A Takeshita

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi TRAM-1, A novel 160-kDa thyroid hormone receptor activator molecule, exhibits distinct properties from steroid receptor coactivator-1
    A Takeshita
    Division of Genetics, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Biol Chem 272:27629-34. 1997
  2. ncbi Thyroid hormone response elements differentially modulate the interactions of thyroid hormone receptors with two receptor binding domains in the steroid receptor coactivator-1
    A Takeshita
    Division of Genetics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 273:21554-62. 1998
  3. ncbi Lack of coactivator interaction can be a mechanism for dominant negative activity by mutant thyroid hormone receptors
    Y Liu
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Endocrinology 139:4197-204. 1998
  4. ncbi Molecular cloning and properties of a full-length putative thyroid hormone receptor coactivator
    A Takeshita
    Department of Medicine, Brigham a Women s Hospital, Boston, MA, USA
    Endocrinology 137:3594-7. 1996
  5. ncbi ROR alpha augments thyroid hormone receptor-mediated transcriptional activation
    N Koibuchi
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Endocrinology 140:1356-64. 1999
  6. ncbi Nuclear receptor coactivators facilitate vitamin D receptor homodimer action on direct repeat hormone response elements
    A Takeshita
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Endocrinology 141:1281-4. 2000
  7. ncbi 15-Deoxy-delta 12,14-prostaglandin J2 and thiazolidinediones activate the MEK/ERK pathway through phosphatidylinositol 3-kinase in vascular smooth muscle cells
    K Takeda
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, 3-1-1 Maidashi, Higashi-ku, 812-8582 Fukuoka, Japan
    J Biol Chem 276:48950-5. 2001
  8. ncbi Decreased amount of mpl and reduced expression of glycoprotein IIb/IIIa and glycoprotein Ib on platelets from patients with refractory anemia: analysis by a non-isotopic quantitative ligand binding assay and immunofluorescence
    M Izumi
    Clinical Laboratories, Hamamatsu University School of Medicine, Japan
    Eur J Haematol 66:245-52. 2001
  9. ncbi Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies
    Y Yamamoto
    Department of Infectious Diseases and the First Department of Internal Medicine, Nagoya University School of Medicine, Japan
    Blood 97:2434-9. 2001
  10. ncbi Identification, characterization, and functional analysis of heart-specific myosin light chain phosphatase small subunit
    T Arimura
    Department of Molecular Pathogenesis, Division of Adult Diseases, Medical Research Institute, Tokyo Medical and Dental University, Tokyo 101 0062, Japan
    J Biol Chem 276:6073-82. 2001

Collaborators

  • Y Liu
  • N Koibuchi
  • M Ikeda
  • E R Norwitz
  • Kazutake Tsujikawa
  • S Misiti
  • K Ohtani
  • K Takeda
  • Y Yamamoto
  • R Ohno
  • T Arimura
  • M Izumi
  • T Motoji
  • R Ueda
  • K Watari
  • K Baba
  • C E Juge-Aubry
  • M Usui
  • K I Hiasa
  • M Ishibashi
  • Y Kaneda
  • Q Zhao
  • R Morishita
  • K Egashira
  • M Aoki
  • Y Nakano
  • T Naoe
  • K Shinjo
  • R Suzuki
  • Y B Zhou
  • F Yagasaki
  • K Naito
  • H Kiyoi
  • A Kimura
  • H Akiyama
  • C Shimazaki
  • K Shinagawa
  • K Ohnishi
  • N Suematsu
  • T Tokunou
  • H Kanaide
  • K Kuriyama
  • H Matsui
  • N Asou
  • S Miyawaki
  • N Iino
  • Y Kodera
  • S Satoh
  • K Shibata
  • H Saito
  • T Kanno
  • J Nishimura
  • M Nishimura
  • T Ichiki
  • K Saito
  • K Tani
  • F Nagamura
  • S Asano
  • T Nagamura-Inoue
  • T Fukushima
  • A Tojo
  • A G Burger
  • C A Meier
  • C Siegrist-Kaiser
  • E Hammar
  • W W Chin
  • N Juni
  • D Yamamoto
  • K Majima
  • S Kondo
  • A Pernin

Detail Information

Publications14

  1. ncbi TRAM-1, A novel 160-kDa thyroid hormone receptor activator molecule, exhibits distinct properties from steroid receptor coactivator-1
    A Takeshita
    Division of Genetics, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Biol Chem 272:27629-34. 1997
    ..These results suggest that TRAM-1 is a coactivator that may exhibit its activity by interacting with subdomains of NRs other than the AF-2 region, in contrast to SRC-1/TIF2...
  2. ncbi Thyroid hormone response elements differentially modulate the interactions of thyroid hormone receptors with two receptor binding domains in the steroid receptor coactivator-1
    A Takeshita
    Division of Genetics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 273:21554-62. 1998
    ....
  3. ncbi Lack of coactivator interaction can be a mechanism for dominant negative activity by mutant thyroid hormone receptors
    Y Liu
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Endocrinology 139:4197-204. 1998
    ....
  4. ncbi Molecular cloning and properties of a full-length putative thyroid hormone receptor coactivator
    A Takeshita
    Department of Medicine, Brigham a Women s Hospital, Boston, MA, USA
    Endocrinology 137:3594-7. 1996
    ..Although F-SRC-1 recognizes the ligand-induced conformational changes of nuclear hormone receptors, our observations suggest that F-SRC-1 may bind directly with subregion(s) in nuclear hormone receptors other than the AF-2 region...
  5. ncbi ROR alpha augments thyroid hormone receptor-mediated transcriptional activation
    N Koibuchi
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Endocrinology 140:1356-64. 1999
    ....
  6. ncbi Nuclear receptor coactivators facilitate vitamin D receptor homodimer action on direct repeat hormone response elements
    A Takeshita
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Endocrinology 141:1281-4. 2000
    ..Our studies suggest the important role of VDR homodimers, in addition to VDR/RXR heterodimers, in vitamin D-induced transactivation. Thus, specific coactivator-VDR interactions on HREs may determine target gene transactivation...
  7. ncbi 15-Deoxy-delta 12,14-prostaglandin J2 and thiazolidinediones activate the MEK/ERK pathway through phosphatidylinositol 3-kinase in vascular smooth muscle cells
    K Takeda
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, 3-1-1 Maidashi, Higashi-ku, 812-8582 Fukuoka, Japan
    J Biol Chem 276:48950-5. 2001
    ..These findings indicate a novel regulatory mechanism of gene expression by 15-d-PGJ2 and thiazolidinediones...
  8. ncbi Decreased amount of mpl and reduced expression of glycoprotein IIb/IIIa and glycoprotein Ib on platelets from patients with refractory anemia: analysis by a non-isotopic quantitative ligand binding assay and immunofluorescence
    M Izumi
    Clinical Laboratories, Hamamatsu University School of Medicine, Japan
    Eur J Haematol 66:245-52. 2001
    ..0001) or gpIb (p=0.774, p<0.0001), and between those of gpIIb/IIIa and gpIb (p=0.728, p<0.0001). We demonstrated a decreased amount of mpl as well as a reduced expression of gpIIb/IIIa and gpIb on platelets from RA patients...
  9. ncbi Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies
    Y Yamamoto
    Department of Infectious Diseases and the First Department of Internal Medicine, Nagoya University School of Medicine, Japan
    Blood 97:2434-9. 2001
    ..These results demonstrate that the FLT3 gene is the target most frequently mutated to become constitutively active in AML...
  10. ncbi Identification, characterization, and functional analysis of heart-specific myosin light chain phosphatase small subunit
    T Arimura
    Department of Molecular Pathogenesis, Division of Adult Diseases, Medical Research Institute, Tokyo Medical and Dental University, Tokyo 101 0062, Japan
    J Biol Chem 276:6073-82. 2001
    ..These observations suggest that the heart-specific small subunit hHS-M(21) plays a regulatory role in cardiac muscle contraction by its binding to the large subunit...
  11. ncbi Identification of a melanoma antigen, PRAME, as a BCR/ABL-inducible gene
    K Watari
    Department of Hematology Oncology, Institute of Medical Science, University of Tokyo, Japan
    FEBS Lett 466:367-71. 2000
    ..Thus PRAME was considered to be a good candidate for a marker of Ph+-leukemic blast cells as well as a new target antigen of leukemic blast cells that cytotoxic T cells can recognize...
  12. pmc The Drosophila Bruton's tyrosine kinase (Btk) homolog is required for adult survival and male genital formation
    K Baba
    Developmental Genetics Group, Mitsubishi Kasei Institute of Life Sciences, Machida, Tokyo 194 8511, Japan
    Mol Cell Biol 19:4405-13. 1999
    ..The stage specificity of the rescuing ability suggests that the Btk gene is required for the development of male genitalia and substrates required for adult survival...
  13. ncbi Regulation of the transcriptional activity of the peroxisome proliferator-activated receptor alpha by phosphorylation of a ligand-independent trans-activating domain
    C E Juge-Aubry
    Division of Endocrinology and Diabetes, University Hospital Geneva, CH 1211 Geneva 14, Switzerland
    J Biol Chem 274:10505-10. 1999
    ..These observations suggest that the AF-1 region of PPARalpha is partially silenced by corepressor proteins, which might interact in a phosphorylation-dependent manner...
  14. ncbi Inhibition of neointimal hyperplasia after balloon injury by cis-element 'decoy' of early growth response gene-1 in hypercholesterolemic rabbits
    K Ohtani
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Gene Ther 11:126-32. 2004
    ..The Egr-1 pathway has an essential role in the pathogenesis of neointimal hyperplasia after balloon injury in hypercholesterolemic rabbits. This decoy strategy is a potential practical form of therapy for human restenosis...