Kelan Tantisira

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. doi request reprint Vitamin D related genes in lung development and asthma pathogenesis
    Alvin T Kho
    Harvard Medical School, Boston, MA, USA
    BMC Med Genomics 6:47. 2013
  2. pmc Genome-wide association identifies the T gene as a novel asthma pharmacogenetic locus
    Kelan G Tantisira
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Am J Respir Crit Care Med 185:1286-91. 2012
  3. pmc Polymorphisms in signal transducer and activator of transcription 3 and lung function in asthma
    Augusto A Litonjua
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    Respir Res 6:52. 2005
  4. ncbi request reprint The pharmacogenetics of asthma treatment
    Kelan Tantisira
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Curr Allergy Asthma Rep 9:10-7. 2009
  5. pmc Chromosome 17: association of a large inversion polymorphism with corticosteroid response in asthma
    Kelan G Tantisira
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Pharmacogenet Genomics 18:733-7. 2008
  6. pmc Genome Wide Association Study to predict severe asthma exacerbations in children using random forests classifiers
    Mousheng Xu
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    BMC Med Genet 12:90. 2011
  7. ncbi request reprint FCER2: a pharmacogenetic basis for severe exacerbations in children with asthma
    Kelan G Tantisira
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Allergy Clin Immunol 120:1285-91. 2007
  8. ncbi request reprint The pharmacogenetics of asthma therapy
    Kelan G Tantisira
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Curr Drug Targets 7:1697-708. 2006
  9. ncbi request reprint Bronchodilation and bronchoconstriction: predictors of future lung function in childhood asthma
    Kelan G Tantisira
    Channing Laboratory, Pulmonary Division, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Allergy Clin Immunol 117:1264-71. 2006
  10. pmc Airway responsiveness in mild to moderate childhood asthma: sex influences on the natural history
    Kelan G Tantisira
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Am J Respir Crit Care Med 178:325-31. 2008

Detail Information

Publications40

  1. doi request reprint Vitamin D related genes in lung development and asthma pathogenesis
    Alvin T Kho
    Harvard Medical School, Boston, MA, USA
    BMC Med Genomics 6:47. 2013
    ..We hypothesized that vitamin D pathway genes are developmentally active in the fetal lung and that these developmental genes would be associated with asthma susceptibility and regulation in asthma...
  2. pmc Genome-wide association identifies the T gene as a novel asthma pharmacogenetic locus
    Kelan G Tantisira
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Am J Respir Crit Care Med 185:1286-91. 2012
    ..To date, most studies aimed at discovering genetic factors influencing treatment response in asthma have focused on biologic candidate genes. Genome-wide association studies (GWAS) can rapidly identify novel pharmacogenetic loci...
  3. pmc Polymorphisms in signal transducer and activator of transcription 3 and lung function in asthma
    Augusto A Litonjua
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    Respir Res 6:52. 2005
    ..Signal transducer and activator of transcription 3 is a transcription factor latent in the cytoplasm; the gene (STAT3) is activated by a wide range of cytokines, and may play a role in lung development and asthma pathogenesis...
  4. ncbi request reprint The pharmacogenetics of asthma treatment
    Kelan Tantisira
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Curr Allergy Asthma Rep 9:10-7. 2009
    ..Although no specific predictive tests have been developed thus far, the existing studies serve as strong proof of concept of the applicability of pharmacogenetics in the future management of asthma...
  5. pmc Chromosome 17: association of a large inversion polymorphism with corticosteroid response in asthma
    Kelan G Tantisira
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Pharmacogenet Genomics 18:733-7. 2008
    ..Additional pharmacogenetic investigations into regions of chromosomal diversity, including copy number variation and inversions, are warranted...
  6. pmc Genome Wide Association Study to predict severe asthma exacerbations in children using random forests classifiers
    Mousheng Xu
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    BMC Med Genet 12:90. 2011
    ..We hypothesized that the use of random forests classifiers to select SNPs would result in an improved predictive model of asthma exacerbations. We tested this hypothesis in a population of childhood asthmatics...
  7. ncbi request reprint FCER2: a pharmacogenetic basis for severe exacerbations in children with asthma
    Kelan G Tantisira
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Allergy Clin Immunol 120:1285-91. 2007
    ..Although inhaled corticosteroids (ICSs) generally protect against severe exacerbations in asthma, they may result in elevated IgE levels, which are associated with exacerbations...
  8. ncbi request reprint The pharmacogenetics of asthma therapy
    Kelan G Tantisira
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Curr Drug Targets 7:1697-708. 2006
    ..Therefore, genetic testing may play a significant role in the care for individuals with asthma in the forseeable future...
  9. ncbi request reprint Bronchodilation and bronchoconstriction: predictors of future lung function in childhood asthma
    Kelan G Tantisira
    Channing Laboratory, Pulmonary Division, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Allergy Clin Immunol 117:1264-71. 2006
    ..Persistently low levels of lung function are associated with subsequent symptoms in patients with asthma as children...
  10. pmc Airway responsiveness in mild to moderate childhood asthma: sex influences on the natural history
    Kelan G Tantisira
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Am J Respir Crit Care Med 178:325-31. 2008
    ..Airway responsiveness is a prognostic marker for asthma symptoms in later life. Objectives: To evaluate characteristics responsible for persistence of airway responsiveness in children with asthma...
  11. ncbi request reprint The pharmacogenetics of asthma: an update
    Kelan G Tantisira
    Brigham and Women s Hospital and Harvard Medical School, Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA
    Curr Opin Mol Ther 7:209-17. 2005
    ..Altogether, the available data indicate that genetics influences the likelihood of an individual responding to a given therapy, indicating that, in the future, optimal care for individuals with asthma may include genetic testing...
  12. pmc TBX21: a functional variant predicts improvement in asthma with the use of inhaled corticosteroids
    Kelan G Tantisira
    Channing Laboratory and Pulmonary Division, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 101:18099-104. 2004
    ..TBX21 may thus be an important determinant pharmacogenetic response to the therapy of asthma with inhaled corticosteroids...
  13. pmc Importin-13 genetic variation is associated with improved airway responsiveness in childhood asthma
    Benjamin A Raby
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Respir Res 10:67. 2009
    ..We hypothesize that common IPO13 genetic variation influences the anti-inflammatory effects of inhaled corticosteroids for the treatment of asthma, as measured by change in methacholine airway hyperresponsiveness (AHR-PC20)...
  14. pmc A role for Wnt signaling genes in the pathogenesis of impaired lung function in asthma
    Sunita Sharma
    Channing Laboratory, Center for Genomic Medicine, 181 Longwood Avenue, Boston, MA 02115, USA
    Am J Respir Crit Care Med 181:328-36. 2010
    ..Animal models demonstrate that aberrant gene expression in utero can result in abnormal pulmonary phenotypes...
  15. pmc Predicting response to short-acting bronchodilator medication using Bayesian networks
    Blanca E Himes
    Harvard MIT Division of Health Sciences and Technology, MA, USA
    Pharmacogenomics 10:1393-412. 2009
    ..We sought to relate candidate gene SNP data with bronchodilator response and measure the predictive accuracy of a model constructed with genetic variants...
  16. pmc Predictors of symptoms are different from predictors of severe exacerbations from asthma in children
    Ann Chen Wu
    Center for Child Health Care Studies, Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston, MA 02215 5301, USA
    Chest 140:100-7. 2011
    ..The goal of our study was (1) to assess the association of asthma symptoms with severe asthma exacerbations and (2) to compare predictors of persistent asthma symptoms and predictors of severe asthma exacerbations...
  17. pmc Effect of vitamin D and inhaled corticosteroid treatment on lung function in children
    Ann Chen Wu
    Center for Child Health Care Studies, Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston, MA 02215 5301, USA
    Am J Respir Crit Care Med 186:508-13. 2012
    ..Low vitamin D levels are associated with asthma and decreased airway responsiveness. Treatment with inhaled corticosteroids improves airway responsiveness and asthma control...
  18. ncbi request reprint DNA sequence variants in epithelium-specific ETS-2 and ETS-3 are not associated with asthma
    Rebecca M Baron
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Am J Respir Crit Care Med 166:927-32. 2002
    ..This study suggests that epithelium-specific ETS-2 and ETS-3 genes are unlikely to contain polymorphic loci that have a major impact on asthma susceptibility in our population...
  19. pmc T-bet polymorphisms are associated with asthma and airway hyperresponsiveness
    Benjamin A Raby
    M D C M, Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Respir Crit Care Med 173:64-70. 2006
    ..Little is known regarding the role of genetic variation surrounding T-bet in the development of human AHR...
  20. pmc Platform dependence of inference on gene-wise and gene-set involvement in human lung development
    Rose Du
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    BMC Bioinformatics 10:189. 2009
    ..0 and the Illumina HumanRef-8 v2 Expression Bead Chips, for comparability in a biological system in which changes may be subtle, namely fetal lung tissue as a function of gestational age...
  21. pmc Genome-wide association study of the age of onset of childhood asthma
    Erick Forno
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA, USA
    J Allergy Clin Immunol 130:83-90.e4. 2012
    ..Although an earlier onset has been associated with more severe disease, there has been no genome-wide association study of the age of onset of asthma in children...
  22. pmc Repeatability of response to asthma medications
    Ann Chen Wu
    Department of Ambulatory Care and Prevention, Harvard Pilgrim Health Care and Harvard Medical School, Boston, Mass, USA
    J Allergy Clin Immunol 123:385-90. 2009
    ..Pharmacogenetic studies of drug response in asthma assume that patients respond consistently to a treatment but that treatment response varies across patients; however, no formal studies have demonstrated this...
  23. pmc RUNX transcription factors: association with pediatric asthma and modulated by maternal smoking
    Kathleen J Haley
    Brigham and Women s Hospital, Division of Pulmonary and Critical Care Medicine, PBB 3, 75 Francis St, Boston, Massachusetts 02115, USA
    Am J Physiol Lung Cell Mol Physiol 301:L693-701. 2011
    ..We speculate that IUS exposure-altered expression of RUNX transcription factors increases the risk of asthma in children with IUS exposure...
  24. ncbi request reprint Corticotropin-releasing hormone deficiency increases allergen-induced airway inflammation in a mouse model of asthma
    Eric S Silverman
    Physiology Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115 6021, USA
    J Allergy Clin Immunol 114:747-54. 2004
    ..Abnormal regulation of CRH and endogenous glucocorticoids has been implicated in the pathogenesis of asthma...
  25. pmc Pharmacogenomic discovery using cell-based models
    Marleen Welsh
    Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    Pharmacol Rev 61:413-29. 2009
    ..The primary focus is recent progress in the pharmacogenomic discovery area through ex vivo models...
  26. ncbi request reprint An elevated breathing reserve index at the lactate threshold is a predictor of mortality in patients with cystic fibrosis awaiting lung transplantation
    Kelan G Tantisira
    Pulmonary and Critical Care Unit, General Medical Services, Boston, Massachusetts 02114, USA
    Am J Respir Crit Care Med 165:1629-33. 2002
    ..70 or more) for those at risk. This measurement may allow improved timing of listing for transplantation, including consideration for living donor transplantation...
  27. ncbi request reprint Asthma steroid pharmacogenetics: a study strategy to identify replicated treatment responses
    Scott T Weiss
    Respiratory, Genetic, and Environmental Epidemiology, Channing Laboratory, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115
    Proc Am Thorac Soc 1:364-7. 2004
    ..The approach of a test and multiple replication populations is a valuable strategy in asthma pharmacogenetics, which can insure valid association findings...
  28. ncbi request reprint Corticosteroid pharmacogenetics: association of sequence variants in CRHR1 with improved lung function in asthmatics treated with inhaled corticosteroids
    Kelan G Tantisira
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Hum Mol Genet 13:1353-9. 2004
    ....
  29. pmc Influence of leukotriene pathway polymorphisms on response to montelukast in asthma
    John J Lima
    The American Lung Association Asthma Clinical Research Centers, Center for Pharmacogenetics, Nemours Children s Clinic, 807 Children s Way, Jacksonville, FL 32207, USA
    Am J Respir Crit Care Med 173:379-85. 2006
    ..Interpatient variability in montelukast response may be related to variation in leukotriene pathway candidate genes...
  30. pmc Prenatal, perinatal, and heritable influences on cord blood immune responses
    Ben M Willwerth
    Pulmonary and Critical Care Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Ann Allergy Asthma Immunol 96:445-53. 2006
    ..Maternal and perinatal environmental exposures, as well as inherited factors, may influence neonatal immune responses...
  31. pmc Associations of cord blood fatty acids with lymphocyte proliferation, IL-13, and IFN-gamma
    Diane R Gold
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    J Allergy Clin Immunol 117:931-8. 2006
    ..However, both n-3 eicosapentaenoic acid (EPA) and n-6 arachidonic acid (AA) are required for normal fetal development...
  32. ncbi request reprint Molecular properties and pharmacogenetics of a polymorphism of adenylyl cyclase type 9 in asthma: interaction between beta-agonist and corticosteroid pathways
    Kelan G Tantisira
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Hum Mol Genet 14:1671-7. 2005
    ..The Met772-AC9 polymorphism represents one of most likely several multi-gene polymorphisms along the receptor-relaxation axis, which together may provide for a composite pharmacogenetic index for asthma therapy...
  33. pmc Maternal antioxidant intake in pregnancy and wheezing illnesses in children at 2 y of age
    Augusto A Litonjua
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Clin Nutr 84:903-11. 2006
    ..Low intakes of dietary antioxidants may contribute to increases in asthma and allergy...
  34. pmc Cord blood cytokines and acute lower respiratory illnesses in the first year of life
    Ngoc P Ly
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Pediatrics 119:e171-8. 2007
    ..The purpose of this work was to examine the relation between cytokine secretions by cord blood mononuclear cells and acute lower respiratory illness in a birth cohort of 297 children...
  35. ncbi request reprint Association of defensin beta-1 gene polymorphisms with asthma
    Hara Levy
    Children s Hospital, Division of Pulmonary Medicine, Boston, MA, USA
    J Allergy Clin Immunol 115:252-8. 2005
    ..Defensins are antimicrobial peptides that may take part in airway inflammation and hyperresponsiveness...
  36. pmc Association of corticotropin-releasing hormone receptor-2 genetic variants with acute bronchodilator response in asthma
    Audrey H Poon
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Pharmacogenet Genomics 18:373-82. 2008
    ..We aim to assess associations between genetic variants of CRHR2 and acute bronchodilator response in asthma...
  37. doi request reprint CRHR1 polymorphisms predict bone density in survivors of acute lymphoblastic leukemia
    Terreia S Jones
    Department of Radiology, Colleges of Pharmacy and Medicine, University of Tennessee, Memphis, TN, USA
    J Clin Oncol 26:3031-7. 2008
    ..Because CRHR1 polymorphisms have been associated with other corticosteroid effects, our goal was to define whether CRHR1 polymorphisms predict which patients with ALL are likely to develop bone mineral deficits...
  38. pmc ARG1 is a novel bronchodilator response gene: screening and replication in four asthma cohorts
    Augusto A Litonjua
    Channing Laboratory, Pulmonary Division, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 178:688-94. 2008
    ..However, a substantial proportion of patients with asthma do not have a favorable response to these drugs, and identifying genetic determinants of drug response may aid in tailoring treatment for individual patients...
  39. ncbi request reprint Beta 2-adrenergic receptor polymorphisms and haplotypes are associated with airways hyperresponsiveness among nonsmoking men
    Augusto A Litonjua
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Chest 126:66-74. 2004
    ..To investigate the relationship of common single nucleotide polymorphisms (SNPs) of the beta(2)-adrenergic receptor (AR) gene at codons 16 and 27, and the intermediate phenotype of airways hyperresponsiveness...
  40. ncbi request reprint Association of lung perfusion disparity and mortality in patients with cystic fibrosis awaiting lung transplantation
    Michael L Stanchina
    Lung Transplant Program, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Heart Lung Transplant 21:217-25. 2002
    ..These patterns were compared with other pulmonary physiologic markers of ventilation and perfusion obtained from pulmonary function and cardiopulmonary exercise tests...