Vivek J Srinivasan

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Quantitative cerebral blood flow with optical coherence tomography
    Vivek J Srinivasan
    Photon Migration Imaging Laboratory, MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital Harvard Medical School, Charlestown, MA 02129, USA
    Opt Express 18:2477-94. 2010
  2. pmc Optical coherence microscopy for deep tissue imaging of the cerebral cortex with intrinsic contrast
    Vivek J Srinivasan
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital Harvard Medical School, Charlestown, Massachusetts, 02129, USA
    Opt Express 20:2220-39. 2012
  3. pmc Optical coherence tomography for the quantitative study of cerebrovascular physiology
    Vivek J Srinivasan
    Department of Radiology, MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Cereb Blood Flow Metab 31:1339-45. 2011
  4. pmc Rapid volumetric angiography of cortical microvasculature with optical coherence tomography
    Vivek J Srinivasan
    Photon Migration Imaging Laboratory, MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Opt Lett 35:43-5. 2010
  5. pmc Microvascular oxygen tension and flow measurements in rodent cerebral cortex during baseline conditions and functional activation
    Mohammad A Yaseen
    Department of Radiology, MGH MIT HMS Athinuola A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA
    J Cereb Blood Flow Metab 31:1051-63. 2011
  6. pmc Depth-resolved microscopy of cortical hemodynamics with optical coherence tomography
    Vivek J Srinivasan
    Photon Migration Imaging Laboratory, MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Opt Lett 34:3086-8. 2009
  7. pmc "Overshoot" of O₂ is required to maintain baseline tissue oxygenation at locations distal to blood vessels
    Anna Devor
    Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02114, USA
    J Neurosci 31:13676-81. 2011
  8. pmc Frontiers in optical imaging of cerebral blood flow and metabolism
    Anna Devor
    Department of Neurosciences, UCSD, La Jolla, CA, USA
    J Cereb Blood Flow Metab 32:1259-76. 2012
  9. pmc Cortical spreading depression impairs oxygen delivery and metabolism in mice
    Izumi Yuzawa
    Department of Radiology, Neurovascular Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA
    J Cereb Blood Flow Metab 32:376-86. 2012
  10. pmc Two-photon microscopy of cortical NADH fluorescence intensity changes: correcting contamination from the hemodynamic response
    Edward Baraghis
    Harvard Medical School, Massachusetts General Hospital, Department of Radiology, 149 13th Street, Charlestown, Massachusetts 02129, USA
    J Biomed Opt 16:106003. 2011

Collaborators

Detail Information

Publications14

  1. pmc Quantitative cerebral blood flow with optical coherence tomography
    Vivek J Srinivasan
    Photon Migration Imaging Laboratory, MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital Harvard Medical School, Charlestown, MA 02129, USA
    Opt Express 18:2477-94. 2010
    ..We show that OCT estimates of absolute CBF values in rats agree with prior measures by autoradiography, suggesting that Doppler OCT can perform absolute flow measurements in animal models...
  2. pmc Optical coherence microscopy for deep tissue imaging of the cerebral cortex with intrinsic contrast
    Vivek J Srinivasan
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital Harvard Medical School, Charlestown, Massachusetts, 02129, USA
    Opt Express 20:2220-39. 2012
    ..Lastly, we show that OCM enables direct visualization of cellular changes during cell depolarization and may therefore provide novel optical markers of cell viability...
  3. pmc Optical coherence tomography for the quantitative study of cerebrovascular physiology
    Vivek J Srinivasan
    Department of Radiology, MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Cereb Blood Flow Metab 31:1339-45. 2011
    ..Moreover, DOCT flow values correlate with hydrogen clearance flow values when both are measured simultaneously. These data validate DOCT as a noninvasive quantitative method to measure tissue perfusion over a physiologic range...
  4. pmc Rapid volumetric angiography of cortical microvasculature with optical coherence tomography
    Vivek J Srinivasan
    Photon Migration Imaging Laboratory, MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Opt Lett 35:43-5. 2010
    ..By imaging during hypercapnia and comparing with simultaneous CCD imaging, the sources of contrast of OCT angiography are investigated...
  5. pmc Microvascular oxygen tension and flow measurements in rodent cerebral cortex during baseline conditions and functional activation
    Mohammad A Yaseen
    Department of Radiology, MGH MIT HMS Athinuola A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA
    J Cereb Blood Flow Metab 31:1051-63. 2011
    ..Understanding O(2) supply on a microscopic level will yield better insight into brain function and the underlying mechanisms of various neuropathologies...
  6. pmc Depth-resolved microscopy of cortical hemodynamics with optical coherence tomography
    Vivek J Srinivasan
    Photon Migration Imaging Laboratory, MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Opt Lett 34:3086-8. 2009
    ..The results show OCT measurements of hemodynamic changes during functional activation and represent an important step toward understanding functional hyperemia at the microscopic level...
  7. pmc "Overshoot" of O₂ is required to maintain baseline tissue oxygenation at locations distal to blood vessels
    Anna Devor
    Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02114, USA
    J Neurosci 31:13676-81. 2011
    ....
  8. pmc Frontiers in optical imaging of cerebral blood flow and metabolism
    Anna Devor
    Department of Neurosciences, UCSD, La Jolla, CA, USA
    J Cereb Blood Flow Metab 32:1259-76. 2012
    ....
  9. pmc Cortical spreading depression impairs oxygen delivery and metabolism in mice
    Izumi Yuzawa
    Department of Radiology, Neurovascular Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA
    J Cereb Blood Flow Metab 32:376-86. 2012
    ..Altogether, these data suggest that CSD is associated with long-lasting oxygen supply-demand mismatch linked to severe vasoconstriction in mice...
  10. pmc Two-photon microscopy of cortical NADH fluorescence intensity changes: correcting contamination from the hemodynamic response
    Edward Baraghis
    Harvard Medical School, Massachusetts General Hospital, Department of Radiology, 149 13th Street, Charlestown, Massachusetts 02129, USA
    J Biomed Opt 16:106003. 2011
    ..The general approach of the correction algorithm can be extended to other TPLSM measurements, where changes in the optical properties of the tissue confound physiological measurements, such as the detection of calcium dynamics...
  11. pmc Two-photon high-resolution measurement of partial pressure of oxygen in cerebral vasculature and tissue
    Sava Sakadzic
    Photon Migration Imaging Laboratory, Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA
    Nat Methods 7:755-9. 2010
    ..The properties of the probe allowed for direct high-resolution measurement of cortical extravascular (tissue) pO(2), opening many possibilities for functional metabolic brain studies...
  12. pmc Optical monitoring of oxygen tension in cortical microvessels with confocal microscopy
    Mohammad A Yaseen
    Photon Migration Imaging Laboratory, MGH MIT HMS Athinuola A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital Harvard Medical School, Charlestown, MA 02129, USA
    Opt Express 17:22341-50. 2009
    ..Here we present high-resolution phosphorescence images of cortical microvasculature and temporal pO(2) profiles from multiple locations in response to varied fraction of inspired oxygen and functional activation...
  13. pmc Optical coherence tractography using intrinsic contrast
    Craig J Goergen
    Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Opt Lett 37:3882-4. 2012
    ..Moreover, as these techniques use intrinsic signals and do not require tissue slicing and staining, they can be used for high-throughput, nondestructive evaluation of fiber architecture across large tissue volumes...
  14. pmc Due to intravascular multiple sequential scattering, Diffuse Correlation Spectroscopy of tissue primarily measures relative red blood cell motion within vessels
    Stefan A Carp
    Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Building 149, 13th Street, Charlestown, Massachusetts 02129, USA
    Biomed Opt Express 2:2047-54. 2011
    ....