Barbara E Stranger

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Progress and promise of genome-wide association studies for human complex trait genetics
    Barbara E Stranger
    Division of Genetics, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Genetics 187:367-83. 2011
  2. pmc Coordinating GWAS results with gene expression in a systems immunologic paradigm in autoimmunity
    Barbara E Stranger
    Division of Genetics, Brigham and Women s Hospital, Boston, MA 02115, USA
    Curr Opin Immunol 24:544-51. 2012
  3. ncbi request reprint Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes
    Towfique Raj
    Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Departments of Neurology and Psychiatry, Brigham and Women s Hospital, Boston, MA 02115, USA
    Science 344:519-23. 2014
  4. pmc Common risk alleles for inflammatory diseases are targets of recent positive selection
    Towfique Raj
    Program in Translational NeuroPsychiatric Genomics, Department of Neurology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Hum Genet 92:517-29. 2013
  5. pmc Genetics of rheumatoid arthritis contributes to biology and drug discovery
    Yukinori Okada
    1 Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA 2 Division of Genetics, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA 3 Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts 02142, USA
    Nature 506:376-81. 2014
  6. pmc CD33: increased inclusion of exon 2 implicates the Ig V-set domain in Alzheimer's disease susceptibility
    Towfique Raj
    Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Departments of Neurology and Psychiatry, Brigham and Women s Hospital, Boston, MA 02115, USA
    Hum Mol Genet 23:2729-36. 2014
  7. pmc Fine-mapping the genetic association of the major histocompatibility complex in multiple sclerosis: HLA and non-HLA effects
    Nikolaos A Patsopoulos
    Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology, Brigham and Women s Hospital, Boston, Massachusetts, United States of America Division of Genetics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America Harvard Medical School, Boston, Massachusetts, United States of America Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
    PLoS Genet 9:e1003926. 2013
  8. pmc Interindividual variation in human T regulatory cells
    Alessandra Ferraro
    Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115
    Proc Natl Acad Sci U S A 111:E1111-20. 2014
  9. pmc Genome-wide association study and gene expression analysis identifies CD84 as a predictor of response to etanercept therapy in rheumatoid arthritis
    Jing Cui
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Genet 9:e1003394. 2013
  10. pmc Regulation of Gene Expression in Autoimmune Disease Loci and the Genetic Basis of Proliferation in CD4+ Effector Memory T Cells
    Xinli Hu
    Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, United States of America Division of Genetics, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, United States of America Partners Center for Personalized Genetic Medicine, Boston, Massachusetts, United States of America Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America Harvard Medical School, Boston, Massachusetts, United States of America Harvard MIT Division of Health Sciences and Technology, Boston, Massachusetts, United States of America
    PLoS Genet 10:e1004404. 2014

Collaborators

Detail Information

Publications12

  1. pmc Progress and promise of genome-wide association studies for human complex trait genetics
    Barbara E Stranger
    Division of Genetics, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Genetics 187:367-83. 2011
    ..This review focuses primarily on the ways in which genome-wide association studies (GWASs) have revolutionized the field of human quantitative genetics...
  2. pmc Coordinating GWAS results with gene expression in a systems immunologic paradigm in autoimmunity
    Barbara E Stranger
    Division of Genetics, Brigham and Women s Hospital, Boston, MA 02115, USA
    Curr Opin Immunol 24:544-51. 2012
    ....
  3. ncbi request reprint Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes
    Towfique Raj
    Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Departments of Neurology and Psychiatry, Brigham and Women s Hospital, Boston, MA 02115, USA
    Science 344:519-23. 2014
    ..This polarization implicates specific immune cell types in these diseases and points to the need to identify the cell-autonomous effects of disease susceptibility variants. ..
  4. pmc Common risk alleles for inflammatory diseases are targets of recent positive selection
    Towfique Raj
    Program in Translational NeuroPsychiatric Genomics, Department of Neurology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Hum Genet 92:517-29. 2013
    ....
  5. pmc Genetics of rheumatoid arthritis contributes to biology and drug discovery
    Yukinori Okada
    1 Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA 2 Division of Genetics, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA 3 Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts 02142, USA
    Nature 506:376-81. 2014
    ....
  6. pmc CD33: increased inclusion of exon 2 implicates the Ig V-set domain in Alzheimer's disease susceptibility
    Towfique Raj
    Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Departments of Neurology and Psychiatry, Brigham and Women s Hospital, Boston, MA 02115, USA
    Hum Mol Genet 23:2729-36. 2014
    ....
  7. pmc Fine-mapping the genetic association of the major histocompatibility complex in multiple sclerosis: HLA and non-HLA effects
    Nikolaos A Patsopoulos
    Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology, Brigham and Women s Hospital, Boston, Massachusetts, United States of America Division of Genetics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America Harvard Medical School, Boston, Massachusetts, United States of America Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
    PLoS Genet 9:e1003926. 2013
    ..This study dissects the independent effects in the MHC, a critical region for MS susceptibility that harbors multiple risk alleles. ..
  8. pmc Interindividual variation in human T regulatory cells
    Alessandra Ferraro
    Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115
    Proc Natl Acad Sci U S A 111:E1111-20. 2014
    ..Although no single transcript showed significant association to diabetes, overall expression of the Treg signature was subtly perturbed in T1D, but not T2D, patients. ..
  9. pmc Genome-wide association study and gene expression analysis identifies CD84 as a predictor of response to etanercept therapy in rheumatoid arthritis
    Jing Cui
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Genet 9:e1003394. 2013
    ..These findings support a model in which CD84 genotypes and/or expression may serve as a useful biomarker for response to etanercept treatment in RA patients of European ancestry...
  10. pmc Regulation of Gene Expression in Autoimmune Disease Loci and the Genetic Basis of Proliferation in CD4+ Effector Memory T Cells
    Xinli Hu
    Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, United States of America Division of Genetics, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, United States of America Partners Center for Personalized Genetic Medicine, Boston, Massachusetts, United States of America Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America Harvard Medical School, Boston, Massachusetts, United States of America Harvard MIT Division of Health Sciences and Technology, Boston, Massachusetts, United States of America
    PLoS Genet 10:e1004404. 2014
    ..Our study underscores the power of examining molecular phenotypes in relevant cells and conditions for understanding pathogenic mechanisms of disease variants. ..
  11. pmc Alzheimer disease susceptibility loci: evidence for a protein network under natural selection
    Towfique Raj
    Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences Department of Neurology, Brigham and Women s Hospital, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Am J Hum Genet 90:720-6. 2012
    ..The context for selection is probably unrelated to AD itself; it is likely that these genes interact in another context, such as in immune cells, where we observe cis-regulatory effects at several of the selected AD loci...