Research Topics
Genomes and Genes | Qi SunSummaryAffiliation: Harvard University Country: USA Publications
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Publications
Plasma levels of fetuin-A and hepatic enzymes and risk of type 2 diabetes in women in the U.SQi Sun
Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
Diabetes 62:49-55. 2013..69 (1.39-2.05) (P for heterogeneity = 0.45). These findings suggest that plasma fetuin-A levels were independently associated with higher risk of developing type 2 diabetes...
Healthy lifestyle and leukocyte telomere length in U.S. womenQi Sun
Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, United States of America
PLoS ONE 7:e38374. 2012..Whether a healthy lifestyle may be associated with longer telomere length is largely unknown...
25-Hydroxyvitamin D levels and the risk of stroke: a prospective study and meta-analysisQi Sun
Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
Stroke 43:1470-7. 2012..We aimed to examine this association in a prospective study in women and to summarize all existing data in a meta-analysis...
Saturated fatty acids and risk of coronary heart disease: modulation by replacement nutrientsPatty W Siri-Tarino
Atherosclerosis Research, Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
Curr Atheroscler Rep 12:384-90. 2010..Therefore, dietary recommendations should emphasize substitution of polyunsaturated fat and minimally processed grains for saturated fat...
Leptin and soluble leptin receptor levels in plasma and risk of type 2 diabetes in U.S. women: a prospective studyQi Sun
Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
Diabetes 59:611-8. 2010....
Vitamin D intake and risk of cardiovascular disease in US men and womenQi Sun
Department of Nutrition and Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Am J Clin Nutr 94:534-42. 2011....
Physical activity at midlife in relation to successful survival in women at age 70 years or olderQi Sun
Department of Nutrition, Harvard School of Public Health, 655 Huntington Ave, Boston, MA 02115, USA
Arch Intern Med 170:194-201. 2010..Physical activity is associated with reduced risks of chronic diseases and premature death. Whether physical activity is also associated with improved overall health among those who survive to older ages is unclear...
White rice, brown rice, and risk of type 2 diabetes in US men and womenQi Sun
Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
Arch Intern Med 170:961-9. 2010..We examined white and brown rice consumption in relation to type 2 diabetes risk prospectively in the Health Professionals Follow-up Study and the Nurses' Health Study I and II...
Alcohol consumption at midlife and successful ageing in women: a prospective cohort analysis in the nurses' health studyQi Sun
Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, United States of America
PLoS Med 8:e1001090. 2011..In this study, we prospectively examined alcohol use assessed at midlife in relation to successful ageing in a cohort of US women...
Adiposity and weight change in mid-life in relation to healthy survival after age 70 in women: prospective cohort studyQi Sun
Department of Nutrition, Harvard School of Public Health, 655 Huntington Avenue, Boston, MA 02115, United States
BMJ 339:b3796. 2009..To examine the hypothesis that mid-life adiposity is associated with a reduced probability of maintaining an optimal health status among those who survive to older ages...
Prospective study of zinc intake and risk of type 2 diabetes in womenQi Sun
Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
Diabetes Care 32:629-34. 2009..The aim of this study is to investigate the intake of zinc in relation to risk of type 2 diabetes in U.S. women...
Excessive body iron stores are not associated with risk of coronary heart disease in womenQi Sun
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
J Nutr 138:2436-41. 2008..05 (0.62, 1.77), 1.19 (0.69, 2.03), and 1.05 (0.60, 1.85; P-trend = 0.90) across quartiles. Our data do not support the hypothesis that excessive body iron stores are associated with risk of CHD...
Comparison of dual-energy x-ray absorptiometric and anthropometric measures of adiposity in relation to adiposity-related biologic factorsQi Sun
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Am J Epidemiol 172:1442-54. 2010....
Increased mortality risk in women with depression and diabetes mellitusAn Pan
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
Arch Gen Psychiatry 68:42-50. 2011..Depression and diabetes mellitus have been associated with an increased risk of all-cause and cardiovascular disease (CVD) mortality. However, data evaluating the joint effects of these 2 conditions on mortality are sparse...
Red meat consumption and mortality: results from 2 prospective cohort studiesAn Pan
Departments of Nutrition and Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
Arch Intern Med 172:555-63. 2012..Red meat consumption has been associated with an increased risk of chronic diseases. However, its relationship with mortality remains uncertain...
Depression and incident stroke in womenAn Pan
Department of Nutrition and Epidemiology, Harvard School of Public Health, and Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02215, USA
Stroke 42:2770-5. 2011..Depression has been associated with an increased risk of coronary heart disease, but prospective data for the association with stroke are limited...
Genome-wide association study identifies polymorphisms in LEPR as determinants of plasma soluble leptin receptor levelsQi Sun
Department of Nutrition, Harvard School of Public Health, 655 Huntington Avenue, Boston, MA 02115, USA
Hum Mol Genet 19:1846-55. 2010..These data provide novel evidence revealing the role of polymorphisms in LEPR in modulating plasma levels of sOB-R and may further our understanding of the complex relationships among leptin, leptin receptor and diabetes-related traits...
Adolescent dairy product consumption and risk of type 2 diabetes in middle-aged womenVasanti S Malik
Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
Am J Clin Nutr 94:854-61. 2011..Type 2 diabetes (T2D) prevention has generally focused on the identification of risk factors in adulthood. Dairy product consumption in adults has been associated with a lower risk of T2D...
Major dietary protein sources and risk of coronary heart disease in womenAdam M Bernstein
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
Circulation 122:876-83. 2010..Our objective was to examine the relation between foods that are major dietary protein sources and incident CHD...
Bidirectional association between depression and type 2 diabetes mellitus in womenAn Pan
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
Arch Intern Med 170:1884-91. 2010..Although it has been hypothesized that the diabetes-depression relation is bidirectional, few studies have addressed this hypothesis in a prospective setting...
Dietary flavonoid intakes and risk of type 2 diabetes in US men and womenNicole M Wedick
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
Am J Clin Nutr 95:925-33. 2012..Data from mechanistic studies support a beneficial effect of specific flavonoids on insulin sensitivity. However, few studies have evaluated the relation between intakes of different flavonoid subclasses and type 2 diabetes...
Rotating night shift work and risk of type 2 diabetes: two prospective cohort studies in womenAn Pan
Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
PLoS Med 8:e1001141. 2011..However, its association with type 2 diabetes remains unclear. Therefore, we aimed to evaluate this association in two cohorts of US women...
Blood concentrations of individual long-chain n-3 fatty acids and risk of nonfatal myocardial infarctionQi Sun
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
Am J Clin Nutr 88:216-23. 2008..Whereas dietary intake of long-chain n-3 fatty acids has been associated with risk of nonfatal myocardial infarction (MI), few studies have examined the relation for blood concentrations...
Plasma and erythrocyte biomarkers of dairy fat intake and risk of ischemic heart diseaseQi Sun
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
Am J Clin Nutr 86:929-37. 2007..The relation between dairy product intake and the risk of ischemic heart disease (IHD) remains controversial...
Red meat consumption and risk of type 2 diabetes: 3 cohorts of US adults and an updated meta-analysisAn Pan
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
Am J Clin Nutr 94:1088-96. 2011..The relation between consumption of different types of red meats and risk of type 2 diabetes (T2D) remains uncertain...
Total and high-molecular-weight adiponectin and resistin in relation to the risk for type 2 diabetes in womenChristin Heidemann
Harvard School of Public Health, Massachusetts General Hospital, Brigham and Women s Hospital, and Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
Ann Intern Med 149:307-16. 2008..Adiponectin and resistin are recently discovered adipokines that may provide a molecular link between adiposity and type 2 diabetes...
Genetic variants in ABO blood group region, plasma soluble E-selectin levels and risk of type 2 diabetesLu Qi
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
Hum Mol Genet 19:1856-62. 2010..Our findings indicate that the genetic variants at ABO locus affect plasma sE-selectin levels and diabetes risk. The genetic associations with diabetes risk were independent of sE-selectin levels...
A prospective study of trans fatty acids in erythrocytes and risk of coronary heart diseaseQi Sun
Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
Circulation 115:1858-65. 2007..We assessed the hypothesis that higher trans fatty acid contents in erythrocytes were associated with an elevated risk of CHD in a nested case-control study among US women...
Walnut consumption is associated with lower risk of type 2 diabetes in womenAn Pan
Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
J Nutr 143:512-8. 2013..Our results suggest that higher walnut consumption is associated with a significantly lower risk of type 2 diabetes in women...
α-Linolenic acid and risk of cardiovascular disease: a systematic review and meta-analysisAn Pan
Department of Nutrition, Harvard School of Public Health, Harvard Medical School, Boston, MA 02115, USA
Am J Clin Nutr 96:1262-73. 2012..Prior studies of α-linolenic acid (ALA), a plant-derived omega-3 (n-3) fatty acid, and cardiovascular disease (CVD) risk have generated inconsistent results...
Higher adiponectin levels predict greater weight gain in healthy women in the Nurses' Health StudyMarie France Hivert
General Medicine Division, Massachusetts General Hospital, Boston, Massachusetts, USA
Obesity (Silver Spring) 19:409-15. 2011..High adiponectin production by adipocytes might be a sign of "healthy" adipose tissue with further capacity to store fat...
Genetic variants at 2q24 are associated with susceptibility to type 2 diabetesLu Qi
Department of Nutrition, Harvard School of Public Health, and Brigham and Women s Hospital, Boston, MA, USA
Hum Mol Genet 19:2706-15. 2010..05). These data suggest that the 2q24 locus may influence the T2D risk by affecting glucose metabolism and insulin resistance...
Dietary and plasma magnesium and risk of coronary heart disease among womenStephanie E Chiuve
Center for Arrhythmia Prevention, Department of Medicine Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
J Am Heart Assoc 2:e000114. 2013..Magnesium influences endothelial function, inflammation, blood pressure, and diabetes, but a direct relation with coronary heart disease (CHD) risk has not been established...
Resistin is associated with biomarkers of inflammation while total and high-molecular weight adiponectin are associated with biomarkers of inflammation, insulin resistance, and endothelial functionJessica L Fargnoli
Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, ST816, Boston, Massachusetts 02115, USA
Eur J Endocrinol 162:281-8. 2010..It remains to be elucidated which of these adipokines is associated primarily with biomarkers of all or only some of these categories, i.e. biomarkers of inflammation, endothelial dysfunction, and/or insulin secretion or insulinemia...
Comparison between plasma and erythrocyte fatty acid content as biomarkers of fatty acid intake in US womenQi Sun
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
Am J Clin Nutr 86:74-81. 2007..Erythrocyte fatty acids may be superior to plasma fatty acids for reflecting long-term fatty acid intake because of less sensitivity to recent intake and a slower turnover rate...
Effects of caffeinated and decaffeinated coffee on biological risk factors for type 2 diabetes: a randomized controlled trialNicole M Wedick
Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
Nutr J 10:93. 2011..The aim of this study was to evaluate the effects of regular and decaffeinated coffee on biological risk factors for type 2 diabetes...
Genome-wide association study identifies variants at the IL18-BCO2 locus associated with interleukin-18 levelsMeian He
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
Arterioscler Thromb Vasc Biol 30:885-90. 2010..We sought to identify the common genetic variants associated with IL-18 levels...
Bidirectional association between depression and metabolic syndrome: a systematic review and meta-analysis of epidemiological studiesAn Pan
Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
Diabetes Care 35:1171-80. 2012..However, the results have been inconsistent. This meta-analysis aimed to summarize the current evidence from cross-sectional and prospective cohort studies that evaluated this association...
White rice consumption and risk of type 2 diabetes: meta-analysis and systematic reviewEmily A Hu
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
BMJ 344:e1454. 2012..To summarise evidence on the association between white rice consumption and risk of type 2 diabetes and to quantify the potential dose-response relation...
Plasma 25-hydroxyvitamin D concentration and risk of incident type 2 diabetes in womenAnastassios G Pittas
Division of Endocrinology, Diabetes and Metabolism, Tufts Medical Center, Boston, Massachusetts, USA
Diabetes Care 33:2021-3. 2010..To determine the association between 25-hydroxyvitamin D (25-OHD) concentration and risk of incident type 2 diabetes...
Depression and risk of stroke morbidity and mortality: a meta-analysis and systematic reviewAn Pan
Department of Nutrition, Harvard School of Public Health, 655 Huntington Ave, Boston, MA 02115, USA
JAMA 306:1241-9. 2011..Several studies have suggested that depression is associated with an increased risk of stroke; however, the results are inconsistent...
Role of adiposity and lifestyle in the relationship between family history of diabetes and 20-year incidence of type 2 diabetes in U.S. womenEsther van 't Riet
Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
Diabetes Care 33:763-7. 2010..To evaluate to what extent the association between family history of diabetes and risk of type 2 diabetes can be explained by excess adiposity and lifestyle risk factors...
Cigarette smoking and poverty in ChinaYuanli Liu
Harvard School of Public Health, Harvard University Cambridge, MA, USA
Soc Sci Med 63:2784-90. 2006..Smoking related expenses pushed a significant proportion of low-income families into poverty in China. Therefore, reducing the smoking rate appears to be not only a public health strategy, but also a poverty reduction strategy...
The Lin28/let-7 axis regulates glucose metabolismHao Zhu
Stem Cell Transplantation Program, Division of Pediatric Hematology Oncology, Children s Hospital Boston and Dana Farber Cancer Institute, Boston, MA, USA
Cell 147:81-94. 2011..These data establish the Lin28/let-7 pathway as a central regulator of mammalian glucose metabolism...
Persistent organic pollutants and type 2 diabetes: a prospective analysis in the nurses' health study and meta-analysisHongyu Wu
Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Environ Health Perspect 121:153-61. 2013..Prospective data regarding persistent organic pollutants (POPs) and risk of type 2 diabetes (T2D) are limited, and the results for individual POPs are not entirely consistent across studies...
Research Grants
- Dietary Polyphenols, Urinary Biomarkers & Risk of Type 2 DiabetesQi Sun; Fiscal Year: 2010..Findings of the proposed application can be used to develop more effective dietary advice and to make changes in food composition to contribute to the prevention of type 2 diabetes. ..
