Ayumi Takakura

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Pyrimethamine inhibits adult polycystic kidney disease by modulating STAT signaling pathways
    Ayumi Takakura
    Renal Division, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02115, USA
    Hum Mol Genet 20:4143-54. 2011
  2. doi The cytoplasmic protein Pacsin 2 in kidney development and injury repair
    Gang Yao
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Kidney Int 83:426-37. 2013
  3. pmc Renal injury is a third hit promoting rapid development of adult polycystic kidney disease
    Ayumi Takakura
    Renal Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 4 Blackfan Circle, Boston, MA 02115, USA
    Hum Mol Genet 18:2523-31. 2009
  4. doi Polycystic kidney disease evaluation by magnetic resonance imaging in ischemia-reperfusion injured PKD1 knockout mouse model: comparison of T2-weighted FSE and true-FISP
    Xiangzhi Zhou
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Invest Radiol 45:24-8. 2010
  5. pmc Failure to ubiquitinate c-Met leads to hyperactivation of mTOR signaling in a mouse model of autosomal dominant polycystic kidney disease
    Shan Qin
    Department of Medicine, Children s Hospital Boston, and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 120:3617-28. 2010
  6. pmc Aberrant regulation of planar cell polarity in polycystic kidney disease
    Annouck Luyten
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Am Soc Nephrol 21:1521-32. 2010
  7. pmc Pkd1 inactivation induced in adulthood produces focal cystic disease
    Ayumi Takakura
    Renal Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Am Soc Nephrol 19:2351-63. 2008
  8. pmc The role of HCA2 (GPR109A) in regulating macrophage function
    Kambiz Zandi-Nejad
    2Division of Nephrology, 330 Brookline Ave, E RN 304, Boston, MA 02215, USA
    FASEB J 27:4366-74. 2013
  9. pmc The novel therapeutic effect of phosphoinositide 3-kinase-γ inhibitor AS605240 in autoimmune diabetes
    Jamil Azzi
    Transplantation Research Center, Renal Division, Brigham and Women s Hospital and Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 61:1509-18. 2012
  10. pmc G alpha 12 inhibits alpha2 beta1 integrin-mediated Madin-Darby canine kidney cell attachment and migration on collagen-I and blocks tubulogenesis
    Tianqing Kong
    Renal Division, Brigham and Women s Hospital, Harvard Institutes of Medicine, Boston, MA 02115, USA
    Mol Biol Cell 20:4596-610. 2009

Collaborators

Detail Information

Publications12

  1. pmc Pyrimethamine inhibits adult polycystic kidney disease by modulating STAT signaling pathways
    Ayumi Takakura
    Renal Division, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02115, USA
    Hum Mol Genet 20:4143-54. 2011
    ..Our results suggest that PC1 acts as a negative regulator of STAT3 and that blocking STAT3 signaling with pyrimethamine or similar drugs may be an attractive therapy for human ADPKD...
  2. doi The cytoplasmic protein Pacsin 2 in kidney development and injury repair
    Gang Yao
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Kidney Int 83:426-37. 2013
    ..Thus, we propose that Pacsin 2 contributes to kidney development and repair in a nephron-specific manner...
  3. pmc Renal injury is a third hit promoting rapid development of adult polycystic kidney disease
    Ayumi Takakura
    Renal Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 4 Blackfan Circle, Boston, MA 02115, USA
    Hum Mol Genet 18:2523-31. 2009
    ..These data demonstrate, for the first time, a role for polycystin-1 in kidney injury and repair and indicate that renal injury constitutes a 'third hit' resulting in rapid cyst formation in adulthood...
  4. doi Polycystic kidney disease evaluation by magnetic resonance imaging in ischemia-reperfusion injured PKD1 knockout mouse model: comparison of T2-weighted FSE and true-FISP
    Xiangzhi Zhou
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Invest Radiol 45:24-8. 2010
    ....
  5. pmc Failure to ubiquitinate c-Met leads to hyperactivation of mTOR signaling in a mouse model of autosomal dominant polycystic kidney disease
    Shan Qin
    Department of Medicine, Children s Hospital Boston, and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 120:3617-28. 2010
    ..We therefore suggest that blockade of c-Met is a potential novel therapeutic approach to the treatment of ADPKD...
  6. pmc Aberrant regulation of planar cell polarity in polycystic kidney disease
    Annouck Luyten
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Am Soc Nephrol 21:1521-32. 2010
    ..Taken together, our data suggest that PC1 controls oriented cell division and that aberrant PCP signaling contributes to cystogenesis...
  7. pmc Pkd1 inactivation induced in adulthood produces focal cystic disease
    Ayumi Takakura
    Renal Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Am Soc Nephrol 19:2351-63. 2008
    ..We propose that an additional genetic or nongenetic "third hit" may be required for rapid development of cysts in polycystic kidney disease...
  8. pmc The role of HCA2 (GPR109A) in regulating macrophage function
    Kambiz Zandi-Nejad
    2Division of Nephrology, 330 Brookline Ave, E RN 304, Boston, MA 02215, USA
    FASEB J 27:4366-74. 2013
    ..04) but not in Hca2(-/-) BMMs. Our results suggest that the nicotinic acid-HCA2 axis is a novel negative regulator of macrophage activation...
  9. pmc The novel therapeutic effect of phosphoinositide 3-kinase-γ inhibitor AS605240 in autoimmune diabetes
    Jamil Azzi
    Transplantation Research Center, Renal Division, Brigham and Women s Hospital and Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 61:1509-18. 2012
    ..These studies demonstrate the key role of the PI3Kγ pathway in determining the balance of Tregs and autoreactive cells regulating autoimmune diabetes...
  10. pmc G alpha 12 inhibits alpha2 beta1 integrin-mediated Madin-Darby canine kidney cell attachment and migration on collagen-I and blocks tubulogenesis
    Tianqing Kong
    Renal Division, Brigham and Women s Hospital, Harvard Institutes of Medicine, Boston, MA 02115, USA
    Mol Biol Cell 20:4596-610. 2009
    ..Taken together, these studies provide direct evidence for G alpha 12-integrin regulation of epithelial cell spreading and migration necessary for normal tubulogenesis...
  11. doi Ischemic injury enhances dendritic cell immunogenicity via TLR4 and NF-kappa B activation
    Mollie Jurewicz
    Transplantation Research Center, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 184:2939-48. 2010
    ..These data may serve to identify novel therapeutic targets to attenuate graft immunogenicity following ischemia...
  12. ncbi Polycystin-1L2 is a novel G-protein-binding protein
    Takeshi Yuasa
    Renal Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Genomics 84:126-38. 2004
    ..We also show that PC1 C-terminal cytosolic domain binds to Galpha12, Galphas, and Galphai1, while it weakly interacts with Galphai2. Our results indicate that both PC1-like molecules may act as G-protein-coupled receptors...