T B Strom

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint The Th1/Th2 paradigm and the allograft response
    T B Strom
    Department of Medicine, Harvard Medical School, Beth Israel Hospital, Boston, MA 02115, USA
    Curr Opin Immunol 8:688-93. 1996
  2. pmc An antagonist IL-15/Fc protein prevents costimulation blockade-resistant rejection
    S Ferrari-Lacraz
    Department of Medicine, Division of Immunology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Immunol 167:3478-85. 2001
  3. ncbi request reprint IL-2 and IL-4 double knockout mice reject islet allografts: a role for novel T cell growth factors in allograft rejection
    X C Li
    Department of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Immunol 161:890-6. 1998
  4. ncbi request reprint Blocking the common gamma-chain of cytokine receptors induces T cell apoptosis and long-term islet allograft survival
    X C Li
    Department of Medicine, Division of Immunology, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Immunol 164:1193-9. 2000
  5. pmc Addition of an IL-15 mutant/FCgamma2A antagonist protein protects islet allografts from rejection overriding costimulation blockade
    S Ferrari-Lacraz
    Department of Medicine, Harvard Medical School, Division of Immunology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Transplant Proc 34:745-7. 2002
  6. ncbi request reprint IL-2 and IL-4 double knock-out mice reject islet allografts: a role for novel T-cell growth factors?
    P Roy-Chaudhury
    Division of Immunology, Beth Israel Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Transplant Proc 29:1083-4. 1997
  7. ncbi request reprint Induction of allograft tolerance in the absence of Fas-mediated apoptosis
    X C Li
    Department of Medicine, Harvard Medical School, Division of Immunology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Immunol 163:2500-7. 1999
  8. pmc On histocompatibility barriers, Th1 to Th2 immune deviation, and the nature of the allograft responses
    X C Li
    Department of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Immunol 161:2241-7. 1998
  9. pmc Overcoming memory T-cell responses for induction of delayed tolerance in nonhuman primates
    Y Yamada
    Transplant Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Am J Transplant 12:330-40. 2012
  10. ncbi request reprint The role of donor and recipient B7-1 (CD80) in allograft rejection
    X X Zheng
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Immunol 159:1169-73. 1997

Collaborators

Detail Information

Publications31

  1. ncbi request reprint The Th1/Th2 paradigm and the allograft response
    T B Strom
    Department of Medicine, Harvard Medical School, Beth Israel Hospital, Boston, MA 02115, USA
    Curr Opin Immunol 8:688-93. 1996
    ..Instead, recent studies suggest that there could be a hierarchy of T-cell growth factors with regard to their ability to block tolerance and induce rejection (rather than a polarized Th1/Th2 demarcation)...
  2. pmc An antagonist IL-15/Fc protein prevents costimulation blockade-resistant rejection
    S Ferrari-Lacraz
    Department of Medicine, Division of Immunology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Immunol 167:3478-85. 2001
    ..Hence, we have demonstrated that targeting the IL-15/IL-15R pathway represents a new and potent strategy to prevent costimulation blockade-resistant CD8(+) T cell-driven rejection...
  3. ncbi request reprint IL-2 and IL-4 double knockout mice reject islet allografts: a role for novel T cell growth factors in allograft rejection
    X C Li
    Department of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Immunol 161:890-6. 1998
    ..Non-T cell-derived TCGFs, especially IL-7 and IL-15, may play an active role in supporting allograft rejection...
  4. ncbi request reprint Blocking the common gamma-chain of cytokine receptors induces T cell apoptosis and long-term islet allograft survival
    X C Li
    Department of Medicine, Division of Immunology, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Immunol 164:1193-9. 2000
    ..Our data suggest that one means of inducing T cell apoptosis and stable allograft survival can be achieved via gammac-chain blockade...
  5. pmc Addition of an IL-15 mutant/FCgamma2A antagonist protein protects islet allografts from rejection overriding costimulation blockade
    S Ferrari-Lacraz
    Department of Medicine, Harvard Medical School, Division of Immunology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Transplant Proc 34:745-7. 2002
  6. ncbi request reprint IL-2 and IL-4 double knock-out mice reject islet allografts: a role for novel T-cell growth factors?
    P Roy-Chaudhury
    Division of Immunology, Beth Israel Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Transplant Proc 29:1083-4. 1997
  7. ncbi request reprint Induction of allograft tolerance in the absence of Fas-mediated apoptosis
    X C Li
    Department of Medicine, Harvard Medical School, Division of Immunology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Immunol 163:2500-7. 1999
    ..Our study suggests that: 1) Fas is not necessarily essential for allograft tolerance, and 2) Fas-mediated apoptosis is not central to the IL-2-dependent mechanism governing the acquisition of allograft tolerance...
  8. pmc On histocompatibility barriers, Th1 to Th2 immune deviation, and the nature of the allograft responses
    X C Li
    Department of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Immunol 161:2241-7. 1998
    ....
  9. pmc Overcoming memory T-cell responses for induction of delayed tolerance in nonhuman primates
    Y Yamada
    Transplant Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Am J Transplant 12:330-40. 2012
    ..Using this modified approach, mixed chimerism was induced successfully in 11 of 13 recipients of previously placed renal allografts and long-term survival without immunosuppression could be achieved in at least 6 of these 11 animals...
  10. ncbi request reprint The role of donor and recipient B7-1 (CD80) in allograft rejection
    X X Zheng
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Immunol 159:1169-73. 1997
    ..These data also indicate that B7-1 and B7-2 are the only CD28 ligands relevant to cardiac allograft rejection in mice...
  11. pmc Prolonged survival of allogeneic islets in cynomolgus monkeys after short-term triple therapy
    M Koulmanda
    Harvard Medical School, Department of Surgery, Transplant Institute at Beth Israel Deaconess Medical Center, Massachusetts General Hospital, Boston, MA, USA
    Am J Transplant 12:1296-302. 2012
    ..Moreover slow progressive loss of islet function in some recipients was not associated with obvious pathologic evidence of rejection...
  12. ncbi request reprint Interleukin-2 and interferon-gamma double knockout mice reject heterotopic cardiac allografts
    M S Zand
    Division of Immunology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
    Transplantation 70:1378-81. 2000
    ..Several studies suggest that MHC-mismatched allografts reject with a Th1 or Th2 immune response, but these models all have low-level expression of the Th1 cytokines interleukin (IL)-2 and interferon-gamma (IFN-gamma)...
  13. ncbi request reprint CTLA4Ig prevents lymphoproliferation and fatal multiorgan tissue destruction in CTLA-4-deficient mice
    E A Tivol
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 158:5091-4. 1997
    ..The lack of long term protective effects of CTLA4Ig treatment suggests that CTLA-4 is needed for the induction and or maintenance of tolerance...
  14. ncbi request reprint Antigen-induced unresponsiveness results in altered T cell signaling
    D B McKay
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 163:6455-61. 1999
    ..Our study demonstrates that Ag-induced tolerance in vivo is accompanied by altered early TCR-mediated signaling events...
  15. pmc Targeting the IL-15 receptor with an antagonist IL-15 mutant/Fc gamma2a protein blocks delayed-type hypersensitivity
    Y S Kim
    Department of Medicine, Harvard Medical School, Brigham and Women s Hospital, Boston, MA 02215, USA
    J Immunol 160:5742-8. 1998
    ..These findings suggest that 1) IL-15/IL-15R+ cells are crucial to these T cell-dependent immune responses, and 2) treatment with IL-15 mutant/Fc gamma2a protein may ameliorate T cell-dependent immune/inflammatory diseases...
  16. ncbi request reprint Adjunctive rapamycin and CsA treatment inhibits monocyte/macrophage associated cytokines/chemokines in sensitized cardiac graft recipients
    B A Wasowska
    Harvard Medical School, Division of Immunology, Beth Israel-Deaconess Medical Center, Boston, MA, USA
    Transplantation 71:1179-83. 2001
    ..CONCLUSIONS: A combination of RPM and CsA is more effective in restraining mRNA expression than RPM alone; however, either therapy is associated with TGF-beta hyperexpression...
  17. ncbi request reprint IL-15 and IL-2: a matter of life and death for T cells in vivo
    X C Li
    Department of Medicine, Harvard Medical School, Division of Immunology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Nat Med 7:114-8. 2001
    ..Our study provides data that IL-2 and IL-15 regulate distinct aspects of primary T-cell expansion in vivo...
  18. pmc Prolonged survival of allogeneic islets in cynomolgus monkeys after short-term anti-CD154-based therapy: nonimmunologic graft failure?
    M Koulmanda
    Harvard Medical School, Department of Surgery, Islet Transplantation Research Laboratory, Transplant Unit, Massachusetts General Hospital, Boston, USA
    Am J Transplant 6:687-96. 2006
    ..Long-term clinically successful islet cell transplantation cannot be realized in the absence of parallel improvements in tolerizing regimens and in the preparation of adequate numbers of islets...
  19. pmc The role of peripheral T-cell deletion in transplantation tolerance
    A D Wells
    Department of Medicine, University of Pennsylvania, 415 Curie Boulevard, Philadelphia, PA 19104, USA
    Philos Trans R Soc Lond B Biol Sci 356:617-23. 2001
    ....
  20. ncbi request reprint 5-Aminosalicylic acid abrogates T-cell proliferation by blocking interleukin-2 production in peripheral blood mononuclear cells
    C Stevens
    Department of Medicine, Beth Israel Hospital, Boston, Massachusetts
    J Pharmacol Exp Ther 272:399-406. 1995
    ..5-ASA inhibits T-cell proliferation in part by blocking IL-2 messenger RNA accumulation and protein production downstream of the rise in cytosolic calcium. Inhibition of IL-2 production is an additional mechanism of action for 5-ASA...
  21. ncbi request reprint Control of viremia and prevention of clinical AIDS in rhesus monkeys by cytokine-augmented DNA vaccination
    D H Barouch
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Science 290:486-92. 2000
    ....
  22. pmc Isolated CD39 expression on CD4+ T cells denotes both regulatory and memory populations
    Q Zhou
    Department of Medicine, The Transplant Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Am J Transplant 9:2303-11. 2009
    ..Thus, besides Tregs, CD39 is also expressed on pre-existing memory T cells of Th1-, Th2- and Th17-types with heightened alloreactivity...
  23. pmc Depletion of CD8 memory T cells for induction of tolerance of a previously transplanted kidney allograft
    I Koyama
    Department of Surgery, Transplantation Unit, Harvard Medical School at Massachusetts General Hospital, Boston, MA, USA
    Am J Transplant 7:1055-61. 2007
    ..The current studies provide 'proof of principle' that the mixed chimerism approach can induce renal allograft tolerance, even late after organ transplantation if memory T-cell function is adequately controlled...
  24. pmc Contrasting effects of cyclosporine and rapamycin in de novo generation of alloantigen-specific regulatory T cells
    W Gao
    Department of Medicine, Division of Transplant Immunology and Transplant Research Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Am J Transplant 7:1722-32. 2007
    ..Thus, the differential effects of RPM and CsA on T(eff) and T(reg) cells favor the use of RPM in shifting the balance of aggressive to protective type alloimmunity...
  25. ncbi request reprint Interleukin-15 signals T84 colonic epithelial cells in the absence of the interleukin-2 receptor beta-chain
    A C Stevens
    Department of Medicine, Beth Israel Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    Am J Physiol 272:G1201-8. 1997
    ..We conclude that normal and T84 colonic epithelial cells express IL-15R alpha and are able to bind IL-15. IL-15 can deliver a nonproliferative functional signal in the absence of IL-2R beta-chain in T84 cells...
  26. ncbi request reprint IL-2 knockout recipient mice reject islet cell allografts
    J Steiger
    Harvard Medical School, Department of Medicine, Beth Israel Hospital, Boston, MA 02215, USA
    J Immunol 155:489-98. 1995
    ..These data indicate that 1) IL-2 is not the sole T cell growth factor capable of supporting allograft rejection and 2) expression of IL-4, but not IL-2, during the allograft response does not lead inevitably to tolerance...
  27. ncbi request reprint B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation
    F Borriello
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Immunity 6:303-13. 1997
    ..Thus, B7-2 has an important role in initiating antibody responses in the absence of adjuvant, but the induction of B7-1 by adjuvant in B7-2-deficient mice can compensate for the absence of B7-2...
  28. ncbi request reprint Rapamycin treatment depresses intragraft expression of KC/MIP-2, granzyme B, and IFN-gamma in rat recipients of cardiac allografts
    K J Wieder
    Harvard Medical School, Department of Medicine, Beth Israel Hospital, Boston, MA 02215
    J Immunol 151:1158-66. 1993
    ....
  29. ncbi request reprint Heritable susceptibility for colitis in mice induced by IL-10 deficiency
    I J Bristol
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Inflamm Bowel Dis 6:290-302. 2000
    ..This study represents a necessary step in elucidating murine genetic modifiers controlling colitis sensitivity...
  30. ncbi request reprint Intragraft activation of genes encoding cytotoxic T lymphocyte effector molecules precedes the histological evidence of rejection in human cardiac transplantation
    N Shulzhenko
    Department of Pediatrics, Escola Paulista de Medicina, , SP, Brazil
    Transplantation 72:1705-8. 2001
    ....
  31. ncbi request reprint A fish oil diet rich in eicosapentaenoic acid reduces cyclooxygenase metabolites, and suppresses lupus in MRL-lpr mice
    V E Kelley
    J Immunol 134:1914-9. 1985
    ..We suggest that this change in endogenous cyclooxygenase metabolite synthesis directly suppresses immunologic and/or inflammatory mediators of murine lupus...