Research Topics
Genomes and Genes | Joel N H SternSummaryAffiliation: Harvard University Country: USA Publications
| Collaborators
|
Detail Information
Publications
Amino acid copolymer-specific IL-10-secreting regulatory T cells that ameliorate autoimmune diseases in miceJoel N H Stern
Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
Proc Natl Acad Sci U S A 105:5172-6. 2008..e., PLP139-151(EAE), MBP85-99 (EAE), and bovine peripheral nerve myelin (experimental autoimmune neuritis), indicating they function by bystander suppression...
Strategies for the identification of loci responsible for the pathogenesis of multiple sclerosisJoel N H Stern
Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, 190 Longwood Ave, Boston, MA, USA
Cell Mol Biol Lett 13:656-66. 2008..We review these developments, advances in technology and discuss recent results in this article...- Molecular signatures distinguishing active from latent tuberculosis in peripheral blood mononuclear cells, after in vitro antigenic stimulation with purified protein derivative of tuberculin (PPD) or Candida: a preliminary reportJoel N H Stern
Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, MA 02115, USA
Immunol Res 45:1-12. 2009.... - Promoting tolerance to proteolipid protein-induced experimental autoimmune encephalomyelitis through targeting dendritic cellsJoel N H Stern
Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
Proc Natl Acad Sci U S A 107:17280-5. 2010..In addition, evidence for a CD4(+) T cell-mediated suppressor mechanism was obtained... - Amelioration of proteolipid protein 139-151-induced encephalomyelitis in SJL mice by modified amino acid copolymers and their mechanismsJoel N H Stern
Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
Proc Natl Acad Sci U S A 101:11743-8. 2004.... 
Copolymer effects on microglia and T cells in the central nervous system of humanized miceZsolt Illes
Center for Neurological Diseases, Harvard Institutes of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02138, USA
Eur J Immunol 35:3683-93. 2005....- Peptide 15-mers of defined sequence that substitute for random amino acid copolymers in amelioration of experimental autoimmune encephalomyelitisJoel N H Stern
Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
Proc Natl Acad Sci U S A 102:1620-5. 2005..These peptide 15-mers provide specific, nonrandom sequences that appear to be at least as effective as random copolymers in suppressing EAE in several models... - Modified amino acid copolymers suppress myelin basic protein 85-99-induced encephalomyelitis in humanized mice through different effects on T cellsZsolt Illes
Center for Neurologic Diseases, Harvard Institute of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 101:11749-54. 2004..Thus, copolymers generated by using different amino acids inhibited disease using different mechanisms to regulate T cell responses... - The autoimmune TCR-Ob.2F3 can bind to MBP85-99/HLA-DR2 having an unconventional mode as in TCR-Ob.1A12Zenichiro Kato
Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, MA 02193, USA
Mol Immunol 48:314-20. 2010.... - T cell receptors in an IL-10-secreting amino acid copolymer-specific regulatory T cell line that mediates bystander immunosuppressionHong Zhang
Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
Proc Natl Acad Sci U S A 106:3336-41. 2009..These data lead to a hypothesis regarding the origin of the epigenetic modifications that lead to selective cytokine secretion in T cells... - Positioning of autoimmune TCR-Ob.2F3 and TCR-Ob.3D1 on the MBP85-99/HLA-DR2 complexZenichiro Kato
Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
Proc Natl Acad Sci U S A 105:15523-8. 2008..Two of them are located near the N terminus of the peptide-binding cleft, whereas the third is near the center. These data are compatible with the hypothesis that the rotation of the TCRs may alter the downstream signaling... - Interaction of KIR genes and G1M immunoglobulin allotypes confer susceptibility to type 2 diabetes in Puerto Rican AmericansJoaquin Zuniga
Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
Hum Immunol 67:907-14. 2006..Our findings are important for understanding the autoimmune or innate immune inflammatory-mediated mechanisms involved in the pathogenesis of T2D... - JNK MAP kinase activation is required for MTOC and granule polarization in NKG2D-mediated NK cell cytotoxicityChanglin Li
Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
Proc Natl Acad Sci U S A 105:3017-22. 2008..Thus, activation of two MAP kinase pathways is required for cytotoxic granule and MTOC polarization and for cytotoxicity of human NK cells when NKG2D is ligated... - A review of the current use of rituximab in autoimmune diseasesHakan M Gürcan
Center for Blistering Diseases, New England Baptist Hospital, Boston, MA 02120, USA
Int Immunopharmacol 9:10-25. 2009..In patients with autoimmune diseases the incidence of serious and severe side effects is low. Systemic infection still remains a major concern and may result in death... - Novel synthetic amino acid copolymers that inhibit autoantigen-specific T cell responses and suppress experimental autoimmune encephalomyelitisMasha Fridkis-Hareli
Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
J Clin Invest 109:1635-43. 2002..Thus, random synthetic copolymers designed according to the binding motif of the human immunodominant epitope MBP 85-99 and the binding pockets of HLA-DR2 might be more beneficial than Cop 1 in treatment of MS... - Cytokine profiles in pemphigus vulgaris patients treated with intravenous immunoglobulins as compared to conventional immunosuppressive therapyDerin B Keskin
Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA, USA
Cytokine 41:315-21. 2008..The conclusions from this limited number of patients, prospectively studied, would suggest that both CIST and IVIg therapies are similar in their ability to influence a panel of cytokines in patients with pemphigus vulgaris... - TGFbeta promotes conversion of CD16+ peripheral blood NK cells into CD16- NK cells with similarities to decidual NK cellsDerin B Keskin
Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
Proc Natl Acad Sci U S A 104:3378-83. 2007..These progenitors also produced NK cells when cultured in conditioned medium from decidual stromal cells supplemented with IL-15 and stem cell factor... - Developmental bias in cleavage-stage mouse blastomeresInna Tabansky
The Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
Curr Biol 23:21-31. 2013..To determine whether blastomere allocation to the two earliest lineages is random, we developed and utilized a recombination-mediated, noninvasive combinatorial fluorescent labeling method for embryonic lineage tracing... - VAMP4- and VAMP7-expressing vesicles are both required for cytotoxic granule exocytosis in NK cellsKonrad Krzewski
Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
Eur J Immunol 41:3323-9. 2011..Furthermore, VAMP7 but not VAMP4 is involved in IFN-γ secretion in NK cells, indicating that VAMP7 is involved in many fusion processes and thus plays a more general function in NK-cell activity than VAMP4...