Cardiology Division, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, GRB 800, Boston, MA 02114, USA
    Eur Heart J 29:1721-8. 2008
    ..OCT is a unique imaging modality capable of characterizing these important morphological features of vulnerable plaque...
  8. pmc Identifying intestinal metaplasia at the squamocolumnar junction by using optical coherence tomography
    John A Evans
    Gastrointestinal Unit, Massachusetts General Hospital, Boston, Massachusetts, USA
    Gastrointest Endosc 65:50-6. 2007
    ..The accuracy of OCT for differentiating tissue types at the squamocolumnar junction (SCJ) has not been established...
  9. pmc Comprehensive esophageal microscopy by using optical frequency-domain imaging (with video)
    Benjamin J Vakoc
    Wellman Center for Photomedicine, Department of Dermatology, Massachusetts General Hospital, Harvard MIT Division of Health Sciences and Technology, Boston, Massachusetts, USA
    Gastrointest Endosc 65:898-905. 2007
    ..However, the relatively slow image-acquisition rate of the present OCT systems inhibits wide-field imaging and limits the clinical utility of OCT for diagnostic imaging in patients with Barrett's esophagus...
  10. pmc Measurement of collagen and smooth muscle cell content in atherosclerotic plaques using polarization-sensitive optical coherence tomography
    Seemantini K Nadkarni
    Department of Dermatology, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, USA
    J Am Coll Cardiol 49:1474-81. 2007
    ..The purpose of this study was to investigate the measurement of collagen and smooth muscle cell (SMC) content in atherosclerotic plaques using polarization-sensitive optical coherence tomography (PSOCT)...
  11. pmc Relationship between a systemic inflammatory marker, plaque inflammation, and plaque characteristics determined by intravascular optical coherence tomography
    O Christopher Raffel
    Cardiology Division, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Arterioscler Thromb Vasc Biol 27:1820-7. 2007
    ....
  12. pmc Comparison of coronary plaque characteristics between diabetic and non-diabetic subjects: An in vivo optical coherence tomography study
    Stanley Chia
    Cardiology Division, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street GRB 800, Boston, MA, United States
    Diabetes Res Clin Pract 81:155-60. 2008
    ..Using OCT imaging, we compared in vivo plaque characteristics between diabetic and non-diabetic subjects...
  13. pmc Speckle reduction in optical coherence tomography images using digital filtering
    Aydogan Ozcan
    Harvard Medical School, Massachusetts General Hospital, Boston 02114, USA
    J Opt Soc Am A Opt Image Sci Vis 24:1901-10. 2007
    ..Our results suggest that by using these digital filters, the number of individual angles required to attain a certain level of speckle reduction can be decreased...
  14. pmc Backscattering spectroscopic contrast with angle-resolved optical coherence tomography
    Adrien E Desjardins
    Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, Boston 02114, USA
    Opt Lett 32:3158-60. 2007
    ..High levels of speckle noise reduction achieved by angular compounding increased the spatial resolution at which backscattering spectra could be accurately differentiated...
  15. pmc Optical coherence tomography for imaging the vulnerable plaque
    Guillermo J Tearney
    Wellman Center for Photomedicine, Department of Pathology, Massachusetts General Hospital, 50 Blossom Street, BAR703, Boston, Massachusetts 02114, USA
    J Biomed Opt 11:021002. 2006
    ....
  16. ncbi request reprint Technology Insight: optical coherence tomography--current status and future development
    Adrian F Low
    Cardiology Division at the Massachusetts General Hospital, Boston, MA 02114, USA
    Nat Clin Pract Cardiovasc Med 3:154-62; quiz 172. 2006
    ..Here, we discuss results from clinical studies which indicate that optical coherence tomography is a promising imaging technique for improved characterization of the coronary atherosclerotic plaque...
  17. ncbi request reprint Fourier fluorescence spectrometer for excitation emission matrix measurement
    Leilei Peng
    Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, 55 Fruit Street, BAR 708, Massachusetts 02114, USA
    Opt Express 16:10493-500. 2008
    ..The system provides a wide spectral range, adjustable spectral resolution, and fast EEM acquisition speed, which allows EEM's to be acquired in 40 seconds at a spectral resolution of 81-cm-1...
  18. ncbi request reprint Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: comparison with intravascular ultrasound
    Ik Kyung Jang
    Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Am Coll Cardiol 39:604-9. 2002
    ..The aim of this study was to evaluate the feasibility and the ability of intravascular optical coherence tomography (OCT) to visualize the components of coronary plaques in living patients...
  19. ncbi request reprint Characterization of human atherosclerosis by optical coherence tomography
    Hiroshi Yabushita
    Cardiology Division, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Circulation 106:1640-5. 2002
    ..The aim of this study was to establish objective OCT image criteria for atherosclerotic plaque characterization in vitro...
  20. ncbi request reprint Improved signal-to-noise ratio in spectral-domain compared with time-domain optical coherence tomography
    Johannes F de Boer
    Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, 50 Blossom Street, BAR 724, Boston, Massachusetts 02114, USA
    Opt Lett 28:2067-9. 2003
    ..A significant SNR gain of several hundredfold is found for acquisition in the spectral domain. The SNR benefit is demonstrated experimentally in a hybrid time-domain-spectral-domain OCT system...
  21. ncbi request reprint In vivo human retinal imaging by ultrahigh-speed spectral domain optical coherence tomography
    Nader Nassif
    Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, 50 Blossom Street, BAR 724, Boston, Massachusetts 02114, USA
    Opt Lett 29:480-2. 2004
    ..In vivo images of the human retina are presented, demonstrating the ability to acquire high-quality structural images with an axial resolution of 6 microm at ultrahigh speed and with an ocular exposure level of less than 600 microW...
  22. ncbi request reprint Focal and multi-focal plaque macrophage distributions in patients with acute and stable presentations of coronary artery disease
    Briain D Macneill
    Cardiology Division, Harvard Medical School, Boston, Massachusetts, USA
    J Am Coll Cardiol 44:972-9. 2004
    ..This study was designed to utilize optical coherence tomography (OCT) images of coronary atherosclerotic plaque macrophages to investigate the relationship between macrophage distributions and clinical syndrome...
  23. ncbi request reprint Mechanical analysis of atherosclerotic plaques based on optical coherence tomography
    Alexandra H Chau
    Department of Mechanical Engineering and Biological Engineering Division, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Ann Biomed Eng 32:1494-503. 2004
    ..Our results indicate that vascular structure and composition determined by OCT provides an adequate basis for investigating the biomechanical factors relevant to atherosclerosis and acute myocardial infarction...
  24. pmc In vivo characterization of coronary atherosclerotic plaque by use of optical coherence tomography
    Ik Kyung Jang
    Cardiology Division, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Circulation 111:1551-5. 2005
    ..Optical coherence tomography (OCT) is a high-resolution ( approximately 10 microm), catheter-based imaging modality capable of investigating detailed coronary plaque morphology in vivo...
  25. ncbi request reprint Optical coherence tomography as a tool for percutaneous coronary interventions
    Larry J Diaz-Sandoval
    Cardiology Division and Cardiovascular Clinical Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Catheter Cardiovasc Interv 65:492-6. 2005
    ..This is the first report of the use of OCT to identify in vivo human intracoronary pathology after PCI...
  26. pmc Characterization of atherosclerotic plaques by laser speckle imaging
    Seemantini K Nadkarni
    Department of Dermatology, Harvard Medical School, Wellman Center for Photomedicine, Massachusetts General Hospital, 40 Blossom St, BAR 718, Boston, MA 02114, USA
    Circulation 112:885-92. 2005
    ..In this article, we describe a new optical technique, laser speckle imaging (LSI), that measures an index of plaque viscoelasticity. We evaluate the potential of LSI for characterizing atherosclerotic plaque...
  27. ncbi request reprint Intravascular optical coherence tomography: cellular imaging
    Briain D Macneill
    Cardiology Division, Massachusetts General Hospital, Boston, MA 02114, USA
    J Nucl Cardiol 12:460-5. 2005
    ..Superimposed on this inflammatory background, local increases in macrophage content, particularly at the cap surface and at areas at high risk for rupture, further promote the instability of individual lesions...
  28. ncbi request reprint Spectral- and frequency-encoded fluorescence imaging
    Jason T Motz
    Harvard Medical School and the Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Opt Lett 30:2760-2. 2005
    ..This method is applicable for developing submillimeter diameter endoscopes. The principles of the technique are validated by imaging indocyanine green fluorescence in microfluidic channels...
  29. ncbi request reprint Spectral domain optical coherence tomography: ultra-high speed, ultra-high resolution ophthalmic imaging
    Teresa C Chen
    Department of Ophthalmology, Harvard Medical School, Boston, Mass, USA
    Arch Ophthalmol 123:1715-20. 2005
    ..To introduce a new ophthalmic optical coherence tomography technology that allows unprecedented simultaneous ultra-high speed and ultra-high resolution...
  30. doi request reprint Automated algorithm for differentiation of human breast tissue using low coherence interferometry for fine needle aspiration biopsy guidance
    BRIAN D GOLDBERG
    Massachusetts General Hospital, Wellman Center for Photomedicine, 40 Blossom Street, Boston, Massachusetts 02114, USA
    J Biomed Opt 13:014014. 2008
    ..1% (89.7 to 99.9) sensitivity and 82.4% (65.5 to 93.2) specificity where the numbers in parentheses represent the 95% confidence intervals. These results suggest that LCI can be used to determine tissue type and guide FNAB of the breast...
  31. pmc Association of statin therapy with reduced coronary plaque rupture: an optical coherence tomography study
    Stanley Chia
    Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Coron Artery Dis 19:237-42. 2008
    ..We aimed to demonstrate the potential utility of OCT in evaluating coronary plaques in patients with or without statin therapy...
  32. pmc Multimodality optical imaging of embryonic heart microstructure
    Ronit Yelin
    Massachusetts General Hospital, Harvard Medical School and the Wellman Center for Photomedicine, 55 Fruit Street, BAR 703, Boston, Massachusetts 02114, USA
    J Biomed Opt 12:064021. 2007
    ..Microstructural abnormalities associated with high levels of ethanol exposure are observed, including compromised heart looping and loss of ventricular trabecular mass...
  33. ncbi request reprint In-vivo comparison of coronary plaque characteristics using optical coherence tomography in women vs. men with acute coronary syndrome
    Stanley Chia
    Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Coron Artery Dis 18:423-7. 2007
    ..Intravascular optical coherence tomography (OCT) is a high-resolution imaging technique capable of in-vivo plaque characterization. The aim of this study was to compare culprit plaque characteristics in women and men presenting with ACS...
  34. ncbi request reprint Real-time microscopic visualization of tissue response to laser thermal therapy
    Benjamin J Vakoc
    Harvard Medical School and Massachusetts General Hospital, Wellman Center for Photomedicine, 55 Fruit Street, BAR 703, Boston, Massachusetts 02114, USA
    J Biomed Opt 12:020501. 2007
    ..Using porcine esophageal specimens ex vivo, we demonstrate that the extent and evolution of laser thermal damage can be assessed in real time...
  35. pmc Comprehensive volumetric optical microscopy in vivo
    Seok H Yun
    Wellman Center for Photomedicine, 55 Fruit Street, Boston, Massachusetts 02114, USA
    Nat Med 12:1429-33. 2006
    ..Our pilot study results suggest that this technology may be a useful clinical tool for comprehensive diagnostic imaging for epithelial disease and for evaluating coronary pathology and iatrogenic effects...
  36. ncbi request reprint Arterial wall imaging: evaluation with 16-section multidetector CT in blood vessel phantoms and ex vivo coronary arteries
    Maros Ferencik
    Department of Radiology, Wellman Laboratories of Photomedicine, Boston, MA 02114, USA
    Radiology 240:708-16. 2006
    ....
  37. pmc Optical coherence tomography to identify intramucosal carcinoma and high-grade dysplasia in Barrett's esophagus
    John A Evans
    Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Clin Gastroenterol Hepatol 4:38-43. 2006
    ..The purpose of this study was to establish OCT image characteristics of IMC and HGD in Barrett's esophagus...
  38. ncbi request reprint Optical coherence tomography of the biliary tree during ERCP
    John M Poneros
    Gastrointestinal Unit, Wellman Laboratories of Photomedicine, Harvard Medical School, Boston, Massachusetts, USA
    Gastrointest Endosc 55:84-8. 2002
    ..Optical coherence tomography (OCT) is a high-resolution imaging technique that produces cross-sectional images in vivo. This is a report of the first use of OCT to acquire images of the biliary tree during ERCP...

Research Grants18

  1. Improving screening & surveillance in Barrett's patients
    Guillermo Tearney; Fiscal Year: 2003
    ....
  2. Chemical analysis of coronary atherosclerosis in patients
    Guillermo Tearney; Fiscal Year: 2009
    ..This study will provide insight on the clinical utility of this new method by comparing chemical and molecular information obtained from patients with different presentations of coronary artery disease. ..
  3. Chemical analysis of coronary atherosclerosis in patients
    Guillermo J Tearney; Fiscal Year: 2010
    ..This study will provide insight on the clinical utility of this new method by comparing chemical and molecular information obtained from patients with different presentations of coronary artery disease. ..
  4. Chemical analysis of coronary atherosclerosis in patients
    Guillermo Tearney; Fiscal Year: 2009
    ..This study will provide insight on the clinical utility of this new method by comparing chemical and molecular information obtained from patients with different presentations of coronary artery disease. ..
  5. Miniature Laser Therapy Endoscope
    Guillermo Tearney; Fiscal Year: 2007
    ..In addition to treatment of TTTS, this device can be used for endoscopically-guided therapy in other applications where ultraminiature instrumentation is critical for tissue access and patient safety. ..
  6. Comprehensive architectural and cellular endoscopic microscopy
    Guillermo Tearney; Fiscal Year: 2007
    ....
  7. Improving screening & surveillance in Barrett's patients
    Guillermo Tearney; Fiscal Year: 2007
    ....
  8. Natural History of Vulnerable Coronary Plaques
    Guillermo Tearney; Fiscal Year: 2007
    ..abstract_text> ..
  9. Improving screening & surveillance in Barrett's patients
    Guillermo Tearney; Fiscal Year: 2006
    ....
  10. Natural History of Vulnerable Coronary Plaques
    Guillermo Tearney; Fiscal Year: 2006
    ..abstract_text> ..
  11. Improving screening & surveillance in Barrett's patients
    Guillermo Tearney; Fiscal Year: 2005
    ....
  12. Natural History of Vulnerable Coronary Plaques
    Guillermo Tearney; Fiscal Year: 2005
    ..abstract_text> ..
  13. Improving screening & surveillance in Barrett's patients
    Guillermo Tearney; Fiscal Year: 2004
    ....
  14. Natural History of Vulnerable Coronary Plaques
    Guillermo Tearney; Fiscal Year: 2004
    ..abstract_text> ..
  15. Improving Screening and Surveillance in Barrett's Patients
    Guillermo J Tearney; Fiscal Year: 2010
    ..We will validate the accuracy of this device and will then compare it to endoscopy, the current standard of care, in a clinical study of 300 patients. ..