Susanne E Swalley
Affiliation: Harvard University
- Screening factors effecting a response in soluble protein expression: formalized approach using design of experimentsSusanne E Swalley
Vertex Pharmaceuticals Inc, 130 Waverly Street, Cambridge, MA 02139 4242, USA
Anal Biochem 351:122-7. 2006..We propose that this technique has universal application in the production of recombinant proteins, providing a powerful tool for the optimization of protein expression...
- Full-length influenza hemagglutinin HA2 refolds into the trimeric low-pH-induced conformationSusanne E Swalley
Department of Biological Chemistry and Molecular Pharmacology, Howard Hughes Medical Institute, Harvard Medical School, 250 Longwood Avenue, Boston, Massachusetts 02115, USA
Biochemistry 43:5902-11. 2004..The refolded chimeric protein described here is a suitable species for undertaking studies of how the fusion peptide inserts into membranes and assessing the nature of possible intermediates in the fusion process...
- Development of a protease production platform for structure-based drug designTed Fox
Vertex Pharmaceuticals Inc, Cambridge, MA 02139, USA
Curr Protein Pept Sci 8:439-45. 2007..We have drawn on examples from our own research programs to illustrate how these strategies have been successfully used in the production of proteases for SBDD...