Susanne J Szabo

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells
    Susanne J Szabo
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Science 295:338-42. 2002
  2. ncbi request reprint T-Bet expression and failure of GATA-3 cross-regulation lead to default production of IFN-gamma by gammadelta T cells
    Zhinan Yin
    Sections of Rheumatology and Pulmonary and Critical Care Medicine, Department of Medicine, and Section of Immunobiology, Yale School of Medicine, New Haven, CT 06520, USA
    J Immunol 168:1566-71. 2002
  3. ncbi request reprint Molecular mechanisms regulating Th1 immune responses
    Susanne J Szabo
    Department of Immunology and Infectious Diseases, Harvard School of Public Health Boston, Massachusetts 02115, USA
    Annu Rev Immunol 21:713-58. 2003
  4. ncbi request reprint T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3
    Eun Sook Hwang
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Science 307:430-3. 2005
  5. pmc T-bet regulates IgG class switching and pathogenic autoantibody production
    Stanford L Peng
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115 6017, USA
    Proc Natl Acad Sci U S A 99:5545-50. 2002
  6. pmc Antigen-driven effector CD8 T cell function regulated by T-bet
    Brandon M Sullivan
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 100:15818-23. 2003
  7. pmc Loss of T-bet, but not STAT1, prevents the development of experimental autoimmune encephalomyelitis
    Estelle Bettelli
    Center for Neurologic Diseases, Harvard Institutes of Medicine, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    J Exp Med 200:79-87. 2004
  8. ncbi request reprint Sustained T-bet expression confers polarized human TH2 cells with TH1-like cytokine production and migratory capacities
    Günther Lametschwandtner
    Novartis Institute for BioMedical Research Vienna, Brunnerstrasse 59, A 1235 Vienna, Austria
    J Allergy Clin Immunol 113:987-94. 2004
  9. ncbi request reprint Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet
    Susetta Finotto
    Critical Care and Pulmonary Division, Division of Gastroenterology, Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Science 295:336-8. 2002
  10. ncbi request reprint T(H) cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes
    Orly Avni
    The Center for Blood Research and the Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Nat Immunol 3:643-51. 2002

Collaborators

Detail Information

Publications11

  1. ncbi request reprint Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells
    Susanne J Szabo
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Science 295:338-42. 2002
    ..This difference is also apparent in the function of these cell subsets. Thus, the regulation of a single cytokine, IFN-gamma, is controlled by distinct transcriptional mechanisms within the T cell lineage...
  2. ncbi request reprint T-Bet expression and failure of GATA-3 cross-regulation lead to default production of IFN-gamma by gammadelta T cells
    Zhinan Yin
    Sections of Rheumatology and Pulmonary and Critical Care Medicine, Department of Medicine, and Section of Immunobiology, Yale School of Medicine, New Haven, CT 06520, USA
    J Immunol 168:1566-71. 2002
    ....
  3. ncbi request reprint Molecular mechanisms regulating Th1 immune responses
    Susanne J Szabo
    Department of Immunology and Infectious Diseases, Harvard School of Public Health Boston, Massachusetts 02115, USA
    Annu Rev Immunol 21:713-58. 2003
    ..Although the picture is still incomplete, the basic pathways leading to Th1 differentiation can now be understood in in vitro and a number of infection and disease models...
  4. ncbi request reprint T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3
    Eun Sook Hwang
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Science 307:430-3. 2005
    ..These results provide a novel function for tyrosine phosphorylation of a transcription factor in specifying alternate fates of a common progenitor cell...
  5. pmc T-bet regulates IgG class switching and pathogenic autoantibody production
    Stanford L Peng
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115 6017, USA
    Proc Natl Acad Sci U S A 99:5545-50. 2002
    ..These results identify T-bet as a selective transducer of IFN-gamma-mediated IgG2a class switching in B cells and emphasize the importance of this regulation in the pathogenesis of humorally mediated autoimmunity...
  6. pmc Antigen-driven effector CD8 T cell function regulated by T-bet
    Brandon M Sullivan
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 100:15818-23. 2003
    ..Furthermore, mice lacking T-bet responded poorly to infection with lymphocytic choriomeningitis virus. T-bet is a key player in the generation of type 1 immunity, in both Th and T cytotoxic cells...
  7. pmc Loss of T-bet, but not STAT1, prevents the development of experimental autoimmune encephalomyelitis
    Estelle Bettelli
    Center for Neurologic Diseases, Harvard Institutes of Medicine, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    J Exp Med 200:79-87. 2004
    ..Although the two transcription factors, STAT1 and T-bet, both induce IFN-gamma gene transcription, our results demonstrate marked differences in their function in regulating pathogenic Th1 cell responses...
  8. ncbi request reprint Sustained T-bet expression confers polarized human TH2 cells with TH1-like cytokine production and migratory capacities
    Günther Lametschwandtner
    Novartis Institute for BioMedical Research Vienna, Brunnerstrasse 59, A 1235 Vienna, Austria
    J Allergy Clin Immunol 113:987-94. 2004
    ..Thus T-bet-mediated inhibition of T(H)2 cytokine production might be beneficial for the treatment of allergic diseases like asthma or atopic dermatitis...
  9. ncbi request reprint Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet
    Susetta Finotto
    Critical Care and Pulmonary Division, Division of Gastroenterology, Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Science 295:336-8. 2002
    ..Thus, T-bet deficiency, in the absence of allergen exposure, induces a murine phenotype reminiscent of both acute and chronic human asthma...
  10. ncbi request reprint T(H) cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes
    Orly Avni
    The Center for Blood Research and the Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Nat Immunol 3:643-51. 2002
    ....
  11. ncbi request reprint Histone deacetylase activities are required for innate immune cell control of Th1 but not Th2 effector cell function
    Jennifer L Brogdon
    Department of Developmental and Molecular Pathways, Novartis Institute for Biomedical Research, Cambridge, MA 02138, USA
    Blood 109:1123-30. 2007
    ..These unexpected findings demonstrate the high specificity of HDAC inhibition in modulating innate and adaptive immune responses, and highlight the potential for HDACi to alter the Th1 and Th2 balance in therapeutic settings...