Kevin M Spencer

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Visual gamma oscillations in schizophrenia: implications for understanding neural circuitry abnormalities
    Kevin M Spencer
    Department of Psychiatry, VA Boston Healthcare System, Brocton, Massachusetts, USA
    Clin EEG Neurosci 39:65-8. 2008
  2. pmc Baseline gamma power during auditory steady-state stimulation in schizophrenia
    Kevin M Spencer
    Research Service, Veterans Affairs Boston Healthcare System Boston, MA, USA
    Front Hum Neurosci 5:190. 2011
  3. pmc Gamma-band auditory steady-state responses are impaired in first episode psychosis
    Kevin M Spencer
    Department of Psychiatry, VA Boston Healthcare System and Harvard Medical School, Brockton 02301, USA
    Biol Psychiatry 64:369-75. 2008
  4. pmc Sensory-evoked gamma oscillations in chronic schizophrenia
    Kevin M Spencer
    Department of Psychiatry, VA Boston Healthcare System, Harvard Medical School, Brockton, Massachusetts 02301, USA
    Biol Psychiatry 63:744-7. 2008
  5. pmc Hemispheric biases and the control of visuospatial attention: an ERP study
    Kevin M Spencer
    Department of Psychiatry, Harvard Medical School, VA Boston Healthcare System, Brockton, Massachusetts, USA
    BMC Neurosci 6:51. 2005
  6. pmc Left auditory cortex gamma synchronization and auditory hallucination symptoms in schizophrenia
    Kevin M Spencer
    Research Service, Veterans Affairs Boston Healthcare System and Department of Psychiatry, Harvard Medical School, Research 151C, 150 S, Huntington Ave, Boston, MA 02130, USA
    BMC Neurosci 10:85. 2009
  7. pmc Enhanced facilitation of spatial attention in schizophrenia
    Kevin M Spencer
    Veterans Affairs Boston Healthcare System Harvard Medical School, Research 151C, 150 S Huntington Avenue, Boston, MA 02130, USA
    Neuropsychology 25:76-85. 2011
  8. pmc Functional and structural deficits in brain regions subserving face perception in schizophrenia
    Toshiaki Onitsuka
    Department of Psychiatry, VA Boston Healthcare System, Brockton Division, Harvard Medical School, Brockton, MA 02301, USA
    Am J Psychiatry 163:455-62. 2006
  9. pmc Attentional networks and cingulum bundle in chronic schizophrenia
    Paul G Nestor
    Department of Psychology, University of Massachusetts, Boston, MA 02125 3393, USA
    Schizophr Res 90:308-15. 2007
  10. doi request reprint Early and late stages of visual processing in individuals in prodromal state and first episode schizophrenia: an ERP study
    Naoya Oribe
    Clinical Neuroscience Division, Laboratory of Neuroscience, VA Boston Healthcare System Brockton Division, Department of Psychiatry, Harvard Medical School, Brockton, MA, United States
    Schizophr Res 146:95-102. 2013

Research Grants

  1. An EEG Study of Neural Dynamics in Schizophrenia
    Kevin Spencer; Fiscal Year: 2006

Detail Information

Publications29

  1. ncbi request reprint Visual gamma oscillations in schizophrenia: implications for understanding neural circuitry abnormalities
    Kevin M Spencer
    Department of Psychiatry, VA Boston Healthcare System, Brocton, Massachusetts, USA
    Clin EEG Neurosci 39:65-8. 2008
    ..The relationships between these abnormalities and neural circuitry abnormalities in schizophrenia are discussed...
  2. pmc Baseline gamma power during auditory steady-state stimulation in schizophrenia
    Kevin M Spencer
    Research Service, Veterans Affairs Boston Healthcare System Boston, MA, USA
    Front Hum Neurosci 5:190. 2011
    ..These baseline increases could be the sign of NMDAR hypofunction on parvalbumin-expressing inhibitory interneurons, which would be consistent with acute NMDAR antagonism and genetic ablation models of schizophrenia...
  3. pmc Gamma-band auditory steady-state responses are impaired in first episode psychosis
    Kevin M Spencer
    Department of Psychiatry, VA Boston Healthcare System and Harvard Medical School, Brockton 02301, USA
    Biol Psychiatry 64:369-75. 2008
    ..Here we examined whether gamma ASSR deficits are also present at first hospitalization for psychosis...
  4. pmc Sensory-evoked gamma oscillations in chronic schizophrenia
    Kevin M Spencer
    Department of Psychiatry, VA Boston Healthcare System, Harvard Medical School, Brockton, Massachusetts 02301, USA
    Biol Psychiatry 63:744-7. 2008
    ..We investigated these issues by examining the VGO and AGO in chronic schizophrenic (SZ) and matched healthy control (HC) subjects...
  5. pmc Hemispheric biases and the control of visuospatial attention: an ERP study
    Kevin M Spencer
    Department of Psychiatry, Harvard Medical School, VA Boston Healthcare System, Brockton, Massachusetts, USA
    BMC Neurosci 6:51. 2005
    ....
  6. pmc Left auditory cortex gamma synchronization and auditory hallucination symptoms in schizophrenia
    Kevin M Spencer
    Research Service, Veterans Affairs Boston Healthcare System and Department of Psychiatry, Harvard Medical School, Research 151C, 150 S, Huntington Ave, Boston, MA 02130, USA
    BMC Neurosci 10:85. 2009
    ..A 5-dipole model was fit from the HC grand average ASSR, with 2 pairs of superior temporal dipoles and a deep midline dipole. Time-frequency decomposition was performed on the scalp EEG and source data...
  7. pmc Enhanced facilitation of spatial attention in schizophrenia
    Kevin M Spencer
    Veterans Affairs Boston Healthcare System Harvard Medical School, Research 151C, 150 S Huntington Avenue, Boston, MA 02130, USA
    Neuropsychology 25:76-85. 2011
    ..We tested this hypothesis with orienting tasks involving the cued detection of a laterally presented target stimulus...
  8. pmc Functional and structural deficits in brain regions subserving face perception in schizophrenia
    Toshiaki Onitsuka
    Department of Psychiatry, VA Boston Healthcare System, Brockton Division, Harvard Medical School, Brockton, MA 02301, USA
    Am J Psychiatry 163:455-62. 2006
    ....
  9. pmc Attentional networks and cingulum bundle in chronic schizophrenia
    Paul G Nestor
    Department of Psychology, University of Massachusetts, Boston, MA 02125 3393, USA
    Schizophr Res 90:308-15. 2007
    ..In addition, left CB fractional anisotropy correlated significantly with orienting of attention. Smaller right CB volume also correlated with reduced alertness, but not when covarying for medication and illness duration...
  10. doi request reprint Early and late stages of visual processing in individuals in prodromal state and first episode schizophrenia: an ERP study
    Naoya Oribe
    Clinical Neuroscience Division, Laboratory of Neuroscience, VA Boston Healthcare System Brockton Division, Department of Psychiatry, Harvard Medical School, Brockton, MA, United States
    Schizophr Res 146:95-102. 2013
    ..Therefore, in this study, we measured the P300 component as well as the P1/N1 in a visual oddball paradigm in prodromal subjects and first episode schizophrenia patients, and compared them with those of healthy controls...
  11. pmc Predicting inter-hemispheric transfer time from the diffusion properties of the corpus callosum in healthy individuals and schizophrenia patients: a combined ERP and DTI study
    Thomas J Whitford
    Psychiatry Neuroimaging Laboratory, Brigham and Women s Hospital, HarvardMedical School, Boston, MA 02215, USA
    Neuroimage 54:2318-29. 2011
    ..The present study investigated whether or not these IHTT abnormalities could be underpinned by structural damage to the visual fibers of the corpus callosum...
  12. pmc Neural synchrony indexes disordered perception and cognition in schizophrenia
    Kevin M Spencer
    Department of Psychiatry, Veterans Affairs Boston Healthcare System, Harvard Medical School, Psychiatry 116A, 940 Belmont Street, Brockton, MA 02301, USA
    Proc Natl Acad Sci U S A 101:17288-93. 2004
    ..These data provide support for linking dysfunctional neural circuitry and the core symptoms of schizophrenia...
  13. pmc Abnormal neural synchrony in schizophrenia
    Kevin M Spencer
    Department of Psychiatry, Harvard Medical School Veterans Affairs Boston Healthcare System, Brockton, Massachusetts 02301, USA
    J Neurosci 23:7407-11. 2003
    ..These findings support the hypothesis that schizophrenia is associated with impaired neural circuitry demonstrated as a failure of gamma band synchronization, especially in the 40 Hz range...
  14. pmc Clinical high risk and first episode schizophrenia: auditory event-related potentials
    Elisabetta C Del Re
    VA Boston Healthcare System, Brockton, MA, USA Department of Psychiatry, Harvard Medical School, Boston, MA, USA Psychiatry Neuroimaging Laboratory, Department of Psychiatry and Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA Electronic address
    Psychiatry Res 231:126-33. 2015
    ..Nonetheless, in logistic regression, only the P3a and N100 distinguished CHR and FESZ from healthy controls, suggesting that ERPs not associated with an overt task might be more sensitive to prediction of group membership. ..
  15. pmc Electrophysiological assessment of auditory stimulus-specific plasticity in schizophrenia
    Ryan P Mears
    Research Service, VA Boston Healthcare System, Department of Psychiatry, Harvard Medical School, Boston, MA 02130, USA
    Biol Psychiatry 71:503-11. 2012
    ..We used event-related brain potentials (ERPs) to assay neuroplasticity after auditory conditioning in chronic schizophrenia patients (SZ) and matched healthy control subjects (HC)...
  16. pmc Long-range synchrony of γ oscillations and auditory hallucination symptoms in schizophrenia
    C Mulert
    Department of Psychiatry, VA Boston Healthcare System and Harvard Medical School, Massachusetts, USA
    Int J Psychophysiol 79:55-63. 2011
    ..These results suggest that long-range synchrony of gamma oscillations is disturbed in schizophrenia and that this deficit is related to clinical symptoms such as auditory hallucinations...
  17. doi request reprint Spontaneous Gamma Activity in Schizophrenia
    Yoji Hirano
    Neural Dynamics Laboratory, Research Service, Veterans Affairs Boston Healthcare System, Boston, Massachusetts2Department of Psychiatry, Harvard Medical School, Boston, Massachusetts3Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyus
    JAMA Psychiatry 72:813-21. 2015
    ..Animal models of SZ based on hypofunction of the N-methyl-d-aspartate receptor (NMDAR) demonstrate increased spontaneous broadband gamma power, but this phenomenon has not been identified clearly in patients with SZ...
  18. pmc Neurophysiological studies of auditory verbal hallucinations
    Judith M Ford
    Psychiatry Service, San Francisco Veterans Affairs Medical Center, Department of Psychiatry, University of California, San Francisco, CA, USA
    Schizophr Bull 38:715-23. 2012
    ..These problems are common to studies of other psychiatric symptoms and should be considered when attempting to understand the basic neural mechanisms responsible for them...
  19. ncbi request reprint Abnormal asymmetry of the face n170 repetition effect in male patients with chronic schizophrenia
    Toshiaki Onitsuka
    Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Boston VA Healthcare System, Brockton Division and Harvard Medical School, Brockton, MA, USA
    Brain Imaging Behav 3:240-5. 2009
    ..01), whereas healthy subjects showed a significant decrease at the right occipitotemporal electrode (t[12] = 2.36, p = 0.04). These results suggest abnormal asymmetry of the N170 face repetition effect in schizophrenia...
  20. pmc The genetic and environmental influences of event-related gamma oscillations on bipolar disorder
    Mei Hua Hall
    Psychology Research Laboratory, Harvard Medical School, McLean Hospital Research Service, Boston, MA, USA
    Bipolar Disord 13:260-71. 2011
    ..The present study aimed to examine whether GBRs derived from two auditory tasks, the oddball task and the dual-click paradigm, are potential BPD endophenotypes...
  21. pmc Abnormal pitch mismatch negativity in individuals with schizotypal personality disorder
    Margaret A Niznikiewicz
    VA Boston Healthcare System Boston VA Healthcare System, Jamaica Plain VA and Brockton VA campuses, United States
    Schizophr Res 110:188-93. 2009
    ..Biological Psychiatry (2006); 59(8):762-772], in recent onset schizophrenia patients. To our knowledge no reports exist of MMN in SPD individuals...
  22. pmc Frontal P3 event-related potential is related to brain glutamine/glutamate ratio measured in vivo
    Mei Hua Hall
    Psychotic Disorders Division, McLean Hospital, Harvard Medical School, Belmont, MA 02452, USA Psychosis Neurobiology Laboratory, McLean Hospital, Harvard Medical School, Belmont, MA 02452, USA Electronic address
    Neuroimage 111:186-91. 2015
    ....
  23. pmc Genomewide association analyses of electrophysiological endophenotypes for schizophrenia and psychotic bipolar disorders: A preliminary report
    Mei Hua Hall
    Department of Psychiatry Psychotic Disorders Division, McLean Hospital, Harvard Medical School, Boston, Massachusetts Department of Psychiatry Psychosis Neurobiology Laboratory, McLean Hospital, Harvard Medical School, Boston, Massachusetts Psychiatric and Neurodevelopmental Genetics Unit Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts
    Am J Med Genet B Neuropsychiatr Genet 168:151-61. 2015
    ..Among patients with psychotic illness, PRS results indicated genetic overlap between SCZ loci and gamma oscillation and between BIP loci and P3 amplitude. © 2015 Wiley Periodicals, Inc. ..
  24. pmc Neurophysiological biomarkers for drug development in schizophrenia
    Daniel C Javitt
    Nathan Kline Institute for Schizophrenia Research New York University School of Medicine, 140 Old Orangeburg Road, Orangeburg, New York 10962, USA
    Nat Rev Drug Discov 7:68-83. 2008
    ..Moreover, many of these neurophysiological processes are phylogenetically conserved and can be modelled in preclinical studies, offering unique opportunities for use as translational biomarkers in schizophrenia drug discovery...
  25. ncbi request reprint Localization of the event-related potential novelty response as defined by principal components analysis
    Joseph Dien
    Department of Psychology, University of Illinois, Urbana Champaign, IL, USA
    Brain Res Cogn Brain Res 17:637-50. 2003
    ..Source modeling on 129-channel data with BESA and BrainVoyager suggests the P300 has sources in the temporal-parietal junction whereas the Novelty P3 has sources in the anterior cingulate...
  26. ncbi request reprint The influence of stimulus deviance and novelty on the P300 and novelty P3
    Abraham Goldstein
    Department of Psychology, Bar Ilan University, Ramat Gan, Israel
    Psychophysiology 39:781-90. 2002
    ....
  27. ncbi request reprint Parsing the late positive complex: mental chronometry and the ERP components that inhabit the neighborhood of the P300
    Joseph Dien
    Department of Psychology, University of Illinois, Urbana Champaign, Urbana, USA
    Psychophysiology 41:665-78. 2004
    ..Conceptually, we dispute the proposed distinction between stimulus evaluation and response selection. We suggest a four-stage ERP model of information processing and place the P3a and the P300 in this framework...

Research Grants1

  1. An EEG Study of Neural Dynamics in Schizophrenia
    Kevin Spencer; Fiscal Year: 2006
    ..This project seeks to further this goal by studying how brainwave synchronization is related to perception and thinking in people who are healthy, and in people who have schizophrenia. [unreadable] [unreadable] [unreadable]..