Cliff Tabin


Affiliation: Harvard University
Country: USA


  1. Kamberov Y, Karlsson E, Kamberova G, Lieberman D, Sabeti P, Morgan B, et al. A genetic basis of variation in eccrine sweat gland and hair follicle density. Proc Natl Acad Sci U S A. 2015;112:9932-7 pubmed publisher
    ..These findings implicate En1 as a newly identified and reciprocal determinant of hair follicle and eccrine gland density and identify a pathway that could have contributed to the evolution of the unique features of human skin. ..
  2. Rodrigues A, Yakushiji Kaminatsui N, Atsuta Y, Andrey G, Schorderet P, Duboule D, et al. Integration of Shh and Fgf signaling in controlling Hox gene expression in cultured limb cells. Proc Natl Acad Sci U S A. 2017;114:3139-3144 pubmed publisher
  3. Nerurkar N, Mahadevan L, Tabin C. BMP signaling controls buckling forces to modulate looping morphogenesis of the gut. Proc Natl Acad Sci U S A. 2017;114:2277-2282 pubmed publisher
  4. Wong S, Agarwal V, Mansfield J, Denans N, Schwartz M, Prosser H, et al. Independent regulation of vertebral number and vertebral identity by microRNA-196 paralogs. Proc Natl Acad Sci U S A. 2015;112:E4884-93 pubmed publisher
    ..By feeding into, and thereby integrating, multiple genetic networks controlling vertebral number and identity, miR-196 is a critical player defining axial formulae. ..
  5. Young J, Grayson P, Tabin C. Developmental Biology: Hox Timing Determines Limb Placement. Curr Biol. 2019;29:R52-R54 pubmed publisher
    ..A new study now finds that differential expression timing of Hox genes in the lateral plate mesoderm determines limb placement as well. ..
  6. Riddle M, Martineau B, Peavey M, Tabin C. Raising the Mexican Tetra Astyanax mexicanus for Analysis of Post-larval Phenotypes and Whole-mount Immunohistochemistry. J Vis Exp. 2018;: pubmed publisher
    ..mexicanus. The nursery method can also be used as a standard protocol for establishing density-matched populations for growth into adults. ..
  7. Nerurkar N, Lee C, Mahadevan L, Tabin C. Molecular control of macroscopic forces drives formation of the vertebrate hindgut. Nature. 2019;565:480-484 pubmed publisher
    ..In addition to providing insight into the early gut development, these findings illustrate how large-scale tissue level forces can be traced to developmental signals during vertebrate morphogenesis. ..
  8. Riddle M, Boesmans W, Caballero O, Kazwiny Y, Tabin C. Morphogenesis and motility of the Astyanax mexicanus gastrointestinal tract. Dev Biol. 2018;441:285-296 pubmed publisher
    ..Exploring this avenue will lead to a better understanding of how the GI tract evolves to maximize energy assimilation from novel food sources. ..
  9. Rohner N, Tschopp P, Tabin C. Development: facial makeup enhancing our looks. Curr Biol. 2014;24:R36-R38 pubmed publisher
    ..The enhancer landscape underlying craniofacial development provides multiple entry points to understand what makes up the face, in natural variation or pathological conditions. ..

More Information


  1. Aspiras A, Rohner N, Martineau B, Borowsky R, Tabin C. Melanocortin 4 receptor mutations contribute to the adaptation of cavefish to nutrient-poor conditions. Proc Natl Acad Sci U S A. 2015;112:9668-73 pubmed publisher
    ..The presence of the same allele in multiple caves appears to be due to selection from standing genetic variation present in surface populations. ..
  2. Tabin J, Aspiras A, Martineau B, Riddle M, Kowalko J, Borowsky R, et al. Temperature preference of cave and surface populations of Astyanax mexicanus. Dev Biol. 2018;441:338-344 pubmed publisher
    ..This work establishes A. mexicanus as a genetically tractable system in which differences in temperature preference can be studied in naturally evolved populations. ..
  3. Shyer A, Huycke T, Lee C, Mahadevan L, Tabin C. Bending gradients: how the intestinal stem cell gets its home. Cell. 2015;161:569-580 pubmed publisher
    ..Villus cluster signals, notably Bmp4, feed back on the overlying epithelium to ultimately restrict the stem cells to the base of each villus. ..
  4. Huycke T, Tabin C. Chick midgut morphogenesis. Int J Dev Biol. 2018;62:109-119 pubmed publisher
    ..Where relevant, we discuss the mechanisms of chick midgut morphogenesis in the context of experimental data from other model systems. ..
  5. Uygur A, Young J, Huycke T, Koska M, Briscoe J, Tabin C. Scaling Pattern to Variations in Size during Development of the Vertebrate Neural Tube. Dev Cell. 2016;37:127-35 pubmed publisher
    ..This mechanism contrasts with previous experimental and theoretical analyses of morphogenic scaling that have focused on compensatory changes in the morphogen gradient itself. ..
  6. Lehoczky J, Tabin C. Lgr6 marks nail stem cells and is required for digit tip regeneration. Proc Natl Acad Sci U S A. 2015;112:13249-54 pubmed publisher
    ..This role is confirmed by analysis of Lgr6-deficient mice, which have both a nail and bone regeneration defect. ..
  7. Young J, Tabin C. Saunders's framework for understanding limb development as a platform for investigating limb evolution. Dev Biol. 2017;429:401-408 pubmed publisher
    ..Other classes of modification to these same patterning systems are seen at the root of other, novel limb morphological alterations and elaborations. ..
  8. Tschopp P, Tabin C. Deep homology in the age of next-generation sequencing. Philos Trans R Soc Lond B Biol Sci. 2017;372: pubmed
    ..This article is part of the themed issue 'Evo-devo in the genomics era, and the origins of morphological diversity'. ..
  9. Hiscock T, Tschopp P, Tabin C. On the Formation of Digits and Joints during Limb Development. Dev Cell. 2017;41:459-465 pubmed publisher
    ..Moreover, extension of the digit rays and the patterning of the joints occur simultaneously at the distal tip, implying that an integrated model is required to fully understand these processes. ..