Research Topics
| Steven StufflebeamSummaryAffiliation: Harvard University Country: USA Publications
Research Grants
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Detail Information
Publications
Clinical magnetoencephalography for neurosurgerySteven M Stufflebeam
Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129, USA
Neurosurg Clin N Am 22:153-67, vii-viii. 2011..This article reviews the history of clinical MEG, introduces the basic concepts about the biophysics of MEG, and outlines the basic neurosurgical applications of MEG...- Localization of focal epileptic discharges using functional connectivity magnetic resonance imagingSteven M Stufflebeam
Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts, USA
J Neurosurg 114:1693-7. 2011..The object of this study was to investigate whether the degree of coupling of spontaneous brain activity as measured with functional connectivity MR imaging (fcMR imaging) can accurately identify and localize epileptic discharges... - Mapping cognitive functionSteven M Stufflebeam
Harvard Medical School, Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Building 149, 13th Street, Charlestown, MA 02129, USA
Neuroimaging Clin N Am 17:469-84, viii-ix. 2007..A unifying theme of this article is the concept that a more complete understanding of cognition only comes through integration of multimodal structural and functional imaging technologies... - Onset timing of cross-sensory activations and multisensory interactions in auditory and visual sensory corticesTommi Raij
MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Bldg 149, 13 St, Charlestown, MA, USA
Eur J Neurosci 31:1772-82. 2010..Audiovisual interactions started at 85 ms in the left auditory, 80 ms in the right auditory and 74 ms in the visual cortex, i.e., 3-21 ms after inputs from the two modalities converged... 
Clinical applications of magnetoencephalographySteven M Stufflebeam
Department of Radiology, Athinoula A Martinos Center for Biomedical Imaging, Harvard Medical School, Massachusetts General Hospital, 149 Thirteenth Street, Charlestown, MA 02129, USA
Hum Brain Mapp 30:1813-23. 2009..We also describe the most common clinical MEG applications that affect the management of patients, and discuss some applications that are close to having a clinical impact on patients...- Primary and multisensory cortical activity is correlated with audiovisual perceptsMargo McKenna Benoit
Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02114, USA
Hum Brain Mapp 31:526-38. 2010.... - Human posterior auditory cortex gates novel sounds to consciousnessIiro P Jaaskelainen
Massachusetts General Hospital, Massachusetts Institute of Technology, Harvard Medical School, Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA
Proc Natl Acad Sci U S A 101:6809-14. 2004..Our converging findings suggest that transient adaptation of feature-specific neurons within human posterior auditory cortex filters superfluous sounds from entering one's awareness... - Patterns of spontaneous magnetoencephalographic activity in patients with schizophreniaPeter J Siekmeier
Harvard Medical School and McLean Hospital, Belmont, Massachusetts 02478, USA
J Clin Neurophysiol 27:179-90. 2010.... - Magnetoencephalographic analysis in patients with vagus nerve stimulatorNaoaki Tanaka
Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA
Pediatr Neurol 41:383-7. 2009..These findings supported the diagnosis of symptomatic generalized epilepsy in this patient. Magnetoencephalography may thus be a useful option for evaluating patients with intractable epilepsy who have a vagus nerve stimulator... - Quantitative analysis and biophysically realistic neural modeling of the MEG mu rhythm: rhythmogenesis and modulation of sensory-evoked responsesStephanie R Jones
Massachusetts General Hospital, Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA
J Neurophysiol 102:3554-72. 2009..These data provide new information on the dynamics of the mu rhythm in humans and the model provides a novel mechanistic interpretation of this rhythm and its functional significance... - Dynamic statistical parametric mapping for analyzing ictal magnetoencephalographic spikes in patients with intractable frontal lobe epilepsyNaoaki Tanaka
Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA
Epilepsy Res 85:279-86. 2009..Analyzing ictal MEG spikes by using dSPMs may provide useful information in presurgical evaluation of epilepsy... 
Functional MRI using regularized parallel imaging acquisitionFa Hsuan Lin
Massachusetts General Hospital, Department of Radiology, MGH HMS MIT, Athinoula A Martinos Center for Biomedical Imaging, Charlestown, Massachusetts 02129, USA
Magn Reson Med 54:343-53. 2005..Human motor and visual fMRI data acquired at different field strengths and array coils also demonstrate that regularized SENSE improves the detection of functionally active brain regions...- Task-free presurgical mapping using functional magnetic resonance imaging intrinsic activityHesheng Liu
Massachusetts General Hospital Massachusetts Institute of Technology Harvard Medical School Athinoula A Martinos Center for Biomedical Imaging, Charlestown, Massachusetts 02129, USA
J Neurosurg 111:746-54. 2009..The ability to use such methods in individual patients may provide a powerful tool for presurgical planning. The authors explore the feasibility of presurgical motor function mapping in which a task-free paradigm is used... - Dynamic statistical parametric mapping for analyzing the magnetoencephalographic epileptiform activity in patients with epilepsyHideaki Shiraishi
MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital Harvard Medical School, Charlestown, MA, USA
J Child Neurol 20:363-9. 2005.... - Mapping the signal-to-noise-ratios of cortical sources in magnetoencephalography and electroencephalographyDaniel M Goldenholz
Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, USA
Hum Brain Mapp 30:1077-86. 2009..Clinically, SNR maps in a patient explained differential sensitivity of MEG and EEG in detecting epileptic activity. Our results emphasize the benefits of recording MEG and EEG simultaneously... - Application of magnetoencephalography in epilepsy patients with widespread spike or slow-wave activityHideaki Shiraishi
MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital Harvard Medical School, Charlestown, Massachusetts, USA
Epilepsia 46:1264-72. 2005.... - Neural correlates of tactile detection: a combined magnetoencephalography and biophysically based computational modeling studyStephanie R Jones
Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
J Neurosci 27:10751-64. 2007..Furthermore, our model provides a biophysically realistic solution to the MEG signal and can predict the electrophysiological correlates of human perception... - Spectral spatiotemporal imaging of cortical oscillations and interactions in the human brainFa-Hsuan Lin
MGH-MIT-MHS Athinoula A. Martinos Center for Biomedical Imaging, 13th Street, Charlestown, MA 02129, USA
Neuroimage 23:582-95. 2004..Spectral spatiotemporal imaging of cortical oscillations and interactions in the human brain can provide further understanding of large-scale neural activity and communication between different brain regions... - Assessing and improving the spatial accuracy in MEG source localization by depth-weighted minimum-norm estimatesFa Hsuan Lin
MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Building 149 13th St Charlestown, MA 02129, USA
Neuroimage 31:160-71. 2006..The application of depth weighting to auditory and somatosensory experimental data illustrated the beneficial effect of depth weighting on the accuracy of spatiotemporal mapping of neuronal sources... - Propagation of epileptic spikes reconstructed from spatiotemporal magnetoencephalographic and electroencephalographic source analysisNaoaki Tanaka
Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA
Neuroimage 50:217-22. 2010..Spatiotemporal source analysis may be useful for planning epilepsy surgery, by predicting the pattern of IEEG spikes... - Current dipole orientation and distribution of epileptiform activity correlates with cortical thinning in left mesiotemporal epilepsyClaus Reinsberger
Department of Radiology, Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA
Neuroimage 52:1238-42. 2010..This finding may, in part, explain the unfavorable outcome in some MTLE patients after epilepsy surgery... - Aids to telemetry in the presurgical evaluation of epilepsy patients: MRI, MEG and other non-invasive imaging techniquesSusanne Knake
Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA
Suppl Clin Neurophysiol 57:494-502. 2004 - MRI-constrained spectral imaging of benzodiazepine modulation of spontaneous neuromagnetic activity in human cortexJyrki Ahveninen
Massachusetts General Hospital Massachusetts Institute of Technology Harvard Medical School Athinoula A Martinos Center for Biomedical Imaging, CNY149 13th Street, Charlestown, MA 02129, USA
Neuroimage 35:577-82. 2007..Anatomically constrained spectral imaging displays the cortical loci of drug effects on oscillatory brain activity, providing a novel tool for human pharmacological neuroimaging... - Aberrant frontoparietal function during recognition memory in schizophrenia: a multimodal neuroimaging investigationAnthony P Weiss
Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Neurosci 29:11347-59. 2009..Inefficient utilization of prefrontal-parietal networks, with compensatory activation in temporal regions, may thus contribute to deficient old-new item recognition in schizophrenia... - Evidence from intrinsic activity that asymmetry of the human brain is controlled by multiple factorsHesheng Liu
Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129, USA
Proc Natl Acad Sci U S A 106:20499-503. 2009..These findings show the feasibility of measuring brain asymmetry using intrinsic activity fluctuations and suggest that multiple genetic or environmental mechanisms control cerebral lateralization... - A non-invasive method to relate the timing of neural activity to white matter microstructural integritySteven M Stufflebeam
Department of Radiology at the Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
Neuroimage 42:710-6. 2008..This preliminary report demonstrates a non-invasive, unbiased method to relate the timing information from evoked-response experiments to the biophysical properties of white matter measured with DTI...
Research Grants
- Superior Temporal Gyrus function in SchizophreniaSteven Stufflebeam; Fiscal Year: 2007..The hypothesis is formulated that multiple deficits in the auditory system are responsible for altered auditory processing in schizophrenia, which are measurable with functional neuroimaging. ..