Cliff Tabin

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc A novel role for Mc1r in the parallel evolution of depigmentation in independent populations of the cavefish Astyanax mexicanus
    Joshua B Gross
    Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Genet 5:e1000326. 2009
  2. pmc Regeneration review reprise
    Jessica L Whited
    Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, NRB 360, Boston, MA 02115, USA
    J Biol 9:15. 2010
  3. pmc Limb regeneration revisited
    Jessica L Whited
    Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    J Biol 8:5. 2009
  4. ncbi request reprint Do we know anything about how left-right asymmetry is first established in the vertebrate embryo?
    Cliff Tabin
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    J Mol Histol 36:317-23. 2005
  5. ncbi request reprint The key to left-right asymmetry
    Clifford J Tabin
    Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Cell 127:27-32. 2006
  6. ncbi request reprint Rethinking the proximodistal axis of the vertebrate limb in the molecular era
    Cliff Tabin
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 21:1433-42. 2007
  7. ncbi request reprint A Tcf4-positive mesodermal population provides a prepattern for vertebrate limb muscle patterning
    Gabrielle Kardon
    Department of Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Dev Cell 5:937-44. 2003
  8. ncbi request reprint Wnt signaling during development of the gastrointestinal tract
    Nicole A Theodosiou
    Department of Genetics, Harvard Medical School, Warren Alpert Bldg, RM 425, 200 Longwood Avenue, Boston, MA 02115, USA
    Dev Biol 259:258-71. 2003
  9. ncbi request reprint Dach1, a vertebrate homologue of Drosophila dachshund, is expressed in the developing eye and ear of both chick and mouse and is regulated independently of Pax and Eya genes
    Tiffany A Heanue
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Mech Dev 111:75-87. 2002
  10. ncbi request reprint Shh and Fgf8 act synergistically to drive cartilage outgrowth during cranial development
    Arhat Abzhanov
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Dev Biol 273:134-48. 2004

Research Grants

  1. REGULATION OF HEART ASYMMETRY
    Clifford Tabin; Fiscal Year: 2001
  2. SONIC HEDGEHOG'S ROLE IN PATTERNING THE LIMB
    Clifford Tabin; Fiscal Year: 2002
  3. Developmental regulation by miRNAs
    Clifford Tabin; Fiscal Year: 2009
  4. REGULATION OF HEART ASYMMETRY
    Clifford Tabin; Fiscal Year: 2000
  5. Lineage in patterning the developing limb and heart
    Clifford Tabin; Fiscal Year: 2006
  6. Lineage in patterning the developing limb and heart
    Clifford Tabin; Fiscal Year: 2009
  7. Lineage in patterning the developing limb and heart
    Clifford Tabin; Fiscal Year: 2007
  8. Developmental regulation by miRNAs
    Clifford Tabin; Fiscal Year: 2006
  9. Developmental regulation by miRNAs
    Clifford Tabin; Fiscal Year: 2005
  10. SONIC HEDGEHOG'S ROLE IN PATTERNING THE LIMB
    Clifford Tabin; Fiscal Year: 2004

Collaborators

Detail Information

Publications66

  1. pmc A novel role for Mc1r in the parallel evolution of depigmentation in independent populations of the cavefish Astyanax mexicanus
    Joshua B Gross
    Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Genet 5:e1000326. 2009
    ..This example of parallelism indicates that certain genes are frequent targets of mutation in the repeated evolution of regressive phenotypes in cave-adapted species...
  2. pmc Regeneration review reprise
    Jessica L Whited
    Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, NRB 360, Boston, MA 02115, USA
    J Biol 9:15. 2010
    ..Increasingly, progress in the regeneration field is being inspired by comparisons with stem cell biology and enabled by newly developed techniques that allow simultaneous examination of thousands of genes and proteins...
  3. pmc Limb regeneration revisited
    Jessica L Whited
    Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    J Biol 8:5. 2009
    ..Classical experiments provide a rich context for interpreting modern functional studies...
  4. ncbi request reprint Do we know anything about how left-right asymmetry is first established in the vertebrate embryo?
    Cliff Tabin
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    J Mol Histol 36:317-23. 2005
  5. ncbi request reprint The key to left-right asymmetry
    Clifford J Tabin
    Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Cell 127:27-32. 2006
    ..A new study suggests that a reaction-diffusion mechanism also plays a key role...
  6. ncbi request reprint Rethinking the proximodistal axis of the vertebrate limb in the molecular era
    Cliff Tabin
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 21:1433-42. 2007
  7. ncbi request reprint A Tcf4-positive mesodermal population provides a prepattern for vertebrate limb muscle patterning
    Gabrielle Kardon
    Department of Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Dev Cell 5:937-44. 2003
    ..We propose that Tcf4-expressing cells establish a prepattern in the limb mesoderm that determines the sites of myogenic differentiation and thus establishes the basic pattern of limb muscles...
  8. ncbi request reprint Wnt signaling during development of the gastrointestinal tract
    Nicole A Theodosiou
    Department of Genetics, Harvard Medical School, Warren Alpert Bldg, RM 425, 200 Longwood Avenue, Boston, MA 02115, USA
    Dev Biol 259:258-71. 2003
    ..The expression profiles of the Wnt signaling components presented in this paper should prove valuable in deciphering additional roles of the Wnt pathways during patterning of the vertebrate gut tube...
  9. ncbi request reprint Dach1, a vertebrate homologue of Drosophila dachshund, is expressed in the developing eye and ear of both chick and mouse and is regulated independently of Pax and Eya genes
    Tiffany A Heanue
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Mech Dev 111:75-87. 2002
    ..Our results indicate that Pax6, Pax2, and Eya1 do not regulate Dach1 expression through a simple linear hierarchy...
  10. ncbi request reprint Shh and Fgf8 act synergistically to drive cartilage outgrowth during cranial development
    Arhat Abzhanov
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Dev Biol 273:134-48. 2004
    ....
  11. ncbi request reprint Dissimilar regulation of cell differentiation in mesencephalic (cranial) and sacral (trunk) neural crest cells in vitro
    Arhat Abzhanov
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Development 130:4567-79. 2003
    ..We also provide evidence that these differences in responsiveness are modulated, at least in part, by differential expression of Hox genes within the neural crest...
  12. ncbi request reprint The limb bud Shh-Fgf feedback loop is terminated by expansion of former ZPA cells
    Paul J Scherz
    Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Science 305:396-9. 2004
    ....
  13. doi request reprint Developmental biology. Grasping limb patterning
    Clifford J Tabin
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Science 321:350-2. 2008
  14. ncbi request reprint Developmental regulation of somite derivatives: muscle, cartilage and tendon
    Ava E Brent
    Harvard Medical School, Department of Genetics, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
    Curr Opin Genet Dev 12:548-57. 2002
    ..The specification of somite derivatives involves the action of patterning signals secreted from adjacent tissue combined with the activation, in particular somitic compartments, of genes promoting cell lineage specification...
  15. ncbi request reprint Developmental roles and clinical significance of hedgehog signaling
    Andrew P McMahon
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Curr Top Dev Biol 53:1-114. 2003
    ..This review focuses on the developing systems themselves, providing a comprehensive survey of the role of Hedgehog signaling in each of these. We also discuss the increasing significance of Hedgehog signaling in the clinical setting...
  16. ncbi request reprint A two-cilia model for vertebrate left-right axis specification
    Clifford J Tabin
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 17:1-6. 2003
  17. ncbi request reprint A somitic compartment of tendon progenitors
    Ava E Brent
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Cell 113:235-48. 2003
    ..The tendon primordia thus form in a location abutting the two tissues that the mature tendons must ultimately connect. Tendon progenitor formation may reveal a general mechanism for the specification of other somitic subcompartments...
  18. ncbi request reprint The microRNA miR-196 acts upstream of Hoxb8 and Shh in limb development
    Eran Hornstein
    Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nature 438:671-4. 2005
    ....
  19. pmc A reevaluation of X-irradiation-induced phocomelia and proximodistal limb patterning
    Jenna L Galloway
    Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nature 460:400-4. 2009
    ..Moreover, molecular evidence that proximodistal patterning is unaffected after X-irradiation does not support the predictions of the progress zone model...
  20. pmc Characterization of a novel ectodermal signaling center regulating Tbx2 and Shh in the vertebrate limb
    Sahar Nissim
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Dev Biol 304:9-21. 2007
    ..This finding explains the tight restriction of Shh expression to the posterior margin throughout limb outgrowth as well as the tight restriction of Shh expression to the anterior margin in many mutants exhibiting preaxial polydactyly...
  21. ncbi request reprint Genetic analysis of interactions between the somitic muscle, cartilage and tendon cell lineages during mouse development
    Ava E Brent
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Development 132:515-28. 2005
    ....
  22. ncbi request reprint A re-examination of proximodistal patterning during vertebrate limb development
    Andrew T Dudley
    Department of Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 418:539-44. 2002
    ..We also find, however, that the distal limb mesenchyme becomes progressively 'determined', that is, irreversibly fixed, to a progressively limited range of potential proximodistal fates...
  23. ncbi request reprint Mechanistic insight into how Shh patterns the vertebrate limb
    Edwina McGlinn
    Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Curr Opin Genet Dev 16:426-32. 2006
    ..Current research has revealed unexpected complexity in how a gradient of Shh activity is both established and received, prompting re-evaluation of the nature of patterning mechanisms within the limb...
  24. ncbi request reprint Bmp4 and morphological variation of beaks in Darwin's finches
    Arhat Abzhanov
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Science 305:1462-5. 2004
    ..When misexpressed in chicken embryos, Bmp4 caused morphological transformations paralleling the beak morphology of the large ground finch G. magnirostris...
  25. pmc In ovo application of antagomiRs indicates a role for miR-196 in patterning the chick axial skeleton through Hox gene regulation
    Edwina McGlinn
    Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 106:18610-5. 2009
    ....
  26. pmc Antagonists of Wnt and BMP signaling promote the formation of vertebrate head muscle
    Eldad Tzahor
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
    Genes Dev 17:3087-99. 2003
    ..Our findings demonstrate that head muscle formation is locally repressed by Wnt and BMP signals and induced by antagonists of these signaling pathways secreted by adjacent tissues...
  27. ncbi request reprint FGF acts directly on the somitic tendon progenitors through the Ets transcription factors Pea3 and Erm to regulate scleraxis expression
    Ava E Brent
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Development 131:3885-96. 2004
    ....
  28. pmc The chirality of gut rotation derives from left-right asymmetric changes in the architecture of the dorsal mesentery
    Nicole M Davis
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Dev Cell 15:134-45. 2008
    ..The resultant differences in cellular organization cause the mesentery to assume a trapezoidal shape, tilting the primitive gut tube leftward...
  29. pmc The Hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates thyroid hormone activation and PTHrP secretion in the developing growth plate
    Monica Dentice
    Thyroid Section, Division of Endocrinology, Diabetes and Hypertension, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Nat Cell Biol 7:698-705. 2005
    ..Thus, ECS(WSB-1) mediates a mechanism by which 'systemic' thyroid hormone can effect local control of the Hedgehog-PTHrP negative feedback loop and thus skeletogenesis...
  30. pmc Development of heart valves requires Gata4 expression in endothelial-derived cells
    JOSE RIVERA-FELICIANO
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Development 133:3607-18. 2006
    ..First, Gata4 functions as an upstream regulator of an Erbb3-Erk pathway necessary for EMT, and second, Gata4 acts to promote cushion mesenchyme growth and remodeling...
  31. ncbi request reprint Regulation of skeletogenic differentiation in cranial dermal bone
    Arhat Abzhanov
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Development 134:3133-44. 2007
    ..These results provide a framework for understanding dermal bone development with an aim of bringing it closer to the molecular and cellular resolution available for the endochondral bone development...
  32. ncbi request reprint Cross-regulatory interactions between Fgf8 and Shh in the avian frontonasal prominence
    Arhat Abzhanov
    Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA
    Congenit Anom (Kyoto) 47:136-48. 2007
    ..Our experiments revealed mutual antagonism between the two molecules, which aids in establishing and maintaining a molecular boundary that subsequently influences patterning and growth of the middle and upper face...
  33. pmc The direction of gut looping is established by changes in the extracellular matrix and in cell:cell adhesion
    Natasza A Kurpios
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:8499-506. 2008
    ..Functional studies demonstrate that N-cadherin acts upstream of the changes in the ECM and is both necessary and sufficient to explain the asymmetric packing of the mesenchymal cells...
  34. pmc Bmp2 instructs cardiac progenitors to form the heart-valve-inducing field
    JOSE RIVERA-FELICIANO
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Dev Biol 295:580-8. 2006
    ..Our results demonstrate that Bmp2 is both necessary and sufficient to specify a field of cardiac progenitor cells as the heart-valve-inducing region amid developing atria and ventricles...
  35. pmc Genetic analysis of the roles of BMP2, BMP4, and BMP7 in limb patterning and skeletogenesis
    Amitabha Bandyopadhyay
    Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Genet 2:e216. 2006
    ..In contrast, we find that the loss of both BMP2 and BMP4 results in a severe impairment of osteogenesis...
  36. pmc Extended exposure to Sonic hedgehog is required for patterning the posterior digits of the vertebrate limb
    Paul J Scherz
    Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Dev Biol 308:343-54. 2007
    ....
  37. ncbi request reprint Reduce your pelvis in 10000 years or less
    Meredith E Protas
    Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Dev Cell 6:613-4. 2004
    ..examine one such example, the genetic basis of pelvic reduction in the threespine stickleback fish (2004). They conclude that a regulatory mutation in the Pitx1 gene is responsible for the pelvic reduction...
  38. ncbi request reprint Sox9 and Nkx2.5 determine the pyloric sphincter epithelium under the control of BMP signaling
    Nicole A Theodosiou
    Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Dev Biol 279:481-90. 2005
    ..5 and its ability to determine the pyloric epithelium. Despite these similarities, our evidence suggests that Sox9 and Nkx2.5 are regulated independently by BMP signaling, and act coordinately to specify the pyloric sphincter...
  39. pmc Classic limb patterning models and the work of Dennis Summerbell
    Jenna L Galloway
    Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Development 135:2683-7. 2008
    ....
  40. ncbi request reprint Regulation of Gremlin expression in the posterior limb bud
    Sahar Nissim
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Dev Biol 299:12-21. 2006
    ..Finally, by blocking Shh activity with cyclopamine, we find evidence that continued Shh activity is also required to maintain refractoriness to Gremlin expression in response to Bmp activity...
  41. pmc Cell movements at Hensen's node establish left/right asymmetric gene expression in the chick
    Jerome Gros
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Science 324:941-4. 2009
    ..The creation of asymmetric expression domains as a passive effect of cell movements represents an alternative strategy for breaking L/R symmetry in gene activity...
  42. ncbi request reprint Local extrinsic signals determine muscle and endothelial cell fate and patterning in the vertebrate limb
    Gabrielle Kardon
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Dev Cell 3:533-45. 2002
    ..Surprisingly, we also find that myogenic and endothelial cells are derived from a common somitic precursor. Thus, local extrinsic signals are critical for determining muscle and endothelial patterning as well as cell fate in the limb...
  43. pmc Identification of unique molecular subdomains in the perichondrium and periosteum and their role in regulating gene expression in the underlying chondrocytes
    Amitabha Bandyopadhyay
    Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA
    Dev Biol 321:162-74. 2008
    ....
  44. pmc miRNA-processing enzyme Dicer is necessary for cardiac outflow tract alignment and chamber septation
    Ankur Saxena
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:87-91. 2010
    ..In sum, we demonstrate here a specific developmental process, that of outflow tract morphogenesis, being hindered by the deletion of miRNAs during cardiogenesis...
  45. ncbi request reprint MicroRNA-responsive 'sensor' transgenes uncover Hox-like and other developmentally regulated patterns of vertebrate microRNA expression
    Jennifer H Mansfield
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Genet 36:1079-83. 2004
    ..Furthermore, miR-196a negatively regulates Hoxb8, indicating that its restricted expression pattern probably reflects a role in the patterning function of the Hox complex...
  46. ncbi request reprint Achieving bilateral symmetry during vertebrate limb development
    Patrick Allard
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Semin Cell Dev Biol 20:479-84. 2009
    ..Through the activity of these signaling loops and their eventual breakdown when the limb bud has reached a certain size, bilateral symmetry can be achieved...
  47. pmc Understanding of bat wing evolution takes flight
    Kimberly L Cooper
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Genes Dev 22:121-4. 2008
  48. pmc Temporomandibular joint formation requires two distinct hedgehog-dependent steps
    Patricia Purcell
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 106:18297-302. 2009
    ..Thus, these experiments establish that Hh signaling acts at two distinct steps in disk morphogenesis, condyle initiation, and disk-condyle separation and provide a molecular framework for future studies of the TMJ...
  49. ncbi request reprint BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing
    Kunikazu Tsuji
    Department of Developmental Biology, Harvard School of Dental Medicine, Boston, Massachusetts 02115, USA
    Nat Genet 38:1424-9. 2006
    ..Collectively, our results identify BMP2 as an endogenous mediator necessary for fracture repair...
  50. ncbi request reprint Regulation of tendon differentiation by scleraxis distinguishes force-transmitting tendons from muscle-anchoring tendons
    Nicholas D Murchison
    Shriners Hospital for Children, Research Division, Portland, OR 97239, and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Development 134:2697-708. 2007
    ..The phenotype of Scx-/- mutants emphasizes the diversity of tendon tissues and represents the first molecular insight into the important process of tendon differentiation...
  51. ncbi request reprint The calmodulin pathway and evolution of elongated beak morphology in Darwin's finches
    Arhat Abzhanov
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 442:563-7. 2006
    ..More generally, our results implicate the CaM-dependent pathway in the developmental regulation of craniofacial skeletal structures...
  52. pmc Somitic origin of limb muscle satellite and side population cells
    Jaclyn Schienda
    Howard Hughes Medical Institute, Program in Genomics, Children s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 103:945-50. 2006
    ..Thus, we show that the somites, which supply embryonic and fetal myoblasts, are also an important source of highly myogenic adult muscle progenitors...
  53. pmc The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb
    Brian D Harfe
    Department of Molecular Genetics and Microbiology, University of Florida College of Medicine, Gainesville, FL 32610, USA
    Proc Natl Acad Sci U S A 102:10898-903. 2005
    ..Thus, Dicer is required for the formation of normal mouse limbs. Strikingly, however, we did not detect defects in basic patterning or in tissue-specific differentiation of Dicer-deficient limb buds...
  54. ncbi request reprint Conserved function for embryonic nodal cilia
    Jeffrey J Essner
    Center for Children, Huntsman Cancer Institute and Department of Oncological Sciences, University of Utah, Salt Lake City, Utah 84112 5550, USA
    Nature 418:37-8. 2002
    ....
  55. ncbi request reprint Early developmental arrest of mammalian limbs lacking HoxA/HoxD gene function
    Marie Kmita
    Department of Zoology and Animal Biology and National Research Centre Frontiers in Genetics, University of Geneva, Sciences III, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland
    Nature 435:1113-6. 2005
    ..Accordingly, these mutant limbs may be reminiscent of an ancestral trunk extension, related to that proposed for arthropods...
  56. ncbi request reprint Developmental biology: asymmetrical threat averted
    Eran Hornstein
    Nature 435:155-6. 2005
  57. ncbi request reprint Tbx5 is required for forelimb bud formation and continued outgrowth
    Charalampos Rallis
    Division of Developmental Biology, National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
    Development 130:2741-51. 2003
    ..Moreover, our results also demonstrate that limb bud outgrowth and specification of limb identity are linked by a requirement for Tbx5...
  58. ncbi request reprint Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities
    Brian D Harfe
    Department of Molecular Genetics and Microbiology, University of Florida College of Medicine, 1600 SW Archer Road, Gainesville, FL 32610, USA
    Cell 118:517-28. 2004
    ..Genetic studies of the effects of limiting accessibility of Shh within the limb support this model, in which the effect of the Shh morphogen is dictated by a temporal as well as a spatial gradient...
  59. ncbi request reprint Deconstructing phosphatases in limb development
    Andrew T Dudley
    Nat Cell Biol 5:499-501. 2003
  60. ncbi request reprint Proximodistal patterning of the limb: insights from evolutionary morphology
    Michael K Richardson
    Institute of Biology, Leiden University, Kaiserstraat 63, 2311GP Leiden, The Netherlands
    Evol Dev 6:1-5. 2004
    ..This model overcomes a major evolutionary problem with the progress zone model, which has not previously been noted: pleiotropy. Parallels with other developmental systems are briefly discussed...
  61. ncbi request reprint Mouse Disp1 is required in sonic hedgehog-expressing cells for paracrine activity of the cholesterol-modified ligand
    Hua Tian
    One DNA Way, Genentech Incorporated, South San Francisco, CA 94080, USA
    Development 132:133-42. 2005
    ..In both respects, Disp function is conserved from Drosophila to mice...
  62. pmc MicroRNAs in the Hox network: an apparent link to posterior prevalence
    Soraya Yekta
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    Nat Rev Genet 9:789-96. 2008
    ..In this way, miRNA-mediated regulation seems to recapitulate interactions at other levels of gene expression, some more ancestral, within a network under stabilizing selection...
  63. ncbi request reprint White meat or dark?
    Ava E Brent
    Nat Genet 36:8-10. 2004
  64. ncbi request reprint Generation of transgenic tendon reporters, ScxGFP and ScxAP, using regulatory elements of the scleraxis gene
    Brian A Pryce
    Shriners Hospital for Children, Research Division, Portland, Oregon 97239, USA
    Dev Dyn 236:1677-82. 2007
    ..These reporter lines will facilitate isolation of tendon cells and phenotypic analysis of these tissues in a variety of genetic backgrounds...
  65. ncbi request reprint The left-right determinant inversin has highly conserved ankyrin repeat and IQ domains and interacts with calmodulin
    David Morgan
    Institute of Human Genetics, University of Newcastle, International Centre for Life, Central Parkway, Newcastle upon Tyne, NE1 3BZ, UK
    Hum Genet 110:377-84. 2002
    ..A yeast two-hybrid screen identified calmodulin in one third of the positive clones, and we confirmed this interaction by immunoprecipitation...
  66. ncbi request reprint BMP4 is dispensable for skeletogenesis and fracture-healing in the limb
    Kunikazu Tsuji
    The Center for Musculoskeletal Research, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Bone Joint Surg Am 90:14-8. 2008
    ..This study demonstrates that BMP4 is not required for bone formation and function in the limb, giving us further insights into the utility of recombinant human BMPs as therapeutic agents...

Research Grants33

  1. REGULATION OF HEART ASYMMETRY
    Clifford Tabin; Fiscal Year: 2001
    ..As a step towards understanding how this occurs, we will screen for targets of LR signaling using a B‑lactamase reporter/gene trap strategy. ..
  2. SONIC HEDGEHOG'S ROLE IN PATTERNING THE LIMB
    Clifford Tabin; Fiscal Year: 2002
    ..In these experiments the Ptc and Gli genes, which are too large for the chick viral vector system, we will be misexpressed in limbs of transgenic mice. ..
  3. Developmental regulation by miRNAs
    Clifford Tabin; Fiscal Year: 2009
    ....
  4. REGULATION OF HEART ASYMMETRY
    Clifford Tabin; Fiscal Year: 2000
    ..As a step towards understanding how this occurs, we will screen for targets of LR signaling using a B‑lactamase reporter/gene trap strategy. ..
  5. Lineage in patterning the developing limb and heart
    Clifford Tabin; Fiscal Year: 2006
    ..Moreover, the same reagents will be used to test whether Hox gene expression is required autonomously in the tendon and skeletal progenitors for proper patterning of the limb. ..
  6. Lineage in patterning the developing limb and heart
    Clifford Tabin; Fiscal Year: 2009
    ..Moreover, the same reagents will be used to test whether Hox gene expression is required autonomously in the tendon and skeletal progenitors for proper patterning of the limb. ..
  7. Lineage in patterning the developing limb and heart
    Clifford Tabin; Fiscal Year: 2007
    ..Moreover, the same reagents will be used to test whether Hox gene expression is required autonomously in the tendon and skeletal progenitors for proper patterning of the limb. ..
  8. Developmental regulation by miRNAs
    Clifford Tabin; Fiscal Year: 2006
    ....
  9. Developmental regulation by miRNAs
    Clifford Tabin; Fiscal Year: 2005
    ....
  10. SONIC HEDGEHOG'S ROLE IN PATTERNING THE LIMB
    Clifford Tabin; Fiscal Year: 2004
    ..In these experiments the Ptc and Gli genes, which are too large for the chick viral vector system, we will be misexpressed in limbs of transgenic mice. ..
  11. SONIC HEDGEHOG'S ROLE IN PATTERNING THE LIMB
    Clifford Tabin; Fiscal Year: 2003
    ..In these experiments the Ptc and Gli genes, which are too large for the chick viral vector system, we will be misexpressed in limbs of transgenic mice. ..
  12. REGULATION OF HEART ASYMMETRY
    Clifford Tabin; Fiscal Year: 2002
    ..As a step towards understanding how this occurs, we will screen for targets of LR signaling using a B‑lactamase reporter/gene trap strategy. ..
  13. SONIC HEDGEHOG'S ROLE IN PATTERNING THE LIMB
    Clifford Tabin; Fiscal Year: 2000
    ..In these experiments the Ptc and Gli genes, which are too large for the chick viral vector system, we will be misexpressed in limbs of transgenic mice. ..
  14. SONIC HEDGEHOG'S ROLE IN PATTERNING THE LIMB
    Clifford Tabin; Fiscal Year: 1999
    ..A related gene, Indian Hedgehog, is expressed in chondrogenic regions of the developing limb. This gene will be cloned, its detailed expression pattern determined, and its function tested by misexpression. ..
  15. REGULATION OF HEART ASYMMETRY
    Clifford Tabin; Fiscal Year: 1999
    ..In collaboration with Andy McMahon's laboratory, mNR-1 will be genetically mapped and the mNR-1 gene will be knocked out. ..
  16. Lineage and cell migration in patterning the limb primordium
    Clifford J Tabin; Fiscal Year: 2010
    ..Moreover, the general lessons we learn about the integration of cellular behavior and extracellular signaling in organizing the limb, will serve as paradigms for understanding these processes during embryogenesis. ..
  17. Lineage in patterning the developing limb and heart
    Clifford Tabin; Fiscal Year: 2005
    ..Moreover, the same reagents will be used to test whether Hox gene expression is required autonomously in the tendon and skeletal progenitors for proper patterning of the limb. ..
  18. REGULATION OF HEART ASYMMETRY
    Clifford Tabin; Fiscal Year: 2003
    ..As a step towards understanding how this occurs, we will screen for targets of LR signaling using a B‑lactamase reporter/gene trap strategy. ..
  19. Hedgehog signaling and organogenesis of the limb
    Clifford Tabin; Fiscal Year: 2007
    ....
  20. Developmental regulation by miRNAs
    Clifford Tabin; Fiscal Year: 2007
    ....
  21. SONIC HEDGEHOG'S ROLE IN PATTERNING THE LIMB
    Clifford Tabin; Fiscal Year: 2001
    ..In these experiments the Ptc and Gli genes, which are too large for the chick viral vector system, we will be misexpressed in limbs of transgenic mice. ..
  22. Patterning and Morphogenesis of the Vertebrate Gut
    Clifford J Tabin; Fiscal Year: 2010
    ....