FILIP SWIRSKI

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. doi request reprint From proliferation to proliferation: monocyte lineage comes full circle
    Filip K Swirski
    Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA
    Semin Immunopathol 36:137-48. 2014
  2. pmc Imaging macrophage development and fate in atherosclerosis and myocardial infarction
    Filip K Swirski
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Immunol Cell Biol 91:297-303. 2013
  3. pmc Leukocyte behavior in atherosclerosis, myocardial infarction, and heart failure
    Filip K Swirski
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, 185 Cambridge Street, Boston, MA 02114, USA
    Science 339:161-6. 2013
  4. pmc Identification of splenic reservoir monocytes and their deployment to inflammatory sites
    Filip K Swirski
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Science 325:612-6. 2009
  5. pmc The spatial and developmental relationships in the macrophage family
    Filip K Swirski
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Simches Research Bldg, 185 Cambridge St, Boston, MA 02114, USA
    Arterioscler Thromb Vasc Biol 31:1517-22. 2011
  6. pmc Heterogeneous in vivo behavior of monocyte subsets in atherosclerosis
    Filip K Swirski
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, 185 Cambridge Street, Boston, MA 02114, USA
    Arterioscler Thromb Vasc Biol 29:1424-32. 2009
  7. pmc Impaired infarct healing in atherosclerotic mice with Ly-6C(hi) monocytosis
    Peter Panizzi
    Center for Systems Biology, Simches Research Building, Massachusetts General Hospital and Harvard Medical School Boston, Massachusetts 02114, USA
    J Am Coll Cardiol 55:1629-38. 2010
  8. pmc Molecular imaging of innate immune cell function in transplant rejection
    Thomas Christen
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Circulation 119:1925-32. 2009
  9. pmc Angiotensin-converting enzyme inhibition prevents the release of monocytes from their splenic reservoir in mice with myocardial infarction
    Florian Leuschner
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, USA
    Circ Res 107:1364-73. 2010
  10. pmc Rapid detection and profiling of cancer cells in fine-needle aspirates
    Hakho Lee
    Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge Street, CPZN 5206, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 106:12459-64. 2009

Collaborators

Detail Information

Publications29

  1. doi request reprint From proliferation to proliferation: monocyte lineage comes full circle
    Filip K Swirski
    Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA
    Semin Immunopathol 36:137-48. 2014
    ....
  2. pmc Imaging macrophage development and fate in atherosclerosis and myocardial infarction
    Filip K Swirski
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Immunol Cell Biol 91:297-303. 2013
    ..Here, we explore how various imaging modalities, from intravital microscopy in mice to organ-level imaging in patients, are contributing to our understanding of macrophages and their progenitors in cardiovascular disease...
  3. pmc Leukocyte behavior in atherosclerosis, myocardial infarction, and heart failure
    Filip K Swirski
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, 185 Cambridge Street, Boston, MA 02114, USA
    Science 339:161-6. 2013
    ..Leukocytes (white blood cells) are important participants at the various stages of cardiovascular disease progression and complication. This Review will discuss leukocyte function in atherosclerosis, MI, and heart failure...
  4. pmc Identification of splenic reservoir monocytes and their deployment to inflammatory sites
    Filip K Swirski
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Science 325:612-6. 2009
    ..These observations uncover a role for the spleen as a site for storage and rapid deployment of monocytes and identify splenic monocytes as a resource that the body exploits to regulate inflammation...
  5. pmc The spatial and developmental relationships in the macrophage family
    Filip K Swirski
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Simches Research Bldg, 185 Cambridge St, Boston, MA 02114, USA
    Arterioscler Thromb Vasc Biol 31:1517-22. 2011
    ..The observations have significant implications for how we image, target, and treat disease...
  6. pmc Heterogeneous in vivo behavior of monocyte subsets in atherosclerosis
    Filip K Swirski
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, 185 Cambridge Street, Boston, MA 02114, USA
    Arterioscler Thromb Vasc Biol 29:1424-32. 2009
    ..In this review we summarize recent advances of our understanding of the behavioral heterogeneity of monocytes during disease progression and outline emerging molecular imaging approaches to address key questions in the field...
  7. pmc Impaired infarct healing in atherosclerotic mice with Ly-6C(hi) monocytosis
    Peter Panizzi
    Center for Systems Biology, Simches Research Building, Massachusetts General Hospital and Harvard Medical School Boston, Massachusetts 02114, USA
    J Am Coll Cardiol 55:1629-38. 2010
    ..The aim of this study was to test whether blood monocytosis in mice with atherosclerosis affects infarct healing...
  8. pmc Molecular imaging of innate immune cell function in transplant rejection
    Thomas Christen
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Circulation 119:1925-32. 2009
    ..Yet, which macrophage functions may provide useful markers for detecting parenchymal rejection remains uncertain...
  9. pmc Angiotensin-converting enzyme inhibition prevents the release of monocytes from their splenic reservoir in mice with myocardial infarction
    Florian Leuschner
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, USA
    Circ Res 107:1364-73. 2010
    ..Monocytes recruited to ischemic myocardium originate from a reservoir in the spleen, and the release from their splenic niche relies on angiotensin (Ang) II signaling...
  10. pmc Rapid detection and profiling of cancer cells in fine-needle aspirates
    Hakho Lee
    Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge Street, CPZN 5206, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 106:12459-64. 2009
    ..We detected as few as 2 cancer cells in 1-microL sample volumes of unprocessed fine-needle aspirates of tumors and profiled the expression of several cellular markers in <15 min...
  11. pmc Myeloperoxidase-rich Ly-6C+ myeloid cells infiltrate allografts and contribute to an imaging signature of organ rejection in mice
    Filip K Swirski
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 120:2627-34. 2010
    ..Thus, MPO imaging represents a potential alternative to the current invasive clinical standard by which transplants are monitored...
  12. pmc The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions
    Matthias Nahrendorf
    Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    J Exp Med 204:3037-47. 2007
    ....
  13. pmc Activatable magnetic resonance imaging agent reports myeloperoxidase activity in healing infarcts and noninvasively detects the antiinflammatory effects of atorvastatin on ischemia-reperfusion injury
    Matthias Nahrendorf
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Circulation 117:1153-60. 2008
    ..We hypothesized that MPO imaging could be used to measure inflammatory responses after myocardial ischemia locally and noninvasively in a murine model...
  14. pmc Hybrid PET-optical imaging using targeted probes
    Matthias Nahrendorf
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 107:7910-5. 2010
    ..The findings also suggest that FMT can serve as a surrogate modality for the screening and development of radionuclide-based imaging agents...
  15. ncbi request reprint Prolonged ovalbumin exposure attenuates airway hyperresponsiveness and T cell function in mice
    Filip K Swirski
    Department of Pathology and Molecular Medicine, Centre for Gene Therapeutics, Hamilton, Canada
    Int Arch Allergy Immunol 141:130-40. 2006
    ..In this study we explored mechanisms underlying attenuation of the airway inflammatory response, assessed whether the phenomenon is strain-specific, and determined its consequences to airway physiology...
  16. pmc Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata
    Filip K Swirski
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Clin Invest 117:195-205. 2007
    ..Conversely, the number of Ly-6C(lo) cells remained unaffected. Thus, we believe that Ly-6C(hi) monocytes represent a newly recognized component of the inflammatory response in experimental atherosclerosis...
  17. ncbi request reprint Labeling of immune cells for in vivo imaging using magnetofluorescent nanoparticles
    Mikael J Pittet
    Center for Molecular Imaging Research, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Nat Protoc 1:73-9. 2006
    ..The present protocol focuses on T-cell labeling but can be used for labeling a variety of circulating cells...
  18. pmc Hybrid in vivo FMT-CT imaging of protease activity in atherosclerosis with customized nanosensors
    Matthias Nahrendorf
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Arterioscler Thromb Vasc Biol 29:1444-51. 2009
    ....
  19. pmc Monocyte subset dynamics in human atherosclerosis can be profiled with magnetic nano-sensors
    Moritz Wildgruber
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    PLoS ONE 4:e5663. 2009
    ....
  20. pmc In vivo imaging of T cell delivery to tumors after adoptive transfer therapy
    Mikael J Pittet
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, 185 Cambridge Street, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 104:12457-61. 2007
    ....
  21. ncbi request reprint Osteogenesis associates with inflammation in early-stage atherosclerosis evaluated by molecular imaging in vivo
    Elena Aikawa
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, 149 13th St, Room 5420, Charlestown, MA 02129, USA
    Circulation 116:2841-50. 2007
    ..Arterial calcification is associated with cardiovascular events; however, mechanisms of calcification in atherosclerosis remain obscure...
  22. pmc Detection of macrophages in aortic aneurysms by nanoparticle positron emission tomography-computed tomography
    Matthias Nahrendorf
    Center for Systems Biology, 185 Cambridge St, Boston, MA 02114, USA
    Arterioscler Thromb Vasc Biol 31:750-7. 2011
    ..We here aimed to develop and validate macrophage-targeted nanoparticles labeled with fluorine-18 ((18)F) for positron emission tomography-computed tomography (PET-CT) detection of inflammation in AAs...
  23. doi request reprint The multiple roles of monocyte subsets in steady state and inflammation
    Clinton S Robbins
    Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Cell Mol Life Sci 67:2685-93. 2010
    ..Future therapeutics may harness this heterogeneity to target harmful functions while sparing those that are beneficial. Here, we review recent advances on the ontogeny and function of monocytes and their subsets in humans and mice...
  24. pmc Monocyte accumulation in mouse atherogenesis is progressive and proportional to extent of disease
    Filip K Swirski
    Center for Molecular Imaging Research and Donald W Reynolds Cardiovascular Clinical Research Center on Atherosclerosis at Harvard Medical School, Massachusetts General Hospital and Harvard Medical School, CNY 149, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 103:10340-5. 2006
    ..These results provide insights into mechanisms of atherogenesis and have implications for the duration of therapies directed at leukocyte recruitment...
  25. pmc Noninvasive in vivo imaging of monocyte trafficking to atherosclerotic lesions
    Moritz F Kircher
    Center for Molecular Imaging Research, Massachusetts General Hospital and Harvard Medical School, Charlestown, Mass, USA
    Circulation 117:388-95. 2008
    ..We sought to establish a noninvasive technique to determine monocyte trafficking to atherosclerotic lesions in live animals...
  26. pmc Nanoparticle PET-CT imaging of macrophages in inflammatory atherosclerosis
    Matthias Nahrendorf
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Circulation 117:379-87. 2008
    ....
  27. pmc Real-time assessment of inflammation and treatment response in a mouse model of allergic airway inflammation
    Virna Cortez-Retamozo
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Invest 118:4058-66. 2008
    ..Both fluorescence-mediated tomography and fiberoptic bronchoscopy techniques have the potential to be translated into the clinic...
  28. ncbi request reprint Dual channel optical tomographic imaging of leukocyte recruitment and protease activity in the healing myocardial infarct
    Matthias Nahrendorf
    Center for Molecular Imaging Research, Massachusetts General Hospital, Boston, USA
    Circ Res 100:1218-25. 2007
    ..Spectrally resolved imaging agents allow for simultaneous assesment of key processes of in vivo cellular functions. Specifically, we show that in vivo FMT detects impaired healing in FXIII-/- mice...
  29. pmc Behavior of endogenous tumor-associated macrophages assessed in vivo using a functionalized nanoparticle
    Antoine Leimgruber
    Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Neoplasia 11:459-68, 2 p following 468. 2009
    ..Noninvasive imaging can also be used to monitor TAM-depleting regimen quantitatively. Thus, AMTA680 or related cell-targeting agents represent appropriate injectable vehicles for in vivo analysis of the tumor microenvironment...

Research Grants2

  1. Monocyte Heterogeneity in Experimental and Human Atherosclerosis
    FILIP SWIRSKI; Fiscal Year: 2009
    ..Immune cells called monocytes are important in how the disease progresses. This grant will investigate whether it's possible to treat atherosclerosis by targeting these cells. ..
  2. Monocyte Heterogeneity in Experimental and Human Atherosclerosis
    Filip K Swirski; Fiscal Year: 2010
    ..Immune cells called monocytes are important in how the disease progresses. This grant will investigate whether it's possible to treat atherosclerosis by targeting these cells. ..