Research Topics
Genomes and Genes
| Clifford J TabinSummaryAffiliation: Harvard University Country: USA Publications
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Detail Information
Publications
Mouse Disp1 is required in sonic hedgehog-expressing cells for paracrine activity of the cholesterol-modified ligandHua Tian
One DNA Way, Genentech Incorporated, South San Francisco, CA 94080, USA
Development 132:133-42. 2005..In both respects, Disp function is conserved from Drosophila to mice...- Mechanistic insight into how Shh patterns the vertebrate limbEdwina McGlinn
Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
Curr Opin Genet Dev 16:426-32. 2006..Current research has revealed unexpected complexity in how a gradient of Shh activity is both established and received, prompting re-evaluation of the nature of patterning mechanisms within the limb... - A two-cilia model for vertebrate left-right axis specificationClifford J Tabin
Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
Genes Dev 17:1-6. 2003 - Genetic analysis of the roles of BMP2, BMP4, and BMP7 in limb patterning and skeletogenesisAmitabha Bandyopadhyay
Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
PLoS Genet 2:e216. 2006..In contrast, we find that the loss of both BMP2 and BMP4 results in a severe impairment of osteogenesis... - Regulation of skeletogenic differentiation in cranial dermal boneArhat Abzhanov
Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
Development 134:3133-44. 2007..These results provide a framework for understanding dermal bone development with an aim of bringing it closer to the molecular and cellular resolution available for the endochondral bone development... - A Tcf4-positive mesodermal population provides a prepattern for vertebrate limb muscle patterningGabrielle Kardon
Department of Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
Dev Cell 5:937-44. 2003..We propose that Tcf4-expressing cells establish a prepattern in the limb mesoderm that determines the sites of myogenic differentiation and thus establishes the basic pattern of limb muscles... - Genetic analysis of interactions between the somitic muscle, cartilage and tendon cell lineages during mouse developmentAva E Brent
Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
Development 132:515-28. 2005.... - The microRNA miR-196 acts upstream of Hoxb8 and Shh in limb developmentEran Hornstein
Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
Nature 438:671-4. 2005.... - Antagonists of Wnt and BMP signaling promote the formation of vertebrate head muscleEldad Tzahor
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
Genes Dev 17:3087-99. 2003..Our findings demonstrate that head muscle formation is locally repressed by Wnt and BMP signals and induced by antagonists of these signaling pathways secreted by adjacent tissues... - In ovo application of antagomiRs indicates a role for miR-196 in patterning the chick axial skeleton through Hox gene regulationEdwina McGlinn
Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 106:18610-5. 2009.... - Somitic origin of limb muscle satellite and side population cellsJaclyn Schienda
Howard Hughes Medical Institute, Program in Genomics, Children's Hospital, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 103:945-50. 2006..Thus, we show that the somites, which supply embryonic and fetal myoblasts, are also an important source of highly myogenic adult muscle progenitors... - Bmp4 and morphological variation of beaks in Darwin's finchesArhat Abzhanov
Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
Science 305:1462-5. 2004..When misexpressed in chicken embryos, Bmp4 caused morphological transformations paralleling the beak morphology of the large ground finch G. magnirostris... - Characterization of a novel ectodermal signaling center regulating Tbx2 and Shh in the vertebrate limbSahar Nissim
Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
Dev Biol 304:9-21. 2007..This finding explains the tight restriction of Shh expression to the posterior margin throughout limb outgrowth as well as the tight restriction of Shh expression to the anterior margin in many mutants exhibiting preaxial polydactyly... - Development of heart valves requires Gata4 expression in endothelial-derived cellsJOSE RIVERA-FELICIANO
Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
Development 133:3607-18. 2006..First, Gata4 functions as an upstream regulator of an Erbb3-Erk pathway necessary for EMT, and second, Gata4 acts to promote cushion mesenchyme growth and remodeling... - Regulation of tendon differentiation by scleraxis distinguishes force-transmitting tendons from muscle-anchoring tendonsNicholas D Murchison
Shriners Hospital for Children, Research Division, Portland, OR 97239, and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
Development 134:2697-708. 2007..The phenotype of Scx-/- mutants emphasizes the diversity of tendon tissues and represents the first molecular insight into the important process of tendon differentiation... - Extended exposure to Sonic hedgehog is required for patterning the posterior digits of the vertebrate limbPaul J Scherz
Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
Dev Biol 308:343-54. 2007.... - Shh and Fgf8 act synergistically to drive cartilage outgrowth during cranial developmentArhat Abzhanov
Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
Dev Biol 273:134-48. 2004.... - Regulation of Gremlin expression in the posterior limb budSahar Nissim
Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
Dev Biol 299:12-21. 2006..Finally, by blocking Shh activity with cyclopamine, we find evidence that continued Shh activity is also required to maintain refractoriness to Gremlin expression in response to Bmp activity... - The limb bud Shh-Fgf feedback loop is terminated by expansion of former ZPA cellsPaul J Scherz
Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
Science 305:396-9. 2004.... - A somitic compartment of tendon progenitorsAva E Brent
Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
Cell 113:235-48. 2003..The tendon primordia thus form in a location abutting the two tissues that the mature tendons must ultimately connect. Tendon progenitor formation may reveal a general mechanism for the specification of other somitic subcompartments... - Synteny and candidate gene prediction using an anchored linkage map of Astyanax mexicanusJoshua B Gross
Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 105:20106-11. 2008..The map we have generated will greatly accelerate the production of viable lists of additional candidate genes involved in the development and evolution of cave-specific traits in A. mexicanus... - Temporomandibular joint formation requires two distinct hedgehog-dependent stepsPatricia Purcell
Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 106:18297-302. 2009..Thus, these experiments establish that Hh signaling acts at two distinct steps in disk morphogenesis, condyle initiation, and disk-condyle separation and provide a molecular framework for future studies of the TMJ... - A reevaluation of X-irradiation-induced phocomelia and proximodistal limb patterningJenna L Galloway
Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
Nature 460:400-4. 2009..Moreover, molecular evidence that proximodistal patterning is unaffected after X-irradiation does not support the predictions of the progress zone model... - A novel role for Mc1r in the parallel evolution of depigmentation in independent populations of the cavefish Astyanax mexicanusJoshua B Gross
Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
PLoS Genet 5:e1000326. 2009..This example of parallelism indicates that certain genes are frequent targets of mutation in the repeated evolution of regressive phenotypes in cave-adapted species... - The chirality of gut rotation derives from left-right asymmetric changes in the architecture of the dorsal mesenteryNicole M Davis
Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
Dev Cell 15:134-45. 2008..The resultant differences in cellular organization cause the mesentery to assume a trapezoidal shape, tilting the primitive gut tube leftward... - miRNA-processing enzyme Dicer is necessary for cardiac outflow tract alignment and chamber septationAnkur Saxena
Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 107:87-91. 2010..In sum, we demonstrate here a specific developmental process, that of outflow tract morphogenesis, being hindered by the deletion of miRNAs during cardiogenesis... - Cross-regulatory interactions between Fgf8 and Shh in the avian frontonasal prominenceArhat Abzhanov
Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA
Congenit Anom (Kyoto) 47:136-48. 2007..Our experiments revealed mutual antagonism between the two molecules, which aids in establishing and maintaining a molecular boundary that subsequently influences patterning and growth of the middle and upper face... - Developmental biology. Grasping limb patterningClifford J Tabin
Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
Science 321:350-2. 2008 - Sox9 and Nkx2.5 determine the pyloric sphincter epithelium under the control of BMP signalingNicole A Theodosiou
Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
Dev Biol 279:481-90. 2005..5 and its ability to determine the pyloric epithelium. Despite these similarities, our evidence suggests that Sox9 and Nkx2.5 are regulated independently by BMP signaling, and act coordinately to specify the pyloric sphincter... - FGF acts directly on the somitic tendon progenitors through the Ets transcription factors Pea3 and Erm to regulate scleraxis expressionAva E Brent
Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
Development 131:3885-96. 2004.... - Bmp2 instructs cardiac progenitors to form the heart-valve-inducing fieldJOSE RIVERA-FELICIANO
Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
Dev Biol 295:580-8. 2006..Our results demonstrate that Bmp2 is both necessary and sufficient to specify a field of cardiac progenitor cells as the heart-valve-inducing region amid developing atria and ventricles... - Wnt signaling during development of the gastrointestinal tractNicole A Theodosiou
Department of Genetics, Harvard Medical School, Warren Alpert Bldg, Rm. 425, 200 Longwood Avenue, Boston, MA 02115, USA
Dev Biol 259:258-71. 2003..The expression profiles of the Wnt signaling components presented in this paper should prove valuable in deciphering additional roles of the Wnt pathways during patterning of the vertebrate gut tube... - Dissimilar regulation of cell differentiation in mesencephalic (cranial) and sacral (trunk) neural crest cells in vitroArhat Abzhanov
Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
Development 130:4567-79. 2003..We also provide evidence that these differences in responsiveness are modulated, at least in part, by differential expression of Hox genes within the neural crest... - BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healingKunikazu Tsuji
Department of Developmental Biology, Harvard School of Dental Medicine, Boston, Massachusetts 02115, USA
Nat Genet 38:1424-9. 2006..Collectively, our results identify BMP2 as an endogenous mediator necessary for fracture repair... - Multi-trait evolution in a cave fish, Astyanax mexicanusMeredith Protas
Department of Genetics, Harvard Medical School, Boston, MA, USA
Evol Dev 10:196-209. 2008.... - Cell movements at Hensen's node establish left/right asymmetric gene expression in the chickJerome Gros
Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
Science 324:941-4. 2009..The creation of asymmetric expression domains as a passive effect of cell movements represents an alternative strategy for breaking L/R symmetry in gene activity... - Identification of unique molecular subdomains in the perichondrium and periosteum and their role in regulating gene expression in the underlying chondrocytesAmitabha Bandyopadhyay
Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA
Dev Biol 321:162-74. 2008.... - The calmodulin pathway and evolution of elongated beak morphology in Darwin's finchesArhat Abzhanov
Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
Nature 442:563-7. 2006..More generally, our results implicate the CaM-dependent pathway in the developmental regulation of craniofacial skeletal structures... - The direction of gut looping is established by changes in the extracellular matrix and in cell:cell adhesionNatasza A Kurpios
Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 105:8499-506. 2008..Functional studies demonstrate that N-cadherin acts upstream of the changes in the ECM and is both necessary and sufficient to explain the asymmetric packing of the mesenchymal cells... - Developmental regulation of somite derivatives: muscle, cartilage and tendonAva E Brent
Harvard Medical School, Department of Genetics, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
Curr Opin Genet Dev 12:548-57. 2002..The specification of somite derivatives involves the action of patterning signals secreted from adjacent tissue combined with the activation, in particular somitic compartments, of genes promoting cell lineage specification... - The Hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates thyroid hormone activation and PTHrP secretion in the developing growth plateMonica Dentice
Thyroid Section, Division of Endocrinology, Diabetes and Hypertension, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Nat Cell Biol 7:698-705. 2005..Thus, ECS(WSB-1) mediates a mechanism by which 'systemic' thyroid hormone can effect local control of the Hedgehog-PTHrP negative feedback loop and thus skeletogenesis... - MicroRNA-responsive 'sensor' transgenes uncover Hox-like and other developmentally regulated patterns of vertebrate microRNA expressionJennifer H Mansfield
Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
Nat Genet 36:1079-83. 2004..Furthermore, miR-196a negatively regulates Hoxb8, indicating that its restricted expression pattern probably reflects a role in the patterning function of the Hox complex... - Genome-wide expression analysis of intra- and extraarticular connective tissueRICHARD V PEARSE
Department of Genetics, Harvard Medical School, NRB 360, Boston, Massachusetts 02115, USA
J Orthop Res 27:427-34. 2009.... - Local extrinsic signals determine muscle and endothelial cell fate and patterning in the vertebrate limbGabrielle Kardon
Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
Dev Cell 3:533-45. 2002..Surprisingly, we also find that myogenic and endothelial cells are derived from a common somitic precursor. Thus, local extrinsic signals are critical for determining muscle and endothelial patterning as well as cell fate in the limb... - Reduce your pelvis in 10000 years or lessMeredith E Protas
Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
Dev Cell 6:613-4. 2004..examine one such example, the genetic basis of pelvic reduction in the threespine stickleback fish (2004). They conclude that a regulatory mutation in the Pitx1 gene is responsible for the pelvic reduction... - Developmental roles and clinical significance of hedgehog signalingAndrew P McMahon
Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
Curr Top Dev Biol 53:1-114. 2003..This review focuses on the developing systems themselves, providing a comprehensive survey of the role of Hedgehog signaling in each of these. We also discuss the increasing significance of Hedgehog signaling in the clinical setting... - Achieving bilateral symmetry during vertebrate limb developmentPatrick Allard
Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
Semin Cell Dev Biol 20:479-84. 2009..Through the activity of these signaling loops and their eventual breakdown when the limb bud has reached a certain size, bilateral symmetry can be achieved... - Classic limb patterning models and the work of Dennis SummerbellJenna L Galloway
Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
Development 135:2683-7. 2008.... - Limb regeneration revisitedJessica L Whited
Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
J Biol 8:5. 2009..Classical experiments provide a rich context for interpreting modern functional studies... - Understanding of bat wing evolution takes flightKimberly L Cooper
Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
Genes Dev 22:121-4. 2008 - Initiation of proximal-distal patterning in the vertebrate limb by signals and growthKimberly L Cooper
Harvard Medical School, Department of Genetics, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
Science 332:1083-6. 2011..In addition, the system we have developed, combining in vitro and in vivo culture, opens the door to a new level of analysis of patterning mechanisms in the limb... - WNT5A/JNK and FGF/MAPK pathways regulate the cellular events shaping the vertebrate limb budJerome Gros
Department of Genetics, Harvard Medical School, and Center for Systems Biology, Massachusetts General Hospital, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
Curr Biol 20:1993-2002. 2010.... - The key to left-right asymmetryClifford J Tabin
Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
Cell 127:27-32. 2006..A new study suggests that a reaction-diffusion mechanism also plays a key role... - A re-examination of proximodistal patterning during vertebrate limb developmentAndrew T Dudley
Department of Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
Nature 418:539-44. 2002..We also find, however, that the distal limb mesenchyme becomes progressively 'determined', that is, irreversibly fixed, to a progressively limited range of potential proximodistal fates... - Dach1, a vertebrate homologue of Drosophila dachshund, is expressed in the developing eye and ear of both chick and mouse and is regulated independently of Pax and Eya genesTiffany A Heanue
Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
Mech Dev 111:75-87. 2002..Our results indicate that Pax6, Pax2, and Eya1 do not regulate Dach1 expression through a simple linear hierarchy... - Expression of Cre Recombinase in the developing mouse limb bud driven by a Prxl enhancerMalcolm Logan
Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
Genesis 33:77-80. 2002..Expression of the Cre recombinase was never detected in the limb bud ectoderm. The use of Prx1-Cre mice should facilitate analysis of gene function in the developing limb... - Regeneration review repriseJessica L Whited
Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, NRB 360, Boston, MA 02115, USA
J Biol 9:15. 2010..Increasingly, progress in the regeneration field is being inspired by comparisons with stem cell biology and enabled by newly developed techniques that allow simultaneous examination of thousands of genes and proteins... - Promotion of avian endothelial cell differentiation by GATA transcription factorsCaramai N Kamei
Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
Dev Biol 353:29-37. 2011..These findings indicate a role for GATA transcription factors in the differentiation of the endothelium... - Dynamic expression of two thrombospondins during axolotl limb regenerationJessica L Whited
Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA
Dev Dyn 240:1249-58. 2011..Our data suggest that thrombospondins may be key regulators of limb regeneration in axolotl, while their activation appears to be relegated solely to wound healing in vertebrates that have lost the ability to regenerate limbs... - Genetic analysis of cavefish reveals molecular convergence in the evolution of albinismMeredith E Protas
Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
Nat Genet 38:107-11. 2006..Thus, the two cave populations evolved albinism independently, through similar mutational events... - Tbx5 is required for forelimb bud formation and continued outgrowthCharalampos Rallis
Division of Developmental Biology, National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
Development 130:2741-51. 2003..Moreover, our results also demonstrate that limb bud outgrowth and specification of limb identity are linked by a requirement for Tbx5... - Deconstructing phosphatases in limb developmentAndrew T Dudley
Nat Cell Biol 5:499-501. 2003 - The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limbBrian D Harfe
Department of Molecular Genetics and Microbiology, University of Florida College of Medicine, Gainesville, FL 32610, USA
Proc Natl Acad Sci U S A 102:10898-903. 2005..Thus, Dicer is required for the formation of normal mouse limbs. Strikingly, however, we did not detect defects in basic patterning or in tissue-specific differentiation of Dicer-deficient limb buds... - Early developmental arrest of mammalian limbs lacking HoxA/HoxD gene functionMarie Kmita
Department of Zoology and Animal Biology and National Research Centre Frontiers in Genetics, University of Geneva, Sciences III, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland
Nature 435:1113-6. 2005..Accordingly, these mutant limbs may be reminiscent of an ancestral trunk extension, related to that proposed for arthropods... - Developmental biology: asymmetrical threat avertedEran Hornstein
Nature 435:155-6. 2005 - Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identitiesBrian D Harfe
Department of Molecular Genetics and Microbiology, University of Florida College of Medicine, 1600 SW Archer Road, Gainesville, FL 32610, USA
Cell 118:517-28. 2004..Genetic studies of the effects of limiting accessibility of Shh within the limb support this model, in which the effect of the Shh morphogen is dictated by a temporal as well as a spatial gradient... - Conserved function for embryonic nodal ciliaJeffrey J Essner
Center for Children, Huntsman Cancer Institute and Department of Oncological Sciences, University of Utah, Salt Lake City, Utah 84112 5550, USA
Nature 418:37-8. 2002.... - The left-right determinant inversin has highly conserved ankyrin repeat and IQ domains and interacts with calmodulinDavid Morgan
Institute of Human Genetics, University of Newcastle, International Centre for Life, Central Parkway, Newcastle upon Tyne, NE1 3BZ, UK
Hum Genet 110:377-84. 2002..A yeast two-hybrid screen identified calmodulin in one third of the positive clones, and we confirmed this interaction by immunoprecipitation... - Generation of transgenic tendon reporters, ScxGFP and ScxAP, using regulatory elements of the scleraxis geneBrian A Pryce
Shriners Hospital for Children, Research Division, Portland, Oregon 97239, USA
Dev Dyn 236:1677-82. 2007..These reporter lines will facilitate isolation of tendon cells and phenotypic analysis of these tissues in a variety of genetic backgrounds... - Proximodistal patterning of the limb: insights from evolutionary morphologyMichael K Richardson
Institute of Biology, Leiden University, Kaiserstraat 63, 2311GP Leiden, The Netherlands
Evol Dev 6:1-5. 2004..This model overcomes a major evolutionary problem with the progress zone model, which has not previously been noted: pleiotropy. Parallels with other developmental systems are briefly discussed... - BMP4 is dispensable for skeletogenesis and fracture-healing in the limbKunikazu Tsuji
The Center for Musculoskeletal Research, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
J Bone Joint Surg Am 90:14-8. 2008..This study demonstrates that BMP4 is not required for bone formation and function in the limb, giving us further insights into the utility of recombinant human BMPs as therapeutic agents... - White meat or dark?Ava E Brent
Nat Genet 36:8-10. 2004 - MicroRNAs in the Hox network: an apparent link to posterior prevalenceSoraya Yekta
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
Nat Rev Genet 9:789-96. 2008..In this way, miRNA-mediated regulation seems to recapitulate interactions at other levels of gene expression, some more ancestral, within a network under stabilizing selection...