Research Topics
Species | FILIP SWIRSKISummaryAffiliation: Harvard University Country: USA Publications
Research Grants
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Publications
Leukocyte behavior in atherosclerosis, myocardial infarction, and heart failureFilip K Swirski
Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, 185 Cambridge Street, Boston, MA 02114, USA
Science 339:161-6. 2013..Leukocytes (white blood cells) are important participants at the various stages of cardiovascular disease progression and complication. This Review will discuss leukocyte function in atherosclerosis, MI, and heart failure...
The spatial and developmental relationships in the macrophage familyFilip K Swirski
Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Simches Research Bldg, 185 Cambridge St, Boston, MA 02114, USA
Arterioscler Thromb Vasc Biol 31:1517-22. 2011..The observations have significant implications for how we image, target, and treat disease...- Identification of splenic reservoir monocytes and their deployment to inflammatory sitesFilip K Swirski
Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Science 325:612-6. 2009..These observations uncover a role for the spleen as a site for storage and rapid deployment of monocytes and identify splenic monocytes as a resource that the body exploits to regulate inflammation... - Heterogeneous in vivo behavior of monocyte subsets in atherosclerosisFilip K Swirski
Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, 185 Cambridge Street, Boston, MA 02114, USA
Arterioscler Thromb Vasc Biol 29:1424-32. 2009..In this review we summarize recent advances of our understanding of the behavioral heterogeneity of monocytes during disease progression and outline emerging molecular imaging approaches to address key questions in the field... - Impaired infarct healing in atherosclerotic mice with Ly-6C(hi) monocytosisPeter Panizzi
Center for Systems Biology, Simches Research Building, Massachusetts General Hospital and Harvard Medical School Boston, Massachusetts 02114, USA
J Am Coll Cardiol 55:1629-38. 2010..The aim of this study was to test whether blood monocytosis in mice with atherosclerosis affects infarct healing... - Rapid detection and profiling of cancer cells in fine-needle aspiratesHakho Lee
Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge Street, CPZN 5206, Boston, MA 02114, USA
Proc Natl Acad Sci U S A 106:12459-64. 2009..We detected as few as 2 cancer cells in 1-microL sample volumes of unprocessed fine-needle aspirates of tumors and profiled the expression of several cellular markers in <15 min... - The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functionsMatthias Nahrendorf
Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
J Exp Med 204:3037-47. 2007.... - Angiotensin-converting enzyme inhibition prevents the release of monocytes from their splenic reservoir in mice with myocardial infarctionFlorian Leuschner
Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, USA
Circ Res 107:1364-73. 2010..Monocytes recruited to ischemic myocardium originate from a reservoir in the spleen, and the release from their splenic niche relies on angiotensin (Ang) II signaling... - Myeloperoxidase-rich Ly-6C+ myeloid cells infiltrate allografts and contribute to an imaging signature of organ rejection in miceFilip K Swirski
Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
J Clin Invest 120:2627-34. 2010..Thus, MPO imaging represents a potential alternative to the current invasive clinical standard by which transplants are monitored... - Molecular imaging of innate immune cell function in transplant rejectionThomas Christen
Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
Circulation 119:1925-32. 2009..Yet, which macrophage functions may provide useful markers for detecting parenchymal rejection remains uncertain... 
Labeling of immune cells for in vivo imaging using magnetofluorescent nanoparticlesMikael J Pittet
Center for Molecular Imaging Research, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
Nat Protoc 1:73-9. 2006..The present protocol focuses on T-cell labeling but can be used for labeling a variety of circulating cells...- Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromataFilip K Swirski
Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
J Clin Invest 117:195-205. 2007..Conversely, the number of Ly-6C(lo) cells remained unaffected. Thus, we believe that Ly-6C(hi) monocytes represent a newly recognized component of the inflammatory response in experimental atherosclerosis... - Hybrid PET-optical imaging using targeted probesMatthias Nahrendorf
Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Proc Natl Acad Sci U S A 107:7910-5. 2010..The findings also suggest that FMT can serve as a surrogate modality for the screening and development of radionuclide-based imaging agents... - Detection of macrophages in aortic aneurysms by nanoparticle positron emission tomography-computed tomographyMatthias Nahrendorf
Center for Systems Biology, 185 Cambridge St, Boston, MA 02114, USA
Arterioscler Thromb Vasc Biol 31:750-7. 2011..We here aimed to develop and validate macrophage-targeted nanoparticles labeled with fluorine-18 ((18)F) for positron emission tomography-computed tomography (PET-CT) detection of inflammation in AAs... - Prolonged ovalbumin exposure attenuates airway hyperresponsiveness and T cell function in miceFilip K Swirski
Department of Pathology and Molecular Medicine, Centre for Gene Therapeutics, Hamilton, Canada
Int Arch Allergy Immunol 141:130-40. 2006..In this study we explored mechanisms underlying attenuation of the airway inflammatory response, assessed whether the phenomenon is strain-specific, and determined its consequences to airway physiology... - Hybrid in vivo FMT-CT imaging of protease activity in atherosclerosis with customized nanosensorsMatthias Nahrendorf
Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Arterioscler Thromb Vasc Biol 29:1444-51. 2009.... - Monocyte subset dynamics in human atherosclerosis can be profiled with magnetic nano-sensorsMoritz Wildgruber
Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
PLoS ONE 4:e5663. 2009.... - In vivo imaging of T cell delivery to tumors after adoptive transfer therapyMikael J Pittet
Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, 185 Cambridge Street, Boston, MA 02114, USA
Proc Natl Acad Sci U S A 104:12457-61. 2007.... - Osteogenesis associates with inflammation in early-stage atherosclerosis evaluated by molecular imaging in vivoElena Aikawa
Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, 149 13th St, Room 5420, Charlestown, MA 02129, USA
Circulation 116:2841-50. 2007..Arterial calcification is associated with cardiovascular events; however, mechanisms of calcification in atherosclerosis remain obscure... - Activatable magnetic resonance imaging agent reports myeloperoxidase activity in healing infarcts and noninvasively detects the antiinflammatory effects of atorvastatin on ischemia-reperfusion injuryMatthias Nahrendorf
Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Circulation 117:1153-60. 2008..We hypothesized that MPO imaging could be used to measure inflammatory responses after myocardial ischemia locally and noninvasively in a murine model... - Nanoparticle PET-CT imaging of macrophages in inflammatory atherosclerosisMatthias Nahrendorf
Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
Circulation 117:379-87. 2008.... - Noninvasive in vivo imaging of monocyte trafficking to atherosclerotic lesionsMoritz F Kircher
Center for Molecular Imaging Research, Massachusetts General Hospital and Harvard Medical School, Charlestown, Mass, USA
Circulation 117:388-95. 2008..We sought to establish a noninvasive technique to determine monocyte trafficking to atherosclerotic lesions in live animals... - The multiple roles of monocyte subsets in steady state and inflammationClinton S Robbins
Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Cell Mol Life Sci 67:2685-93. 2010..Future therapeutics may harness this heterogeneity to target harmful functions while sparing those that are beneficial. Here, we review recent advances on the ontogeny and function of monocytes and their subsets in humans and mice... - Monocyte accumulation in mouse atherogenesis is progressive and proportional to extent of diseaseFilip K Swirski
Center for Molecular Imaging Research and Donald W. Reynolds Cardiovascular Clinical Research Center on Atherosclerosis at Harvard Medical School, Massachusetts General Hospital and Harvard Medical School, CNY 149, Charlestown, MA 02129, USA
Proc Natl Acad Sci U S A 103:10340-5. 2006..These results provide insights into mechanisms of atherogenesis and have implications for the duration of therapies directed at leukocyte recruitment... - Real-time assessment of inflammation and treatment response in a mouse model of allergic airway inflammationVirna Cortez-Retamozo
Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
J Clin Invest 118:4058-66. 2008..Both fluorescence-mediated tomography and fiberoptic bronchoscopy techniques have the potential to be translated into the clinic... - Dual channel optical tomographic imaging of leukocyte recruitment and protease activity in the healing myocardial infarctMatthias Nahrendorf
Center for Molecular Imaging Research, Massachusetts General Hospital, Boston, USA
Circ Res 100:1218-25. 2007..Spectrally resolved imaging agents allow for simultaneous assesment of key processes of in vivo cellular functions. Specifically, we show that in vivo FMT detects impaired healing in FXIII-/- mice... - Behavior of endogenous tumor-associated macrophages assessed in vivo using a functionalized nanoparticleAntoine Leimgruber
Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Neoplasia 11:459-68, 2 p following 468. 2009..Noninvasive imaging can also be used to monitor TAM-depleting regimen quantitatively. Thus, AMTA680 or related cell-targeting agents represent appropriate injectable vehicles for in vivo analysis of the tumor microenvironment...
Research Grants
- Monocyte Heterogeneity in Experimental and Human AtherosclerosisFILIP SWIRSKI; Fiscal Year: 2009..Immune cells called monocytes are important in how the disease progresses. This grant will investigate whether it's possible to treat atherosclerosis by targeting these cells. ..
- Monocyte Heterogeneity in Experimental and Human AtherosclerosisFilip K Swirski; Fiscal Year: 2010..Immune cells called monocytes are important in how the disease progresses. This grant will investigate whether it's possible to treat atherosclerosis by targeting these cells. ..