William R Swindell

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Data mining identifies Digit Symbol Substitution Test score and serum cystatin C as dominant predictors of mortality in older men and women
    William R Swindell
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Rejuvenation Res 15:405-13. 2012
  2. pmc Dietary restriction in rats and mice: a meta-analysis and review of the evidence for genotype-dependent effects on lifespan
    William R Swindell
    Department of Genetics, Harvard Medical School, Boston, MA 02115, United States
    Ageing Res Rev 11:254-70. 2012
  3. pmc Meta-profiles of gene expression during aging: limited similarities between mouse and human and an unexpectedly decreased inflammatory signature
    William R Swindell
    Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 7:e33204. 2012
  4. pmc Transcriptional profiles of leukocyte populations provide a tool for interpreting gene expression patterns associated with high fat diet in mice
    William R Swindell
    Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 5:e11861. 2010
  5. pmc Genome-wide expression profiling of five mouse models identifies similarities and differences with human psoriasis
    William R Swindell
    Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 6:e18266. 2011
  6. pmc Heterogeneity of inflammatory and cytokine networks in chronic plaque psoriasis
    William R Swindell
    Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 7:e34594. 2012
  7. pmc Metallothionein and the biology of aging
    William R Swindell
    Department of Genetics, Harvard Medical School New Research Building, Room 0464, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Ageing Res Rev 10:132-45. 2011

Detail Information

Publications7

  1. pmc Data mining identifies Digit Symbol Substitution Test score and serum cystatin C as dominant predictors of mortality in older men and women
    William R Swindell
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Rejuvenation Res 15:405-13. 2012
    ..However, the relative prognostic value of information contained in clinical profiles of nonfrail older adults is often unclear...
  2. pmc Dietary restriction in rats and mice: a meta-analysis and review of the evidence for genotype-dependent effects on lifespan
    William R Swindell
    Department of Genetics, Harvard Medical School, Boston, MA 02115, United States
    Ageing Res Rev 11:254-70. 2012
    ..This will broaden the scope of genotypes studied in aging research, but may also be critical for translation of findings from rodents to historically outbred and genetically heterogeneous primate species...
  3. pmc Meta-profiles of gene expression during aging: limited similarities between mouse and human and an unexpectedly decreased inflammatory signature
    William R Swindell
    Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 7:e33204. 2012
    ..These processes are accompanied by a large-scale shift in gene expression, but underlying mechanisms are not understood and conservation of these mechanisms between humans and mice is uncertain...
  4. pmc Transcriptional profiles of leukocyte populations provide a tool for interpreting gene expression patterns associated with high fat diet in mice
    William R Swindell
    Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 5:e11861. 2010
    ..These effects of high fat (atherogenic) diet may be due to infiltration of tissues by leukocytes in coordination with inflammatory processes...
  5. pmc Genome-wide expression profiling of five mouse models identifies similarities and differences with human psoriasis
    William R Swindell
    Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 6:e18266. 2011
    ....
  6. pmc Heterogeneity of inflammatory and cytokine networks in chronic plaque psoriasis
    William R Swindell
    Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 7:e34594. 2012
    ..Such heterogeneous aspects may shape clinical course and treatment responses, and can provide avenues for development of personalized treatments...
  7. pmc Metallothionein and the biology of aging
    William R Swindell
    Department of Genetics, Harvard Medical School New Research Building, Room 0464, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Ageing Res Rev 10:132-45. 2011
    ..Further investigation will therefore be needed to understand how MT contributes to the response of invertebrates and mice to CR and the endocrine mutations studied by aging researchers...