Research Topics
Genomes and Genes | Julie St-PierreSummaryAffiliation: Harvard University Country: USA Publications
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Publications
Superoxide activates mitochondrial uncoupling proteinsKarim S Echtay
Medical Research Council Dunn Human Nutrition Unit, Hills Road, Cambridge CB2 2XY, UK
Nature 415:96-9. 2002..Our findings indicate that the interaction of superoxide with UCPs may be a mechanism for decreasing the concentrations of reactive oxygen species inside mitochondria...- Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivatorsJulie St-Pierre
Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
Cell 127:397-408. 2006..These studies reveal that PGC-1alpha is a broad and powerful regulator of ROS metabolism, providing a potential target for the therapeutic manipulation of these important endogenous toxins... - Topology of superoxide production from different sites in the mitochondrial electron transport chainJulie St-Pierre
MRC Medical Research Council Dunn Human Nutrition Unit, Hills Road, Cambridge CB2 2XY, England
J Biol Chem 277:44784-90. 2002..This difference was solely due to an elevated concentration of complex I in rat compared with pigeon heart mitochondria... - Superoxide and hydrogen peroxide production by Drosophila mitochondriaSatomi Miwa
MRC Dunn Human Nutrition Unit, Cambridge, England, United Kingdom
Free Radic Biol Med 35:938-48. 2003.... - Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null miceJiandie Lin
Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
Cell 119:121-35. 2004..These data illustrate a central role for PGC-1alpha in the control of energy metabolism but also reveal novel systemic compensatory mechanisms and pathogenic effects of impaired energy homeostasis... 
Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPKMelina Fan
Dana Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
Genes Dev 18:278-89. 2004..The discovery of p160MBP as a PGC-1alpha regulator has important implications for the understanding of energy balance and diabetes...- Superoxide-mediated activation of uncoupling protein 2 causes pancreatic beta cell dysfunctionStefan Krauss
Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
J Clin Invest 112:1831-42. 2003..Therefore, superoxide-mediated activation of UCP2 could play an important role in the pathogenesis of beta cell dysfunction and type 2 diabetes... - Bioenergetic analysis of peroxisome proliferator-activated receptor gamma coactivators 1alpha and 1beta (PGC-1alpha and PGC-1beta) in muscle cellsJulie St-Pierre
Dana Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 278:26597-603. 2003..Together, these data indicate that PGC-1alpha and PGC-1beta profoundly alter mitochondrial metabolism and suggest that these proteins are likely to play different physiological functions... - Visceral obesity attenuates the effect of the hepatic lipase -514C>T polymorphism on plasma HDL-cholesterol levels in French-Canadian menJulie St-Pierre
Dyslipidemia, Diabetes and Atherosclerosis Group and the Community Genetics Research Center, Complexe Hospitalier de la Sagamie, Que, Chicoutimi, Canada
Mol Genet Metab 78:31-6. 2003..CONCLUSION: In summary, the presence of visceral obesity attenuates the impact of the LIPC -514C>T polymorphism on plasma HDL(2)-cholesterol levels... - Adaptive plasticity of skeletal muscle energetics in hibernating frogs: mitochondrial proton leak during metabolic depressionRobert G Boutilier
Department of Zoology, Downing Street, University of Cambridge, Cambridge CB2 3EJ, UK
J Exp Biol 205:2287-96. 2002..Taken together, our studies show that protonmotive force is lowered aerobically by restricting electron supply and during anoxia by restricting mitochondrial ATPase activity... - Going with the flow or life in the fast lane: contrasting mitochondrial responses to thermal changeHelga Guderley
Departement de Biologie, Universite Laval, Quebec, P Q, Canada G1T 2M7
J Exp Biol 205:2237-49. 2002.... - Primary causes of decreased mitochondrial oxygen consumption during metabolic depression in snail cellsTammie Bishop
Medical Research Council, Dunn Human Nutrition Unit, Cambridge CB2 2XY, United Kingdom
Am J Physiol Regul Integr Comp Physiol 282:R372-82. 2002..At least 75% of the total response of mitochondrial respiration to estivation was caused by primary changes in the kinetics of substrate oxidation, with only 25% or less of the response occurring through primary effects on ATP turnover... - AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alphaSibylle Jäger
Dana Farber Cancer Institute, Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 104:12017-22. 2007..These data indicate that AMPK phosphorylation of PGC-1alpha initiates many of the important gene regulatory functions of AMPK in skeletal muscle...