Julie St-Pierre

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Superoxide activates mitochondrial uncoupling proteins
    Karim S Echtay
    Medical Research Council Dunn Human Nutrition Unit, Hills Road, Cambridge CB2 2XY, UK
    Nature 415:96-9. 2002
  2. ncbi request reprint Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators
    Julie St-Pierre
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Cell 127:397-408. 2006
  3. ncbi request reprint Topology of superoxide production from different sites in the mitochondrial electron transport chain
    Julie St-Pierre
    MRC Medical Research Council Dunn Human Nutrition Unit, Hills Road, Cambridge CB2 2XY, England
    J Biol Chem 277:44784-90. 2002
  4. ncbi request reprint Superoxide and hydrogen peroxide production by Drosophila mitochondria
    Satomi Miwa
    MRC Dunn Human Nutrition Unit, Cambridge, England, United Kingdom
    Free Radic Biol Med 35:938-48. 2003
  5. ncbi request reprint Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice
    Jiandie Lin
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Cell 119:121-35. 2004
  6. pmc Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK
    Melina Fan
    Dana Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 18:278-89. 2004
  7. pmc Superoxide-mediated activation of uncoupling protein 2 causes pancreatic beta cell dysfunction
    Stefan Krauss
    Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 112:1831-42. 2003
  8. ncbi request reprint Bioenergetic analysis of peroxisome proliferator-activated receptor gamma coactivators 1alpha and 1beta (PGC-1alpha and PGC-1beta) in muscle cells
    Julie St-Pierre
    Dana Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 278:26597-603. 2003
  9. ncbi request reprint Visceral obesity attenuates the effect of the hepatic lipase -514C>T polymorphism on plasma HDL-cholesterol levels in French-Canadian men
    Julie St-Pierre
    Dyslipidemia, Diabetes and Atherosclerosis Group and the Community Genetics Research Center, Complexe Hospitalier de la Sagamie, Que, Chicoutimi, Canada
    Mol Genet Metab 78:31-6. 2003
  10. ncbi request reprint Adaptive plasticity of skeletal muscle energetics in hibernating frogs: mitochondrial proton leak during metabolic depression
    Robert G Boutilier
    Department of Zoology, Downing Street, University of Cambridge, Cambridge CB2 3EJ, UK
    J Exp Biol 205:2287-96. 2002

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Superoxide activates mitochondrial uncoupling proteins
    Karim S Echtay
    Medical Research Council Dunn Human Nutrition Unit, Hills Road, Cambridge CB2 2XY, UK
    Nature 415:96-9. 2002
    ..Our findings indicate that the interaction of superoxide with UCPs may be a mechanism for decreasing the concentrations of reactive oxygen species inside mitochondria...
  2. ncbi request reprint Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators
    Julie St-Pierre
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Cell 127:397-408. 2006
    ..These studies reveal that PGC-1alpha is a broad and powerful regulator of ROS metabolism, providing a potential target for the therapeutic manipulation of these important endogenous toxins...
  3. ncbi request reprint Topology of superoxide production from different sites in the mitochondrial electron transport chain
    Julie St-Pierre
    MRC Medical Research Council Dunn Human Nutrition Unit, Hills Road, Cambridge CB2 2XY, England
    J Biol Chem 277:44784-90. 2002
    ..This difference was solely due to an elevated concentration of complex I in rat compared with pigeon heart mitochondria...
  4. ncbi request reprint Superoxide and hydrogen peroxide production by Drosophila mitochondria
    Satomi Miwa
    MRC Dunn Human Nutrition Unit, Cambridge, England, United Kingdom
    Free Radic Biol Med 35:938-48. 2003
    ....
  5. ncbi request reprint Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice
    Jiandie Lin
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Cell 119:121-35. 2004
    ..These data illustrate a central role for PGC-1alpha in the control of energy metabolism but also reveal novel systemic compensatory mechanisms and pathogenic effects of impaired energy homeostasis...
  6. pmc Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK
    Melina Fan
    Dana Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 18:278-89. 2004
    ..The discovery of p160MBP as a PGC-1alpha regulator has important implications for the understanding of energy balance and diabetes...
  7. pmc Superoxide-mediated activation of uncoupling protein 2 causes pancreatic beta cell dysfunction
    Stefan Krauss
    Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 112:1831-42. 2003
    ..Therefore, superoxide-mediated activation of UCP2 could play an important role in the pathogenesis of beta cell dysfunction and type 2 diabetes...
  8. ncbi request reprint Bioenergetic analysis of peroxisome proliferator-activated receptor gamma coactivators 1alpha and 1beta (PGC-1alpha and PGC-1beta) in muscle cells
    Julie St-Pierre
    Dana Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 278:26597-603. 2003
    ..Together, these data indicate that PGC-1alpha and PGC-1beta profoundly alter mitochondrial metabolism and suggest that these proteins are likely to play different physiological functions...
  9. ncbi request reprint Visceral obesity attenuates the effect of the hepatic lipase -514C>T polymorphism on plasma HDL-cholesterol levels in French-Canadian men
    Julie St-Pierre
    Dyslipidemia, Diabetes and Atherosclerosis Group and the Community Genetics Research Center, Complexe Hospitalier de la Sagamie, Que, Chicoutimi, Canada
    Mol Genet Metab 78:31-6. 2003
    ..A functional, non-coding -514C>T single nucleotide polymorphism (SNP) of the hepatic lipase gene (LIPC) has been related to variation in HDL-cholesterol concentrations...
  10. ncbi request reprint Adaptive plasticity of skeletal muscle energetics in hibernating frogs: mitochondrial proton leak during metabolic depression
    Robert G Boutilier
    Department of Zoology, Downing Street, University of Cambridge, Cambridge CB2 3EJ, UK
    J Exp Biol 205:2287-96. 2002
    ..Taken together, our studies show that protonmotive force is lowered aerobically by restricting electron supply and during anoxia by restricting mitochondrial ATPase activity...
  11. ncbi request reprint Going with the flow or life in the fast lane: contrasting mitochondrial responses to thermal change
    Helga Guderley
    Departement de Biologie, Universite Laval, Quebec, P Q, Canada G1T 2M7
    J Exp Biol 205:2237-49. 2002
    ....
  12. ncbi request reprint Primary causes of decreased mitochondrial oxygen consumption during metabolic depression in snail cells
    Tammie Bishop
    Medical Research Council, Dunn Human Nutrition Unit, Cambridge CB2 2XY, United Kingdom
    Am J Physiol Regul Integr Comp Physiol 282:R372-82. 2002
    ..At least 75% of the total response of mitochondrial respiration to estivation was caused by primary changes in the kinetics of substrate oxidation, with only 25% or less of the response occurring through primary effects on ATP turnover...
  13. pmc AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha
    Sibylle Jäger
    Dana Farber Cancer Institute, Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 104:12017-22. 2007
    ..These data indicate that AMPK phosphorylation of PGC-1alpha initiates many of the important gene regulatory functions of AMPK in skeletal muscle...