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Genomes and Genes | T B StromSummaryAffiliation: Harvard University Country: USA Publications
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Publications
The Th1/Th2 paradigm and the allograft responseT B Strom
Department of Medicine, Harvard Medical School, Beth Israel Hospital, Boston, MA 02115, USA
Curr Opin Immunol 8:688-93. 1996..Instead, recent studies suggest that there could be a hierarchy of T-cell growth factors with regard to their ability to block tolerance and induce rejection (rather than a polarized Th1/Th2 demarcation)...- An antagonist IL-15/Fc protein prevents costimulation blockade-resistant rejectionS Ferrari-Lacraz
Department of Medicine, Division of Immunology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
J Immunol 167:3478-85. 2001..Hence, we have demonstrated that targeting the IL-15/IL-15R pathway represents a new and potent strategy to prevent costimulation blockade-resistant CD8(+) T cell-driven rejection... - IL-2 and IL-4 double knockout mice reject islet allografts: a role for novel T cell growth factors in allograft rejectionX C Li
Department of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
J Immunol 161:890-6. 1998..Non-T cell-derived TCGFs, especially IL-7 and IL-15, may play an active role in supporting allograft rejection... - Blocking the common gamma-chain of cytokine receptors induces T cell apoptosis and long-term islet allograft survivalX C Li
Department of Medicine, Division of Immunology, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
J Immunol 164:1193-9. 2000..Our data suggest that one means of inducing T cell apoptosis and stable allograft survival can be achieved via gammac-chain blockade... - Addition of an IL-15 mutant/FCgamma2A antagonist protein protects islet allografts from rejection overriding costimulation blockadeS Ferrari-Lacraz
Department of Medicine, Harvard Medical School, Division of Immunology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
Transplant Proc 34:745-7. 2002 - IL-2 and IL-4 double knock-out mice reject islet allografts: a role for novel T-cell growth factors?P Roy-Chaudhury
Division of Immunology, Beth Israel Hospital, Harvard Medical School, Boston, Massachusetts, USA
Transplant Proc 29:1083-4. 1997 - Induction of allograft tolerance in the absence of Fas-mediated apoptosisX C Li
Department of Medicine, Harvard Medical School, Division of Immunology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
J Immunol 163:2500-7. 1999..Our study suggests that: 1) Fas is not necessarily essential for allograft tolerance, and 2) Fas-mediated apoptosis is not central to the IL-2-dependent mechanism governing the acquisition of allograft tolerance... - On histocompatibility barriers, Th1 to Th2 immune deviation, and the nature of the allograft responsesX C Li
Department of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
J Immunol 161:2241-7. 1998.... 
Overcoming memory T-cell responses for induction of delayed tolerance in nonhuman primatesY Yamada
Transplant Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Am J Transplant 12:330-40. 2012..Using this modified approach, mixed chimerism was induced successfully in 11 of 13 recipients of previously placed renal allografts and long-term survival without immunosuppression could be achieved in at least 6 of these 11 animals...- The role of donor and recipient B7-1 (CD80) in allograft rejectionX X Zheng
Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
J Immunol 159:1169-73. 1997..These data also indicate that B7-1 and B7-2 are the only CD28 ligands relevant to cardiac allograft rejection in mice... 
Prolonged survival of allogeneic islets in cynomolgus monkeys after short-term triple therapyM Koulmanda
Harvard Medical School, Department of Surgery, Transplant Institute at Beth Israel Deaconess Medical Center, Massachusetts General Hospital, Boston, MA, USA
Am J Transplant 12:1296-302. 2012..Moreover slow progressive loss of islet function in some recipients was not associated with obvious pathologic evidence of rejection...- Interleukin-2 and interferon-gamma double knockout mice reject heterotopic cardiac allograftsM S Zand
Division of Immunology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
Transplantation 70:1378-81. 2000..Several studies suggest that MHC-mismatched allografts reject with a Th1 or Th2 immune response, but these models all have low-level expression of the Th1 cytokines interleukin (IL)-2 and interferon-gamma (IFN-gamma)... - CTLA4Ig prevents lymphoproliferation and fatal multiorgan tissue destruction in CTLA-4-deficient miceE A Tivol
Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
J Immunol 158:5091-4. 1997..The lack of long term protective effects of CTLA4Ig treatment suggests that CTLA-4 is needed for the induction and or maintenance of tolerance... - Antigen-induced unresponsiveness results in altered T cell signalingD B McKay
Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
J Immunol 163:6455-61. 1999..Our study demonstrates that Ag-induced tolerance in vivo is accompanied by altered early TCR-mediated signaling events... - Targeting the IL-15 receptor with an antagonist IL-15 mutant/Fc gamma2a protein blocks delayed-type hypersensitivityY S Kim
Department of Medicine, Harvard Medical School, Brigham and Women s Hospital, Boston, MA 02215, USA
J Immunol 160:5742-8. 1998..These findings suggest that 1) IL-15/IL-15R+ cells are crucial to these T cell-dependent immune responses, and 2) treatment with IL-15 mutant/Fc gamma2a protein may ameliorate T cell-dependent immune/inflammatory diseases... - Adjunctive rapamycin and CsA treatment inhibits monocyte/macrophage associated cytokines/chemokines in sensitized cardiac graft recipientsB A Wasowska
Harvard Medical School, Division of Immunology, Beth Israel-Deaconess Medical Center, Boston, MA, USA
Transplantation 71:1179-83. 2001..CONCLUSIONS: A combination of RPM and CsA is more effective in restraining mRNA expression than RPM alone; however, either therapy is associated with TGF-beta hyperexpression... - IL-15 and IL-2: a matter of life and death for T cells in vivoX C Li
Department of Medicine, Harvard Medical School, Division of Immunology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
Nat Med 7:114-8. 2001..Our study provides data that IL-2 and IL-15 regulate distinct aspects of primary T-cell expansion in vivo... - Prolonged survival of allogeneic islets in cynomolgus monkeys after short-term anti-CD154-based therapy: nonimmunologic graft failure?M Koulmanda
Harvard Medical School, Department of Surgery, Islet Transplantation Research Laboratory, Transplant Unit, Massachusetts General Hospital, Boston, USA
Am J Transplant 6:687-96. 2006..Long-term clinically successful islet cell transplantation cannot be realized in the absence of parallel improvements in tolerizing regimens and in the preparation of adequate numbers of islets... - The role of peripheral T-cell deletion in transplantation toleranceA D Wells
Department of Medicine, University of Pennsylvania, 415 Curie Boulevard, Philadelphia, PA 19104, USA
Philos Trans R Soc Lond B Biol Sci 356:617-23. 2001.... - 5-Aminosalicylic acid abrogates T-cell proliferation by blocking interleukin-2 production in peripheral blood mononuclear cellsC Stevens
Department of Medicine, Beth Israel Hospital, Boston, Massachusetts
J Pharmacol Exp Ther 272:399-406. 1995..5-ASA inhibits T-cell proliferation in part by blocking IL-2 messenger RNA accumulation and protein production downstream of the rise in cytosolic calcium. Inhibition of IL-2 production is an additional mechanism of action for 5-ASA... - Control of viremia and prevention of clinical AIDS in rhesus monkeys by cytokine-augmented DNA vaccinationD H Barouch
Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
Science 290:486-92. 2000.... - Isolated CD39 expression on CD4+ T cells denotes both regulatory and memory populationsQ Zhou
Department of Medicine, The Transplant Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
Am J Transplant 9:2303-11. 2009..Thus, besides Tregs, CD39 is also expressed on pre-existing memory T cells of Th1-, Th2- and Th17-types with heightened alloreactivity... - Depletion of CD8 memory T cells for induction of tolerance of a previously transplanted kidney allograftI Koyama
Department of Surgery, Transplantation Unit, Harvard Medical School at Massachusetts General Hospital, Boston, MA, USA
Am J Transplant 7:1055-61. 2007..The current studies provide 'proof of principle' that the mixed chimerism approach can induce renal allograft tolerance, even late after organ transplantation if memory T-cell function is adequately controlled... - Contrasting effects of cyclosporine and rapamycin in de novo generation of alloantigen-specific regulatory T cellsW Gao
Department of Medicine, Division of Transplant Immunology and Transplant Research Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
Am J Transplant 7:1722-32. 2007..Thus, the differential effects of RPM and CsA on T(eff) and T(reg) cells favor the use of RPM in shifting the balance of aggressive to protective type alloimmunity... - Interleukin-15 signals T84 colonic epithelial cells in the absence of the interleukin-2 receptor beta-chainA C Stevens
Department of Medicine, Beth Israel Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
Am J Physiol 272:G1201-8. 1997..We conclude that normal and T84 colonic epithelial cells express IL-15R alpha and are able to bind IL-15. IL-15 can deliver a nonproliferative functional signal in the absence of IL-2R beta-chain in T84 cells... - IL-2 knockout recipient mice reject islet cell allograftsJ Steiger
Harvard Medical School, Department of Medicine, Beth Israel Hospital, Boston, MA 02215, USA
J Immunol 155:489-98. 1995..These data indicate that 1) IL-2 is not the sole T cell growth factor capable of supporting allograft rejection and 2) expression of IL-4, but not IL-2, during the allograft response does not lead inevitably to tolerance... - B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formationF Borriello
Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Immunity 6:303-13. 1997..Thus, B7-2 has an important role in initiating antibody responses in the absence of adjuvant, but the induction of B7-1 by adjuvant in B7-2-deficient mice can compensate for the absence of B7-2... - Rapamycin treatment depresses intragraft expression of KC/MIP-2, granzyme B, and IFN-gamma in rat recipients of cardiac allograftsK J Wieder
Harvard Medical School, Department of Medicine, Beth Israel Hospital, Boston, MA 02215
J Immunol 151:1158-66. 1993.... - Heritable susceptibility for colitis in mice induced by IL-10 deficiencyI J Bristol
The Jackson Laboratory, Bar Harbor, Maine 04609, USA
Inflamm Bowel Dis 6:290-302. 2000..This study represents a necessary step in elucidating murine genetic modifiers controlling colitis sensitivity... - Intragraft activation of genes encoding cytotoxic T lymphocyte effector molecules precedes the histological evidence of rejection in human cardiac transplantationN Shulzhenko
Department of Pediatrics, Escola Paulista de Medicina, , SP, Brazil
Transplantation 72:1705-8. 2001.... - A fish oil diet rich in eicosapentaenoic acid reduces cyclooxygenase metabolites, and suppresses lupus in MRL-lpr miceV E Kelley
J Immunol 134:1914-9. 1985..We suggest that this change in endogenous cyclooxygenase metabolite synthesis directly suppresses immunologic and/or inflammatory mediators of murine lupus...