Research Topics
Genomes and Genes | RULLA MAY TAMIMISummaryAffiliation: Harvard University Country: USA Publications
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Publications
Nondense mammographic area and risk of breast cancerAndreas Pettersson
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
Breast Cancer Res 13:R100. 2011..We investigated separately the absolute dense area and the absolute nondense area on mammograms in relation to breast cancer risk...- Columnar cell lesions and subsequent breast cancer risk: a nested case-control studySarah A Aroner
Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
Breast Cancer Res 12:R61. 2010..However, the risk of subsequent breast cancer associated with the presence of CCL in a benign breast biopsy is poorly understood... - Circulating carotenoids, mammographic density, and subsequent risk of breast cancerRulla M Tamimi
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Cancer Res 69:9323-9. 2009..05). Our results suggest that plasma levels of carotenoids may play a role in reducing breast cancer risk, particularly among women with high mammographic density... - Circulating colony stimulating factor-1 and breast cancer riskRulla M Tamimi
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Cancer Res 68:18-21. 2008..45; 95% CI, 1.02-2.07; P(trend) = 0.06) and ER+/PR+ tumors (RR, 1.72; 95% CI, 1.11-2.66; P(trend) = 0.04). Thus, the association of circulating CSF1 levels and breast cancer varies by menopausal status... - Breast cancer susceptibility loci and mammographic densityRulla M Tamimi
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA, 02115, USA
Breast Cancer Res 10:R66. 2008.... 
Single nucleotide polymorphisms and breast cancer: not yet a success storyRulla M Tamimi
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Breast Cancer Res 8:108. 2006..Future studies should perhaps also consider alternative designs such as using surrogate (preferably continuous) markers of breast cancer, focusing on high-risk populations, and defining pathologically distinct outcomes...
Endogenous sex hormone levels and mammographic density among postmenopausal womenRulla M Tamimi
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
Cancer Epidemiol Biomarkers Prev 14:2641-7. 2005..The mechanism by which breast density increases breast cancer risk is unclear although it has been hypothesized that breast density reflects cumulative exposure to estrogens...- Benign breast disease, recent alcohol consumption, and risk of breast cancer: a nested case-control studyRulla M Tamimi
Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
Breast Cancer Res 7:R555-62. 2005.... - Expression of IGF1R in normal breast tissue and subsequent risk of breast cancerRulla M Tamimi
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Breast Cancer Res Treat 128:243-50. 2011..Further studies to confirm these findings are necessary... - Traditional breast cancer risk factors in relation to molecular subtypes of breast cancerRulla M Tamimi
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
Breast Cancer Res Treat 131:159-67. 2012..Identifying risk factors for less common subtypes such as luminal B, HER2-type and basal-like tumors has important implications for prevention of these more aggressive subtypes... - Comparison of molecular phenotypes of ductal carcinoma in situ and invasive breast cancerRulla M Tamimi
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA, 02115, USA
Breast Cancer Res 10:R67. 2008..The purpose of this study was to compare the prevalence of these distinct molecular subtypes among cases of DCIS and invasive breast cancer... - Endogenous hormone levels, mammographic density, and subsequent risk of breast cancer in postmenopausal womenRulla M Tamimi
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Ave, Boston, MA 02115, USA
J Natl Cancer Inst 99:1178-87. 2007..Whether mammographic density reflects levels of endogenous sex hormones is unclear. We examined whether these predictors are independently associated with breast cancer risk in a prospective study... - The HRAS1 variable number of tandem repeats and risk of breast cancerRulla M Tamimi
Department of Epidemiology, Harvard School of Public Health, and Channing Laboratory, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Cancer Epidemiol Biomarkers Prev 12:1528-30. 2003..These results suggest that there is no overall association between rare alleles of the HRAS1 VNTR and breast cancer... - Manganese superoxide dismutase polymorphism, plasma antioxidants, cigarette smoking, and risk of breast cancerRulla M Tamimi
Department ofEpidemiology, Harvard School of Public Health, Boston, MA, USA
Cancer Epidemiol Biomarkers Prev 13:989-96. 2004..41; 95% confidence interval 0.77-2.60; P for interaction = 0.03). These data suggest that the Ala allele of MnSOD may modify breast cancer risk among current smokers, but is not an independent risk factor for breast cancer... - Evaluation of a breast cancer risk prediction model expanded to include category of prior benign breast disease lesionRulla M Tamimi
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Cancer 116:4944-53. 2010..Given the substantial heterogeneity in breast cancer risk dependent on the type of benign lesion, the authors evaluated whether incorporating this level of detail would improve the discriminatory power of risk classification models... - Plasma carotenoids, retinol, and tocopherols and risk of breast cancerRulla M Tamimi
Channing Laboratory, Department of Medicine, 181 Longwood Avenue, Boston, MA 02115, USA
Am J Epidemiol 161:153-60. 2005..Although the association was strongest for alpha-carotene, the high degree of collinearity among plasma carotenoids limits our ability to conclude that this association is specific to any individual carotenoid... - Genetic variation and circulating levels of IGF-I and IGFBP-3 in relation to risk of proliferative benign breast diseaseXuefen Su
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Int J Cancer 126:180-90. 2010..These results suggest that genetic variants and circulating levels of IGFBP-3 may play a role in the early stage of breast carcinogenesis... - Estrogen receptor-beta expression in invasive breast cancer in relation to molecular phenotype: results from the Nurses' Health StudyJonathan D Marotti
Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
Mod Pathol 23:197-204. 2010..The role of ER-beta in the development and progression of breast cancers defined by lack of expression of ER-alpha merits further investigation... - Measures of energy balance and mammographic density in the Nurses' Health StudyGoli Samimi
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
Breast Cancer Res Treat 109:113-22. 2008..There was no association between recent physical activity and mammographic density. These findings indicate that childhood and adult body fatness and weight change from age 18 are inversely associated with mammographic density... 
Birth weight, breast cancer susceptibility loci, and breast cancer riskRulla M Tamimi
Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
Cancer Causes Control 21:689-96. 2010....- Lobule type and subsequent breast cancer risk: results from the Nurses' Health StudiesHeather J Baer
Division of General Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02120, USA
Cancer 115:1404-11. 2009..Lobules in normal breast tissue can be classified based on their degree of development, which may affect their susceptibility to carcinogenesis. However, few epidemiologic studies to date have addressed this... - Mammographic density, plasma vitamin D levels and risk of breast cancer in postmenopausal womenAngela K Green
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Int J Cancer 127:667-74. 2010..Further research examining vitamin D, mammographic density and breast cancer risk is warranted... - Prospective study of growth and development in older girls and risk of benign breast disease in young womenCatherine S Berkey
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Cancer 117:1612-20. 2011..The authors prospectively evaluated these childhood/adolescent characteristics and BBD risk... - Genome-wide association scans for secondary traits using case-control samplesGenevieve M Monsees
Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Genet Epidemiol 33:717-28. 2009.... - Prospective study of adolescent alcohol consumption and risk of benign breast disease in young womenCatherine S Berkey
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Pediatrics 125:e1081-7. 2010..To investigate prospectively, using alcoholic beverage consumption data collected in real time, the association between adolescent drinking and risk of biopsy-confirmed benign breast disease (BBD) in young women... - Potential role of tissue microarrays for the study of biomarker expression in benign breast disease and normal breast tissueLaura C Collins
Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Appl Immunohistochem Mol Morphol 17:438-41. 2009..Whether or not TMAs may also be a potentially useful platform for assessing biomarkers in benign proliferative breast lesions (BPBL) and normal breast tissue has not been previously studied in detail... - Insulin-like growth factor-1- and interleukin-6-related gene variation and risk of multiple myelomaBrenda M Birmann
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Cancer Epidemiol Biomarkers Prev 18:282-8. 2009..Nonetheless, the data are consistent with the hypothesis that IGF-1- and IL-6-related gene variation influences susceptibility to multiple myeloma and warrant confirmation in larger populations... - A prospective study of XRCC1 haplotypes and their interaction with plasma carotenoids on breast cancer riskJiali Han
Department of Nutrition, Harvard Center for Cancer Prevention, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Cancer Res 63:8536-41. 2003.... - Outcome of patients with ductal carcinoma in situ untreated after diagnostic biopsy: results from the Nurses' Health StudyLaura C Collins
Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
Cancer 103:1778-84. 2005..Studies of patients with ductal carcinoma in situ (DCIS) "treated" by diagnostic biopsy alone have been rare, but provide important opportunities to gain insights into the natural history of these lesions... - The influence of family history on breast cancer risk in women with biopsy-confirmed benign breast disease: results from the Nurses' Health StudyLaura C Collins
Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
Cancer 107:1240-7. 2006..However, the influence of a positive family history (FH) on breast cancer risk among women with biopsy-confirmed BBD is less certain... - Common ataxia telangiectasia mutated haplotypes and risk of breast cancer: a nested case-control studyRulla M Tamimi
Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
Breast Cancer Res 6:R416-22. 2004..Five biallelic haplotype tagging single nucleotide polymorphisms are estimated to capture 99% of the haplotype diversity in Caucasian populations... - Gene x Gene interaction between MnSOD and GPX-1 and breast cancer risk: a nested case-control studyDavid G Cox
Program in Molecular and Genetic Epidemiology, Epidemiology Department, Harvard School of Public Health, 677 Huntington Ave, Boston, MA 02115, USA
BMC Cancer 6:217. 2006..We investigated whether variants at both polymorphisms, while not independently associated with breast cancer risk, could influence breast cancer risk when considered together... - Magnitude and laterality of breast cancer risk according to histologic type of atypical hyperplasia: results from the Nurses' Health StudyLaura C Collins
Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
Cancer 109:180-7. 2007..Atypical hyperplasia (AH) in a benign breast biopsy is associated with an increased breast cancer risk. However, the influence of the histologic type of AH on the magnitude and laterality of breast cancer risk is poorly defined... - Common genetic variation in IGF1, IGFBP-1, and IGFBP-3 in relation to mammographic density: a cross-sectional studyRulla M Tamimi
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
Breast Cancer Res 9:R18. 2007.... - Comparison of estrogen receptor results from pathology reports with results from central laboratory testingLaura C Collins
Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
J Natl Cancer Inst 100:218-21. 2008..78, P < .001). Thus, ER assay results from pathology reports appear to be a reasonable alternative to central laboratory ER testing for large, population-based studies of patients with breast cancer... - A prospective study of genetic polymorphism in MPO, antioxidant status, and breast cancer riskChunyan He
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
Breast Cancer Res Treat 113:585-94. 2009..Further research is needed to confirm these possible associations... - Combined estrogen and testosterone use and risk of breast cancer in postmenopausal womenRulla M Tamimi
Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA
Arch Intern Med 166:1483-9. 2006..CONCLUSION: Consistent with the elevation in risk for endogenous testosterone levels, women using estrogen and testosterone therapies have a significantly increased risk of invasive breast cancer... - Birth weight and mammographic density among postmenopausal women in SwedenRulla M Tamimi
Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
Int J Cancer 126:985-91. 2010..These results indicate that adult breast density, a powerful predictor of breast cancer risk, has intrauterine roots, as reflected in birth size... - Intake of fiber and nuts during adolescence and incidence of proliferative benign breast diseaseXuefen Su
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, 3rd Floor, Boston, MA 02115, USA
Cancer Causes Control 21:1033-46. 2010..We examined the association between adolescent fiber intake and proliferative BBD, a marker of increased breast cancer risk, in the Nurses' Health Study II... - Pregnancy estriol, estradiol, progesterone and prolactin in relation to birth weight and other birth size variables (United States)Lorelei A Mucci
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
Cancer Causes Control 14:311-8. 2003..CONCLUSIONS: Because E3 is a dominant estrogen during pregnancy, the positive association of it with birth weight allows the use of the latter as a proxy of in utero exposure to estrogens in breast cancer investigations... - Average energy intake among pregnant women carrying a boy compared with a girlRulla M Tamimi
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
BMJ 326:1245-6. 2003
Research Grants
- Molecular Predictors of Mammographic DensityRulla M Tamimi; Fiscal Year: 2010..This is an efficient study design to determine the association between hormonal biomarkers and mammographic density and the effects of both on breast cancer risk. ..
- Whole Genome Association Study of Mammographic DensityRulla Tamimi; Fiscal Year: 2009....
- Molecular Predictors of Mammographic DensityRulla Tamimi; Fiscal Year: 2009..Understanding the relation between the two and how they influence breast cancer risk will be useful in risk prediction and may help to identify women at particularly high risk of breast cancer. ..
- BENIGN BREAST DISEASE AND RISK OF BREAST CANCERRulla Tamimi; Fiscal Year: 2009..The creation of tissue microarrays using benign breast tissue will lay the foundation for this and future studies to efficiently examine the role of molecular markers in the development of breast cancer. ..
- Vitamin D and Mammographic DensityRulla Tamimi; Fiscal Year: 2007..Given that vitamin D levels are readily modifiable and that mammographic density is a noninvasive intermediate marker of breast cancer this proposal has important implications for breast cancer prevention. ..
- BENIGN BREAST DISEASE AND RISK OF BREAST CANCERRulla Tamimi; Fiscal Year: 2007..The creation of tissue microarrays using benign breast tissue will lay the foundation for this and future studies to efficiently examine the role of molecular markers in the development of breast cancer. ..
- Whole Genome Association Study of Mammographic DensityRulla M Tamimi; Fiscal Year: 2010....