Jianhua Sui

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses
    Jianhua Sui
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street JFB 826, Boston, Massachusetts 02115, USA
    Nat Struct Mol Biol 16:265-73. 2009
  2. pmc Broadening of neutralization activity to directly block a dominant antibody-driven SARS-coronavirus evolution pathway
    Jianhua Sui
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
    PLoS Pathog 4:e1000197. 2008
  3. pmc Receptor and viral determinants of SARS-coronavirus adaptation to human ACE2
    Wenhui Li
    Department of Microbiology and Molecular Genetics, Harvard Medical School, New England Primate Research Center, Southborough, MA 01772 9102, USA
    EMBO J 24:1634-43. 2005
  4. pmc Evaluation of human monoclonal antibody 80R for immunoprophylaxis of severe acute respiratory syndrome by an animal study, epitope mapping, and analysis of spike variants
    Jianhua Sui
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, 44 Binney St, JFB 824, Boston, MA 02115, USA
    J Virol 79:5900-6. 2005
  5. pmc The S proteins of human coronavirus NL63 and severe acute respiratory syndrome coronavirus bind overlapping regions of ACE2
    Wenhui Li
    Department of Microbiology and Molecular Genetics, Harvard Medical School, New England Primate Research Center, Southborough, MA 01772 9102, USA
    Virology 367:367-74. 2007
  6. pmc Potent neutralization of severe acute respiratory syndrome (SARS) coronavirus by a human mAb to S1 protein that blocks receptor association
    Jianhua Sui
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 101:2536-41. 2004
  7. pmc Lentivirus display: stable expression of human antibodies on the surface of human cells and virus particles
    Ran Taube
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, Massachusetts, United States of America
    PLoS ONE 3:e3181. 2008
  8. ncbi request reprint Histone deacetylase inhibitor trichostatin A and proteasome inhibitor PS-341 synergistically induce apoptosis in pancreatic cancer cells
    Jirong Bai
    Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 0221, USA
    Biochem Biophys Res Commun 348:1245-53. 2006
  9. pmc Influenza A virus neuraminidase limits viral superinfection
    I Chueh Huang
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Southborough, Massachusetts 01772, USA
    J Virol 82:4834-43. 2008
  10. ncbi request reprint Human anti-CXCR4 antibodies undergo VH replacement, exhibit functional V-region sulfation, and define CXCR4 antigenic heterogeneity
    Chen Xu
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, MA, USA
    J Immunol 179:2408-18. 2007

Collaborators

Detail Information

Publications20

  1. pmc Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses
    Jianhua Sui
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street JFB 826, Boston, Massachusetts 02115, USA
    Nat Struct Mol Biol 16:265-73. 2009
    ..Our data further suggest that this region is recalcitrant to neutralization escape and that nAb-based immunotherapy is a promising strategy for broad-spectrum protection against seasonal and pandemic influenza viruses...
  2. pmc Broadening of neutralization activity to directly block a dominant antibody-driven SARS-coronavirus evolution pathway
    Jianhua Sui
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
    PLoS Pathog 4:e1000197. 2008
    ....
  3. pmc Receptor and viral determinants of SARS-coronavirus adaptation to human ACE2
    Wenhui Li
    Department of Microbiology and Molecular Genetics, Harvard Medical School, New England Primate Research Center, Southborough, MA 01772 9102, USA
    EMBO J 24:1634-43. 2005
    ..Collectively, these data describe molecular interactions important to the adaptation of SARS-CoV to human cells, and provide insight into the severity of the 2002-2003 SARS epidemic...
  4. pmc Evaluation of human monoclonal antibody 80R for immunoprophylaxis of severe acute respiratory syndrome by an animal study, epitope mapping, and analysis of spike variants
    Jianhua Sui
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, 44 Binney St, JFB 824, Boston, MA 02115, USA
    J Virol 79:5900-6. 2005
    ..Our study also cautions that for any prophylaxis strategy based on neutralizing antibody responses, whether by passive or active immunization, a genotyping monitor will be necessary for effective use...
  5. pmc The S proteins of human coronavirus NL63 and severe acute respiratory syndrome coronavirus bind overlapping regions of ACE2
    Wenhui Li
    Department of Microbiology and Molecular Genetics, Harvard Medical School, New England Primate Research Center, Southborough, MA 01772 9102, USA
    Virology 367:367-74. 2007
    ..These studies indicate that HCoV-NL63, like SARS-CoV, associates region of human ACE2 that includes a key loop formed by beta-strands 4 and 5...
  6. pmc Potent neutralization of severe acute respiratory syndrome (SARS) coronavirus by a human mAb to S1 protein that blocks receptor association
    Jianhua Sui
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 101:2536-41. 2004
    ....
  7. pmc Lentivirus display: stable expression of human antibodies on the surface of human cells and virus particles
    Ran Taube
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, Massachusetts, United States of America
    PLoS ONE 3:e3181. 2008
    ..Here we describe a discovery platform that utilizes self-inactivating (SIN) lentiviral vectors for the surface display of high-affinity single-chain variable region (scFv) antibody fragments on human cells and lentivirus particles...
  8. ncbi request reprint Histone deacetylase inhibitor trichostatin A and proteasome inhibitor PS-341 synergistically induce apoptosis in pancreatic cancer cells
    Jirong Bai
    Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 0221, USA
    Biochem Biophys Res Commun 348:1245-53. 2006
    ..The combined drug regimen effectively inflicted an average of 71.5% apoptotic cell death (55.2-80%) in diverse pancreatic cancer cell lines by activating the intrinsic apoptotic pathway...
  9. pmc Influenza A virus neuraminidase limits viral superinfection
    I Chueh Huang
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Southborough, Massachusetts 01772, USA
    J Virol 82:4834-43. 2008
    ..Our data indicate that NA alone among viral proteins limits influenza A virus superinfection...
  10. ncbi request reprint Human anti-CXCR4 antibodies undergo VH replacement, exhibit functional V-region sulfation, and define CXCR4 antigenic heterogeneity
    Chen Xu
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, MA, USA
    J Immunol 179:2408-18. 2007
    ..These Abs also provide valuable tools to explore the selective in vivo targeting of CXCR4 isoforms that may be preferentially expressed in certain disease states and involved in steady-state CXCR4-SDF-1 homeostasis...
  11. pmc Humanization of an anti-CCR4 antibody that kills cutaneous T-cell lymphoma cells and abrogates suppression by T-regulatory cells
    De Kuan Chang
    Dana Farber Cancer Institute Harvard Medical School, 450 Brookline Ave, Boston, MA 02215, USA
    Mol Cancer Ther 11:2451-61. 2012
    ..Taken together, this high-affinity humanized mAb2-3 with potent antitumor effect and a broad range of mechanisms of action may provide a novel immunotherapy for CTCL and other solid tumors...
  12. pmc Fine epitope mapping of monoclonal antibodies against hemagglutinin of a highly pathogenic H5N1 influenza virus using yeast surface display
    Thomas Han
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, 450 Brookline Ave, Boston, MA 02215, USA
    Biochem Biophys Res Commun 409:253-9. 2011
    ..These data further augment our toolchest for studying HA antigenicity, epitope diversity and accessibility in response to natural and experimental influenza infection and vaccines...
  13. pmc Human anti-CCR4 minibody gene transfer for the treatment of cutaneous T-cell lymphoma
    Thomas Han
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 7:e44455. 2012
    ..Although several therapeutic options have become available for patients with Cutaneous T-cell Lymphoma (CTCL), no therapy has been curative. Recent studies have demonstrated that CTCL cells overexpress the CC chemokine receptor 4 (CCR4)...
  14. ncbi request reprint Predominant Bcl-XL knockdown disables antiapoptotic mechanisms: tumor necrosis factor-related apoptosis-inducing ligand-based triple chemotherapy overcomes chemoresistance in pancreatic cancer cells in vitro
    Jirong Bai
    Department of Surgery, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Cancer Res 65:2344-52. 2005
    ..Bcl-XL plays a vital role in pancreatic cancer chemoresistance. Geldanamycin, PS-341, and TRAIL triple combination may be a novel therapeutic strategy for pancreatic cancer...
  15. ncbi request reprint Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus
    Wenhui Li
    Partners AIDS Research Center, Brigham and Women s Hospital, Department of Medicine Microbiology and Molecular Genetics, Boston, Massachusetts 02115, USA
    Nature 426:450-4. 2003
    ..Finally, anti-ACE2 but not anti-ACE1 antibody blocked viral replication on Vero E6 cells. Together our data indicate that ACE2 is a functional receptor for SARS-CoV...
  16. pmc Wide prevalence of heterosubtypic broadly neutralizing human anti-influenza A antibodies
    Jianhua Sui
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Clin Infect Dis 52:1003-9. 2011
    ..A greater understanding of the broad-spectrum "heterosubtypic" neutralizing human antibody (BnAb) response to influenza should bring us closer toward a universal influenza vaccine...
  17. ncbi request reprint The growth and potential of human antiviral monoclonal antibody therapeutics
    Wayne A Marasco
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute and Department of Medicine, Harvard Medical School 44, Binney Street, Boston, Massachusetts 02115, USA
    Nat Biotechnol 25:1421-34. 2007
    ..These successes, in both industrial and academic laboratories, coupled with ongoing changes in the biomedical and regulatory environments, herald an era when the commercial development of human antiviral mAb therapies will likely surge...
  18. ncbi request reprint Identification of CD4 and transferrin receptor antibodies by CXCR4 antibody-guided Pathfinder selection
    Jianhua Sui
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Eur J Biochem 270:4497-506. 2003
    ..Refinements of these techniques are required to improve target specificity and selectivity...
  19. ncbi request reprint Evidence against Ebola virus sGP binding to human neutrophils by a specific receptor
    Jianhua Sui
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, Massachusetts, 02115, USA
    Virology 303:9-14. 2002
    ..It is unlikely that sGP plays a role in the Ebola virus pathogenesis through interfering with the innate immunity by targeting neutrophils...
  20. ncbi request reprint Inhibition of Tat-mediated transactivation and HIV-1 replication by human anti-hCyclinT1 intrabodies
    Jirong Bai
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    J Biol Chem 278:1433-42. 2003
    ....