Affiliation: Harvard University
- Epidemiology of tardive dyskinesia before and during the era of modern antipsychotic drugsDaniel Tarsy
Department of Neurology, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Handb Clin Neurol 100:601-16. 2011....
- Treatment of Parkinson disease: a 64-year-old man with motor complications of advanced Parkinson diseaseDaniel Tarsy
Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
JAMA 307:2305-14. 2012..The case of Mr L, a man with an 11-year history of Parkinson disease, illustrates these emerging motor complications and the manner in which they may be managed both medically and surgically...
- Progression of Parkinson's disease following thalamic deep brain stimulation for tremorDaniel Tarsy
Department of Neurology, Movement Disorders Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
Stereotact Funct Neurosurg 83:222-7. 2005..UPDRS III motor scores were unchanged. However, global assessment of PD progression and increased mean L-dopa dose and L-dopa equivalent daily dose at the time of last follow-up visit indicated that a progression of PD had occurred...
- Epidemiology of tardive dyskinesia: is risk declining with modern antipsychotics?Daniel Tarsy
Department of Neurology, Harvard Medical School, and Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
Mov Disord 21:589-98. 2006..Long-term use of APDs should continue to be based on research-supported indications, with regular specific examination for emerging TD...
- Unusual position-sensitive jaw tremor responsive to botulinum toxinDaniel Tarsy
Parkinson s Disease and Movement Disorders Center, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
Mov Disord 21:277-8. 2006..Electromyography demonstrated a rhythmic 5 Hz alternating tremor involving masseter and digastric muscles with normal reciprocal inhibition. The tremor was markedly reduced with botulinum toxin injections...
- Adverse effects of subthalamic nucleus DBS in a patient with multiple system atrophyDaniel Tarsy
Department of Neurology, Division of Neurosurgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
Neurology 61:247-9. 2003..Pulse generators were turned off. Clinical features and brain MRI in this case were indicative of multiple system atrophy (MSA). STN DBS is not recommended for patients with MSA...
- Cancer incidence in a trial of an antiapoptotic agent for Parkinson's diseaseSteven R Schwid
Department of Neurology, University of Rochester, Rochester, New York, USA
Mov Disord 25:1801-8. 2010..Melanoma occurrence in our PD patients was greater than predicted compared with the general population and was unrelated to dopaminergic therapy. Clinical surveillance of PD patients for melanoma may be warranted...
- The c.-237_236GA>TT THAP1 sequence variant does not increase risk for primary dystoniaJianfeng Xiao
Department of Neurology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
Mov Disord 26:549-52. 2011..Sequence variants in coding and noncoding regions of THAP1 have been associated with primary dystonia...
- Sustained dyskinesias following elective cessation and reactivation of chronic subthalamic nucleus deep brain stimulation for a surgical procedureLudy C Shih
Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
Neuromodulation 14:512-4; discussion 514. 2011..We report a patient with previously well-controlled dyskinesias who had severe and prolonged dyskinesias following reactivation of deep brain stimulation (DBS) following an orthopedic procedure...
- End of day dyskinesia in advanced Parkinson's disease can be eliminated by bilateral subthalamic nucleus or globus pallidus deep brain stimulationDiana Apetauerova
Department of Neurology, Lahey Clinic Medical Center, Burlington, Massachusetts, USA
Mov Disord 21:1277-9. 2006..Globus pallidus (GPi) DBS in 1 case and subthalamic (STN) DBS in the second case produced full resolution of end of day dyskinesia...
- Loss of benefit in VIM thalamic deep brain stimulation (DBS) for essential tremor (ET): how prevalent is it?Ludy C Shih
Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
Parkinsonism Relat Disord 19:676-9. 2013..In addition, this data suggests that a disease-based explanation rather than technical factors are more likely to explain the decline in benefit...
- Singing in groups for Parkinson's disease (SING-PD): a pilot study of group singing therapy for PD-related voice/speech disordersLudy C Shih
Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
Parkinsonism Relat Disord 18:548-52. 2012..This study suggests that a group singing therapy intervention at this intensity and frequency does not result in significant improvement in objective and subject-rated measures of voice and speech impairment...
- Survey of U.S. neurologists' attitudes towards deep brain stimulation for Parkinson's diseaseLudy C Shih
Department of Neurology, National Parkinson Foundation Center of Excellence, Harvard Medical School, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
Neuromodulation 14:208-13; discussion 213. 2011..Our aim was to assess attitudes of U.S. neurologists towards the role of DBS in management of advanced PD...
- A web-based system for home monitoring of patients with Parkinson's disease using wearable sensorsBor Rong Chen
Harvard School of Engineering and Applied Sciences, Cambridge, MA 02138, USA
IEEE Trans Biomed Eng 58:831-6. 2011..These results indicate that the proposed platform is suitable to monitor patients with PD to facilitate the titration of medications in the late stages of the disease...
- A heteroplasmic mitochondrial complex I gene mutation in adult-onset dystoniaDavid K Simon
Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Boston, MA 02115, USA
Neurogenetics 4:199-205. 2003..01). This difference remains significant even after excluding the index patient (P=0.04). These data suggest that, among haplogroup H subjects, the presence of the A3796G mutation increases the risk of developing adult-onset dystonia...
- A longitudinal program for biomarker development in Parkinson's disease: a feasibility studyBernard Ravina
Department of Neurology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
Mov Disord 24:2081-90. 2009..The PostCEPT cohort and associated studies strongly support the feasibility of the LABS-PD approach of retaining and repurposing clinical trial cohorts to collect longitudinal clinical and biomarker data...
- Long-term evaluation of deep brain stimulation of the thalamusRajesh Pahwa
Department of Neurology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
J Neurosurg 104:506-12. 2006..The aim of this study was to evaluate the long-term safety and efficacy of DBS of the ventralis intermedius nucleus (VIM) of the thalamus for PD and ET...
- Phonemic verbal fluency decline after subthalamic nucleus deep brain stimulation does not depend on number of microelectrode recordings or lead tip placementKara M Smith
Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA Electronic address
Parkinsonism Relat Disord 20:400-4. 2014..Evidence suggests that both motor improvement and decline in verbal fluency in Parkinson's disease (PD) patients undergoing deep brain stimulation (DBS) may be attributed to a lead implantation effect...
- Tardive tremor due to metoclopramideDaniel Tarsy
Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
Mov Disord 17:620-1. 2002..We describe a patient with persistent tardive tremor that was associated with tardive dyskinesia, who closely resembles previously reported cases...
- High-throughput mutational analysis of TOR1A in primary dystoniaJianfeng Xiao
Department of Neurology, University of Tennessee Health Science Center, Memphis, TN, USA
BMC Med Genet 10:24. 2009..The aim of this study was to identify TOR1A Exon 5 mutations in a large cohort of subjects with mainly non-generalized primary dystonia...
- Home monitoring of patients with Parkinson's disease via wearable technology and a web-based applicationShyamal Patel
Department of Physical Medicine and Rehabilitation, Harvard Medical School, Spaulding Rehabilitation Hospital, Boston, MA 02114, USA
Conf Proc IEEE Eng Med Biol Soc 2010:4411-4. 2010..The work herein presented shows that wearable sensors combined with a web-based application provide reliable quantitative information that can be used for clinical decision making...
- Serum urate as a predictor of clinical and radiographic progression in Parkinson diseaseMichael A Schwarzschild
MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Boston, USA
Arch Neurol 65:716-23. 2008..To determine whether concentration of serum urate, a purine metabolite and potent antioxidant that has been linked to a reduced risk of Parkinson disease (PD), predicts prognosis in PD...
- Effects of newer antipsychotics on extrapyramidal functionDaniel Tarsy
Department of Neurology, Harvard Medical School and the Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
CNS Drugs 16:23-45. 2002..In summary, with the exception of clozapine, and perhaps quetiapine, atypical antipsychotics have brought only relative avoidance of EPS, strongly encouraging continued searches for novel antipsychotic agents...
- Deep brain stimulation for the treatment of atypical parkinsonismLudy C Shih
Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
Mov Disord 22:2149-55. 2007..We review in detail the experience of DBS surgery in patients with several forms of AP including multiple system atrophy. On the basis of the limited available data reviewed here, DBS for patients with AP is not recommended...
- DystoniaDaniel Tarsy
Department of Neurology, Parkinson s Disease and Movement Disorders Center, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, USA
N Engl J Med 355:818-29. 2006
- Diabetic gastroparesisDaniel Tarsy
N Engl J Med 357:419; author reply 419-20. 2007
- Double-blind, randomized, controlled trial of rasagiline as monotherapy in early Parkinson's disease patientsMatthew B Stern
University of Pennsylvania, Philadelphia, Pennsylvania, USA
Mov Disord 19:916-23. 2004..05, Fisher's exact test). The frequency and types of adverse events reported by rasagiline-treated and placebo-treated patients were similar. These results suggest that rasagiline monotherapy is well tolerated and efficacious in early PD...
- Nonlinear sensory cortex response to simultaneous tactile stimuli in writer's crampTerence D Sanger
Department of Child Neurology, Stanford University Medical Center, Stanford, California USA
Mov Disord 17:105-11. 2002..Results indicate a nonlinear interaction between the sensory cortical response to individual finger stimulation in writer's cramp. This altered interaction may contribute to the motor abnormalities...
- Treatment of dystoniaRoongroj Bhidayasiri
Chulalongkorn University Hospital, Chulalongkorn Comprehensive Movement Disorders Center, Division of Neurology, 1873 Rama 4 Road Bangkok 10330, Thailand
Expert Rev Neurother 6:863-86. 2006..Therefore, more research is needed to better understand the underlying cause and pathophysiology of dystonia and to explore newer medications and surgical techniques for its treatment...
- Deep-brain stimulation for dystonia: new twists in assessmentDaniel Tarsy
Lancet Neurol 6:201-2. 2007
- Topiramate in essential tremor: findings from double-blind, placebo-controlled, crossover trialsGregory S Connor
Neurological Center of Oklahoma, Inc, Tulsa, OK 74136, USA
Clin Neuropharmacol 31:97-103. 2008..To evaluate topiramate in adults with essential tremor...