Reisa Sperling

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Preclinical Alzheimer disease-the challenges ahead
    Reisa A Sperling
    Center for Alzheimer Research and Treatment, Departments of Neurology, Brigham and Women s Hospital and Massachusetts General Hospital, Harvard Medical School, 221 Longwood Avenue Boston, MA 02115, USA
    Nat Rev Neurol 9:54-8. 2013
  2. ncbi Amyloid deposition detected with florbetapir F 18 ((18)F-AV-45) is related to lower episodic memory performance in clinically normal older individuals
    Reisa A Sperling
    Center for Alzheimer Research and Treatment, Departments of Neurology, Brigham and Women s Hospital and Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Neurobiol Aging 34:822-31. 2013
  3. ncbi Potential of functional MRI as a biomarker in early Alzheimer's disease
    Reisa Sperling
    Center for Alzheimer Research and Treatment, Brigham and Women s Hospital, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA
    Neurobiol Aging 32:S37-43. 2011
  4. ncbi Amyloid-related imaging abnormalities in patients with Alzheimer's disease treated with bapineuzumab: a retrospective analysis
    Reisa Sperling
    Center for Alzheimer Research and Treatment, Brigham and Women s Hospital, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Lancet Neurol 11:241-9. 2012
  5. ncbi Amyloid-related imaging abnormalities in amyloid-modifying therapeutic trials: recommendations from the Alzheimer's Association Research Roundtable Workgroup
    Reisa A Sperling
    Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women s Hospital, Boston, MA, USA
    Alzheimers Dement 7:367-85. 2011
  6. ncbi Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
    Reisa A Sperling
    Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Alzheimers Dement 7:280-92. 2011
  7. ncbi Regional magnetic resonance imaging lesion burden and cognitive function in multiple sclerosis: a longitudinal study
    R A Sperling
    Memory Disorders Unit, Brigham and Women s Hospital, 221 Longwood Ave, Boston, MA 02115, USA
    Arch Neurol 58:115-21. 2001
  8. ncbi Functional alterations in memory networks in early Alzheimer's disease
    Reisa A Sperling
    Department of Neurology, Center for Alzheimer s Research and Treatment, Brigham and Women s Hospital, 221 Longwood Avenue, Boston, MA 02115, USA
    Neuromolecular Med 12:27-43. 2010
  9. ncbi Amyloid deposition is associated with impaired default network function in older persons without dementia
    Reisa A Sperling
    Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Neuron 63:178-88. 2009
  10. ncbi Functional MRI studies of associative encoding in normal aging, mild cognitive impairment, and Alzheimer's disease
    Reisa Sperling
    Department of Neurology, Memory Disorders Unit, Brigham and Women s Hospital, Alzheimer s Disease Research Center, Boston, MA 02215, USA
    Ann N Y Acad Sci 1097:146-55. 2007

Research Grants

  1. Evolution of memory-related fMRI activation over the course of MCI and AD
    Reisa Sperling; Fiscal Year: 2007
  2. Evolution of memory-related fMRI activation over the course of MCI and AD
    Reisa A Sperling; Fiscal Year: 2010

Detail Information

Publications23

  1. ncbi Preclinical Alzheimer disease-the challenges ahead
    Reisa A Sperling
    Center for Alzheimer Research and Treatment, Departments of Neurology, Brigham and Women s Hospital and Massachusetts General Hospital, Harvard Medical School, 221 Longwood Avenue Boston, MA 02115, USA
    Nat Rev Neurol 9:54-8. 2013
    ..A number of challenges remain to be overcome before this concept can be validated and translated into clinical practice...
  2. ncbi Amyloid deposition detected with florbetapir F 18 ((18)F-AV-45) is related to lower episodic memory performance in clinically normal older individuals
    Reisa A Sperling
    Center for Alzheimer Research and Treatment, Departments of Neurology, Brigham and Women s Hospital and Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Neurobiol Aging 34:822-31. 2013
    ..Longitudinal follow-up is ongoing to determine whether (18)F-AV-45 may also predict subsequent cognitive decline...
  3. ncbi Potential of functional MRI as a biomarker in early Alzheimer's disease
    Reisa Sperling
    Center for Alzheimer Research and Treatment, Brigham and Women s Hospital, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA
    Neurobiol Aging 32:S37-43. 2011
    ....
  4. ncbi Amyloid-related imaging abnormalities in patients with Alzheimer's disease treated with bapineuzumab: a retrospective analysis
    Reisa Sperling
    Center for Alzheimer Research and Treatment, Brigham and Women s Hospital, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Lancet Neurol 11:241-9. 2012
    ..Our aim was to investigate the incidence of ARIA during treatment with bapineuzumab, and evaluate associated risk factors...
  5. ncbi Amyloid-related imaging abnormalities in amyloid-modifying therapeutic trials: recommendations from the Alzheimer's Association Research Roundtable Workgroup
    Reisa A Sperling
    Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women s Hospital, Boston, MA, USA
    Alzheimers Dement 7:367-85. 2011
    ..The workgroup proposes recommendations for the detection and monitoring of ARIA in ongoing AD clinical trials, as well as directions for future research...
  6. ncbi Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
    Reisa A Sperling
    Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Alzheimers Dement 7:280-92. 2011
    ....
  7. ncbi Regional magnetic resonance imaging lesion burden and cognitive function in multiple sclerosis: a longitudinal study
    R A Sperling
    Memory Disorders Unit, Brigham and Women s Hospital, 221 Longwood Ave, Boston, MA 02115, USA
    Arch Neurol 58:115-21. 2001
    ..To investigate the relationship between magnetic resonance imaging regional lesion burden and cognitive performance in multiple sclerosis (MS) over a 4-year follow-up period...
  8. ncbi Functional alterations in memory networks in early Alzheimer's disease
    Reisa A Sperling
    Department of Neurology, Center for Alzheimer s Research and Treatment, Brigham and Women s Hospital, 221 Longwood Avenue, Boston, MA 02115, USA
    Neuromolecular Med 12:27-43. 2010
    ..Research is ongoing to determine if these early network alterations will serve as sensitive predictors of clinical decline, and eventually, as markers of pharmacological response to potential disease-modifying treatments for AD...
  9. ncbi Amyloid deposition is associated with impaired default network function in older persons without dementia
    Reisa A Sperling
    Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Neuron 63:178-88. 2009
    ....
  10. ncbi Functional MRI studies of associative encoding in normal aging, mild cognitive impairment, and Alzheimer's disease
    Reisa Sperling
    Department of Neurology, Memory Disorders Unit, Brigham and Women s Hospital, Alzheimer s Disease Research Center, Boston, MA 02215, USA
    Ann N Y Acad Sci 1097:146-55. 2007
    ..Further studies to validate fMRI in these populations are needed, particularly longitudinal studies to investigate the pattern of alterations in functional activity over the course of prodromal AD and the relationship to AD pathology...
  11. ncbi Encoding novel face-name associations: a functional MRI study
    R A Sperling
    Department of Neurology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Hum Brain Mapp 14:129-39. 2001
    ..These data suggest that the process of forming new face-name associations is supported by a distributed network of brain regions, and provide additional evidence for the essential role of the hippocampus in associative memory processes...
  12. ncbi Functional MRI detection of pharmacologically induced memory impairment
    Reisa Sperling
    Massachusetts General Hospital, Boston, MA 02129, USA
    Proc Natl Acad Sci U S A 99:455-60. 2002
    ....
  13. ncbi fMRI studies of associative encoding in young and elderly controls and mild Alzheimer's disease
    R A Sperling
    Memory Disorders Unit, Department of Neurology, Brigham and Women s Hospital, 221 Longwood Avenue, Boston, MA 02115, USA
    J Neurol Neurosurg Psychiatry 74:44-50. 2003
    ..To examine alterations in patterns of brain activation seen in normal aging and in mild Alzheimer's disease by functional magnetic resonance imaging (fMRI) during an associative encoding task...
  14. ncbi Putting names to faces: successful encoding of associative memories activates the anterior hippocampal formation
    Reisa Sperling
    Center for Neurocognitive Studies, Department of Neurology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Neuroimage 20:1400-10. 2003
    ....
  15. ncbi Testing the right target and right drug at the right stage
    Reisa A Sperling
    Center for Alzheimer Research and Treatment, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02446, USA
    Sci Transl Med 3:111cm33. 2011
    ..So why do we keep testing drugs aimed at the initial stages of the disease process in patients at the end-stage of the illness?..
  16. ncbi Hippocampal hyperactivation associated with cortical thinning in Alzheimer's disease signature regions in non-demented elderly adults
    Deepti Putcha
    Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 31:17680-8. 2011
    ....
  17. ncbi Longitudinal changes in white matter disease and cognition in the first year of the Alzheimer disease neuroimaging initiative
    Owen Carmichael
    Department of Neurology, School of Medicine, University of California, Davis, CA, USA
    Arch Neurol 67:1370-8. 2010
    ....
  18. ncbi Reliability of functional magnetic resonance imaging associative encoding memory paradigms in non-demented elderly adults
    Deepti Putcha
    Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Hum Brain Mapp 32:2027-44. 2011
    ....
  19. ncbi Two macroscopic and microscopic brain imaging studies of human hippocampus in early Alzheimer's disease and schizophrenia research
    Nicholas Lange
    Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    Stat Med 23:327-50. 2004
    ....
  20. ncbi Increased T cell reactivity to amyloid beta protein in older humans and patients with Alzheimer disease
    Alon Monsonego
    Center for Neurologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts 02115, USA
    J Clin Invest 112:415-22. 2003
    ....
  21. ncbi Mapping the road forward in Alzheimer's disease
    David M Holtzman
    Department of Neurology, Washington University, St Louis, MO 63110, USA
    Sci Transl Med 3:114ps48. 2011
    ..We hope these recommendations will boost research progress in AD and increase the likelihood of developing effective therapies in the near future...
  22. ncbi The role of neuroimaging in elucidating delirium pathophysiology
    David C Alsop
    Department of Radiology, Ansin 226, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Gerontol A Biol Sci Med Sci 61:1287-93. 2006
    ....
  23. ncbi Pro: Can biomarkers be gold standards in Alzheimer's disease?
    Reisa Sperling
    Brigham and Women s Hospital, Massachusetts General Hospital, Harvard Medical School, Longwood Avenue Boston, MA 02115, USA
    Alzheimers Res Ther 2:17. 2010
    ....

Research Grants5

  1. Evolution of memory-related fMRI activation over the course of MCI and AD
    Reisa Sperling; Fiscal Year: 2007
    ..The proposed research will provide essential validation studies for fMRI as a biomarker in AD clinical trials, and enhance our fundamental understanding of the early pathophysiological alterations in AD. ..
  2. Evolution of memory-related fMRI activation over the course of MCI and AD
    Reisa A Sperling; Fiscal Year: 2010
    ..The proposed research will provide essential validation studies for fMRI as a biomarker in AD clinical trials, and enhance our fundamental understanding of the early pathophysiological alterations in AD. ..