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Genomes and Genes | Kelan TantisiraSummaryAffiliation: Harvard University Country: USA Publications
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Publications
Genome-wide association identifies the T gene as a novel asthma pharmacogenetic locusKelan G Tantisira
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
Am J Respir Crit Care Med 185:1286-91. 2012..To date, most studies aimed at discovering genetic factors influencing treatment response in asthma have focused on biologic candidate genes. Genome-wide association studies (GWAS) can rapidly identify novel pharmacogenetic loci...
Polymorphisms in signal transducer and activator of transcription 3 and lung function in asthmaAugusto A Litonjua
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
Respir Res 6:52. 2005..Signal transducer and activator of transcription 3 is a transcription factor latent in the cytoplasm; the gene (STAT3) is activated by a wide range of cytokines, and may play a role in lung development and asthma pathogenesis...
The pharmacogenetics of asthma therapyKelan G Tantisira
Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Curr Drug Targets 7:1697-708. 2006..Therefore, genetic testing may play a significant role in the care for individuals with asthma in the forseeable future...- FCER2: a pharmacogenetic basis for severe exacerbations in children with asthmaKelan G Tantisira
Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
J Allergy Clin Immunol 120:1285-91. 2007..Although inhaled corticosteroids (ICSs) generally protect against severe exacerbations in asthma, they may result in elevated IgE levels, which are associated with exacerbations... - Airway responsiveness in mild to moderate childhood asthma: sex influences on the natural historyKelan G Tantisira
Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
Am J Respir Crit Care Med 178:325-31. 2008..Airway responsiveness is a prognostic marker for asthma symptoms in later life. Objectives: To evaluate characteristics responsible for persistence of airway responsiveness in children with asthma... - The pharmacogenetics of asthma: an updateKelan G Tantisira
Brigham and Women s Hospital and Harvard Medical School, Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA
Curr Opin Mol Ther 7:209-17. 2005..Altogether, the available data indicate that genetics influences the likelihood of an individual responding to a given therapy, indicating that, in the future, optimal care for individuals with asthma may include genetic testing... - Chromosome 17: association of a large inversion polymorphism with corticosteroid response in asthmaKelan G Tantisira
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Pharmacogenet Genomics 18:733-7. 2008..Additional pharmacogenetic investigations into regions of chromosomal diversity, including copy number variation and inversions, are warranted... - The pharmacogenetics of asthma treatmentKelan Tantisira
Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Curr Allergy Asthma Rep 9:10-7. 2009..Although no specific predictive tests have been developed thus far, the existing studies serve as strong proof of concept of the applicability of pharmacogenetics in the future management of asthma... - TBX21: a functional variant predicts improvement in asthma with the use of inhaled corticosteroidsKelan G Tantisira
Channing Laboratory and Pulmonary Division, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 101:18099-104. 2004..TBX21 may thus be an important determinant pharmacogenetic response to the therapy of asthma with inhaled corticosteroids... - Genome Wide Association Study to predict severe asthma exacerbations in children using random forests classifiersMousheng Xu
Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
BMC Med Genet 12:90. 2011..We hypothesized that the use of random forests classifiers to select SNPs would result in an improved predictive model of asthma exacerbations. We tested this hypothesis in a population of childhood asthmatics... - Bronchodilation and bronchoconstriction: predictors of future lung function in childhood asthmaKelan G Tantisira
Channing Laboratory, Pulmonary Division, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
J Allergy Clin Immunol 117:1264-71. 2006..Persistently low levels of lung function are associated with subsequent symptoms in patients with asthma as children... - Importin-13 genetic variation is associated with improved airway responsiveness in childhood asthmaBenjamin A Raby
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
Respir Res 10:67. 2009..We hypothesize that common IPO13 genetic variation influences the anti-inflammatory effects of inhaled corticosteroids for the treatment of asthma, as measured by change in methacholine airway hyperresponsiveness (AHR-PC20)... - Predicting response to short-acting bronchodilator medication using Bayesian networksBlanca E Himes
Harvard MIT Division of Health Sciences and Technology, MA, USA
Pharmacogenomics 10:1393-412. 2009..We sought to relate candidate gene SNP data with bronchodilator response and measure the predictive accuracy of a model constructed with genetic variants... - Predictors of symptoms are different from predictors of severe exacerbations from asthma in childrenAnn Chen Wu
Center for Child Health Care Studies, Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston, MA 02215 5301, USA
Chest 140:100-7. 2011..The goal of our study was (1) to assess the association of asthma symptoms with severe asthma exacerbations and (2) to compare predictors of persistent asthma symptoms and predictors of severe asthma exacerbations... - Effect of vitamin D and inhaled corticosteroid treatment on lung function in childrenAnn Chen Wu
Center for Child Health Care Studies, Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston, MA 02215 5301, USA
Am J Respir Crit Care Med 186:508-13. 2012..Low vitamin D levels are associated with asthma and decreased airway responsiveness. Treatment with inhaled corticosteroids improves airway responsiveness and asthma control... - A role for Wnt signaling genes in the pathogenesis of impaired lung function in asthmaSunita Sharma
Channing Laboratory, Center for Genomic Medicine, 181 Longwood Avenue, Boston, MA 02115, USA
Am J Respir Crit Care Med 181:328-36. 2010..Animal models demonstrate that aberrant gene expression in utero can result in abnormal pulmonary phenotypes... - DNA sequence variants in epithelium-specific ETS-2 and ETS-3 are not associated with asthmaRebecca M Baron
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
Am J Respir Crit Care Med 166:927-32. 2002..This study suggests that epithelium-specific ETS-2 and ETS-3 genes are unlikely to contain polymorphic loci that have a major impact on asthma susceptibility in our population... - T-bet polymorphisms are associated with asthma and airway hyperresponsivenessBenjamin A Raby
M D C M, Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
Am J Respir Crit Care Med 173:64-70. 2006..Little is known regarding the role of genetic variation surrounding T-bet in the development of human AHR... - Genome-wide association study of the age of onset of childhood asthmaErick Forno
Channing Laboratory, Brigham and Women s Hospital, Boston, MA, USA
J Allergy Clin Immunol 130:83-90.e4. 2012..Although an earlier onset has been associated with more severe disease, there has been no genome-wide association study of the age of onset of asthma in children... - Repeatability of response to asthma medicationsAnn Chen Wu
Department of Ambulatory Care and Prevention, Harvard Pilgrim Health Care and Harvard Medical School, Boston, Mass, USA
J Allergy Clin Immunol 123:385-90. 2009..Pharmacogenetic studies of drug response in asthma assume that patients respond consistently to a treatment but that treatment response varies across patients; however, no formal studies have demonstrated this... - Corticotropin-releasing hormone deficiency increases allergen-induced airway inflammation in a mouse model of asthmaEric S Silverman
Physiology Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115 6021, USA
J Allergy Clin Immunol 114:747-54. 2004..Abnormal regulation of CRH and endogenous glucocorticoids has been implicated in the pathogenesis of asthma... - Platform dependence of inference on gene-wise and gene-set involvement in human lung developmentRose Du
Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
BMC Bioinformatics 10:189. 2009..0 and the Illumina HumanRef-8 v2 Expression Bead Chips, for comparability in a biological system in which changes may be subtle, namely fetal lung tissue as a function of gestational age... - RUNX transcription factors: association with pediatric asthma and modulated by maternal smokingKathleen J Haley
Brigham and Women s Hospital, Division of Pulmonary and Critical Care Medicine, PBB 3, 75 Francis St, Boston, Massachusetts 02115, USA
Am J Physiol Lung Cell Mol Physiol 301:L693-701. 2011..We speculate that IUS exposure-altered expression of RUNX transcription factors increases the risk of asthma in children with IUS exposure... - Pharmacogenomic discovery using cell-based modelsMarleen Welsh
Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
Pharmacol Rev 61:413-29. 2009..The primary focus is recent progress in the pharmacogenomic discovery area through ex vivo models... - Beta 2-adrenergic receptor polymorphisms and haplotypes are associated with airways hyperresponsiveness among nonsmoking menAugusto A Litonjua
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
Chest 126:66-74. 2004..To investigate the relationship of common single nucleotide polymorphisms (SNPs) of the beta(2)-adrenergic receptor (AR) gene at codons 16 and 27, and the intermediate phenotype of airways hyperresponsiveness... - An elevated breathing reserve index at the lactate threshold is a predictor of mortality in patients with cystic fibrosis awaiting lung transplantationKelan G Tantisira
Pulmonary and Critical Care Unit, General Medical Services, Boston, Massachusetts 02114, USA
Am J Respir Crit Care Med 165:1629-33. 2002..70 or more) for those at risk. This measurement may allow improved timing of listing for transplantation, including consideration for living donor transplantation... - Corticosteroid pharmacogenetics: association of sequence variants in CRHR1 with improved lung function in asthmatics treated with inhaled corticosteroidsKelan G Tantisira
Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Hum Mol Genet 13:1353-9. 2004.... - Associations of cord blood fatty acids with lymphocyte proliferation, IL-13, and IFN-gammaDiane R Gold
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
J Allergy Clin Immunol 117:931-8. 2006..However, both n-3 eicosapentaenoic acid (EPA) and n-6 arachidonic acid (AA) are required for normal fetal development... - Association of defensin beta-1 gene polymorphisms with asthmaHara Levy
Children s Hospital, Division of Pulmonary Medicine, Boston, MA, USA
J Allergy Clin Immunol 115:252-8. 2005..Defensins are antimicrobial peptides that may take part in airway inflammation and hyperresponsiveness... - Prenatal, perinatal, and heritable influences on cord blood immune responsesBen M Willwerth
Pulmonary and Critical Care Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
Ann Allergy Asthma Immunol 96:445-53. 2006..The implications of these findings for future development of allergy or asthma are, as yet, unknown... - Maternal antioxidant intake in pregnancy and wheezing illnesses in children at 2 y of ageAugusto A Litonjua
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
Am J Clin Nutr 84:903-11. 2006..Low intakes of dietary antioxidants may contribute to increases in asthma and allergy... - Cord blood cytokines and acute lower respiratory illnesses in the first year of lifeNgoc P Ly
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Pediatrics 119:e171-8. 2007..The purpose of this work was to examine the relation between cytokine secretions by cord blood mononuclear cells and acute lower respiratory illness in a birth cohort of 297 children... - Influence of leukotriene pathway polymorphisms on response to montelukast in asthmaJohn J Lima
The American Lung Association Asthma Clinical Research Centers, Center for Pharmacogenetics, Nemours Children s Clinic, 807 Children s Way, Jacksonville, FL 32207, USA
Am J Respir Crit Care Med 173:379-85. 2006..Interpatient variability in montelukast response may be related to variation in leukotriene pathway candidate genes... - Association of corticotropin-releasing hormone receptor-2 genetic variants with acute bronchodilator response in asthmaAudrey H Poon
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
Pharmacogenet Genomics 18:373-82. 2008..We aim to assess associations between genetic variants of CRHR2 and acute bronchodilator response in asthma... - Asthma steroid pharmacogenetics: a study strategy to identify replicated treatment responsesScott T Weiss
Respiratory, Genetic, and Environmental Epidemiology, Channing Laboratory, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115
Proc Am Thorac Soc 1:364-7. 2004..The approach of a test and multiple replication populations is a valuable strategy in asthma pharmacogenetics, which can insure valid association findings... 
CRHR1 polymorphisms predict bone density in survivors of acute lymphoblastic leukemiaTerreia S Jones
Department of Radiology, Colleges of Pharmacy and Medicine, University of Tennessee, Memphis, TN, USA
J Clin Oncol 26:3031-7. 2008..Because CRHR1 polymorphisms have been associated with other corticosteroid effects, our goal was to define whether CRHR1 polymorphisms predict which patients with ALL are likely to develop bone mineral deficits...- ARG1 is a novel bronchodilator response gene: screening and replication in four asthma cohortsAugusto A Litonjua
Channing Laboratory, Pulmonary Division, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Am J Respir Crit Care Med 178:688-94. 2008..However, a substantial proportion of patients with asthma do not have a favorable response to these drugs, and identifying genetic determinants of drug response may aid in tailoring treatment for individual patients... - Molecular properties and pharmacogenetics of a polymorphism of adenylyl cyclase type 9 in asthma: interaction between beta-agonist and corticosteroid pathwaysKelan G Tantisira
Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Hum Mol Genet 14:1671-7. 2005..The Met772-AC9 polymorphism represents one of most likely several multi-gene polymorphisms along the receptor-relaxation axis, which together may provide for a composite pharmacogenetic index for asthma therapy... - Association of lung perfusion disparity and mortality in patients with cystic fibrosis awaiting lung transplantationMichael L Stanchina
Lung Transplant Program, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
J Heart Lung Transplant 21:217-25. 2002....