A F Straight

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Dissecting temporal and spatial control of cytokinesis with a myosin II Inhibitor
    Aaron F Straight
    Department of Cell Biology and Institute of Chemistry and Cell Biology, Harvard Medical School, 250 Longwood Avenue, Boston, MA 02115, USA
    Science 299:1743-7. 2003
  2. pmc Time-lapse microscopy reveals unique roles for kinesins during anaphase in budding yeast
    A F Straight
    Department of Physiology, School of Medicine, University of California San Francisco, San Francisco, California 94143, USA
    J Cell Biol 143:687-94. 1998
  3. ncbi Microtubules, membranes and cytokinesis
    A F Straight
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Biol 10:R760-70. 2000
  4. ncbi Cell cycle: checkpoint proteins and kinetochores
    A F Straight
    Department of Physiology, School of Medicine, University of California, San Francisco 94143 0444, USA
    Curr Biol 7:R613-6. 1997
  5. ncbi Self- and actin-templated assembly of Mammalian septins
    Makoto Kinoshita
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Dev Cell 3:791-802. 2002
  6. ncbi GFP tagging of budding yeast chromosomes reveals that protein-protein interactions can mediate sister chromatid cohesion
    A F Straight
    Department of Physiology, School of Medicine, University of California, San Francisco 94143 0444, USA
    Curr Biol 6:1599-608. 1996
  7. ncbi A small-molecule inhibitor of skeletal muscle myosin II
    A Cheung
    Institute for Chemistry and Cell Biology, Harvard Medical School, 250 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nat Cell Biol 4:83-8. 2002
  8. ncbi Net1, a Sir2-associated nucleolar protein required for rDNA silencing and nucleolar integrity
    A F Straight
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115 5730, USA
    Cell 97:245-56. 1999
  9. ncbi Kinetic mechanism of blebbistatin inhibition of nonmuscle myosin IIb
    Bhagavathi Ramamurthy
    Department of Physiology, University of Pennsylvania School of Medicine, 3700 Hamilton Walk, Philadelphia, Pennsylvania 19104 6085, USA
    Biochemistry 43:14832-9. 2004
  10. pmc Anillin binds nonmuscle myosin II and regulates the contractile ring
    Aaron F Straight
    Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305, USA
    Mol Biol Cell 16:193-201. 2005

Collaborators

Detail Information

Publications14

  1. ncbi Dissecting temporal and spatial control of cytokinesis with a myosin II Inhibitor
    Aaron F Straight
    Department of Cell Biology and Institute of Chemistry and Cell Biology, Harvard Medical School, 250 Longwood Avenue, Boston, MA 02115, USA
    Science 299:1743-7. 2003
    ..Continuous signals from microtubules are required to maintain the position of the cleavage furrow, and these signals control the localization of myosin II independently of other furrow components...
  2. pmc Time-lapse microscopy reveals unique roles for kinesins during anaphase in budding yeast
    A F Straight
    Department of Physiology, School of Medicine, University of California San Francisco, San Francisco, California 94143, USA
    J Cell Biol 143:687-94. 1998
    ..The kip3Delta and kip1Delta mutants affect the duration of anaphase, but cin8Delta does not...
  3. ncbi Microtubules, membranes and cytokinesis
    A F Straight
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Biol 10:R760-70. 2000
    ..Specialized microtubule structures are responsible for directing membrane vesicles to the site of cell cleavage, and vesicle fusion is required for the proper completion of cytokinesis...
  4. ncbi Cell cycle: checkpoint proteins and kinetochores
    A F Straight
    Department of Physiology, School of Medicine, University of California, San Francisco 94143 0444, USA
    Curr Biol 7:R613-6. 1997
    ..Vertebrate homologs of yeast spindle assembly checkpoint proteins are localized to kinetochores and may act as a sensor for proper chromosome attachment to the mitotic spindle...
  5. ncbi Self- and actin-templated assembly of Mammalian septins
    Makoto Kinoshita
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Dev Cell 3:791-802. 2002
    ..We conclude that septins alone self-assemble into rings, that adaptor proteins recruit septins to actin bundles, and that septins help organize these bundles...
  6. ncbi GFP tagging of budding yeast chromosomes reveals that protein-protein interactions can mediate sister chromatid cohesion
    A F Straight
    Department of Physiology, School of Medicine, University of California, San Francisco 94143 0444, USA
    Curr Biol 6:1599-608. 1996
    ..Studies on these problems in budding yeast are hampered by the inability to resolve its chromosomes by light or electron microscopy...
  7. ncbi A small-molecule inhibitor of skeletal muscle myosin II
    A Cheung
    Institute for Chemistry and Cell Biology, Harvard Medical School, 250 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nat Cell Biol 4:83-8. 2002
    ..The isolation of BTS and the recently discovered Eg5 kinesin inhibitor, monastrol, suggests that motor proteins may be potential targets for therapeutic applications...
  8. ncbi Net1, a Sir2-associated nucleolar protein required for rDNA silencing and nucleolar integrity
    A F Straight
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115 5730, USA
    Cell 97:245-56. 1999
    ..Our findings suggest that a protein complex shown to regulate exit from mitosis is also involved in gene silencing...
  9. ncbi Kinetic mechanism of blebbistatin inhibition of nonmuscle myosin IIb
    Bhagavathi Ramamurthy
    Department of Physiology, University of Pennsylvania School of Medicine, 3700 Hamilton Walk, Philadelphia, Pennsylvania 19104 6085, USA
    Biochemistry 43:14832-9. 2004
    ..These effects are likely mediated by binding of blebbistatin within the myosin cleft that progressively closes in forming the acto-myosin rigor state...
  10. pmc Anillin binds nonmuscle myosin II and regulates the contractile ring
    Aaron F Straight
    Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305, USA
    Mol Biol Cell 16:193-201. 2005
    ..We propose a role for anillin in spatially regulating the contractile activity of myosin II during cytokinesis...
  11. ncbi Blebbistatin, a myosin II inhibitor, is photoinactivated by blue light
    Takeshi Sakamoto
    Laboratory of Molecular Cardiology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 1762, USA
    Biochemistry 44:584-8. 2005
    ..This property may be useful in locally reversing the action of blebbistatin treatment in a cell. However, caution should be exercised as free radicals may be produced upon irradiation of blebbistatin that could result in cell damage...
  12. ncbi Specificity of blebbistatin, an inhibitor of myosin II
    John Limouze
    Laboratory of Molecular Cardiology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Muscle Res Cell Motil 25:337-41. 2004
    ..The drug potently inhibits Dictyostelium myosin II, but poorly inhibits Acanthamoeba myosin II. Blebbistatin did not inhibit representative myosin superfamily members from classes I, V, and X...
  13. pmc Centromeric chromatin gets loaded
    Christopher W Carroll
    Department of Biochemistry, Stanford University, Stanford, CA 94305, USA
    J Cell Biol 176:735-6. 2007
    ..Together, these studies advance our understanding of centromeric chromatin assembly and provide a framework for investigating the molecular mechanisms that underlie the centromere-specific loading of CENP-A...
  14. ncbi Fluorescent protein applications in microscopy
    Aaron F Straight
    Department of Biochemistry, Stanford Medical School, Stanford University, California 94305, USA
    Methods Cell Biol 81:93-113. 2007