Research Topics
| Alex Y TanSummaryAffiliation: Harvard University Country: USA Publications
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Detail Information
Publications
Atrial fibrillation and atrial fibrosisAlex Y Tan
Division of Cardiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
J Cardiovasc Pharmacol 57:625-9. 2011..This article reviews the role that atrial fibrosis plays in AF, the mechanisms of atrial fibrosis, and emerging therapeutic approaches to AF aimed at attenuating atrial fibrosis...
Neural mechanisms of paroxysmal atrial fibrillation and paroxysmal atrial tachycardia in ambulatory caninesAlex Y Tan
Division of Cardiology, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, CA, USA
Circulation 118:916-25. 2008..The relationship between autonomic activation and the mechanisms of paroxysmal atrial fibrillation remains unclear...- Ectopic atrial arrhythmias arising from canine thoracic veins during in vivo stellate ganglia stimulationAlex Y Tan
Division of Cardiology, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, CA, USA
Am J Physiol Heart Circ Physiol 295:H691-8. 2008.... 
Spontaneous stellate ganglion nerve activity and ventricular arrhythmia in a canine model of sudden deathShengmei Zhou
Division of Cardiology, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, California, USA
Heart Rhythm 5:131-9. 2008..Little information is available on the temporal relationship between instantaneous sympathetic nerve activity and ventricular arrhythmia in ambulatory animals...- The mechanisms of atrial fibrillationPeng Sheng Chen
Division of Cardiology, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
J Cardiovasc Electrophysiol 17:S2-7. 2006..Therefore, thoracic vein isolation is an important technique in AF control. We conclude that thoracic veins are important in the generation and maintenance of AF... - Antiarrhythmic effects of beta3-adrenergic receptor stimulation in a canine model of ventricular tachycardiaShengmei Zhou
Division of Cardiology, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, California, USA
Heart Rhythm 5:289-97. 2008..Beta3-adrenergic receptor (beta3-AR) stimulation inhibits cardiac contractility... - Left stellate ganglion and vagal nerve activity and cardiac arrhythmias in ambulatory dogs with pacing-induced congestive heart failureMasahiro Ogawa
Division of Cardiology, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, California, USA
J Am Coll Cardiol 50:335-43. 2007..The purpose of this study was to determine the patterns of autonomic nerve activity in congestive heart failure (CHF)... - Autonomic nerves in pulmonary veinsAlex Y Tan
Division of Cardiology, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, California, USA
Heart Rhythm 4:S57-60. 2007..This review summarizes recent developments in the understanding of the anatomy of autonomic nerves in and around pulmonary veins and their implications for atrial fibrillation... - Cryoablation of stellate ganglia and atrial arrhythmia in ambulatory dogs with pacing-induced heart failureMasahiro Ogawa
Division of Cardiology, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, California, USA
Heart Rhythm 6:1772-9. 2009..There is an association between autonomic nerve discharges and atrial arrhythmias (including bradycardia and tachycardia) in ambulatory dogs with pacing-induced heart failure (HF)... - Atrial sympathetic and parasympathetic nerve sprouting and hyperinnervation induced by subthreshold electrical stimulation of the left stellate ganglion in normal dogsMoshe Swissa
Division of Cardiology, Department of Medicine, Cedars Sinai Medical Center Los Angeles, CA 90027, USA
Cardiovasc Pathol 17:303-8. 2008..It is unclear whether a similar neural plasticity involving both sympathetic and parasympathetic innervation also exists in the atria... - Autonomic nerve activity and atrial fibrillationPeng Sheng Chen
Division of Cardiology, Department of Medicine, Cedars Sinai Medical Center and David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA
Heart Rhythm 4:S61-4. 2007..ANS activity and Ca(i) transient dynamics are important in the development of PAF. These studies suggest that new methods or drugs aimed at modification of cardiac ANS activity may lead to new opportunities for AF control... - Electrical connections between left superior pulmonary vein, left atrium, and ligament of Marshall: implications for mechanisms of atrial fibrillationAlex Y Tan
Division of Cardiology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA
Am J Physiol Heart Circ Physiol 290:H312-22. 2006..LOM-LSPV connection forms an accessory pathway that contributes to the electrical coupling between LSPV and LA during SR and AF. This pathway may contribute to rapid activations within the LSPV during AF... - Vein of Marshall activity during sustained atrial fibrillationSantosh Kamanu
Division of Cardiology, Department of Medicine, Cedars-Sinai Medical Center and the David Geffen School of Medicine, UCLA, Los Angeles, CA, USA
J Cardiovasc Electrophysiol 17:839-46. 2006..The rate of activation at VOM is significantly faster than other atrial and PV sites during AF. These findings show that rapid activation is present in the VOM during sustained AF in human patients... - Intracellular calcium and vulnerability to fibrillation and defibrillation in Langendorff-perfused rabbit ventriclesGyo-Seung Hwang
Division of Cardiology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA
Circulation 114:2595-603. 2006..The Ca(i) prefluorescence at the first postshock early site suggests that reverse excitation-contraction coupling might be responsible for the initiation of postshock activations that lead to ventricular fibrillation... - Autonomic innervation and segmental muscular disconnections at the human pulmonary vein-atrial junction: implications for catheter ablation of atrial-pulmonary vein junctionAlex Y Tan
Division of Cardiology, Department of Medicine, Los Angeles, California, USA
J Am Coll Cardiol 48:132-43. 2006..Adrenergic and cholinergic nerves have highest densities within 5 mm of the PV-LA junction, but are highly co-located, indicating that it is impossible to selectively target either vagal or sympathetic nerves during ablation procedures... - Circadian variations of stellate ganglion nerve activity in ambulatory dogsByung-Chun Jung
Division of Cardiology, Department of Medicine, Cedars-Sinai Medical Center, CA 90048-1865, USA
Heart Rhythm 3:78-85. 2006..CONCLUSION: There is a circadian variation in sympathetic outflow from canine stellate ganglia. Circadian variation of SGNA is an important cause of circadian variations of cardiac sympathetic tone... - High-density mapping of pulmonary veins and left atrium during ibutilide administration in a canine model of sustained atrial fibrillationChung-Chuan Chou
Division of Cardiology, Department of Medicine, Rm. 5537, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90048, USA
Am J Physiol Heart Circ Physiol 289:H2704-13. 2005..These findings suggest that the PV FD during AF is due to nonreentrant mechanisms. High doses of ibutilide may completely terminate all reentrant activity, converting AF to PV tachycardia before the resumption of sinus rhythm...